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4-Chloro-M-Cresol

    • Product Name 4-Chloro-M-Cresol
    • Alias p-Chlorocresol
    • Einecs 202-213-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    656291

    Chemical Name 4-Chloro-m-cresol
    Synonyms 4-Chloro-3-methylphenol
    Molecular Formula C7H7ClO
    Molecular Weight 142.58 g/mol
    Cas Number 59-50-7
    Appearance White to pale yellow crystalline powder
    Melting Point 64-66 °C
    Boiling Point 235 °C
    Solubility In Water Slightly soluble
    Density 1.29 g/cm³
    Flash Point 118 °C
    Pubchem Cid 6115

    As an accredited 4-Chloro-M-Cresol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 4-Chloro-M-Cresol is packaged in a 500g amber glass bottle with hazard labeling, tamper-evident seal, and chemical-grade details.
    Shipping 4-Chloro-m-cresol is shipped in tightly sealed, chemical-resistant containers to prevent leaks or contamination. It must be handled with care, following hazardous material regulations, including proper labeling and documentation. Avoid exposure to extreme temperatures and incompatible substances during transport. Use appropriate protective equipment when handling shipping containers to ensure safety.
    Storage 4-Chloro-m-cresol should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as oxidizers and strong acids. Keep the storage area clearly labeled and restrict access to trained personnel. Protect from moisture, direct sunlight, and excessive heat. Use proper chemical containment to prevent leaks or spills.
    Application of 4-Chloro-M-Cresol

    Applications of 4-Chloro-M-Cresol in Industrial Manufacturing

    As a direct manufacturer of 4-Chloro-M-Cresol, we support leading formulators and industrial processors worldwide by delivering material that meets stringent regulatory standards for critical applications. Below, we provide a detailed overview of its real-world functional roles in key downstream sectors, outlining compliance standards, recommended dosage guidelines, process integration points, and end-use finished goods for each sector.

    1. Preservative in Pharmaceutical Topical Formulations

    In the pharmaceutical industry, 4-Chloro-M-Cresol acts as an antimicrobial preservative, particularly for creams, ointments, and injectable solutions requiring reliable microbial control during storage and patient use. It remains compliant with pharmacopeial guidelines for preservative systems in both over-the-counter and prescription topical preparations, as well as certain sterile products where parenteral-grade excipients are permitted. Manufacturers rely on its broad-spectrum antimicrobial activity to improve shelf life and product safety without interfering with active pharmaceutical ingredients.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) Monograph 4.1.3
    • British Pharmacopoeia (BP)
    • United States Pharmacopeia (USP), when specified
    • GMP WHO guidelines for finished dosage forms

    Typical usage ratio

    • Concentration generally ranges from 0.1% to 0.2% w/w of total formulation. Final percentage is determined based on product type, pH, and compatibility studies with actives and excipients.

    Downstream process integration

    • Material is dissolved in aqueous or semi-solid phase during initial blending or compounding steps. For sterile products, addition occurs prior to final filtration or aseptic fill, ensuring homogenous distribution and preservative function throughout the batch.

    Final product types

    • Dermatological creams and ointments
    • Injectable suspensions (as per monograph allowance)
    • Gels for topical application
    • Ear and nasal drops

    2. Antimicrobial Preservative in Personal Care Emulsions

    Personal care manufacturers incorporate 4-Chloro-M-Cresol into cosmetic creams, lotions, and other oil-in-water or water-in-oil emulsions to ensure product safety and resistance to bacterial and fungal growth during shelf life and end-user handling. Owing to its efficacy across a broad pH range and strong compatibility with non-ionic surfactants or fatty alcohols, it is valued in both rinse-off and leave-on formulations targeting global markets where microbiological integrity must be demonstrated under ISO and SCCS cosmetic regulations.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009 – Annex V (Preservative use)
    • ASEAN Cosmetic Directive
    • International Organization for Standardization (ISO) 29621:2017
    • SCCS safety assessments for preservative systems

    Typical usage ratio

    • Commonly added at 0.05% to 0.2% w/w of finished formula. Level is chosen based on intrinsic water activity, packaging type, and preservative challenge test outcomes.

    Downstream process integration

    • Introduced during the aqueous phase preparation or emulsion blending stage. Homogenization ensures distribution throughout the product matrix before cooling and packaging.

    Final product types

    • Face and body moisturizers
    • Hand creams
    • Children’s creams (subject to regional restrictions)
    • After-sun and barrier creams

    3. Active Ingredient in Veterinary Antiseptic Formulations

    The veterinary sector utilizes 4-Chloro-M-Cresol as a principal biocidal component in antiseptic solutions, skin disinfectants, and wound washing products for livestock and pets. Its recognized spectrum of activity against Gram-positive and Gram-negative organisms supports veterinary pharmaceutical compliance, particularly for products targeting pre-surgical skin preparation and treatment of minor injuries in animals.

    Industry compliance standards

    • European Medicines Agency (EMA) Veterinary Medicinal Products Regulation
    • US FDA CVM guidance for animal drugs
    • VICH GL33 Good Manufacturing Practice (GMP) for Veterinary Products
    • Relevant national pharmacopoeias (e.g., British Veterinary Pharmacopoeia)

    Typical usage ratio

    • Formulated at 0.2% to 0.5% w/v, adjusted for application method, required microbiocidal performance, and species-specific tolerability.

    Downstream process integration

    • Added to the aqueous phase during solution preparation or at final dilution prior to sterile filtration, then filled into ready-to-use bottles or sprays. Manufacturing process control verifies uniformity and antimicrobial test compliance before release.

    Final product types

    • Veterinary wound antiseptics
    • Preoperative animal skin cleansers
    • Disinfectant washes for hooves or skin conditions
    • Topical sprays for minor cuts and abrasions

    4. Functional Preservative in Water-Based Paints and Coatings

    Paint and industrial coatings manufacturers integrate 4-Chloro-M-Cresol as an in-can preservative in waterborne paint systems to prevent microbial spoilage during storage, transport, and end-use application. This additive helps control both bacterial and fungal growth in high-moisture content formulations, maintaining product consistency and safety from factory to job site under relevant chemical safety and environmental guidelines.

    Industry compliance standards

    • REACH Registration, Evaluation, Authorization and Restriction of Chemicals Regulation (EC) No 1907/2006
    • Biocidal Products Regulation (BPR) (EU) No 528/2012 – Product Type 6 (Preservatives for Products during Storage)
    • ASTM D2574 – Standard Test Method for Resistance of Emulsion Paints to Microbial Attack
    • ISO 11998:2006 for Paints and Varnishes Performance Testing

    Typical usage ratio

    • Standard application levels are 0.05% to 0.15% by weight of total paint mass, calculated according to in-can contamination risk, storage conditions, and compatibility with latex or acrylic systems.

    Downstream process integration

    • Dispersed into the water phase or pigment grind side during the initial mixing step, allowing for effective control of microbial contamination risks before and after final batch blending. Often retained through filtration and packaging stages.

    Final product types

    • Waterborne emulsion paints
    • Environmentally compliant varnishes
    • Low-VOC architectural wall coatings
    • Industrial maintenance coatings for metal and wood

    5. Biocidal Component in Metalworking Fluid Preservatives

    Manufacturers of metalworking fluids use 4-Chloro-M-Cresol within preservative packages that sustain the microbiological and physical integrity of water-miscible cutting, grinding, and cooling emulsions. Its stable biocidal function in aqueous and alkaline environments prevents bacterial degradation of fluid properties, extending machinery and tool lifespans and improving occupational safety in compliance with occupational hygiene protocols.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals, especially regarding biocides
    • European Chemical Agency (ECHA) Biocidal Products Regulation – PT 13 (Metalworking Fluids)
    • German TRGS 611 (Technical Rules for Hazardous Substances: Substitution of Hazardous Substances in Metalworking Fluids)
    • EN ISO 14001:2015 for environmental management in industrial applications

    Typical usage ratio

    • Effective dosage typically set in the 0.1% to 0.3% range, optimized through challenge tests against bacteria and fungi and fluid service-life expectations.

    Downstream process integration

    • Added during concentrate manufacturing or as a tank-side additive during dilution with water. QC laboratories monitor activity throughout storage and recirculation cycles on industrial shop floors.

    Final product types

    • Water-based metal cutting fluids
    • Grinding and honing emulsions
    • Machine coolant preservation systems
    • Multi-purpose maintenance lubricants for industrial machinery
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    Certification & Compliance
    More Introduction

    Introducing 4-Chloro-M-Cresol: Quality by Experience in Chlorinated Phenolics

    Our Experience with 4-Chloro-M-Cresol Production

    Walking through our chemical facilities, it’s clear that manufacturing 4-Chloro-M-Cresol is no straightforward task. This compound, known scientifically as 4-chloro-3-methylphenol, forms the backbone for many industrial and pharmaceutical applications. The process, honed over years of practice and attention to detail, brings out the consistency and purity serious users demand. Quality comes from painstaking selection of raw materials and knowledgeable reaction monitoring, with seasoned technicians guiding each batch.

    Chlorinated cresols occupy an important niche: they offer sharp antimicrobial power. Among them, 4-Chloro-M-Cresol stands out with a reliable antibacterial and antifungal profile—reaching a potency well known to formulators working in antiseptics, disinfectants, and preservatives for cosmetics, paints, and pharmaceutical products. Crosstalk with users over the years has taught that there’s rarely a margin for half-measures in this space. Each specification nuance translates into real-world results, and it’s the job of the manufacturer to bridge technical expertise with ongoing market and field feedback.

    Product Specifications: Serving Practical Needs

    4-Chloro-M-Cresol comes from our reactors as a free-flowing, pale white to faint tan crystalline powder. Users often care less about a pretty appearance and more about purity and reliable analytic performance. We deliver typical assay values above 99%, with tight controls on moisture, pH, and residual solvents. Particle size, often overlooked by distributors, gets tailored to minimize dust and settle correctly in final blends—whether preparing a liquid disinfectant concentrate or incorporating into dust-free solids.

    Batch consistency matters most to the end-user: one day you’re producing surgical scrubs, the next you’re adjusting a veterinary wash for livestock. During each run, our quality analysts test for the tiniest traces of related impurities. We’ve learned that even minor variations in impurity levels can alter shelf life and sensory performance, so every stage of the process must remain predictable.

    Why 4-Chloro-M-Cresol Matters in Daily Production

    Disinfectant and antiseptic products shift with evolving microorganisms and changes in regulations. Formulators come back to 4-Chloro-M-Cresol for a reason—it delivers broad-spectrum protection in tricky conditions. We've had bulk buyers recount years where alternative preservatives have failed, resulting in costly recalls or regulatory headaches. Immune to common antibiotic resistance patterns, this compound resists inactivation by organic matter.

    Manufacturers in the pharmaceutical industry rely on us for a consistent product that remains effective even in the presence of proteins or detergents. In personal care, preservative power must balance safety. Our experience points toward careful charge on purity and controlled residue to ensure gentle, non-irritating formulations. It’s not unusual to receive feedback from necessity-driven brand owners, especially as global preservative regulations tighten, reminding us that real-world performance cannot be traded for theoretical shelf stability.

    Working With the End User in Mind

    Delivering barrels or drums of 4-Chloro-M-Cresol is far more than a shipping exercise. Each order lands in labs or plants with different goals and constraints. We’ve learned that accurate, reliable documentation allows clients to speed up their registration and approval cycles. Regulatory compliance runs headlong into formulation creativity. Supporting our customers means giving transparent details on trace impurities and relevant test methods, learned from actually running side-by-side stability and challenge studies.

    Lab results alone never satisfy savvy technical buyers. Their staff runs a battery of analytical tests—high-performance liquid chromatography and melting point checks among them—so our own internal control must withstand scrutiny. Clients from Europe and North America, pressed by ever-shifting REACH and FDA demands, ask pointed questions about potential byproducts. Over years of dialogue, we’ve built test protocols robust enough to satisfy the most rigorous audits.

    Differentiation: How 4-Chloro-M-Cresol Compares

    The cresol family offers a handful of isomers, each with its own quirks. 4-Chloro-M-Cresol stands apart for a balanced solubility and effective biocidal spectrum. Some manufacturers working with o-cresol or 2-methyl-4-chlorophenol notice limited antibacterial range or compatibility problems in greasy or highly buffered systems. In our experience, 4-Chloro-M-Cresol plots a middle path—strong enough for institutional disinfectants, yet mild enough for topical products in skin and wound care.

    Unlike non-chlorinated cousins, this molecule manages higher activity at lower concentrations. That translates into lower dosing and reduced cost-in-use for large-scale production runs. We’ve seen formulators try to switch to cheaper materials and regret the move due to recurring contamination or instability. The chlorine atom, strategically placed, provides enhanced antimicrobial action without excessive toxicity—a benefit borne out by decades of in-use testing.

    Dealing with Industry Change: Regulations, Sustainability, and Innovation

    Compliance takes work. Global shifts toward greener chemistry and reduced VOC emissions force every producer to reconsider synthetic routes and waste streams. From our vantage point, changes in effluent standards and hazardous waste categorization challenge the efficiencies of legacy manufacturing methods. We have addressed these by building closed-loop recovery for solvents and investing in greener chlorination agents.

    Customers come to us with questions: How does 4-Chloro-M-Cresol measure up in today’s safety environment? How does it relate to newer, less-characterized alternatives? A reality of the business is that established molecules, backed by published safety and efficacy data, command trust and regulatory familiarity. Over time, we have steered dozens of customers through compliance reviews, providing fresh toxicology and environmental fate studies when authorities ask tough questions.

    Listening and Responding to Product Feedback

    Products succeed only as long as they do what they promise in the real world. A hospital infection control supervisor, several years ago, alerted us to a disinfection product failure traced to an out-of-spec impurity in a poorly sourced 4-Chloro-M-Cresol lot. As a manufacturer, the lesson stuck. Traceability, from lot number to certificate of analysis, became a watchword. Now, each inquiry receives complete spectra and detailed impurity breakdowns.

    We regularly conduct customer feedback sessions and after-action reviews on large-scale product launches. One such review led to an improvement in particle size distribution that cut handling dust for a plant customer by 40%, improving worker comfort during manual bagging. Divining these improvements out of direct field reports—rather than by reading market surveys—gives the result authenticity.

    Challenges in Raw Material Supply and Security

    Much of the reliability story starts upstream—sourcing raw materials that carry consistent purity and sustainable credentials. The supply chain for chlorinated toluenes and related intermediates has grown tighter with increased environmental oversight. As a manufacturer, we secure our main feedstocks from suppliers with proven records and insist on third-party audits. Every feedstock supplier receives a full annual on-site review. This diligence guards against wins in price that can often drop quality silently, showing up only after end users encounter issues.

    Contingency plans developed through hard experience now form an essential part of our procurement workflow. During a period of regional shortages, we qualified secondary raw material lines and invested in in-house analytical testing to verify conformity before introducing new sources into live production streams.

    Supporting Responsible Use

    4-Chloro-M-Cresol offers powerful biocidal properties, so responsible handling and application matter as much as quality. Drawing on our experience, it’s clear that education counts. Field support includes not only answering technical questions, but also working closely with safety managers and environmental teams to provide honest assessments of usage hazards, storage requirements, and waste management best practices.

    Downstream industries value this straightforward advice. In livestock care, for example, safe dilution and disposal matter just as much as endpoint efficacy. By offering on-site training and up-to-date user guidelines based on evolving field conditions, we enable our customers to handle this compound safely throughout its lifecycle.

    Looking to Tomorrow: Innovation and Development

    Next-generation applications challenge us to stretch what’s possible. Pharmaceutical innovators press for lower impurity specifications and find new formulation arenas for old molecules. Our R&D teams have experimented with microencapsulated forms to extend shelf life and reduce volatility in complex blends, for instance in water-based surface disinfectants.

    Environmental questions never slow down. We invest in lifecycle studies to verify the degradability profile and environmental impact of 4-Chloro-M-Cresol under real disposal conditions. These inform not only our practices, but help downstream users face modulating regulatory caps on certain preservatives and biocides.

    We work with partners—academic groups, consortia, and contract research labs—to stay ahead of the scientific curve, ensuring our technical recommendations evolve with new knowledge and regulatory precedent.

    The Place of 4-Chloro-M-Cresol in Modern Industry

    With time, manufacturers serving the healthcare, personal care, and paint sectors learn to value predictability. Substituting chemical building blocks always brings risk, so specification control and field-tested reliability keep 4-Chloro-M-Cresol featuring on raw material lists. While some users chase the next new alternative, many prefer the history, the published safety data, the know-how built up by generations of users.

    Our experience guides us to offer the product in pack sizes appropriate to user needs—from small research-grade quantities for R&D to drums and IBCs for high-throughput production. Product handling advice draws on years of customer feedback: stable under normal storage, yet safeguarded in cool, dry areas and away from incompatible substances.

    Continuous Improvement: Learning from Every Batch

    Meeting a dynamic market takes more than keeping up with paperwork or routine process runs. We invest in new equipment, automated process controls, and deeper analytical capabilities. Even the most classic compounds deserve fresh eyes: each production run yields insight into fine-tuning process steps, reducing waste, shortening reaction cycles, or improving yields—all serving better customer experiences.

    Quality management here is not a slogan—it’s embedded in daily routines, from technician training to executive review of supplier performance. The lessons learned from decades in the industry shape our ongoing development of 4-Chloro-M-Cresol and reinforce the trust placed in us by technical and regulatory customers.

    Addressing Industry Pain Points: Purity, Documentation, and Regulation

    Markets only grow more demanding. Pharmaceutical companies regularly require sub-ppm (parts per million) impurity levels, with trace heavy metal and residual solvent data supplied transparently. We respond by tightening our filtration, crystallization, and drying steps—often at significant operational cost—to keep leading in quality.

    Every shipment carries a detailed certificate of analysis, supported by a secure, digitized records system that allows for complete traceability from raw material intake to product dispatch. Our compliance teams maintain close relationships with the primary regulatory agencies in all our regions of operation, staying current on the latest requirements affecting antimicrobial agents and preservatives.

    Shaping Technologies for Greater Impact

    As the world gets more complex, the role of reliable chemical inputs grows even more important. 4-Chloro-M-Cresol sits at the intersection of proven science and emerging needs—from pandemic-era surface cleaners to preservative systems in fast-evolving consumer products. Our practical intelligence, gained from long operations in the field, supports both incremental improvements and major breakthroughs in application.

    Listening to engineers, plant operators, and product managers from many industries grounds our product development in real-world challenges. Implementing automation in inventory management and blending has cut error rates and improved customer outcomes. These changes come straight from collaborative fieldwork with clients tracking every input and yield on high-throughput lines.

    Why Consistency and Integrity Matter

    To keep 4-Chloro-M-Cresol as a trusted option, strict consistency from lot to lot is non-negotiable. Drift in process parameters, caused by shortcutting on equipment maintenance or changes in supplier chemistry, puts everything at risk—from formulation stability to regulatory approval. Our teams spend time with every batch, validating instrumentation and running comparison tests to reference samples kept under controlled conditions.

    This attention to technical integrity has prevented costly recalls and legal disputes for our customers. Beyond product, we share what works (and what doesn’t) with direct conversations, field visits, and honest technical feedback. Many solutions come not from standards committees but from shop-floor insights and urgent troubleshooting. In the world of real materials, hands-on experience still leads.

    End Use: Addressing Real-World Needs

    Diversity of use characterizes 4-Chloro-M-Cresol, from antiseptics in healthcare to preservation of paints and cutting fluids. Production managers from different sectors contact us for technical guidance, sometimes looking for insight into how subtle formulation tweaks can change the scope or quality of their finished products. Our staff can point to case studies where a specification change, based on user-provided failure reports, solved production issues and improved ultimate product lifespan.

    Working alongside technical teams in customer facilities, we investigate root causes of performance variability and contribute fixes, whether they involve adjustments to dissolution rates, reducing foaming in blending, or optimizing heat stability under sterilization. These interactions sharpen our technical responses and fuel advancements in product formulation.

    Summary Commentary

    Nearly every aspect of 4-Chloro-M-Cresol’s success comes down to long-term engagement with buyers and users. Our manufacturing ethos centers on the belief that close relationships and constant knowledge-sharing raise the collective quality and safety of finished goods across sectors. Combining laboratory excellence with responsive service, we back our cresol chemistries with a track record built not just on data, but on real-world, in-plant performance.

    Through investment, listening, and relentless focus on field outcomes, we maintain 4-Chloro-M-Cresol as a reliable cornerstone for antibacterial and preservative formulations across a spectrum of technical challenges. As regulations tighten and demand for high-performance stabilizers and biocides grows, we stand ready to adapt, improve, and deliver—batch by batch, project by project, with every customer we serve.