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4-Chloronitrobenzene

    • Product Name 4-Chloronitrobenzene
    • Alias p-Chloronitrobenzene
    • Einecs 202-810-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    467971

    Chemicalname 4-Chloronitrobenzene
    Casnumber 100-00-5
    Molecularformula C6H4ClNO2
    Molecularweight 157.55 g/mol
    Appearance Pale yellow crystalline solid
    Meltingpoint 82-86 °C
    Boilingpoint 242 °C
    Density 1.49 g/cm³
    Solubilityinwater Slightly soluble
    Flashpoint 112 °C
    Refractiveindex 1.589
    Vaporpressure 0.04 mmHg at 25 °C
    Pubchemcid 7509

    As an accredited 4-Chloronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging for 4-Chloronitrobenzene (500g) is a sealed amber glass bottle with hazard labeling, inside a cushioned cardboard box.
    Shipping 4-Chloronitrobenzene is shipped in tightly sealed containers, compliant with hazardous material regulations. It must be labeled as a toxic and environmentally hazardous substance (UN 1578, Class 6.1). Transport requires cool, dry, ventilated conditions, away from incompatible materials like strong reducers and bases. Proper documentation and handling measures are essential during shipping.
    Storage 4-Chloronitrobenzene should be stored in a tightly sealed container, away from direct sunlight, heat, and sources of ignition. Store in a cool, dry, well-ventilated area, separate from incompatible materials such as strong reducing agents or bases. Ensure proper labeling and keep away from humidity and moisture. Use suitable chemical-resistant shelving and follow all applicable regulatory requirements for hazardous chemicals.
    Application of 4-Chloronitrobenzene

    Applications of 4-Chloronitrobenzene in Industrial Manufacturing

    4-Chloronitrobenzene serves as a core intermediate in multiple industrial segments. Our manufacturing consistently meets the demands for high-purity material across complex chemical synthesis routes. Below, we present key downstream application channels with process-specific details, compliance requirements, dosage parameters, production staging, and reference final products.

    1. Agrochemical Intermediate Synthesis

    Within agrochemical production, 4-chloronitrobenzene supports large-scale synthesis of selective herbicides. Its chlorinated aromatic ring undergoes controlled reduction and further transformation steps, forming the backbone for specific phenoxy and substituted aniline compounds. We provide tailored shipments with batch documentation, enabling downstream compliance for pesticide actives. Stringent monitoring during nitration and chlorination steps ensures consistent reactivity and minimized byproducts, critical for subsequent coupling or amination in herbicide manufacturing lines.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • FAO/WHO Specifications for Pesticide Actives
    • ISO 9001:2015 Quality Management System (agrochemical intermediates)
    • China National Standard GB 20660-2006 for Pesticide Raw Material

    Typical usage ratio

    • Utilized at 0.8–1.5 molar ratio relative to downstream active core, tuned based on crop-specific compound synthesis
    • Formulation adjustment per targeted purity of end compound

    Downstream process integration

    • Feeds as nitrated aromatic during initial amination/coupling in batch reactors
    • Integrated into multi-stage condensation and reduction trains
    • Continuous supply supports automated chain operations in agrochemical plants
    • QC sampling at entry and exit of each synthesis stage

    Final product types

    • 2-Chloro-4-nitroaniline (herbicide precursor)
    • MCPA and MCPB analogues
    • Selective phenoxy herbicide actives
    • Paddy rice and wheat-specific weed control agents

    2. Dye and Pigment Manufacture

    Major dye and pigment producers use this material as a pivotal building block for azo and anthraquinone dye synthesis. The electron-withdrawing nitro and chloro substituents regulate the reactivity of coupling partners during diazotization and azo coupling. Plants emphasize precise batch control, as resonance structures affect hue and fastness in textile dyes. Our supply integrates with automated dosing for reproducible color properties in final batches, with all deliveries supported by standardized spectral analysis certificates.

    Industry compliance standards

    • OEKO-TEX Standard 100 (input chemicals)
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • DIN EN 71-3 for pigment safety
    • BASF and Dystar internal chemical stewardship protocols

    Typical usage ratio

    • Applied at 0.7–1.2 equivalents versus co-monomer, depending on target dye type
    • Adjusted to manage chromatic intensity and reduction conditions

    Downstream process integration

    • Charged in the diazotization reactor for formation of azo bridge
    • Feeds directly into high-shear mixing and filtration trains
    • Supports step-growth polymerization lines for pigment intermediates
    • Facilitates inline NIR/colorimetry QA checkpoints

    Final product types

    • Disperse and acid dyes for polyester and polyamide fibers
    • High-performance pigments for plastics, inks, and coatings
    • Azo dye intermediates used in textile printing
    • Leather colorants and automotive pigment dispersions

    3. Pharmaceutical Intermediate Production

    This compound enters pharmaceutical API synthesis primarily for nitroaniline transformations, key to antibacterial and CNS drug backbones. In GMP-compliant facilities, material undergoes catalytic hydrogenation and subsequent substitution, yielding protected intermediates for further functionalization. Detailed release testing accompanies every shipment, aligning traceability with Ph. Eur. or USP compendial guidance. Material-specific impurity profiling assures safe transition to clinical supply chains, with full data transparency in DMF submissions.

    Industry compliance standards

    • EudraLex Volume 4 (EU GMP guidelines for APIs)
    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • FDA 21 CFR Part 210/211 (US GMP for finished pharmaceuticals)
    • European Pharmacopoeia and US Pharmacopeia monographs (intermediate tracking)

    Typical usage ratio

    • Generally charged at 0.95–1.05 molar equivalents per batch of target intermediate
    • Ratio variability depends on catalyst efficiency and desired yield

    Downstream process integration

    • Processed in hydrogenation vessels for nitro group reduction
    • Feeds directly into protected aniline intermediate synthesis
    • Sampling by QC for residual solvents and heavy metals at each unit operation
    • Controlled storage under GMP audit trail requirements

    Final product types

    • Chlorinated nitroaniline API intermediates
    • Sulfanilamide antibiotic precursors
    • CNS-active API scaffolds
    • Pharmaceutical-grade process chemicals (non-commercialized intermediates)

    4. Rubber Chemical Additive Synthesis

    The specialty rubber chemicals sector employs 4-chloronitrobenzene in the synthesis of antioxidants and vulcanization accelerators. Its reactive functional groups participate in nucleophilic substitution, generating intermediates for thiazole and sulfenamide accelerators. We provide large-volume batches with finite trace impurity caps essential for high-MW rubber processing, supporting continuous reactor train production and in-process analytical verification for residual chlorine and nitro contaminants.

    Industry compliance standards

    • ASTM D4678 Standard Practice for Rubber Compounding Materials
    • ISO 9001:2015 (rubber processing quality)
    • REACH Annex XVII (restrictions on specific hazardous chemicals)
    • Automotive OEM restricted substances lists

    Typical usage ratio

    • Commonly dosed at 0.6–1.2 equivalents versus downstream amine or thiol reactant
    • Adjusted per batch for polymer grade and target molecular architecture

    Downstream process integration

    • Batch-fed into sulfenamide and thiazole formation stages under nitrogen atmosphere
    • Integrated at early stage of accelerator synthesis sequence
    • Subjected to inline HPLC and GC-MS impurity controls before final formulation
    • Supports post-reaction melt-mixing in rubber compounding units

    Final product types

    • 2-Mercaptobenzothiazole-based accelerators (MBT, MBTS, etc.)
    • Antioxidant additives for tire compounds
    • Vulcanization accelerator blends for synthetic elastomers
    • Processing additives in automotive and industrial rubber

    5. Fine Chemical and Specialty Monomer Synthesis

    Manufacturers specializing in fine chemicals utilize this building block to synthesize high-value specialty monomers and linkers. Its dual-substituted ring permits regioselective reactions, including nucleophilic aromatic substitution or palladium-catalyzed coupling. Our plant delivers the required purity level for high-yield, low-residue routes. Full batch records ensure customers meet performance criteria on polymer properties such as optical density or dielectric strength in their advanced materials.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management Systems
    • REACH SVHC candidate list (material declarations)
    • Chemical Substance Control Law (Japan)
    • Enterprise-specific supply chain audit requirements (semiconductor sector)

    Typical usage ratio

    • Applied at 1.0–1.3 equivalents versus organometallic or nucleophile reagent
    • Ratio flexed for process optimization in kinetic or batch flow regimes

    Downstream process integration

    • Added directly in continuous-flow reactors for precision monomer development
    • Charging scheduled in parallel to catalyst activation phase
    • Effluent monitored for residual aromatic halides
    • Batch-tracked using LIMS for traceability to finished materials

    Final product types

    • Rigid aromatic monomers for high-performance polymers
    • Specialty linkage units in OLED and optoelectronic components
    • Crosslinkable moieties in advanced photoresists
    • Dielectric additives for electronics encapsulation

    6. Explosives Intermediate Manufacturing

    In the energetics sector, companies use this chemical for controlled production of nitroaromatic intermediates fundamental to certain industrial explosives. The material undergoes reduction followed by further derivatization to generate donor fragments for stable, detonator-sensitive compounds. Close traceability prevents diversion, as mandated by international trade compliance. We implement batch controlled shipments under hazardous material handling protocols, enabling defense and mining customers to maintain full regulatory alignment.

    Industry compliance standards

    • UN Recommendations on the Transport of Dangerous Goods (Orange Book)
    • US ATF Explosives Law and Regulations (27 CFR Part 555)
    • EU Regulation (EC) No 273/2004 (precursors reporting & controls)
    • ISO 22301 Business Continuity in Hazardous Chemicals Supply

    Typical usage ratio

    • Processed at 1.1–1.5 molar equivalents, adjusted by target energetic formulation yield
    • Fine-tuned to minimize undesired byproduct formation during scaling

    Downstream process integration

    • Supplied to reduction and condensation reactors for intermediate conversion
    • Batch spray-dried for controlled particle size in sensitive blends
    • Subject to precursor reporting and full chain-of-custody audit trail
    • Handled under explosion-proof containment and inert gas blanket

    Final product types

    • Nitroaromatic donor intermediates for detonators
    • Initiator additives in mining explosives
    • Military-grade booster compound components
    • Energetic binders for fuse and cap manufacturing
    Free Quote

    Competitive 4-Chloronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing Our 4-Chloronitrobenzene: Experience and Value Built into Every Batch

    Real Chemical Manufacturing, Real Consistency

    Decades ago, our facility started with a handful of reactors and a commitment to steady output. Today, our process for producing 4-Chloronitrobenzene—casually called 4-CNB among those who work with it daily—reflects our team’s hard-earned knowledge. In these lines, we share not just what defines our product, but what it feels like to work with this compound from the ground up.

    The Real Face of 4-Chloronitrobenzene: What We Make

    Anyone manufacturing intermediates for agrochemicals or dyes meets 4-Chloronitrobenzene early in the chain. This compound, with its clean pale-yellow crystalline form, stands apart from related materials thanks to both its reactivity and selectivity—attributes we’ve tuned by refining our temperature profiles, agitation rates, and recovery methods over many years. Our most common material runs a minimum purity of 99.0% by GC, and water content regularly tracks below 0.5%, measured batch by batch for confirmation. Trace contaminants, especially ortho-isomers or unreacted nitrobenzene, can spoil downstream reactions. Chemists working at scale can't afford inconsistent feedstock. That’s a truth we address directly, because our own production lines depend on it just as much as our partners’.

    From Experience: Why Manufacturing Quality Matters

    Much of the 4-Chloronitrobenzene reaching customers around the world starts in facilities that put output ahead of traceability. Our approach is simpler: run fairly, document well, and let the numbers from each lot speak for themselves. We still use in-line process controls and detailed logbooks for every lot—no shortcuts. Our QA engineers chase down even minor fluctuations in melting point, color, or by-product profiles. We’ve seen what happens when those details get overlooked: whole downstream syntheses gone off track, or a plant halted for days while a supplier sidesteps the conversation. Our method takes longer and sometimes costs more, but repeat business and a lower complaint rate were never about flashing labels or fancy brochures. They’re the payoff for investing in thick-walled reactors, quality raw materials, and diligent supervision at every stage.

    Real-World Applications: Supporting Chemistry, Not Headlines

    The bulk of our 4-CNB flows straight into manufacture of pesticides, particularly intermediates leading to products like chlorphenilines and related organophosphates. The reaction route often runs through nucleophilic aromatic substitution on the para-chlorine, a step that rewards a low contaminant load—especially for pharmaceuticals or specialty dyes, where trace impurities can disrupt quality controls. Out-of-specification isomer content can mean days of lost production and scraped product. We work hand in hand with R&D specialists on both sides of the globe, often adjusting specifications or running pilot batches side-by-side to optimize for yield and reactivity.

    Some customers use our 4-CNB as a reference in analytical labs, where consistency goes beyond a QC checkbox. In these environments, variation ruins repeatability. From Asia to Europe, our material continues to find homes in facilities unwilling to compromise on results.

    Comparing 4-Chloronitrobenzene Variants: Understanding the Details

    In decades past, generic 4-CNB from varying sources meant trying to run reactions with a blindfold. Today, differences come down to how tightly the crystallinity is controlled, how much cross-contamination from ortho isomers or dinitro compounds creeps in, and how many cycles of purification the material undergoes before it leaves our hands. All 4-CNB is not created equal. Material from hastily run nitration processes typically shows more color, higher water, and can carry faint odors from incomplete washing or oil residues. Even a tenth of a percent extra impurity can lead to unstable final products or color streaking in dyes.

    We also draw a line between bulk technical grade and refined material. Technical grade covers most agricultural purposes, but pharmaceutical or electronics customers select premium lots, which we prepare with extra care—more washing, additional screening, and tighter controls on trace metals and volatile by-products.

    Shedding Light on Global Supply Chains: Our View From Inside

    Supply risk rarely hits the spotlight until something goes wrong. We’ve lived through feedstock interruptions, currency swings, and logistics snarls. We don’t leave customers in the lurch with sudden gaps. Our contingency network draws on both in-house inventory and cooperative contracts with upstream suppliers. We buffer typical swings in demand by producing ahead and storing 4-CNB under tight environmental controls to preserve its integrity. Warm, humid storage creates trouble—crystals can cake, or color can drift. We use sealed drums, desiccant, and temperature-controlled storage, based on actual failures we've tracked since the 1990s.

    Some competitors move product shortly after filtration, ignoring storage loss. Our batches often rest for weeks so we can retest and confirm stability. Stock held too long in the wrong conditions turns up as a customer complaint months down the line. We trace every drum, every shipment, back to original production data. This isn’t for show. Long-term customers have learned the difference—and so, for that matter, have we. Each problem that comes back to us triggers new standards, not apologies and excuses.

    Safety, Handling, and the Honest Realities of Production

    We’ve witnessed the importance of good practices firsthand. Nitration reactions don’t suffer fools; the process generates heat, gases, and requires attention at every stage. Our operators are seasoned—our turnover stays low in part because new hires train side-by-side with those who’ve seen close calls and solved them, not just read files. Safe handling for us starts upstream, with personal protection, trained teams, and proven shutdown protocols. Days lost to accidents cost more than any paperwork penalty, and the lessons those events teach shape our protocols. Each batch certificate or shipping document we issue reflects that experience, not just a regulatory demand.

    Some buyers ask only about compliance or downstream hazards, but real safety comes from repeated good habits at the point of manufacture. Trace contamination of wastewaters or by-products can create regulatory headaches; we’ve built extra reclamation steps over the years, learning what cuts costs without cutting corners. Disposal partners run spot checks on every tank. Good relationships with them took time—testing boundaries, swapping data, solving minor spills before they become front-page news.

    Why Choice of Source Matters: Product in Practice

    Recipe book chemistry rarely matches factory floor reality. From upstream nitration to final purification, 4-CNB’s properties flex with upstream decisions. We tune nitrogen dioxide and temperature ratios to optimal ranges, based on test runs and lab feedback. Slight adjustments here decide whether the para-isomer dominates, or if off-flavors sneak in. Under-cooked nitration means waste, over-cooking means unwanted by-products. Our operators trust eyes and instincts—pale-yellow means right, amber hints at trouble.

    Every operator knows that tests and care matter more than fancy equipment. From the first charge of chlorobenzene through every cutoff and isolation, we focus on reproducibility. If a customer ever questions batch consistency, our response is more than a printout: we provide batch and trend data, so customers understand every link in the story.

    Issues with Quality: Downstream and Beyond

    No one forgets the day a multi-tonne shipment landed off-spec. One batch several years ago turned out with a faint green tint—trace iron contaminated a valve, unnoticed until crystallization. Hours spent retracing steps, scrapping product, and digging for clues taught us something no pamphlet could. Since then, we chase contaminants with a vengeance, and even the smallest unwanted peak in the chromatogram draws attention. Downstream users told us how off-colors or strange odors contributed to lost yields and machinery headaches. We work with them to trace each issue—sending experts with drums, not just samples, showing our willingness to face the problem together.

    Partnering with Customers: Building Reliability Together

    We view every partnership as a real-world test of both our batch quality and our willingness to listen. Customers reach out not for generic answers but honest troubleshooting. In some cases, we’ve redesigned parts of our drying or washing process after feedback. Joint trials, pilot-scale tweaks, and transparent dialogues form the backbone of loyalty that a brochure can’t buy. Repeat orders come because we invest the hours and custom attention long before the invoice prints. Relationships matter: with small buyers who need a single drum and with global corporations who call for railcar lots and technical support on demand.

    We also help customers adapt to shifting regulations, especially as standards for purity, traceability, and emissions tighten around the world. Our team spends time exchanging information—sometimes visiting users’ plants, sometimes running comparative trials. This isn’t about ticking boxes; it’s about learning together what results matter most in each application. It’s the difference between a supplier that merely ships a product and one that enables customers to solve changing challenges.

    Moving Forward: Sustainability and Process Improvements

    Waste and emissions stand as a daily challenge for any nitroaromatic operation. Through process improvements, we’ve slashed both water use and energy consumption over the past ten years. Investing in closed-loop water circuits and better heat recovery meant both lower costs and a safer working environment. Our engineers track and report their findings—what works, what doesn’t, and what needs a redesign. Each improvement starts with honest review of a setback or complaint, not a consultant’s sales pitch.

    Our customers value what they can see and verify: tracked waste numbers, transparent discharge records, shared audits all matter more than marketing claims. By keeping focus on practical day-to-day operation, we not only meet emerging local and international standards—we lead by example. That pays off with longer equipment life, safer operations, and fewer costly surprises down the line.

    Learning from Setbacks: Building on Real Experience

    Every manufacturing challenge—whether a stuck filter, an off-color reaction, or a missed target on yield—becomes a lesson. Our facility logs and shares these learnings so that both old hands and new hires can see how problems get solved on the floor. These stories, not procedure sheets, drive better performance. Sometimes what seems a minor issue marks the difference between a line running smoothly all year or standing idle for days. Every operator contributes solutions, not just managers, because results don’t come from a single desk or directive.

    Differences You Can Test: From Lab to Full Production

    Running semi-bulk nitration isn’t for the faint-hearted. Irregular off-gases, temperature swings, or feed spikes challenge even the most seasoned crew. We keep close track of impurity profiles—4-Chloronitrobenzene needs more than a color check. We run full GC, UV-vis, and trace metal tests on every batch, and let customers review the data if they request. Other manufacturers may promise, but we stake our name and repeat business on what the laboratory analysis says, not what a certificate claims.

    A side-by-side test with independent labs showed our product outperformed alternatives on reactivity, solubility, and isomer purity. Downstream users in dyes noticed better color reproducibility; agchem workers cut re-crystallization steps. Each application reveals a different dimension of quality, but chemical fundamentals always drive the difference.

    Proud of Our Product, Honed by Experience

    Nobody taking shortcuts or focusing on volume alone could match the reliability we’ve built into our 4-Chloronitrobenzene. This chemical needs careful attention, practiced eyes, and willingness to answer tough questions day after day. Our team, facility, and customers push us—and we welcome it.

    Whether your work calls for consistent technical grade in agrochemical manufacture, extra-pure batches for dye synthesis, or just an honest partner ready for a challenge, our 4-Chloronitrobenzene stands ready. Each drum, each shipment, every spec and analysis: these represent our best work, earned the only way that counts—through experience, transparency, and genuine attention to the needs of chemical producers worldwide.