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(4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate

    • Product Name (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate
    • Alias chlorpropham
    • Einecs 416-380-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    624405

    Productname (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate
    Molecularformula C11H9Cl2NO2
    Molecularweight 258.10 g/mol
    Casnumber 1868-53-7
    Appearance White to off-white crystalline solid
    Meltingpoint 94-96°C
    Solubility Insoluble in water; soluble in organic solvents
    Boilingpoint Decomposes before boiling
    Density 1.41 g/cm³
    Purity Typically ≥98%
    Smiles C#CC(CCl)OC(=O)Nc1cccc(c1)Cl
    Inchi InChI=1S/C11H9Cl2NO2/c12-7-3-1-2-8(10-5-4-9(13)6-10)14-11(15)16-6-5-4-9(13)6-10

    As an accredited (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed HDPE bottle containing 25 grams, labeled with chemical name, hazard symbols, lot number, and handling/storage instructions in bold.
    Shipping The chemical (4-Chloro-2-butyn-1-yl) N-(3-chlorophenyl)carbamate is shipped in tightly sealed containers, protected from light and moisture. It is transported as a hazardous material, complying with relevant safety and regulatory standards, such as UN/IMDG/IATA guidelines. Ensure proper labeling, handling precautions, and use of personal protective equipment during transportation and receipt.
    Storage Store (4-Chloro-2-butyn-1-yl) N-(3-chlorophenyl)carbamate in a tightly sealed container, in a cool, dry, and well-ventilated area, away from direct sunlight, heat, and incompatible substances such as strong acids, bases, and oxidizing agents. Handle with appropriate personal protective equipment, and ensure access to spill containment and eyewash facilities in the storage area. Store away from sources of ignition.
    Application of (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate

    Applications of (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate in Industrial Manufacturing

    As the direct manufacturer, we supply (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate for several advanced industrial sectors. The following application scenarios reflect real downstream usage, each with distinct compliance responsibilities, controlled usage ratios, process requirements, and defined final products.

    1. Active Ingredient in Herbicide Formulations

    Agrochemical companies use this compound as a core active in the synthesis of targeted, broadleaf herbicides. The molecule's structural properties provide selective activity by disrupting specific plant physiological pathways. Formulators blend it with safeners and surfactants in pre-emergent or post-emergent crop protection products. Quality control teams apply residue analysis using HPLC to ensure batch consistency before packaging for agricultural distributors.

    Industry compliance standards

    • FAO Specifications for Plant Protection Products
    • EU Regulation (EC) No 1107/2009 on Plant Protection Products
    • China National GB 20701-2006 for Pesticide Formulation
    • OECD Guidelines for the Testing of Chemicals – Residues in Crops

    Typical usage ratio

    • Pure compound comprises 5–30% of total herbicide concentrate
    • Exact proportion adjusts based on weed spectrum and crop selectivity data
    • Lower end for tank-mix adjuvant use or lower crop tolerance
    • Quality assurance labs follow prescribed method validation for dosing accuracy

    Downstream process integration

    • Dosed during initial wet milling or blending with solvent carriers
    • Mixed with co-active ingredients and inert adjuvants before emulsion
    • QC sampling at pre-filling stage for purity and dispersibility assessment
    • Packaged as suspension concentrate or water-dispersible granule

    Final product types

    • Commercial pre- and post-emergence herbicide products
    • Crop protection formulations for cereals, maize, and soybeans
    • Turf and ornamental selective weed control agents
    • Retail and bulk packaging for regional agri-input suppliers

    2. Intermediate for Synthesis of Plant Growth Regulators

    Leading fine chemical manufacturers utilize this compound as a core building block for advanced plant growth regulator molecules. The carbon-chlorine and carbamate functionalities enable subsequent coupling, halogen exchange, and ring-forming reactions. Teams employ it during the multi-step organic synthesis of regulator candidates, with attention to thermal stability and solvent compatibility. Analytical chemists monitor reaction completion by spectroscopy and titration to optimize conversion.

    Industry compliance standards

    • ISO 9001:2015-certified quality management for specialty synthesis
    • REACH Registration (EC 1907/2006) for precursor tracking in the EU
    • US EPA Criteria for Registration of Biochemical Products
    • Local authority reporting on precursor and intermediate management

    Typical usage ratio

    • 5–18 mol% as a primary reactant in stepwise synthesis schemes
    • Ratio determined based on desired substitution index and functionalization
    • Intermediate concentrations targeted to maximize step yield
    • In multi-ton runs, engineers standardize input to reactor load protocol

    Downstream process integration

    • Added at a controlled temperature to prevent side reactions
    • Combined with alkylating or acylating agents in sealed vessels
    • Residual content controlled by post-reaction purification and solvent exchange
    • Transferred to crystallization or distillation units for downstream transformation

    Final product types

    • Active substances for crop growth enhancement (gibberellin analogs, auxins)
    • Seed treatment additives with controlled release profiles
    • Intermediate blends for downstream formulation houses
    • Regulatory-registered growth regulator end-products

    3. Precursor for Specialty Pharmaceutical Synthesis

    Selective pharmaceutical manufacturers incorporate this compound as a key synthetic precursor, reflecting its functional group diversity and chemical reactivity. Experts employ it in multi-step syntheses for developing carbamate-linked molecules, such as antiproliferative candidates and certain neuro-pharmaceuticals. Production teams carefully monitor process parameters like solvent polarity, pH, and temperature for each coupling reaction. In sterile facilities, compliance teams document all batchwise additions and residual analysis using LC-MS/MS for trace-level impurity profiling.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) for intermediate purity
    • EU GMP Annex 15 for Qualification and Validation
    • FDA 21 CFR Part 211 for manufacturing control records

    Typical usage ratio

    • Constitutes 1–12 mol% in target molecule synthesis
    • Adjusted based on molar equivalents with the coupling agent used
    • Higher ratio possible for cascade reactions or complete conversion
    • Validated by small-scale pilot before scale-up to production

    Downstream process integration

    • Meticulously weighed and added to reaction feed for intermediate formation
    • Incorporated during N-carbamate or arylation reaction steps
    • Intermediates isolated by preparative chromatography for product trials
    • Output routed to final API synthetization or secondary modification lines

    Final product types

    • Novel carbamate-based actives for CNS therapeutics under development
    • Registered pharmaceutical intermediates for clinical supply
    • Small-molecule antiproliferative candidate compounds
    • Specialty blocks for contract development and manufacturing organizations (CDMO)

    4. Raw Material in High-Performance Polymer Additive Manufacturing

    Manufacturers of performance polymers rely on this compound as a specialty additive precursor for tuning resin properties. By incorporating the carbamate and alkyne motifs, engineers control crosslinking density and UV-resistance in automotive and electronics resins. Technicians optimize hot melt or solution blending cycles, monitoring viscosity and compatibilization with base polymers. Process engineers ensure residue levels meet downstream QC tests for color, mechanical integrity, and shelf stability in polymer composite products.

    Industry compliance standards

    • RoHS Directive (2011/65/EU) for additive substance use in electronics
    • ISO 14001 for environmental management in plastics compounding
    • ASTM D256 for impact property evaluation of polymer products
    • EN 71-3 for migration of certain elements in children’s article applications

    Typical usage ratio

    • Integrates at 0.2–1.8 wt% in total polymer blend
    • Higher ratios for UV-stabilized and high-crosslink formulations
    • Adjusted after batchwise mechanical and weathering tests
    • Maintains strict traceability by lot and compounding record

    Downstream process integration

    • Fed into compounding extruder during additive mixing stage
    • Uniformly dispersed under controlled temperature profiles
    • Monitored by in-line FTIR to confirm chemical integration
    • Extrudates cooled, pelletized, and packed for downstream molding

    Final product types

    • UV-durable automotive trim and interior compounds
    • Electronics encapsulation plastics with improved dielectric performance
    • High-stability technical films and adhesive layers
    • Advanced cable insulation materials for export certification

    5. Component in Fine Chemical Biocide Blends

    Specialty chemical producers apply this material as a reactive component for custom biocide and industrial hygiene blends. Its molecular structure allows precise targeting against microbial contaminants in industrial cooling water and pulp/paper processing. Production chemists combine it with isothiazolinone or phenolic co-biocide systems, calibrating dosing for target application and local legislation. R&D labs validate antimicrobial performance by ISO-referenced suspension and carrier tests before full-scale commercialization.

    Industry compliance standards

    • BPR Regulation (EU) No 528/2012 on biocidal product use
    • US EPA 40 CFR Part 158 for antimicrobial product registration
    • China GB 38507-2020 Guidelines for Industrial Antimicrobial Agents
    • ISO 11930 for microbiological quality of finished products

    Typical usage ratio

    • 0.1–2.5% as part of total active content in biocidal blends
    • Level selected by spectrum test results and required use dilution
    • Lower end for continuous dosing in water systems; higher in pulp/paper shock treatments
    • Reviewed quarterly for compliance with evolving regulatory reports

    Downstream process integration

    • Injected during batch blending of liquid biocide concentrates
    • Quality verified by GC-MS and microbial challenge test
    • Excess raw material neutralized post-batch, with waste handled as per SOP
    • Final blend filled into IBC drums or specialty packaging for industrial use sites

    Final product types

    • Water treatment biocides for cooling towers and heat exchangers
    • Antimicrobial agents for wet pulp and textile processing
    • Treated paper products with built-in microbial resistance
    • Industrial detergent concentrates with enhanced preservative action
    Free Quote

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    Certification & Compliance
    More Introduction

    (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate: Engineered Precision from Core Chemistry

    Shaping Quality at the Bench: A Chemist’s Approach

    We approach chemicals with the direct knowledge that every reaction step can impact a final result. The product (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate took years of meticulous process development. As molecular engineers, we stay close to every parameter, because even minor adjustments can cause yield fluctuations, impurity drifts, or reproducibility setbacks. Our experience in optimizing the route from raw materials means tighter control over each kilo as it leaves our reactors.

    One details the synthesis, handling each phase transition, cooling profile, and purification sequence. Some operators rely on batch-to-batch 'average outcomes.' We never cut corners: Each phase receives direct attention, eyes and hands on glassware and instrumentation, not just following a protocol but reading the pulse of reactions. This human oversight underpins the purity and consistency that chemists will notice when they unpack their shipment; the confidence comes only when one has guided the product through countless optimization cycles, not once but always.

    Precision and Performance: Letting Data Talk

    Our process emphasizes chemical integrity. HPLC and NMR profiling reveal lot-to-lot consistency within tight spec windows, because we’ve mapped out each impurity down to trace levels. The analytical chemist doesn’t guess here—data shows precise retention and splitting patterns, spectral clarity, and purity metrics that remain stable, month after month.

    Unlike some counterparts that hover above minimum purity claims, we rarely see outliers. Deep familiarity with the route, from initial alkynylation to the careful formation of the carbamate bond, allows us to predict and control hydrolysis and side reactions. It is not enough to hit spec once; long-term customers demand the same structure, impurity fingerprint, and stability profile. That stability translates to predictable behavior in scale-up, whether for further synthesis or end-use applications.

    Origins and Structure: Why Each Atom Matters

    (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate stands apart for chemists who care about each substituent’s influence on reactivity and selectivity. Our team first mapped out the molecular landscape by analyzing how the chloro substitutions affect resonance, solubility, and nucleophilic addition. That triple-bonded butynyl backbone delivers rigidity that resists unwanted rearrangement during downstream reactions.

    Many generic carbamates don’t offer this level of stability, leading to side products in subsequent steps or instability under process conditions. Each of our batches comes with the precise stereochemistry and electronic properties our customers expect. Over the years, feedback from researchers and process engineers guided us to refine our purification process—special attention to light exposure, temperature, and solvent selection ensures that functional groups don’t degrade before delivery.

    Specifications at Work: Meaningful Numbers, Not Jargon

    Those who work at the bench know that numbers on datasheets are more than checkboxes. We control for water content, ensure tightly defined melting and boiling points, and monitor for residual solvents so end-users do not see surprises in reactivity or crystal form. Every work-up step—from organic extraction to rotavap drying to final vacuum storage—has been refined so the product retains its performance profile.

    During production, we monitor for tell-tale analytical signals—uncharacteristic peaks, color shifts, or viscosity changes. We learned not to ignore small signs; once, a faint color change led us to a microcontaminant source in an upstream intermediate. By resolving that, we avoided future production headaches for ourselves and headaches for our customers.

    Beyond purity percentages, solubility profile counts. Our (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate dissolves predictably in standard solvents—dichloromethane, acetonitrile, even some nonpolar systems, depending on use. That flexibility matters for those who need to run reactions under varying conditions; knowing that the product doesn’t introduce solubility limitations saves valuable development time.

    Why This Carbamate Beats Commodity Alternatives

    Several differences set our product apart from what traders and resellers bring to the table. The material that passes through too many hands risks storage abuses—exposure to humidity, light, temperature swings, or improper containers. As original manufacturers, we oversee both the chemistry and the logistics. We ship under conditions proven to protect the structural integrity and avoid cross-contamination.

    Some labs told us they faced unexplained reaction failures using typical commodity-grade carbamates. On tracing the supply chain, the samples showed degraded alkynyl functions—products sat at uncontrolled temperatures too long or picked up acidic vapors from shared warehouses. We catalogue, monitor, and guarantee chain of custody. Every batch travels from our controlled plant directly to customers.

    There’s a difference between making something for the spot market and maintaining a long-term partnership with demanding process chemists. As manufacturers, we thrive on technical feedback. If a customer’s downstream yields dropped, we have the technical history to review, batch history, and analytical benchmarks to trace back to root causes—facts instead of speculation and accountability instead of finger-pointing.

    Applications: Beyond Shelf Chemistry

    Our material features in both development and production projects. In pharmaceutical intermediate synthesis, reactivity of both the butynyl group and the carbamate moiety unlocks several useful transformations—addition, substitution, cyclization. Agrochemical innovators use the powerful combination of halogenated groups and the butynyl backbone for selective triggering in crop protection agents. Advanced materials companies sometimes reach for our carbamate as a specialty building block in coatings or performance resins where ordinary carbamates fall short under thermal load or prolonged storage.

    Instead of generic claims about “versatility,” long-term collaborations taught us to document exactly how the functional groups enable selective addition, help anchor further modifications, or provide useful physical properties. More than once, our direct line to end users led to process tweaks that improved compatibility with tailored catalysts (“off-the-shelf” alternatives struggled here), or that simplified isolation steps in chromatography.

    Process engineers told us about knock-on savings—lower amounts of waste, less downtime chasing impurities, easier QC throughout their syntheses. Having direct visibility into how the material interacts with other building blocks helps us guide newer users to avoid common stumbling blocks.

    Listening to the Voice of Experience: Continuous Improvement

    After more than a decade of focused production, we’ve learned to pause and study every complaint, question, or observation our customers bring. A few years ago, a formulation specialist noticed faint changes in crystallinity during a summer shipment. Rather than chalk it up to shipping, we initiated a root-cause review: We calendared our supply chain, observed temperature data loggers, and ultimately discovered a previously undetected interaction between a carton lining and the active ingredient under high humidity. That led to an upgrade in both container design and tertiary packaging. The lesson: never stop improving, and never assume a system cannot improve further.

    This spirit doesn’t come from policy but from years in the plant, in the lab, and with our colleagues around the world. Our team believes in regular process audits, trial runs under stress-test scenarios, retraining each technician in the nuances of this specific compound. Training provides results—a hand-eye knowledge that no machine has matched yet.

    Each customer interaction, whether positive or critical, enriches this bank of working knowledge. No process runs perfectly if left on autopilot, but skill in rapidly diagnosing glitches, sharing technical data transparently, and borrowing insights from field users keeps us agile and relevant.

    Sustainability and Compliance: Responsible Chemistry

    Modern chemical manufacturing must respond to tough questions about sustainability, lifecycle impacts, and safety. We source starting materials with chain of custody documentation, screened for both regulatory and environmental status. Our waste streams undergo chemical analysis before responsible handling; this discipline didn’t come overnight. It took several years to build our closed-loop solvent recovery and emission capture systems. Colleagues from neighboring plants now consult us to model their improvements after our system.

    In the realm of hazardous materials, we know compliance goes beyond checking boxes. Shipping documentation, materials compatibility checks, hazard communication protocols—these flow directly from in-plant standards to each shipped drum or flask. Workers carry out regular drills and undergo continuous safety training. We keep timelines, not just for traceability, but as an active feedback loop to upgrade every system, every year.

    Cross-border shipping brings further scrutiny—formatting to multiple regulatory standards, updating labeling practices based on new guidelines, and responding quickly if any law changes. These procedures get updated rapidly, drawn from our own plant’s adaptation to updated best practices, not dictated by outside “tick-box” consultants.

    Working hands-on with regulated chemicals, we encounter complex export questions and local compliance demands. Years of application mean we don’t just push product out the door; we help address documentation, storage, and handling needs, giving research teams time to innovate instead of battling red tape.

    Difference Begins with Direct Accountability

    There’s a real distinction between direct manufacturers and those who simply repack or redistribute. We field the technical inquiries, host plant audits, open our batch records for review, and we stake our name on every shipment. More than once, academic and pharmaceutical partners traced troublesome supply issues to a lack of such accountability elsewhere.

    Direct input also sharpens our view of the unique problems faced at bench scale, pilot, and full-scale operations. For instance, in moving from lab notebooks to industrial synthesis, subtle process differences in pH or agitation can spark wildly different results. Users surprised by variations in performance from generic alternatives point to unclear technical support and little recourse beyond returning materials. In contrast, we train our technical team to walk through issues, not just offer stock responses.

    We highlight such stories not as advertising, but as a clear signal: buying from the original manufacturer means direct troubleshooting, custom solutions, and openness about both strengths and constraints of the material. As chemists, we don’t just sell molecules—we offer the experience that shapes them.

    Insights from Long-Term Observation

    Our investment in long-term studies revealed trends that impact storage, reactivity, and downstream applications. Over years of monitoring, we noted a marginal shift in stability when exposed to certain types of UV. Addressing that, our packaging team worked with external partners to custom-develop inner linings that now extend shelf life. Other labs, relying on bulk commodity supplies, discovered shortened shelf life caused by absent analytics and minimal packaging standards—a comparison that highlights our approach.

    Customers scaling their chemistry have looped us in on pilot plant trials, where the smallest deviations in intermediate purity or physical form can spiral into batch failures. We draw on both our historic and current batch data, sharing specific insights on solubility, handling, and downstream processing so both small and large buyers see fewer costly surprises.

    Empirical learning matters more than theoretical promises. For example, we flagged temperature sensitivity in a specific downstream process after years of watching crystallization curves under different cooling rates. Sharing that information prevented other teams from repeating past mistakes and reinforced the importance of hands-on knowledge transfer.

    Future Outlook in Specialty Carbamates

    Those working at the intersection of synthesis and scale appreciate the difficulty of designing molecules that both innovate and endure. Developers in agrochemicals, pharmaceuticals, and advanced polymers demand specialty intermediates with precise specifications—carbamates that go beyond commodity benchmarks.

    Our experience shows that close collaborations lead to faster troubleshooting, deeper technical exchanges, and fewer unwelcome surprises in real-world workflows. As research pushes molecular boundaries, materials like (4-Chloro-2-Butyn-1-Yl) N-(3-Chlorophenyl)Carbamate play a crucial role. We invest in continuous process refinement—listening to users, studying unanticipated effects, and building data around real conditions, not just theoretical claims.

    With growing demands for reliability, safety, and sustainability, specialty chemicals will remain central to both innovation and operational success. We recognize that our ongoing commitment—to chemical rigor, transparency, and direct accountability—matters more now than ever.

    Our team keeps its focus on delivering molecules that work not only on paper, but across thousands of kilograms and hundreds of customer projects. That discipline, built over hard years of trial, error, feedback, and improvement, keeps us grounded and advancing, molecule by molecule, batch by batch.