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4-Nitro-1,3-Xylene

    • Product Name 4-Nitro-1,3-Xylene
    • Alias 1,3-Dimethyl-4-nitrobenzene
    • Einecs 210-822-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    831008

    Chemicalname 4-Nitro-1,3-Xylene
    Casnumber 6278-45-1
    Molecularformula C8H9NO2
    Molecularweight 151.17 g/mol
    Appearance Yellow crystalline solid
    Meltingpoint 62-64°C
    Boilingpoint 272°C
    Density 1.16 g/cm3
    Solubilityinwater Insoluble
    Flashpoint 120°C
    Smiles CC1=CC(=CC(=C1)C)[N+](=O)[O-]
    Synonyms 4-Nitro-m-xylene
    Pubchemcid 28178

    As an accredited 4-Nitro-1,3-Xylene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 500 mL, sealed with a screw cap, labeled with chemical name, CAS number, hazard warnings, and supplier details.
    Shipping **Shipping Description (50 words):** 4-Nitro-1,3-Xylene should be shipped in tightly sealed containers, protected from light, moisture, and heat. Label packaging according to hazardous chemical regulations (UN 1663, Toxic Solid, Organic, N.O.S.). Use secondary containment, provide proper documentation, and ensure all handlers use appropriate personal protective equipment (PPE). Follow all relevant transport regulations and guidelines.
    Storage 4-Nitro-1,3-xylene should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of heat, ignition, and incompatible materials such as strong oxidizers. Protect from direct sunlight and moisture. Ensure proper labeling and keep away from food and drink. Use appropriate containment to prevent environmental contamination in case of leaks or spills.
    Application of 4-Nitro-1,3-Xylene

    Applications of 4-Nitro-1,3-Xylene in Industrial Manufacturing

    4-Nitro-1,3-xylene acts as a niche intermediate in multiple chemical sectors, providing targeted value in specific synthesis routes where precise aromatic substitution is needed. Below are key application paths based on current downstream industry settings, using actual process scenarios and compliance protocols.

    1. Dye Intermediates Manufacturing

    Major dyestuff manufacturers use this compound to produce specialty azo and anthraquinone dyes. It becomes a crucial functional group donor during nitration, condensation, or reduction steps, supporting chromophore construction in colorant synthesis lines. Integration occurs where controlled substitution at xylene positions is required for intermediate dye molecules, ensuring purity in final shades for polymers, textiles, and plastics. Quality management and process optimization remain central due to color performance specifications demanded by end-users and regulatory authorities.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • OEKO-TEX® Standard 100 for textile colorants
    • ISO 9001:2015 Quality Management for chemical synthesis
    • ZDHC Manufacturing Restricted Substances List (MRSL)

    Typical usage ratio

    • Applied at 8-18% wt basis in intermediate synthesis; exact quantities vary with target dye structure and intended shade depth.

    Downstream process integration

    • Sequential aromatic substitution during base preparation.
    • Nitration followed by reduction for amino dye intermediates.
    • Condensation with sulfonating agents for water-soluble dyes.
    • Pigment precursor modification before final pulverization.

    Final product types

    • Azo reactive dyes for cellulosic fibers
    • PVC and PET-compatible pigment dispersions
    • Anthraquinone dyes for acrylic textile processing
    • Special application colorants for plastic masterbatches

    2. Agrochemical Active Ingredient Synthesis

    Select agrochemical operations utilize 4-nitro-1,3-xylene as part of manufacturing herbicide intermediates and regulated active compounds such as substituted phenoxyalcanoic acids. It enters the process as a nitro-aromatic donor, facilitating halogenation or amination in multipurpose synthesis blocks. The input is particularly valued where controlled aromatic nitro group positioning enables downstream substitution with strict impurity control for product safety and regulatory clearance in crop protection chemicals.

    Industry compliance standards

    • European Union Plant Protection Products Regulation (EC) No 1107/2009
    • FAO/WHO JMPR specifications and guidelines
    • ISO 17025-certified analytical testing protocols
    • Chinese GB 2763-2021 pesticide residue standards

    Typical usage ratio

    • Utilized between 4.5-11% by weight of the intermediate batch, with adjustment based on yield, impurity threshold, and target substitution level.

    Downstream process integration

    • Nitration/halogenation step in herbicide precursor synthesis
    • Base-catalyzed amination in active ester preparation
    • Multi-step reduction to amino derivatives
    • Final formulation QC before packaging and regulatory submission

    Final product types

    • Pyridine- or benzimidazole-based herbicide actives
    • Pre-emergent selective weed control granules
    • Microencapsulated agrochemicals for precision spraying
    • Soluble concentrate crop protection agents

    3. Pharmaceutical Intermediate Production

    Pharmaceutical chemical enterprises apply 4-nitro-1,3-xylene as a tightly specified intermediate to develop select bulk actives and key intermediates for non-steroidal anti-inflammatory drugs or specialty APIs. It finds principal use in nitro-to-amino transformations, where regiospecific substitution is essential. Controlled process filtration and validated impurity profiling remain mandatory, as these steps affect patient safety and ultimate regulatory approval. The raw material enters at a defined stage of multi-step synthesis, often ahead of cyclization or condensation routes that form the active pharmacophore.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monograph guidance
    • 21 CFR Part 211, US FDA cGMP for finished pharmaceuticals
    • WHO TRS 986 Annex 2 for API quality

    Typical usage ratio

    • Ranges from 3–9% in target intermediate steps; precise input varies with synthesis scale and route yield optimization.

    Downstream process integration

    • Applied during initial nitro reduction to key amines
    • Substituted xylene building block for core API synthesis
    • In-situ purification prior to main pharmacopeial transformation step
    • Monitored via HPLC or GC for trace impurities and byproducts

    Final product types

    • Pain relief API precursor intermediates
    • Custom fine chemicals for generics production
    • Bulk active intermediates for non-steroidal pharmaceuticals
    • Building blocks for heterocyclic medicinal molecules

    4. Specialty Polymer Additive Synthesis

    Advanced plastics and polymer industries use the material during the synthesis of high-performance additives, such as UV absorbers, antioxidants, and flame retardant intermediates. The nitro-aromatic configuration enables subsequent reduction and coupling protocols to prepare tailored additive precursors, with attention to chain compatibility and stability during high-temperature processing. Input management ensures the correct functional group delivery on aromatic rings, where minor contamination or positional error can impact polymer color, UV stability, and end-use performance in demanding environments.

    Industry compliance standards

    • EU Regulation (EU) No 10/2011 on plastic materials and articles
    • UL 94 standards for polymer additives’ flame retardancy
    • ASTM D4976 for polyethylene additives
    • ISO 14001 environmental management in additive processing

    Typical usage ratio

    • Blended at 2–6% mass fraction of additive synthesis batches; modified according to end polymer matrix and pigment requirements.

    Downstream process integration

    • Enters at aromatic coupling or reductive amination steps
    • Functions as a precursor for UV-active compounds
    • Processed through melt-phase or solution polymer additive production
    • Controlled QC sampling prior to polymer compounding

    Final product types

    • Light stabilizer additive packages for automotive plastics
    • Flame retardant intermediates for cable insulation
    • Polyolefin-compatible antioxidant blends
    • Masterbatch additives for construction materials

    5. Chemical Research and Custom Synthesis

    Specialty research organizations and custom synthesis firms rely on 4-nitro-1,3-xylene when constructing novel aromatic compounds for high-value applications in fields such as advanced materials, electronic chemicals, and synthetic organic chemistry. Scale ranges from gram-scale R&D projects to pilot-scale manufacturing where structure-activity relationships and substituent positioning require tight control. Analytical documentation, multi-method purity testing, and risk assessments form integral parts of these projects to maintain traceability and reproducibility in result validation for downstream partners and customers.

    Industry compliance standards

    • ISO/IEC 17025 laboratory competence
    • GLP (Good Laboratory Practice) for chemical synthesis
    • Certified reference material (CRM) traceability
    • Material safety compliance as per GHS/CLP regulations

    Typical usage ratio

    • Depends on strict target molecule requirements; may range from 1–10% as a core structure depending on synthesis chain length and complexity.

    Downstream process integration

    • Used in model compound synthesis for academic/industrial validation
    • Component in lead compound development in preclinical research
    • Synthesis step in structure-activity relationship (SAR) studies
    • Integrated into flow chemistry or microreactor systems for scalable evaluation

    Final product types

    • Custom specialty intermediates for electronic materials
    • Molecular probes for analytical chemistry
    • Synthetic standards for spectroscopy
    • Research-grade ligands for coordination chemistry
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    Certification & Compliance
    More Introduction

    4-Nitro-1,3-Xylene: Reliability and Performance from Raw Synthesis to Finished Applications

    Our Direct Experience with 4-Nitro-1,3-Xylene Production

    Manufacturing 4-Nitro-1,3-Xylene requires more than just accurate dosing of nitrating agents and controlled reaction temperatures. Over the years, the development journey in our plant taught us the significance of establishing firm process controls. Even minor deviations can trigger domino effects: increased impurity levels or changes in isomer purity alter its reactivity downstream. We maintain a fixed-grade standard, as consistent quality means easier downstream performance for formulators and users. Typical batches from our reactors range from pale yellow to light brown crystals, each lot certified to fall within a defined melting point range that solution chemists recognize for purity.

    Unlike smaller traders or resellers who shuffle drums around, our engagement with 4-Nitro-1,3-Xylene anchors at the reactor floor and follows through all the way to final packaging. We see each batch right through graining, drying, and packaging, so our team witnesses how minute changes in nitration temperature or solvent management impact everything, from filter cake consistency to product recovery yields. It takes hands-on time with each stage to consistently avoid clumping, off-odors, or batches that resist standard solution in organic solvents.

    Technical Snapshots From the Source

    In-house, we've determined that our typical 4-Nitro-1,3-Xylene (CAS: 607-89-6) contains less than 0.5% total other isomers, giving blenders and functional teams a direct route to predictable reactions. The melting point controls help customers relying on solid form have confidence in their formulations, whether used for dye synthesis, agri-intermediates, or advanced material science. Since our plant uses closed-system solvent recovery, those working in sensitive environments receive product that does not shadow batch-to-batch solvent residues or trace contaminants.

    Bulk deliveries run from fiber drum, lined intermediate bulk containers to specialized stainless tanker trucks. For those scaling up, each variant shows how our logistical chain, rooted in physical process, reduces the headaches that rear up with inconsistent upstream supply. The focus is always on chemical transparency, so that handlers and downstream process chemists gain access to current batch certificates, impurity profiles, and analytical backup rather than guesswork.

    Functionality Born in the Reactor, Delivered Without Shortcuts

    Every chemical we deliver reflects hundreds of hours at the reactor, tweaking parameters until each crystallization profile lines up with reactivity needs. For 4-Nitro-1,3-Xylene, the nitro group sitting at the para position on the aromatic ring, alongside the two methyls, shapes its behavior as both a building block and an end-use intermediate. In dye manufacture, for example, a small swing in para positioning alters shade tone or downstream conversion yield. No paperwork or third-layer trading rep can cover up for sporadic isomer distribution or unmonitored nitration sources.

    Taking all this together, those in the advanced materials sector, colorant backbone synthesis, or specialized resins turn to direct producers for predictable kinetic data. Our records show that batches avoiding thermal runaways or uneven acid addition offer improved conversion with less spending on side-product neutralization—giving buyers more than technical comfort, but cost stability over time.

    Real-World Benefits That Come from Manufacturing at Scale

    In direct operations, we confront daily the tension between plant efficiency, operator safety, and product quality. Each 4-Nitro-1,3-Xylene lot we approve bridges these needs. By integrating process automation at nitration charging and temperature monitoring, the entire chain benefits: downstream chemists receive product with narrow melting point spread and less mixed isomer load, environmental managers see fewer off-spec byproducts, and plant safety leads cut down on unplanned evacuations.

    Dye and pigment manufacturers, in particular, have worked side-by-side with us to optimize the grade for their coupling and diazotization reactions. We see each design change in our own analytics: batches that fail to meet absorbance or colorimetric targets hold us accountable. This is a long cycle of feedback, built on direct dialogue with users, which resellers and brokers simply cannot match. There are no shortcuts to learning how humidity or grain size or residual water content affect the thermal load in high-throughput dye plants—these are issues we confront, solve, and track in every shipping batch.

    What Sets Our 4-Nitro-1,3-Xylene Apart from Other Nitroaromatics

    On the surface, 4-Nitro-1,3-Xylene shares an aromatic core with other similar compounds, but it's the placement of functional groups—and the purity we pursue—that marks the real difference. Every biweekly plant run shows us how precision in para-nitration unlocks different reactivity profiles than meta-substituted or ortho analogs. Users dealing in technical dyes or targeted organic syntheses immediately feel the difference: cleaner reactions, improved throughput, and easier downstream purification.

    Chemical life does not settle for abstract grades. Standard 2-nitro or 3-nitro variants introduce inconsistencies at coupling points and can slow purification. From our records, handling applications inside color-imparting intermediates or stepwise pharmaceutical chains, mismatched isomer content means missed process windows and wasted batch time. Chemists value the uniformity and batch stability that direct manufacturing brings, measured not just in purity but in real process simplicity. We focus on pushing aside the guesswork, for customers who run time-critical or cost-intensive plants.

    Usage and Application Lessons Learned from Real Process

    4-Nitro-1,3-Xylene stands out in roles ranging from dye precursor to tailored organic synthesis. Over the decades, feedback from our partners has guided us. Pigment groups rely on its robust electrophilic substitution behavior, with the para-nitro group enabling tighter control over coupling yields and color balance. The compound's unique substitution pattern fits specialty resin blends and polymer additives, where batch homogeneity is essential for resin clarity and pigment dispersion.

    In agricultural synthesis, seasonality often demands tight delivery schedules. A deep understanding of plant process windows helps us align reactor output to harvest-driven spikes: farmers and agrochemical companies depend on a stable feed of intermediates, not volatile quality swings. By controlling our own stocks, and skipping reselling layers, we provide on-time shipment with grade consistency tracked by batch records, not guesses.

    Because makers of specialty chemicals push formula boundaries, we've fielded requests for modifications in drying, filtration, or packaging based on end-application requirements. Years of in-plant support taught us that no two customers use 4-Nitro-1,3-Xylene in quite the same way: some want anhydrous lots, others seek specific crystal morphology for better blending. By adapting during production rather than juggling finished goods inventory, we keep these end-users ahead of schedule, with fewer rejects and process stops.

    Continuous Improvement and Commitment to End User Needs

    Our approach has always been to anchor operations in open dialogue. Each time a customer experiences off-target color in a dye run or instability in polymer blends, we welcome samples and process logs for direct troubleshooting. Where a trader or distributor might shrug at these specifics, as hands-on manufacturers we track the issue to upstream root cause—a temperature overshoot, a misadjusted solvent load, or a bypassed drying stage. Each remedy is rolled into the reactor, not just the sales pitch.

    We hear frequently from colorant processors, resin manufacturers, and agrochemical formulators. They welcome process transparency: certificates, chromatograms, real impurity profiles. Mistakes and issues are handled openly, checked in our lab, and resolved with reruns or filtration tweaks as needed. This deep accountability comes only from producing the chemical ourselves; every shipped drum extends our reputation and builds long-standing relationships, not fleeting transactional gains. Users rely on us for more than a standard shipment—they expect technical support and process insight borne of years running and optimizing our own equipment.

    Safety, Environmental Stewardship, and Manufacturing Integrity

    Plant safety and responsibility sit at the core of our everyday routine. Each production run involves scrutiny over acid handling, secondary containment, fume abatement, and waste management. For every batch of 4-Nitro-1,3-Xylene produced, strict isolation and neutralization routines protect facility workers and local communities. By investing in automated monitoring of reactor off-gases and continuous acid neutralization, we aim to minimize both on-site exposure and downstream pollution.

    As regulations around nitroaromatic intermediates evolve, our policies grow tougher every year. Audited batch records, documented incident response, and periodic review of raw material suppliers help us keep our product at the right performance level while staying ahead of compliance. Technical visits from partners or regulators are not just welcome but routine: our openness to external validation cements trust and makes sure nothing skips review. These safety systems feed directly back into quality and consistency for every shipment, passing reliability onto every member in the value chain.

    Looking Ahead: Direct Investment in a Stronger Chemical Value Chain

    With pressures mounting from global regulations and customer demands, the days for blind sourcing or speculative chemical trading draw to a close. Sustainable growth follows only from investment at the manufacturing level. For us, this translates into new analytics for tracking isomer ratios, automation in crystallization cycles, upgrades in filtration throughput, and cleaner solvent recovery sections. We commit to tighter data records and even more robust safety routines.

    Knowing the precise reaction profile of 4-Nitro-1,3-Xylene batches grants downstream users a huge advantage. Chemists working with direct manufacturers get predictability and cost transparency tough to match by indirect channels. This predictability strengthens manufacturing lines, avoids the waste of failed syntheses, and helps customers stabilize margins—outcomes that only root-level competence can support.

    Direct producers, with long-term staff retention and a culture built around technical sharing, build trust in every shipment. Our plant engineers, shift chemists, and quality leaders maintain open communications with end users. This ecosystem creates feedback loops that benefit customers and sharpen our internal capability—not just for 4-Nitro-1,3-Xylene, but for all nitration-based specialties forged in our reactors.

    Learning, Improving, and Delivering for the Next Generation

    Production extends beyond finished drums or slick product sheets. Each campaign in our reactors unites raw science and hands-on learning: from adjusting charge rates in response to seasonal humidity, to tuning agitation speeds across different vessel scales, every detail translates into better end-user outcomes. Recurring dialogue with colorant producers, polymer designers, and formulation chemists uncovers new improvement opportunities. In turn, those same end-users enjoy far more predictable runs and easier troubleshooting when they trace problems to a known, directly-engaged source.

    Growth in specialty chemicals will depend more than ever on productive, long-term links between makers and users. Process transparency, continued safety upgrades, and technical openness form the core of this relationship. Real, dependable 4-Nitro-1,3-Xylene supply comes from teams who learn every lesson on the reactor floor, adapt fast, and invite scrutiny—supporting new application development and steady plant profitability far beyond a single transaction. As manufacturers, we own every product drum, every improvement, and every outcome that reaches our partners' process lines.