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4-Chloro-2-Aminophenol

    • Product Name 4-Chloro-2-Aminophenol
    • Alias 4-CAP
    • Einecs 221-586-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    496749

    Cas Number 95-85-2
    Molecular Formula C6H6ClNO
    Molecular Weight 143.57 g/mol
    Appearance Light brown to beige crystalline powder
    Melting Point 122-126 °C
    Boiling Point 329.6 °C at 760 mmHg
    Solubility In Water Slightly soluble
    Density 1.39 g/cm³
    Synonyms 4-Chloro-o-aminophenol, 2-Amino-4-chlorophenol
    Purity Typically ≥98%
    Storage Temperature Store at room temperature, keep container tightly closed

    As an accredited 4-Chloro-2-Aminophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g package of 4-Chloro-2-Aminophenol is in a sealed amber glass bottle with hazard labeling and handling instructions.
    Shipping 4-Chloro-2-Aminophenol should be shipped in tightly sealed containers, clearly labeled, and protected from moisture and incompatible substances. It must comply with relevant local, national, and international regulations, and should be handled as a hazardous chemical. Adequate cushioning and secondary containment are recommended to prevent leaks or spills during transport.
    Storage 4-Chloro-2-aminophenol should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and direct sunlight. Keep it separated from incompatible materials such as strong oxidizers and acids. Store at room temperature and ensure appropriate labeling and secure handling to prevent accidental exposure or spills. Use secondary containment where necessary.
    Application of 4-Chloro-2-Aminophenol

    Applications of 4-Chloro-2-Aminophenol in Industrial Manufacturing

    As a direct manufacturer of 4-Chloro-2-Aminophenol, we supply high-purity product to specialized sectors where precise chemical performance and compliance are critical. Below, we outline its established downstream industrial applications, categorized by distinct end-use scenarios, with detailed focus on compliance, formulation, integration, and final product categories.

    1. Pharmaceutical Intermediate for Paracetamol Derivatives

    4-Chloro-2-Aminophenol serves as an intermediate in advanced synthesis routes for certain paracetamol derivatives and related analgesic compounds. Controlled manufacturing procedures incorporate it at specific stages to achieve target molecular configurations, ensuring batch-to-batch consistency to support regulatory submissions and commercial pharmaceutical production.

    Industry compliance standards

    • Current Good Manufacturing Practices (cGMP, ICH Q7)
    • US Pharmacopeia (USP) monographs for APIs
    • EU GMP Directive 2003/94/EC
    • Regulatory filing support (e.g., DMF, CEP dossiers)

    Typical usage ratio

    • Used at 0.8–2.5 molar equivalents relative to primary backbone compound, dependent on desired substitution pattern and impurity profile controls

    Downstream process integration

    • Charged during the aminolysis or coupling stage following primary reactant preparation; reaction monitored for conversion and in-process impurity control

    Final product types

    • Active pharmaceutical ingredients (paracetamol analogs)
    • Bulk pharmaceutical intermediates for onward synthesis

    2. Hair Dye Formulation in Oxidative Coloring Systems

    Cosmetic manufacturers incorporate 4-Chloro-2-Aminophenol as a critical primary intermediate in permanent oxidative hair dye recipes. Its presence influences color depth and tone, especially for cool and ashy brown-black shades, based on its ability to participate predictably in oxidation reactions alongside other aminophenols and couplers.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No. 1223/2009
    • IFRA Code of Practice for fragrance and color additives
    • ASEAN Cosmetic Directive
    • National registration in China (NMPA) with approved concentration limits

    Typical usage ratio

    • Used at 0.05–1.0% by weight in finished colorant cream; level calibrated to shade formulation and combined dyestuff content

    Downstream process integration

    • Added during the pigment dispersion stage before blending with peroxide developers; dispersion and stability assessed by HPLC and accelerated aging

    Final product types

    • Permanent oxidative hair dyes (boxed kits)
    • Salon cream colorants

    3. Analytical Reagent Formulation for Laboratory Use

    Chemical solution manufacturers blend 4-Chloro-2-Aminophenol into analytical reagents, most commonly as a chromogenic substrate in colorimetric assays for trace metal or enzyme activity detection. Stringent purity control is maintained to guarantee accurate signal response and method reproducibility.

    Industry compliance standards

    • ISO 6353-1: Specification for laboratory chemicals
    • REACH Annex XVII for laboratory chemical safety
    • Analytical reagent grade specifications (ACS, Merck standards)
    • UL laboratory chemical regulatory requirements

    Typical usage ratio

    • Dosed at 0.005–0.02% w/v for most spectrophotometric test kits; exact quantity optimized by molar absorptivity and matrix background

    Downstream process integration

    • Introduced during buffer or indicator reagent preparation, with in-process testing for purity (UV/Vis, TLC, MS verification)

    Final product types

    • Colorimetric water analysis test kits
    • Research-use-only (RUO) biochemical assay reagents

    4. Intermediate in Specialty Agrochemical Synthesis

    Active ingredient manufacturers utilize 4-Chloro-2-Aminophenol during controlled synthesis of select herbicides and pesticides, where it provides a reactive amine and halogenated aromatic structure for subsequent functionalization. Precision in reaction charge and impurity removal is vital for regulatory-compliant technical grade products.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 for agrochemical manufacturing
    • EPA Product Chemistry Guidelines (U.S.)
    • Chinese Ministry of Agriculture GB/T standards for pesticides

    Typical usage ratio

    • Typically 1.0 equivalent relative to downstream acid chloride or isocyanate reactant, adjustable to optimize yield in stepwise reactions

    Downstream process integration

    • Fed into batch or continuous reactor systems following catalyst or base addition; downstream processing includes solvent recovery and technical purification

    Final product types

    • Technical-grade pesticide intermediates
    • Herbicide active ingredient pre-cursors

    5. Dye and Pigment Manufacturing for Printing Inks

    Ink and pigment makers select 4-Chloro-2-Aminophenol as an aromatic amine source in synthesizing complex azo and metal-complex dyes. This role contributes to achieving specific absorption wavelengths and improved fastness characteristics in inks for specialty and security printing.

    Industry compliance standards

    • ISO 2846-1: Graphic technology - color measurement for inks
    • EN 71-3: Safety requirements for toy inks and coatings
    • REACH Registration for pigment intermediates (EU)
    • GMP for food-contact packaging inks (BfR Recommendations, Swiss Ordinance)

    Typical usage ratio

    • Dosed at 5–15% relative to base diazonium compound in batch dye coupling reactions; quantity tailored to target hue intensity and process efficiency

    Downstream process integration

    • Introduced post-diazotization to couple with aromatic substrates; purified by liquid-liquid extraction and filtration prior to further formulation into dispersions or dry pigment powders

    Final product types

    • Water- and solvent-based printing inks
    • Specialty pigment concentrates for security printing and plastics coloration
    Free Quote

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    Certification & Compliance
    More Introduction

    4-Chloro-2-Aminophenol: Engineered for Reliable Performance in Demanding Applications

    A Hands-On Introduction from the Manufacturer's Viewpoint

    With decades behind us in specialty chemical production, we approach every new product with fresh eyes, practical experience, and a deep respect for those who work with these materials day in and day out. 4-Chloro-2-Aminophenol stands out among our tailored aromatic intermediates for its versatility and reliability, moving from raw material to finished product in the hands of manufacturers who demand predictable outcomes. As producers, we focus not just on processing, but on steady quality and reproducibility batch after batch. It has become a staple in sectors that rely on careful formulation, including pharmaceuticals, dyes, and specialty resins, and our day-to-day work drives us to exceed the expectations set by the industries it serves.

    Model and Manufacturing Observations

    Our 4-Chloro-2-Aminophenol model is manufactured under tightly monitored conditions, with parameters calibrated to strengthen purity and minimize impurities that could compromise subsequent synthesis steps. We value direct oversight of technical operations, because downstream applications—many of which convert this product into complex molecules—leave no room for avoidable contaminants. Consistency forms the backbone of everything we do; specification sheets reflect real, not theoretical, yields backed by archived batch data. Our workforce operates ISO-certified lines that have not just passed audits, but have stood the test of time under continuous customer scrutiny in both regulated and non-regulated environments.

    The Specifics: What Goes into Our Product and Why

    Every kilogram of 4-Chloro-2-Aminophenol leaving our site brings with it our full attention to detail. We target a high assay (typically above 98 percent) and maintain strict controls over moisture and residual solvents. Particle sizing is monitored because downstream reactors can be sensitive to dissolution rates, and even minor changes in crystal habit can influence reaction times or filtration performance. Years of feedback from plant chemists and process engineers have taught us that no two applications are identical, but the core need—reliable, contaminant-free input—never changes.

    We aim to strip down unnecessary complexity in our processes, offering a product with a manageable profile for easy storage and handling, but we still invest heavily in analytical validation. Every production lot is tested using HPLC and other key techniques, with IR and NMR available for clients who want extra confidence in structure confirmation. Our experience shows that a few extra hours spent double-checking the identity and purity profile at this stage forestalls headaches and delays once the product enters the customer’s plant. We take these precautions not for the sake of paperwork, but because we have fielded enough urgent calls through the years to know the cost of missed contamination or degradation.

    Real-World Use Cases: From Bench to Scale

    Most of the 4-Chloro-2-Aminophenol we produce finds its way into active pharmaceutical ingredient (API) synthesis routes, particularly in intermediates where selective chlorination and amination make a meaningful impact on yield or stereochemistry. This compound often serves as a building block for more elaborate molecules in both medicinal and agrochemical pipelines. We have participated in projects where researchers needed direct access to scalable quantities with predictable performance, so our plant is designed to ramp up output without sacrificing the analytical scrutiny applied at bench scale.

    We have hosted on-site audits with pharmaceutical companies who bring their own people to inspect not just our final testing, but raw supply chain records, cleaning protocols, and even wastewater treatment solutions. The goal has always been safe, repeated outcomes that support product registrations globally. This collaboration with end-users and regulators has trained our workforce to document carefully, respond quickly, and preempt challenges before they can ripple through a larger manufacturing chain.

    What Sets This Compound Apart: Lessons from Continuous Production

    After years in operation, we’ve learned that subtle differences in starting material choice and process adjustments can have outsized effects on 4-Chloro-2-Aminophenol’s physical form, reactivity, and shelf life. By controlling the source and lot quality of chlorinated and aminated precursors, minimizing exposure to air and light in sensitive steps, and embracing robust purification techniques, we deliver a product that performs with reliable repeatability—even in high-throughput or high-purity settings.

    A key difference stems from our avoidance of process shortcuts that trade purity for yield. Short-term gains from incomplete purification or non-optimized crystallization never pay off over a product’s lifecycle. In the early years, we saw how even trace metallic residues or oxidizable impurities could trigger unwanted side reactions. So our targeted approach leverages tested solvents and filtration media, supported by full traceability from raw material origin to finished packaging.

    Our engineering team has also learned to adapt production based on clients’ evolving needs. In the dye industry, for example, specific shades and performance profiles can be sensitive to minor shifts in starting material characteristics. By maintaining tight dialogue with downstream users and adapting particle size distribution or trace impurity limits, we help customers avoid reformulation bottlenecks and unforeseen coloration shifts.

    Why 4-Chloro-2-Aminophenol Remains Relevant in a Crowded Market

    Plenty of aromatic amines crowd the market, but actual performance sets ours apart. Generic or poorly controlled analogues often arrive with inconsistent purity, variable isomer content, or instability during transport and storage. Our in-process checks identify and control crystal habit, shipment stability, and packaging type in ways that directly impact customer yields. The compound’s ability to react cleanly—delivering minimal side products and manageable color formation—keeps it in demand for both established and emerging chemical pathways.

    We remain committed to transparent, ongoing improvement. Years spent troubleshooting off-spec material or handling complaints about out-of-tolerance product have convinced us that no expense saved in quality control outweighs the price of a lost batch or a missed product launch. Because we own the entire production chain, we can trace even small variations in output to specific process parameters or raw material lots, giving customers the data they need for risk assessments and long-term planning.

    Environmental and Regulatory Considerations

    Compliance is much more than a formality. 4-Chloro-2-Aminophenol production generates waste streams that require thoughtful treatment and responsible disposal. Our on-site water treatment operates with redundant systems to manage organic load and mineral content, holding tight to local and international standards on effluent. Clients in regulated industries—notably those submitting DMFs or registering new chemical entities—rely on our full disclosure of environmental controls and emissions data to meet their own legal obligations.

    We invest in the real tools that matter—not just paper systems—because we are held accountable by both law and by the expectations of firms who are themselves under scrutiny. Regulatory agencies may drop in with little notice, so everything from solvent receipt to final shipment leaves a traceable record, and our local community expects ongoing stewardship.

    Packaging and Handling: Insights from Daily Operations

    Choice of packaging comes from practical setbacks as much as from specification checklists. Over time, we’ve moved from basic liners to specialized barrier films that help limit moisture ingress and oxidation during long transports, particularly for ocean freight or warehouse storage in humid climates. Feedback from integrators and formulators encouraged us to adjust container size and closure type for easier plant transfer, reducing both labor costs and material loss in bulk applications.

    Our shipping protocols focus on both protection and accessibility. Visual inspection, batch segregation, and clear labeling help prevent cross-contamination before empties reach the reactor deck. Direct relationships with freight partners allow us to manage transit conditions proactively, flags for temperature excursions, or misplaced packages, keeping our timelines resilient despite supply chain challenges.

    Quality Assurance through Real Experience

    Quality is not just a set of numbers. Operators and technicians learn from customer feedback, adapting ground-level routines to anticipate mixing, storage, or reactivity concerns encountered during downstream use. We continuously update training programs with insights from each return shipment or plant trial that doesn’t meet expectations. Stories from the line loom large—whether it’s a batch that clumped due to humidity or a lot that failed to dissolve promptly and slowed a customer’s process flow. These day-to-day lessons push us toward better handling, packaging, and specification management, feeding back directly into our next cycle of testing and release.

    Customers have also turned to us for rush orders when projects hit unexpected snags, and we’ve moved resources within our plant to accommodate timelines without compromising batch integrity. These partnerships keep us grounded in the practical realities of production, not just the paperwork or numbers. Quality assurance comes alive as a dynamic process, not a fixed destination—a living system informed by experience, attention, and the shared stakes of every successful outcome.

    Safety and Working Realities

    Our crews pay close attention to occupational safety—both for their sake and that of everyone who touches the product after it leaves our gates. Plant operators understand the hazards associated with aromatic amines and chlorinated compounds through regular briefings, drills, and hands-on safety audits. Equipment is built with redundant containment and dust control systems, and we audit ventilation, PPE use, and cleaning procedures regularly as part of daily practice.

    Safety culture grows from the ground up; it doesn’t work as a top-down command. As a result, the information we pass on to customers is rooted in field experience, not copied guidelines. Real stories from plant operation inform the way we communicate risks and mitigation practices. We know from experience what a missed glove or vent failure can mean, and we build our advice around those lessons. Shipping documents and labels reflect knowledge accumulated across decades, not just recent audits.

    Customer Collaboration: Real Impact, Real Solutions

    Ongoing partnerships with customers have shaped every product variant and every protocol we use. Many of our innovations—like improved drying techniques for climates with high humidity, or the development of stable, low-dust forms—came directly out of urgent calls from clients stuck mid-batch. We treat these not as problems, but as opportunities to build stronger processes.

    By hosting client audits, offering open tours of our facility, and investing in technical training for our partners, we build relationships grounded in trust and shared purpose—not just transactions. Engineers and chemists on our team participate in technical exchanges, learning as much from client challenges as we teach through our process walkthroughs. Rarely does a year pass without at least a handful of process upgrades or new analytical methods added, sparked directly by collaborative troubleshooting.

    Continuous Improvement: Built on Feedback, Backed by Data

    Every return shipment, every customer complaint, and every piece of praise feeds a loop of review and revision. Our tech team meets weekly to review outcomes, inspect outlier data, and prioritize improvements large and small. We track trends in impurity profiles, validate alternative analytical methods, and experiment with pilot-scale process tweaks. We log every change, because we know that small shifts can add up.

    Experience tells us that even well-established products like 4-Chloro-2-Aminophenol benefit from constant scrutiny. We share periodic reports with clients, supporting their audits with scanned batch data, process flow charts, and recorded operator interventions wherever needed. Transparency—and the willingness to admit and address issues promptly—has earned us repeat business from firms whose own markets depend on our consistency.

    Final Thoughts: Trust Built Over Generations

    Our legacy as a chemical manufacturer goes deeper than any product spec sheet. 4-Chloro-2-Aminophenol showcases what consistent focus, responsible stewardship, and close customer partnership can make possible. Over the years, we have learned that resilience comes not just from technical skill, but from fostering a culture of honesty, adaptability, and hard-won experience.

    We thank those who work with us for the shared journey, and we commit to supporting your production processes with the same care we put into ours. Every kilo of 4-Chloro-2-Aminophenol we deliver is more than a transaction; it represents a shared investment in quality, safety, and progress in the industries we serve.