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4-Chloro-2-Nitrotoluene

    • Product Name 4-Chloro-2-Nitrotoluene
    • Alias 4-chloro-2-methylnitrobenzene
    • Einecs 221-030-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    373971

    Chemicalname 4-Chloro-2-Nitrotoluene
    Casnumber 89-60-1
    Molecularformula C7H6ClNO2
    Molecularweight 171.58
    Appearance Yellow crystalline solid
    Meltingpoint 46-49°C
    Boilingpoint 261°C
    Density 1.37 g/cm3
    Solubilityinwater Insoluble
    Flashpoint 130°C
    Synonyms p-Chloro-o-nitrotoluene
    Odor Aromatic
    Refractiveindex 1.579
    Storageconditions Store in a cool, dry, well-ventilated place

    As an accredited 4-Chloro-2-Nitrotoluene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Brown glass bottle, tightly sealed, labeled with hazard warnings and chemical details, containing 500 grams of 4-Chloro-2-Nitrotoluene.
    Shipping 4-Chloro-2-Nitrotoluene is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It should be handled as a hazardous material, with proper labeling, according to DOT and international shipping regulations. Adequate ventilation and spill containment must be ensured during transport. Use UN-approved packaging to prevent leaks or spills.
    Storage 4-Chloro-2-nitrotoluene should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition. It should be kept away from strong oxidizers, acids, and reducing agents. Store it away from direct sunlight and incompatible substances. Ensure containers are properly labeled, and access is restricted to trained personnel in compliance with safety regulations.
    Application of 4-Chloro-2-Nitrotoluene

    Applications of 4-Chloro-2-Nitrotoluene in Industrial Manufacturing

    4-Chloro-2-Nitrotoluene plays a critical role in several industrial applications as a key intermediate. Our manufacturing expertise ensures consistent purity and supply security for customers with stringent process requirements. Below, we outline verified downstream applications, specifying essential compliance standards, formulation details, integration stages in customer processes, and targeted final product outcomes.

    1. Agrochemical Active Ingredient Synthesis (Herbicide Intermediates)

    Agrochemical producers rely on 4-Chloro-2-Nitrotoluene for the synthesis of specific herbicidal actives, particularly those featuring nitroaryl substructures. In this context, it serves as a core building block in multi-stage organic synthesis. Downstream integration occurs through nucleophilic substitution and reduction routes, with precise in-process control to ensure purity for safe agricultural application.

    Industry compliance standards

    • FAO/WHO Specification for Pesticide Active Ingredients
    • ISO 9001:2015 Quality Management System requirements
    • REACH Regulation (EC) No 1907/2006 (for Europe)
    • Hazardous Substances Control Law (Japan), as applicable to starting materials

    Typical usage ratio

    • 10–20% of total reaction mass in synthesis, adjusted based on target molecule
    • Stoichiometric proportion determined by the desired batch yield and nature of coupling partners

    Downstream process integration

    • Introduced as a principal aromatic intermediate in the initial or mid-stage condensation reactions
    • Directly involved in nitro group transformations, followed by coupling or cyclization, depending on the herbicide route

    Final product types

    • Active herbicidal compounds (e.g., nitroaniline or nitrophenyl-based herbicides)
    • Granular and emulsifiable concentrate herbicide formulations
    • Pre-mix technical concentrates for agricultural use

    2. Dye and Pigment Intermediate Manufacturing

    Dye manufacturers incorporate 4-Chloro-2-Nitrotoluene during the production of azo and disperse dyes, especially those formulated for synthetic fiber coloration in textiles. This compound provides the halogen and nitro functionalities required for specific chromophores, supporting colorfastness and process yield. Manufacturers must monitor reaction conditions closely to prevent unwanted side reactions affecting color purity.

    Industry compliance standards

    • Oeko-Tex Standard 100 (textile safety and ecological standards)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • EN ISO 105 (Textiles – Tests for Colour Fastness)
    • Regulation (EC) No 1907/2006 REACH (Aromatic amine precursor controls)

    Typical usage ratio

    • 15–35% of dye intermediate batch, tailored according to the specific molecular structure of the dye
    • Ratio modified based on target shade, dye class (azo or disperse), and fiber compatibility

    Downstream process integration

    • Added to diazotization or coupling reaction phases for construction of chromophoric systems
    • Engages in substitution and condensation steps forming colorant backbones with required stability

    Final product types

    • Disperse dyes for polyester and synthetic fibers
    • Azo dye intermediates for textiles and plastics
    • Colorants for automotive, textile, and industrial coatings

    3. Pharmaceutical Intermediate (API Precursor Synthesis)

    4-Chloro-2-Nitrotoluene serves as a controlled intermediate in the pharmaceutical industry for the synthesis of select active pharmaceutical ingredients, notably in the anti-infective and anti-inflammatory classes. Its structural features are exploited in multi-step API syntheses where halogenated nitro aromatic groups impart target bioactivity. Handling and quality evaluation follow strict cGMP protocols to mitigate impurities and ensure traceability.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Parts 210/211 (Current Good Manufacturing Practice – CGMP regulations)
    • European Pharmacopoeia (Ph.Eur.) requirements for API intermediates
    • WHO GMP (World Health Organization Good Manufacturing Practices)

    Typical usage ratio

    • 5–18% of total synthetic batch weight, precisely calculated per API route of synthesis
    • Optimized to minimize residual levels during purification and minimize risk of genotoxic impurities

    Downstream process integration

    • Introduced at early to intermediate stages of API build-up
    • Participates in key nitro-group reductions or halogen substitutions forming pharmacophores

    Final product types

    • API molecules (e.g., intermediates for chlorinated or nitroaromatic pharmaceuticals)
    • Bulk drugs completed after further downstream transformations
    • Pharmaceutical fine chemicals for subsequent API synthesis

    4. Chemical Synthesis of Specialty Optical Brighteners

    Optical brightener manufacturers utilize 4-Chloro-2-Nitrotoluene in the production of specialty stilbene-based and benzoxazole-type agents. Its chemical properties facilitate the introduction of electron-withdrawing nitro groups, which are further reduced and functionalized for improved brightening intensity. Careful formulation ensures compatibility with detergents, textile auxiliaries, and papermaking chemistries.

    Industry compliance standards

    • Regulation (EC) No 648/2004 on Detergents (Europe)
    • Toy and Textile Safety Directives (EN 71, ISO 17072)
    • GHS-CLP Regulation for chemical safety and labelling
    • RoHS (Restriction of Hazardous Substances Directive) for electronics brighteners

    Typical usage ratio

    • 12–28% of reaction charge, tuned based on the structural target and product brightness specification
    • Exact ratio selected to balance reaction throughput with conversion efficiency

    Downstream process integration

    • Used during early steps to construct the aromatic backbone of brightener compounds
    • Treated by reduction or further substitution to yield high-purity stilbene/benzoxazole derivatives

    Final product types

    • Optical brightening agents for laundry detergents
    • Fluorescent whitening agents for textile finishing
    • Pulper and papermaking enhancers for enhanced whiteness

    5. Manufacture of High-Performance Plastic Additive Intermediates

    Polymer and plastics additive manufacturers employ 4-Chloro-2-Nitrotoluene as a precursor in the formation of stabilizers and processing aids intended for engineering thermoplastics and resins. These intermediates enhance UV-stability and mechanical durability of finished polymers. The ingredient enters controlled chlorination or derivatization steps tailored to end-use resin systems.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for polymer additives
    • EU REACH Regulation (Annex XVII restrictions and substance registration requirements)
    • UL 94 (Standard for Flammability of Plastic Materials)
    • ICES Regulatory Compliances in Japan for plastics ingredients

    Typical usage ratio

    • 8–22% of intermediate preparation mass, variable by target additive chemistry and function
    • Adjusted based on molecular weight of the stabilizer or antioxidant being synthesized

    Downstream process integration

    • Fed into the halogenation or condensation phase to build functional plastic additive molecules
    • Pre-curing or post-curing stages as dictated by the polymer compatibility and final additive performance

    Final product types

    • UV stabilizers for automotive and architectural plastics
    • Process aids for polyolefins and engineering resins
    • Custom additives for electronics and specialty packaging films
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 4-Chloro-2-Nitrotoluene: Our Approach to Consistency and Reliability

    Our Commitment to Chemical Quality Begins with 4-Chloro-2-Nitrotoluene

    Every batch of 4-Chloro-2-Nitrotoluene that leaves our facility represents years of technical know-how. Our process prioritizes consistency, purity, and transparency because customers in agricultural-chemical production, dye intermediates, and specialty coatings depend on products that perform exactly as described. We know how valuable trust is, especially in a market where any deviation in specification can disrupt downstream reactions or introduce unpredictable risks into finished goods.

    How We Define and Control the Product

    We treat every stage of 4-Chloro-2-Nitrotoluene production as a point of critical control. Before any reaction starts, all input raw materials undergo strict quality checks. From raw to purified product, continuous monitoring protects against cross-contamination and ensures target percentages of moisture, ash, and organic residue fall within our internally-developed limits. No shortcuts here—years in business have taught us that unmonitored process variables turn into inconsistent batches or unwanted by-products.

    4-Chloro-2-Nitrotoluene serves as a key intermediate in diazo, azo, and nitro dye reactions. Its presence in herbicides and fine chemical synthesis comes down to its reactivity, where both the chloro and nitro groups maintain high selectivity without introducing unpredictable side reactions. We maintain a melting point of 54–56°C and guarantee a minimum purity of 99.0%. A small adjustment in process temperatures or solvent ratios can tip a reaction toward the wrong isomer or increase content of trace by-products—so our operators and engineers keep tight records and real-time checks throughout each step.

    How Our Specifications Make a Difference

    Not every batch seen on the market lives up to the full potential of 4-Chloro-2-Nitrotoluene’s chemistry. Through direct experience supporting hundreds of industrial customers, we’ve observed that off-spec material—be it lower purity, excessive color, or hidden water content—often sneaks in downstream and wastes more time in purification or repair than any apparent savings in purchase price. Our assurance isn’t just about certificates; it comes from real samples sent to independent laboratories and from direct conversations with partners who have built colorants or protective coatings using our base materials.

    Comparing with other aromatic nitrotoluenes, the 4-chloro substitution significantly shifts the molecule’s reactivity profile. We see this in the way certain metallic catalysts respond, or in the less aggressive nature toward some common coupling agents. Choosing between 4-Chloro-2-Nitrotoluene and isomers or alternatives like 2-Chloro-4-Nitrotoluene is not a matter of cost, but of reaction route and desired safety margins—especially in high-throughput settings.

    End-User Applications and Industry Experience

    In dyestuff synthesis, no substitute fully replicates the clean intermediate-step conversions provided by 4-Chloro-2-Nitrotoluene. The nitro and chloro groups, held at defined positions, enable direct introductions onto aromatic rings without excessive rearrangement or by-product formation. We provide technical support for customers scaling up reactions—offering not just best-case laboratory yields, but hard-won data on mixing rates, catalyst tolerances, and neutralization steps that only long-term manufacturing yields.

    Herbicide production also benefits from exacting purity. Batch inconsistencies, even at the ppm level, generate out-of-specification intermediates that put registration or downstream certification at risk. Over years, partnering with large-scale agrochemical plants, we’ve field-tested batches to check for any trace amines, halides, or unforeseen residual solvents, preventing costly process interruptions.

    Transparency Across the Supply Chain

    Traders and resellers rely on the efforts of true manufacturers. Our origin in direct chemical manufacturing means we handle every stage from raw aromatics procurement all the way through to final packaging. Real control over supply chain inputs, combined with feedback from our own process technicians and partner labs, produces information that our customers can actually depend on. We make every effort to document changes—whether upstream feedstock adjustments or protocol shifts from regulatory additions—and todo so in plain language, not just dense technical reports.

    More than a few customers have encountered product mismatches from blended or relabeled material. This pushes us even harder to offer thorough batch records, clear shipment histories, and easily trackable sample data, so buyers always know where, how, and to what standards each drum originated. Our in-house team is available to discuss not just what’s in the product, but also what isn’t, because trace organics below regulatory reporting thresholds can still impact sensitive pharmaceutical, pigment, or agrochemical applications.

    What Sets Our Facility Apart

    Manufacturing experience makes all the difference. Automated reactors, closed-loop distillation, and real-time chromatography equipment allow us to go beyond what traditional batch production can guarantee. Operators carefully measure runtimes, exact ratios, and the removal of reaction heat, so each batch matches the intended regioselectivity and isomer profile.

    Temperature swings, solvent residue, or improper storage will affect both stability and reactivity—and in our process, we control these with the same attention we apply to initial reactions. Storing finished product away from direct sunlight and in sealed containers is not simply best practice—it’s based on years observing color drift, caking, or loss of reactivity from lax post-processing. We never ship until shelf-life and storage stability are properly verified internally.

    Working Directly With Manufacturers Benefits End Products

    Switching sources, people often find unexpected consequences. We have seen new clients trying to salvage off-color, lower-purity batches from brokers, only to invest far more in reprocessing than they would have spent for a factory-guaranteed supply. Our long-term customers report fewer batch failures and cleaner analytical results, spending less on downstream filtration or corrective chemistry. Our chemists spend as much time advising on optimal storage and process handling as on initial delivery, because small mishandlings quickly escalate in sensitive synthesis.

    We engage directly with customers’ engineering teams, reviewing historical process data together. This helps catch issues, like solvent substitution sensitivities or side-reaction triggers, that hidden impurities from uncontrolled supply can introduce. As chemical processes grow more tightly regulated and product tracing becomes essential for compliance, knowing the actual producer has grown into a supply chain need—no one wants to scramble for documentation or discover inconsistencies at audit time.

    Differences Between 4-Chloro-2-Nitrotoluene and Other Alternatives

    The position of the chloro and nitro groups on the toluene ring impacts downstream synthetic flexibility. In 4-Chloro-2-Nitrotoluene, the para relationship between the nitro and methyl groups facilitates selective couplings and straightforward reductions. Substituting with another isomer alters yields, intermediate by-products, and sometimes leads to complete process redesigns in dye or API synthesis.

    Through years of comparative trials in our own labs and at customer sites, we’ve documented improved yields and faster reaction cleanups with 4-Chloro-2-Nitrotoluene where para-selectivity matters most. Replacement with unsubstituted nitrotoluenes fails to deliver these benefits, instead producing more complex waste streams requiring additional separation. In cases where end-use stability is critical—such as extended storage herbicide intermediates or long-life pigments—unintended side-products lead to customer complaints, regulatory returns, or short-shelf-life consignments.

    Customers heading toward high-purity or high-color applications, such as in pigments for printing inks or demanding active ingredient synthesis, require negligible residuals from isomers and starting materials. Only a tightly controlled 4-Chloro-2-Nitrotoluene process, rooted in hands-on manufacturing oversight, reaches this standard. Differences in melting point, volatility, and chemical reactivity matter for equipment calibration, yield calculation, and production safety. No reseller or generic batch, lacking full process history, can guarantee these details.

    Supporting Responsible Use and Compliance

    Beyond chemistry and process, safe and legal use of 4-Chloro-2-Nitrotoluene matters to everyone involved along the supply chain. Customers in Europe, North America, and Asia demand not only outright compliance with REACH and regional chemical registration, but also traceability for every shipment. Our documentation meets or exceeds each market’s regulations, thanks to close collaboration with legal, environmental, and product stewardship teams. Experience with global audits and ongoing reporting keeps our team prepared for regulatory updates, strict border controls, or customer safety data requests.

    We also know that regulatory bodies increasingly check for hidden pollutants. As part of our stewardship, we offer full trace-metal and chlorinated organics analyses, even those below the threshold of standard market practice. We help customers document and disclose efficacy, test results, and compliance in a way that survives both paperwork audits and real-world laboratory scrutiny. This thorough, real-data approach means our product can support even highly scrutinized supply chains, covering everything from agricultural active ingredients to complex dye intermediates.

    Never Standing Still—Continuous Improvement as a Manufacturer’s Mindset

    Knowing the chemistry and process isn’t enough in the modern chemical landscape. Each year, we revisit production protocols to lower input waste, reduce energy consumption, and capture greater yield without sacrificing purity. Through investment in new reactor controls, up-to-date analytical equipment, and supplier development, every member of our team feels empowered to raise improvements. Recent upgrades in distillation columns, solids handling, and in-line monitoring have cut both batch cycle times and the chances of cross-contamination.

    Industry events, technical conferences, and customer site visits regularly challenge us to benchmark performance and drive improvements. The push from the marketplace—whether driven by global pricing or increased regulatory checks—means every lot shipped reflects months of behind-the-scenes optimization. Our own workforce receives ongoing training about safe handling, emergency measures, and new analysis techniques, so that both product and people keep pace with the latest developments.

    Meeting Today’s Needs and Tomorrow’s Demands

    4-Chloro-2-Nitrotoluene continues to play a crucial role in progressing colorant, pharmaceutical, and agrochemical manufacturing. End-users seeking process reliability, batch traceability, and regulatory compliance benefit from dealing with the source producer and not a disconnected reseller. The real difference shows up in lower downstream filter and cleanout costs, more consistent quality audits, and reduced manufacturing delays—all based on years refining our processes to meet new challenges.

    Close partnership with industrial users, formulators, and process engineers informs each update and improvement in our methods. By soliciting feedback and rigorously testing every claim, we build products that serve as building blocks for higher-value chemistry, not just commodities to trade. Experience with real-world large-scale processes, coupled with our ongoing investment in analytical and manufacturing capabilities, keeps us ready for whatever new specifications tomorrow might bring.

    Conclusion: Building Trust, Batch After Batch

    Through careful stewardship, continual process review, and direct responsibility for every batch of 4-Chloro-2-Nitrotoluene, we deliver more than just a chemical. We extend a partnership based on reliability and a track record built from ground-level manufacturing expertise. In a world where quality often starts and ends with the producer’s attention and accountability, dedicated manufacturing offers confidence for the long term.