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4-Chlorophenol

    • Product Name 4-Chlorophenol
    • Alias p-Chlorophenol
    • Einecs 200-293-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    157463

    Chemical Name 4-Chlorophenol
    Cas Number 106-48-9
    Molecular Formula C6H5ClO
    Molecular Weight 128.56 g/mol
    Appearance White to light pink crystalline solid
    Melting Point 42-44°C
    Boiling Point 218°C
    Density 1.305 g/cm³
    Solubility In Water 2.4 g/100 mL (20°C)
    Odor Phenolic, medicinal
    Pka 9.38
    Vapor Pressure 0.049 mmHg (25°C)
    Flash Point 80°C
    Refractive Index 1.567 (20°C)
    Ec Number 203-398-6

    As an accredited 4-Chlorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4-Chlorophenol is supplied in a sealed, amber glass bottle with a secure cap and hazard labeling.
    Shipping 4-Chlorophenol is shipped in tightly sealed containers, typically made of glass or high-density polyethylene, to prevent leaks and contamination. It is classified as a hazardous material, so packaging complies with international regulations. Proper labeling and documentation are required, and the chemical should be stored upright in a cool, well-ventilated area during transit.
    Storage 4-Chlorophenol should be stored in a tightly sealed container in a cool, dry, well-ventilated area, away from sources of ignition, incompatible chemicals (such as strong oxidizers and acids), and direct sunlight. Containers should be clearly labeled, and the storage area should have appropriate spill containment measures. Protective equipment and emergency washing facilities should be readily accessible in case of accidental exposure.
    Application of 4-Chlorophenol

    Applications of 4-Chlorophenol in Industrial Manufacturing

    4-Chlorophenol is a key intermediate in multiple industrial value chains involving chemical synthesis, specifically in the production of downstream chemicals, agrochemicals, pharmaceuticals, and performance materials. As a primary manufacturer, we supply this raw material to global firms implementing mature regulatory control and batch-traceable integrated operations.

    1. Synthesis of Herbicide Intermediates in Agrochemical Manufacturing

    Leading agrochemical producers utilize 4-chlorophenol as a building block in the manufacture of selective herbicide active substances. The material undergoes alkylation and etherification steps in multi-stage reactor lines. It forms the essential nucleus in phenoxy herbicide intermediates, supporting precise formulation to match region-specific cropping requirements and resistance management programs. Facilities typically operate under multi-batch processing to accommodate variable campaign sizes.

    Industry compliance standards

    • EU REACH Registration
    • US EPA Pesticide Registration (FIFRA)
    • China Pesticide Management Regulations
    • ISO 9001:2015 Quality Management System

    Typical usage ratio

    • 15–28% of total active intermediate batch mass depending on the specific herbicide target molecule; formulation labs adjust loading based on synthesis yield and target impurity profile.

    Downstream process integration

    • Direct inclusion in closed-system batch reactors during O-alkylation phase for herbicide core building.
    • Inline purification and intermediate stabilization before successive reaction steps.

    Final product types

    • 2,4-Dichlorophenoxyacetic acid derivatives
    • MCPA and MCPB technical concentrates
    • Formulated liquid or granular herbicides for cereal, maize, and turf applications
    • Custom pre-mixes for contract spray service providers

    2. Manufacture of Pharmaceutical Antiseptic Intermediates

    We supply pharmaceutical-grade 4-chlorophenol for synthesizing critical intermediates in antiseptic and disinfectant active ingredient production. The material features in route-step synthesis of chlorinated phenols, which undergo controlled nitration or further halogenation. Multi-point in-process controls ensure batch-to-batch purity consistency required by regulated finished dosage manufacturers. Downstream partners maintain stringent environmental and occupational health stewardship aligned with medical-grade material handling.

    Industry compliance standards

    • Ph. Eur. (European Pharmacopoeia) monographs
    • US Pharmacopeia (USP) guidelines
    • cGMP (ICH Q7) for active pharmaceutical ingredients
    • ISO 13485 for medical device disinfectants

    Typical usage ratio

    • 12–22% w/w in intermediate formation bottle, with loading rates specified by target chlorinated phenolic output and pharmaceutical impurity thresholds.

    Downstream process integration

    • Initiation of chlorination in jacketed glass-lined reactors during principal synthesis step of active component precursors.
    • Downstream extraction and purification via multi-solvent filtration or fractional distillation.

    Final product types

    • Chloroxylenol (PCMX) active for wound antiseptics
    • Intermediate compounds for hospital disinfectant bases
    • Phenolic solutions for surgical instrument sterilants
    • Pharmaceutical-grade concentrated disinfectant blends

    3. Dye and Pigment Intermediate Synthesis

    Major dye industry manufacturers employ 4-chlorophenol as a controlled aromatic ring substrate within colorant precursor synthesis, particularly for azo and anthraquinone series pigments. The raw material enters sulfonation or coupling steps, supporting downstream processes requiring tight control over chromophore formation and by-product management. Our plant delivers consistent molecular purity, supporting large-volume pigment supply contracts for textile, plastic, and ink formulators.

    Industry compliance standards

    • OEKO-TEX Standard 100 requirements for dye intermediates
    • EU CLP (Classification, Labelling, Packaging) Regulation for chemicals
    • ISO 9001:2015-certified batch traceability
    • SDS and global transport regulatory documentation (GHS)

    Typical usage ratio

    • 10–35% of pre-reactor bulk, with final value set according to target pigment series; adjustments consider desired absorption/coating depth and yield of color intensive batch.

    Downstream process integration

    • Entry into stirred autoclaves during diazotization or sulfonation for dye intermediate manufacture.
    • Inline monitoring for reaction heat and formation of target intermediates prior to final chromophore assembly.

    Final product types

    • Azo dye intermediates for textile coloration
    • Anthraquinone pigment bases
    • Inkjet and flexographic ink colorants
    • Granulated pigment dispersions for plastics compounding

    4. Synthesis of Plastic and Resin Additives

    4-Chlorophenol acts as a raw feedstock in manufacturing heat stabilizers and UV absorbers for engineering plastics and specialty resins. Polymer manufacturers introduce the material during additive pre-polymerization to impart thermal resistance and photo-stability. Strict dosing protocol and on-line QC ensure additive loading meets both performance and regulatory migration criteria for consumer-facing goods and industrial components.

    Industry compliance standards

    • EU RoHS and REACH compliance for additive use in plastics
    • FDA 21 CFR regulations for polymer additives in food contact materials
    • ISO 14001 Environmental Management Certification in production sites
    • Industry-specific migration test protocols for finished plastic goods

    Typical usage ratio

    • 5–18% w/w for additive masterbatch; determine rate based on functional test results, end-product usage, and regulatory migration limit constraints.

    Downstream process integration

    • Direct addition to additive melt compounding units in masterbatch manufacture.
    • Subsequent dispersion into resin or polymerization reactors under controlled temperature and agitation for final product blending.

    Final product types

    • Heat and UV stabilizer concentrates for PVC profiles
    • Antioxidant additive masterbatches
    • UV absorber compounds for polyolefin and engineering resins
    • Finished molded and extruded plastic parts for automotive, appliance, and consumer applications

    5. Production of Wood Preservative Chemicals

    Downstream wood protection product formulators rely on 4-chlorophenol to create biocidal actives used in timber preservation. The compound functions as a precursor in synthesizing phenolic biocides, ensuring deep penetration and long-lasting fungal control. Manufacturers apply tight parameter control of reaction time, pH, and dosage in emulsion or solvent-based systems to achieve required biocidal concentration and environmental emission compliance.

    Industry compliance standards

    • Biocidal Products Regulation (EU) 528/2012
    • US EPA Wood Preservative Standards
    • Australian APVMA Biocide Approvals
    • EN 599-1:2013 Wood Preservatives – Efficacy

    Typical usage ratio

    • 8–20% of active ingredient phase; wood treatment specialists determine value based on timber species, preservative system type (oil or water-based), and decay test requirement outcomes.

    Downstream process integration

    • Emulsification or dissolution with co-biocides during blending of preservative concentrate.
    • Batch QC tests for active distribution and residual chlorophenol analysis before packaging.

    Final product types

    • Timber treatment solutions for industrial and outdoor use
    • Ready-to-use wood preservatives for construction lumber
    • Mold and decay-resistant surface coatings
    • Pressure-impregnation preservative fluids

    6. Chemical Synthesis of Specialty Aromatic Compounds

    Chemical synthesis houses in the fragrance and flavor sectors use 4-chlorophenol as a substrate for constructing highly functionalized specialty aromatics. Direct or stepwise modification produces intermediates for complex fine chemical blends. Real-time GC-HPLC methods test for conversion rates and residual marker compounds, meeting downstream purity needs for specialty end-uses with defined olfactory or stability characteristics.

    Industry compliance standards

    • IFRA Code of Practice for fragrance ingredients
    • USP-NF and FCC for food-safe aromatic intermediates
    • EU REACH for fine chemical intermediates
    • Good Manufacturing Practice (GMP) in specialty ingredient synthesis

    Typical usage ratio

    • 1–15% as a reaction starting substrate; chemists size input relative to target multi-functional aromatic output and recovery efficiency.

    Downstream process integration

    • Entry into aromatization or etherification units as the initial aromatic core for ingredient synthesis.
    • Subsequent stepwise conversion through controlled catalytic processes.

    Final product types

    • Fine fragrance blend intermediates
    • Flavor compound precursors for F&F industry
    • Specialty aromatic solvents for coatings
    • Industrial-grade aroma chemicals for consumer goods
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    Certification & Compliance
    More Introduction

    4-Chlorophenol: Practical Value from a Chemical Manufacturer’s Perspective

    What Sets Our 4-Chlorophenol Apart

    At the foundation of our business, production runs are scheduled, controlled, and sampled directly at the source, not left to chance or outsourced storage lots. 4-Chlorophenol holds a special place on our lines—not as a high-volume commodity, but as a precise specialty chemical crucial for several downstream users. We produce this compound through chlorination processes that require careful monitoring. Around here, workers keep a close eye on reaction temperatures and chlorine feed rates because slight deviations cost time, quality, and even safety. Processes in our facilities follow strict checks to ensure results meet customer expectations.

    Every day, our technicians check appearance, purity, and impurity profiles. Each batch of 4-Chlorophenol exits the plant as white-to-pale crystals with a phenolic odor. Our standard product offers above 99% purity as confirmed by gas chromatography; this is not a casual target but something we document and deliver. We do not lean on blended stock or loosely controlled imports, but on continuous feedback from our own lab’s tracked batches. For customers, this means less downtime spent on requalifying supply—quality comes from the manufacturing floor itself.

    We supply variants based on customer needs, whether in bulk drums, smaller technical grade packages, or specialty grades such as low-ash or reduced residual moisture. Stability and reproducibility matter most. There is a real consequence if the product comes in too wet, carries too much color, or contains high organic impurities. Stakeholders at our plants have no illusions: a single off-spec batch in a year can erode trust won over a decade of consistent performance. That’s why at each step, someone reviews not just purity and color, but manufacturability and customer feedback.

    Applications Driven by Real-World Industrial Needs

    End-users turn to 4-Chlorophenol not for its name, but because its function meets pivotal points in their own processes. We watch how it performs in practical service—cleaning, formulating, or reacting with other materials—since claims made from a lab bench can fall apart in a reactor or mixing tank.

    In the production of pharmaceuticals, 4-Chlorophenol often becomes an intermediate for more complex molecules like anesthetics, antiseptics, and active pharmaceutical ingredients. We understand the limitations that come with upstream variability, so our control over precursor purity stands as a competitive advantage. Sometimes, a project manager from a pharmaceutical firm will call to ask about trace halogens or possible byproducts—these are expected conversations because what gets ignored in synthesis might show up as a problem further down their pipes. They want a partner who doesn’t make excuses about inconsistent input.

    Another common use, especially from companies making pesticides and herbicides, involves the transformation of 4-Chlorophenol into phenoxy herbicides and other crop protection chemicals. Timing matters here: if a blender pulls a drum that’s sat in a humid corner, moisture picks up, discoloration might start, and batch-to-batch consistency drifts. We keep environmental controls tight, track material by lot, and carry out shipment close to production to keep conditions optimal. Crop science teams depend on quick information and predictable inputs—seasonal demand waits for no one.

    Preservatives manufacturing uses our material for compounds that protect adhesives, lubricants, paints, and coatings from microbial decay. Our staff regularly helps troubleshoot: in waterborne adhesives, even ppm-level chlorophenol impurities shift the performance of fungicidal blends. We set our specifications to ensure the right antimicrobial activity, paying attention to stability under real-world storage rather than promising results that only show up in ideal conditions.

    Talk to a plant maintenance engineer about what happens if raw material performance drifts outside the standard. Vessels need additional cleaning, residue builds up, and filters block sooner—direct consequences we have learned to avoid through rigorous in-house process control. We handle complaints seriously and adjust our practices based on feedback from technicians who see the problems on the ground, not just spreadsheet traces of purity.

    Comparing 4-Chlorophenol with Similar Aromatic Compounds

    As a phenolic aromatic, 4-Chlorophenol shares a lot of shelf space with siblings: phenol, cresols, and other chlorinated phenols. Chemists debate the merits of these compounds depending on reactivity, toxicity, and volatility. From our experience, users don’t make these decisions lightly—substituting one phenol for another can force requalification, regulatory review, and changes in waste disposal.

    Compared with phenol, 4-Chlorophenol provides a stronger antimicrobial effect because of the presence of chlorine at the para position; that single atom makes a big difference both in antimicrobial performance as well as odor and volatility. Where phenol itself works well for lab disinfection or as a simple precursor, most formulators ask specifically for the 4-chloro version when tackling microbial persistence in more challenging environments.

    3-Chlorophenol and 2-Chlorophenol, both produced at much lower volumes, bring additional complexity in separation and possible byproduct formation during manufacture. Based on our direct handling, 4-Chlorophenol holds an edge in cost efficiency and reactivity for downstream synthesis into agrochemical and medicinal intermediates. Requests for the 2- and 3-isomers mostly come from research and specialty sectors; in high-volume applications, these alternatives often increase compliance costs due to differences in toxicity profiles and regulatory reporting.

    Purity and appearance distinguish higher-quality batches. Contamination with other chlorophenols, or excessive residual phenol, limits product acceptance. Our process controls hinge on separation efficiency during distillation and crystallization, managed by operators who know their columns and maintain filters capable of handling fluctuating feedstock. We track complaints about off-odors and discoloration internally—many buyers return to us when they’ve tried alternatives that cut corners on odor control or contain specific contaminants we avoid through procedural rigor.

    User experience cannot be left out. We have seen competitors focus entirely on cost, only for buyers to discover long-term headaches washed down into process streams, lost batches to contamination, and safety headaches from volatile impurities. We invest in regular line maintenance and spend more on raw chlorine and phenol inputs that deliver cleaner product at the end. In our view, that return is worth more than a fleeting cost edge.

    Workplace Realities: Safety, Storage, and Handling

    Unlike basic organics, 4-Chlorophenol presents several hands-on challenges. Some operations treat it as a learning experience, but we understand from history that hazardous feedstock creates risk if treated without respect. Powdered residue sticks to gloves, odor clings, and even brief skin contact means a trip to the wash station. Everybody working the packing lines undergoes regular safety briefings. All drums and containers receive labeling at the time of packing—no prints done weeks in advance—reducing the risk of mismatch or misidentification.

    Warehouse teams learn to store 4-Chlorophenol in dry, ventilated areas away from direct sunlight and incompatible materials such as oxidizers and reducers. Container selection matters, whether handling 50-kg fiber drums or smaller HDPE packs; we’ve seen what happens when product sits in corroded steel tanks, picking up rust and moisture. These details come from years of failed experiments—by sticking to the lessons learned, we build reliability both for our logistics teams and the downstream buyer.

    Transport adds another layer of reality to manufacturing. Regulatory paperwork tracks every kilogram leaving our facility. Staff maintain consistent procedures to avoid contamination. Transporters direct questions about freezing or container heating: we’ve had containers shipped on single-digit winter days and in desert heat, and maintain that product safety and quality during transit is worth every added step or cost.

    Spill management drills, regular review of MSDS information, and mandatory use of protective goggles and gloves shape workplace culture about chlorophenols. We’ve seen too many examples outside the plant where a lack of respect for chemical handling causes harm or cost. By building the right systems, emphasizing documentation, and making continual investments in technology, incidents declined and morale improved. A safer workplace doesn’t just protect us; it means less risk handed to those who receive our product down the supply chain.

    Insights on Sustainability and Regulatory Pressures

    The regulatory environment surrounding chlorinated phenols shifts regularly. Decades ago, loose disposal filled headlines alongside environmental disasters. Today’s standards require in-house compliance teams who keep an eye on the evolving patchwork of rules in every country that receives our product. We don’t treat waste management or hazard labelling as afterthoughts. Instead, reduction in fugitive emissions, reduction of dioxin formation, and improved waste treatment capacity stay central to our projects. Our experience with routine third-party audits helps us pinpoint gaps before they reach regulatory complaint levels.

    As concern over chlorinated organics grows, many customers want assurances about process safety and environmental stewardship. Down the line, someone asks where every kilogram came from, not just how it works. We invest in real-time monitoring on our stacks and water outflows, and stay ahead of local and national emission standards. Doing so is good for business and for community relations; neighbors have a right to expect clean air and water, backed by inspection reports that reflect what we see on our own dashboards.

    Destruction of spent 4-Chlorophenol—whether on our site or at a customer’s facility—demands attention. We guide users toward best practices for solvent recovery, incineration, or biochemical degradation. Sharing knowledge adds to a culture of safety; it keeps our partners productive and regulators off everyone’s back. Not every solution is easy or cheap, but nobody profits from shortcuts. Over time, these investments return loyalty, repeat business, and fewer overnight compliance headaches.

    Expectations on supply chain transparency continue to tighten. Inquiries sometimes reach our office on raw material sourcing, child labor, or environmental compliance certifications connected even to upstream suppliers. It’s not lost on us that reputations can hinge on responses to such inquiries. By building direct relationships with our feedstock sources and documenting compliance, we not only answer today’s questions but get ahead of tomorrow’s.

    We don’t claim sainthood but take pride in measurable gains: Our waste treatment residue, process volatilization, and water discharge readings improved steadily for the past several years. Even with increased production, these gains resulted from staff focus, management investment, and ongoing willingness to change how things are done. These achievements rarely make headlines outside the industry, but to us and our customers, they signal a business built for the long-term, not just the next sale.

    Challenges and Lessons Learned

    Sourcing high-quality raw materials proves tough in volatile markets. Fluctuations in phenol and chlorine prices, plant outages at upstream suppliers, and geopolitical disruptions routinely test a manufacturer’s planning. Each disruption means shifting schedules, supplier agility, and, sometimes, paying a premium. We’ve experienced years where long-term supplier relationships and early investment in process modifications allowed us to ride out shortages that shut competitors down. Building secondary sources, qualifying alternatives, and keeping a reserve are lessons absorbed through hard years, not easily replaced by textbook advice.

    Continuous improvement defines our approach to plant operation. Customer audits, product recalls by lesser suppliers, and the occasional field failure force us to analyze where we went wrong and what preventive measures to put in place. Additional in-line monitors, staff training, and digital batch tracking transformed guesswork into a managed process. The benefit? Customers see fewer hiccups and more reliability.

    Another lesson: customer service starts with honesty. We don’t hide or sugarcoat production setbacks. Shipping short notification, unexpected specification issues, or force majeure events quickly communicated protect trust—and encourage joint problem solving with our long-term partners. Transparent dialogue makes both sides stronger.

    Pricing pressures keep everyone honest but can erode quality if handled carelessly. External buyers sometimes chase lower quotes, only to see higher technical service costs and quality complaints in the field. We work to keep cycles trimmed and overhead low, but cut corners only where automation and genuine innovation allow. Decisions must reflect durability—not a bargain that blows up a year later.

    Supporting Users through Knowledge and Collaboration

    Technical exchange with users forms a big part of our daily work. From process troubleshooting to data sharing on new synthesis trends, our staff invest time in understanding how 4-Chlorophenol interacts in actual production trains. Periodic meetings let us hear about evolving regulatory limits, green chemistry initiatives, or new product launches that demand shifts in our manufacturing focus.

    We emphasize practical training—offering webinars, technical bulletins, and on-site troubleshooting where feasible. Many issues boil down to actionable best practices: keeping storage dry, minimizing headspace in drums, or matching pack sizes to batch schedules. Through such collaboration, users make the most of their material, and our own quality returns as fewer complaint calls or rejected shipments.

    Joint development with partners on custom grades, lower residuals, or tighter tolerances happens in dialog, not isolation. Some projects stretch over several years and dozens of email threads and trial shipments; the value is mutual. In the end, these collaborations often open up new uses or regions for 4-Chlorophenol, keeping the product relevant as markets and standards shift.

    Every lesson, every adjustment, and every shipment reflects a real-world partnership. Our reputation is built not just on technical sheets, but on the years spent standing behind our product. Customers expect, and receive, more than a list of specifications: they get dependable service from the same faces, batch over batch, year over year.

    Forward View: Keeping Pace with Industry and Customer Evolution

    Today’s market for 4-Chlorophenol isn’t frozen in time. Pharmaceutical companies are developing novel intermediates. Agrochemical users need higher environmental and safety standards on every input. Preservation chemistries change as eco-labels and biocide regulations grow stricter each year. As we see it, every modification in industry standards or customer strategy translates directly into our job: modifying, optimizing, or requalifying 4-Chlorophenol to keep pace.

    We invest in process upgrades—new distillation columns with tighter control, online analytical instruments, and energy-saving reactor designs. Continuous feedback from end-users validates the investment or tells us where we still fall short. Often, major trends—digitalization, global regulation, sustainable chemistry—arrive as incremental changes to specification sheets and shipping documents. But real adaptation comes through the experience of workers, supervisors, and technical leads working side by side solving the latest challenge.

    Research in alternative preservatives or green phenol derivatives creates both opportunity and challenge for our operations. Some believe chlorinated phenols may one day face outright restriction, or at least tighter regulatory pressure. We stay open to continuous adaptation, whether that means new purification lines, pilot projects on bio-based alternatives, or investment in integrated waste recovery. Customers and suppliers will see these developments up close—not a distant promise, but direct changes in their next orders, specs, and technical conversations.

    From the very outset, we have maintained a belief that manufacturing goes far beyond delivering a chemical in a drum. Each day brings technical questions, evolving standards, supply fluctuations, and occasional setbacks. Our job isn’t only to solve them, but to keep learning, so that for every use of 4-Chlorophenol—whether a critical pharmaceutical step, a biocidal blend, or a custom-engineered agricultural additive—the people who rely on it get more than expected, batch after batch.