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4-Cyanobenzoic Acid

    • Product Name 4-Cyanobenzoic Acid
    • Alias p-Cyanobenzoic acid
    • Einecs 214-330-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    300994

    Chemical Name 4-Cyanobenzoic Acid
    Cas Number 619-18-1
    Molecular Formula C8H5NO2
    Molecular Weight 147.13 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 274-278°C
    Boiling Point No data available (decomposes)
    Solubility In Water Slightly soluble
    Density 1.37 g/cm³
    Pka 3.8
    Smiles C1=CC(=CC=C1C#N)C(=O)O
    Inchi InChI=1S/C8H5NO2/c9-6-7-2-1-3-8(4-7)5(10)11/h1-4H,(H,10,11)
    Storage Conditions Store at room temperature, tightly closed

    As an accredited 4-Cyanobenzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 4-Cyanobenzoic Acid, 100g: Supplied in a sealed, amber glass bottle with tamper-evident cap and clear hazard labels for laboratory use.
    Shipping 4-Cyanobenzoic Acid is shipped in tightly sealed containers to prevent moisture uptake and contamination. It should be kept in a cool, dry place, away from incompatible substances. Shipping is in accordance with all local, national, and international regulations, typically as a non-hazardous solid chemical, with appropriate labeling and documentation.
    Storage 4-Cyanobenzoic acid should be stored in a tightly closed container, kept in a cool, dry, and well-ventilated area away from incompatible substances such as strong acids and bases. Protect it from moisture, heat, and direct sunlight. Ensure good labeling and avoid exposure to ignition sources. Store at ambient temperature and follow all relevant safety and chemical storage guidelines.
    Application of 4-Cyanobenzoic Acid

    Applications of 4-Cyanobenzoic Acid in Industrial Manufacturing

    4-Cyanobenzoic Acid serves as a high-purity intermediate widely utilized in advanced material synthesis, specialty polymers, pharmaceutical intermediates, and liquid crystal production. As a manufacturer, we deliver consistent quality to meet tight formulation tolerances required by international downstream plants.

    1. Liquid Crystal Monomers for Display Technologies

    The electronics sector depends on 4-Cyanobenzoic Acid to prepare liquid crystal monomers, especially for advanced nematic and smectic phase LCDs. Downstream manufacturers utilize these monomers during the synthesis of biphenyl and terphenyl core structures, which directly influence electro-optical performance of high-resolution screens. Compliance with purity and trace ion thresholds is critical due to display panel reliability demands and export regulations to major display OEMs in Asia, Europe, and North America. Our material integrates at the feedstock stage, reacting via esterification and further condensation to produce core LC intermediates for alignment layer formulation.

    Industry compliance standards

    • IEC 61747 (Liquid Crystal Display devices)
    • RoHS 3 Directive (2015/863/EU) for electronic components
    • REACH Annex XVII Substances compliance
    • ISO 9001-based QC management for LC raw material production

    Typical usage ratio

    • 15%-25% of monomer precursor batch; adjusted by desired chain length and substitution pattern
    • Batch concentration tailored by HPLC purity and residual water content for esterification yield

    Downstream process integration

    • Major reactant during acylation/esterification post-oxidation feed
    • Core intermediate in LC biphenyl and cyanophenyl derivative synthesis
    • Quality check for metal ions before stage transfer for LC formulation

    Final product types

    • TFT-LCD panels for TVs and monitors
    • Touchscreen displays
    • Electronic shelf labels (ESL) and e-paper modules
    • Specialty optical films

    2. Building Block for High-Performance Polyesters

    Polyester producers select 4-Cyanobenzoic Acid as a monofunctional chain modifier to engineer polymers with improved thermal stability and mechanical properties. It enables formation of aromatic polyesters such as liquid crystalline polymers (LCPs) used in electronic and automotive components. Our plant manages feedstock purity and water content to control molecular weight and achieve tight IV (Intrinsic Viscosity) specs, critical for downstream pellet extrusion. The acid group allows direct condensation with diols under melt polycondensation conditions.

    Industry compliance standards

    • UL 94 flammability rating for electronic polymers
    • ISO 1043 (Polymer identification)
    • ISO 9001:2015 certified process management
    • REACH and SVHC substance controls

    Typical usage ratio

    • 2%-8% by weight of total carboxylic monomers in LCP formulations
    • Ratio varies by desired crystalline melting point and processability

    Downstream process integration

    • Direct addition to polyester melt polycondensation vessel as co-monomer
    • Closely monitored introduction during vacuum and inert gas purging phases
    • Upstream blending with other aromatic acids and diols

    Final product types

    • LCP granules for precision injection molding
    • High-temperature-resistant electrical connectors
    • Micro-electronic housings
    • Specialty technical yarns

    3. Pharmaceutical Intermediate in Active Ingredient Synthesis

    API manufacturers incorporate this acid as a key nitrile source for downstream functionalization in non-steroidal anti-inflammatory drugs (NSAIDs) and anti-cancer actives. Highly controlled impurity levels and particle size distribution are essential for regulatory submissions and batch reproducibility. The main transformation includes conversion to amide, acid chloride, or direct coupling reactions in multi-step synthetic routes. We maintain cGMP and export quality standards, collaborating with formulation partners for robust supply chain qualification.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF and EP monograph relevance (if listed in route)
    • ISO 13485 (for medical device intermediates)
    • US FDA 21 CFR Part 211 for intermediates QC

    Typical usage ratio

    • Stoichiometric to 1.2 equivalence per reaction step depending on targeted intermediate yield
    • Adjusted for excess to drive nitrile-to-amide conversions

    Downstream process integration

    • Initial substrate for aromatic nitrile-based pharmaceutical building blocks
    • Incorporation during initial condensation or amidation steps
    • Packed-bed or batch reactors for amide/ester conversion scale-up

    Final product types

    • NSAID actives (e.g., derivatives for advanced anti-inflammatory medicines)
    • Synthesized small-molecule oncology compounds
    • Aromatic amide intermediates
    • Contract-manufactured APIs

    4. Intermediate for Agrochemical Synthesis

    Leading crop science firms employ 4-Cyanobenzoic Acid as a core nitrile intermediate for the synthesis of selective herbicides and plant growth regulators. The substance enters catalytic hydrogenation and alkylation processes, with impurity management and metal ion screening critical due to downstream field residue regulations. Material traceability and production documentation support compliance during active ingredient registration in multiple agricultural markets.

    Industry compliance standards

    • FAO/WHO Specification for Pesticides
    • ISO 17025 testing for purity and residue analysis
    • OECD Good Laboratory Practice (GLP)
    • REACH registration for agrochemicals

    Typical usage ratio

    • 0.5–2.5 molar equivalents relative to pyridine or phenoxy precursors per batch
    • Ratio based on desired alkylation efficiency and active yield optimization

    Downstream process integration

    • Batch or continuous-feed into catalytic nitrile alkylation reactors
    • Entry point in multi-stage synthetic sequence for pro-herbicide cores
    • Inline impurity removal before downstream halogenation or sulfonation

    Final product types

    • Pre-emergent selective herbicide technicals
    • Plant growth regulation agents
    • Pyridine-type crop protection molecules
    • Custom-synthesized agricultural actives for regional registrations

    5. Precursor in Specialty Dye Synthesis

    Dye and pigment manufacturers use this acid to synthesize aryl nitrile intermediates, essential for developing high-purity colorants with excellent thermal and lightfastness in synthetic fibers. Material enters diazotization and condensation reactions to tailor shade strength and solubility. End-users in the textile and plastics industry audit upstream traceability and batch homogeneity to meet OEKO-TEX ® and GOTS colorant compliance. We supply traceable lots for integrated production, minimizing iron and copper contamination for reactive and disperse dye precursors.

    Industry compliance standards

    • OEKO-TEX ® Standard 100 for harmful substance control
    • ISO 105-B02 (Color fastness to light)
    • GOTS (Global Organic Textile Standard) for colorant inputs
    • EN 71-3 for migration in toy colorants

    Typical usage ratio

    • 2%-10% of total aromatic feedstock per condensation batch
    • Adjusted by chromophore target, reagent reactivity, and final absorption peak requirements

    Downstream process integration

    • Addition post-diazotization for aryl modification or as nucleophile in C-N coupling
    • Quality check prior to filtration and purification for dye intermediate isolation
    • Pre-processing blending for custom dye lot production

    Final product types

    • Reactive dyes for cellulosic fibers
    • Disperse dyes for polyester applications
    • Synthetic fiber pigment dispersions
    • Specialty colorant pastes for masterbatch and ink applications
    Free Quote

    Competitive 4-Cyanobenzoic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

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    Certification & Compliance
    More Introduction

    Introducing 4-Cyanobenzoic Acid: Proven Quality from Direct Manufacturing

    Our Experience with 4-Cyanobenzoic Acid

    Daily production environments shape the way we understand chemicals like 4-Cyanobenzoic Acid. At our plant, chemists and operators have handled this compound for years. It stands as a staple in both small-scale and industrial processes, especially where precision in organic synthesis is essential. Each batch that leaves our reactors comes with the assurance that only a tightly controlled process can bring. Unlike chemicals that pass through multiple hands before reaching customers, our product travels directly from reaction vessel to finished packaging within the same site. This level of control has eliminated many sources of contamination and inconsistency that we used to encounter in the early days, back when we occasionally relied on outside processing.

    Specifications and Consistency

    Our 4-Cyanobenzoic Acid follows tight metrics, guided by the longstanding needs of dye intermediates, pharmaceuticals, and polymer applications. We have honed the typical purity range to 99% minimum, with a white to faintly off-white crystalline appearance. Melting point checks and HPLC assays are daily tasks, not afterthoughts. Each drum receives a unique identifier traceable back to a specific reaction run, a practice we put in place after a few early episodes of batch confusion on the line nearly two decades ago.

    Moisture content poses a challenge with benzoic acid derivatives. We keep water levels low, not simply because pharma applications demand it, but because higher moisture interferes with process yields during scale-up—something our polymer and dye clients pointed out to us before we made changes to our drying process back in the mid-2000s. Consistent dryness has made a measurable difference both in shelf life and in how easily downstream chemists can handle the material.

    Challenges Unique to 4-Cyanobenzoic Acid Manufacturing

    4-Cyanobenzoic Acid’s nitrile group separates it from the common benzoic acids in terms of reactivity and odor. Workers on the floor notice the sharpness during charging and blending. It behaves differently in filtration and crystallization than its analogs. Most notably, nitrile-bearing acids demand stricter monitoring for trace byproducts during synthesis. The hydrolysis reactions can turn inconsistent without vigilant pH and temperature management, and even minor deviations create side products that interfere with certain applications.

    We discovered early on that traditional benzoic acid purification didn’t suffice. We invested in secondary filtration and upgraded our column purification, after direct feedback from a customer in the East Asia coatings industry. They demonstrated that residual impurities, though minor by weight, caused color shifting in their application. Lessons like this dictated new methods, not from theoretical advice, but from the factory floor and customer batch complaints.

    Key Applications Observed

    Research teams working with our 4-Cyanobenzoic Acid frequently mention its role in the synthesis of liquid crystal compounds. Even small impurities can interfere with liquid crystal performance, and our feedback loops with these teams have directly shaped the minimum impurity thresholds we use today. In dye manufacturing, where color stability depends on the starting acid’s quality, our customers pointed out the need for narrow melting point ranges—so our staff refined our drying and cooling controls to hit those targets. In pharmaceutical development, where every impurity needs records, our in-house QC crew runs full spectral analysis as a routine, not just for regulatory batches.

    Polymer developers often need kilogram to multi-ton quantities for specialty resins. Our ability to scale up while maintaining batch-to-batch consistency saved several long-term relationships that might have drifted to competitors. Their feedback after switching to our direct supply often credits our raw material predictability with reducing their own downstream waste and process adjustments.

    Handling, Storage, and Worker Safety: Hard-Earned Lessons

    Back in our early expansion years, we underestimated the impact of minute dust levels in high-turnover environments. Operators often reported skin and eye irritation until we installed better air handling and trained teams to manage open transfers. We store our 4-Cyanobenzoic Acid in tightly sealed drums in cool, dry storage, driven by both customer requirements and our own lessons with seasonal humidity. Tanks with basic benzoic acids did not demand this rigor, but we learned that this material’s sensitivity justified better internal SOPs.

    Transportation brings another set of challenges. Stabilizing the product against vibration and thermal swings, especially on longer hauls, kept our returns nearly zero. Each shipment uses liners and secondary containment that we designed for both regulatory compliance and real-world feedback from logistics partners who haul mixed chemical lots. The complaints declined when we stopped assuming basic packaging worked for all acids and started engineering contents-specific solutions.

    How 4-Cyanobenzoic Acid Stands Apart

    In comparison to substituted benzoic acids like 4-methylbenzoic acid or 4-aminobenzoic acid, 4-Cyanobenzoic Acid brings a unique set of reactivity profiles. The nitrile substituent significantly affects both its electronic character and subsequent transformations. Customers who once swapped it freely with other benzoic acids reported failed couplings and unwanted side reactions. This feedback led us to further train both our technical teams and customers on the practical differences, not just the textbook contrasts.

    Unlike the parent benzoic acid, 4-Cyanobenzoic Acid resists certain oxidative steps and supports construction of complex heterocycles. Its tolerance to some tough coupling conditions gives medicinal chemists the flexibility they often demand for rapid analog development. On the pigment side, the nitrile group brings depth to dye precursors. Our direct observations of how real reactions run—rather than what reference works suggest—gave us confidence to guide customers toward or away from this product, depending on their needs.

    In the realm of specialty polymers, our long-term customers highlight its role in the formation of liquid crystalline polyesters. The purity expectations in this application exceed the demands of more routine synthesis. Small color changes or degraded thermal properties signal underlying impurity problems. We don’t just guarantee purity on paper. Our team worked hand-in-hand with production engineers at several customer sites to troubleshoot and optimize real-world use, adjusting our own processes until the results held in operational settings. That trust forms the backbone of every drum we ship.

    Supporting the Wider Ecosystem

    Regulatory environments keep shifting, and our direct communication with authorities means we adapt quickly. Early REACH registration challenges for organic acid derivatives forced considerable changes in our documentation and record-keeping. Over the years, we have seen how real data, recorded thoroughly at each batch stage, helps build credibility with both regulators and discerning customers.

    Customers need more than data sheets. They ask why one lot behaves better than another in a specific reaction. Our process engineers often analyze these situations with customers, using reaction-side samples and internal diagnostic reports to spot root causes. In some cases, we’ve modified our purification steps after repeated customer observations. In others, we advised changes in their workup that led to much better performance. Rarely do you get these practical insights from third parties; they only materialize from firsthand manufacturing experience.

    The Importance of Direct Manufacturer Relationships

    Receiving chemicals directly from the manufacturer reduces uncertainty and increases traceability. Issues or variations can be pinpointed—down to a shift in reactor feed or a tweak in purification conditions. Unlike trading houses or resellers, we maintain records on every kilo produced, down to pH logs and filtration pressure data. Customers who once experienced mysterious variations in performance with third-party sources soon saw the value in being able to trace back every shipment.

    During a spike in global demand, resellers often allocated inventory with unpredictable results. Our regular customers, supplied directly, received consistent product and transparent updates about scheduling or adjustments. Over time, this level of partnership helped several of our clients weather both regulatory and market shocks. We have seen how gaps in the supply chain—especially for materials sensitive to storage and handling—can interrupt production and increase costs. Dealing directly allows both sides to fine-tune responses based on real data, not assumptions.

    Sustainability and Continuous Improvement

    Production efficiency, waste reduction, and solvent recycling are priorities we didn’t always meet in the past. Growing customer concern about environmental impact led our team to revisit our process map for 4-Cyanobenzoic Acid. By retooling solvent recovery and switching to greener cleaning agents, we reduced hazardous waste output by more than twenty percent compared to our early processes. These were not abstract improvements but the types you see in everyday operation—less spent solvent leaving the plant, fewer complaints about odor from neighbors, and better morale among plant staff.

    Process automation brought another round of gains. Manual steps like filtration and transfer once introduced more variability. We observed that direct feedback from line operators, not just management, shaped improvements in maintenance and calibration schedules. Error rates and contamination events dropped. Less downtime boosted the predictability for customers counting on stable scheduling.

    Transparency and Real-World Data Sharing

    Customers appreciate knowing not just what goes into the drum, but how it got there. We run open plant walk-throughs with key accounts and share in-process data, not only finished batch results. At times, plant visitors point out ways to streamline or error-proof steps—collaboration we value highly. This policy of openness helps both parties spot improvement opportunities and establish new best practices.

    We collect and analyze every complaint and deviation. Feedback led us to switch packaging types for certain climate zones and optimize palletization for easier warehouse handling. Real-world testing with customer teams uncovered small but crucial improvements; for instance, they pointed out that our standard labeling worked fine for us, but ran afoul of their automated bin systems. Small changes, grounded in firsthand manufacturing knowledge, increased accuracy during their scale-up.

    What Sets Our 4-Cyanobenzoic Acid Apart

    Many suppliers claim high purity, safe handling, and efficient logistics. What distinguishes our 4-Cyanobenzoic Acid is the accountability that comes from ownership of every step, from raw material intake through to delivery. Our team’s deep familiarity with this product and its quirks means fewer mistakes, more adaptable problem-solving, and practical support to customer innovations.

    Each improvement—whether initiated on our end or suggested by a customer—feeds into a continuous cycle of better quality and deeper trust. The product’s differences compared to related acids become clearest during demanding applications. For customers in the thick of research, manufacturing, or new product development, receiving consistent and fully supported 4-Cyanobenzoic Acid means faster project turnaround and fewer hidden surprises. As manufacturers, we have seen that making a difference comes from details: every controlled reactor, every cleaned valve, every accurately labeled drum, and every after-sales check-in.

    Moving Forward—Serving Industry and Research with Real Expertise

    Our journey with 4-Cyanobenzoic Acid has been shaped by years of problem solving, innovation, and customer dialogue. The extra work to ensure tightly controlled manufacturing, enhanced traceability, and hands-on customer support doesn’t always show up on a spec sheet. Yet the difference shows up on the production floor and in end-use processes across the globe. We draw our expertise from real-world challenges, guided by customer needs and grounded in effective, sustainable manufacturing. That remains the difference direct experience offers—the constant pursuit of better quality and reliability.