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4-Aminophenylarsonic Acid

    • Product Name 4-Aminophenylarsonic Acid
    • Alias Arsanilic acid
    • Einecs 203-595-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    663560

    CAS_Number 98-50-0
    Molecular_Formula C6H8AsNO3
    Molecular_Weight 233.06 g/mol
    IUPAC_Name 4-aminophenylarsonic acid
    Appearance White to off-white powder
    Melting_Point 256-260 °C (decomposes)
    Solubility_in_Water Moderately soluble
    Density 1.7 g/cm3 (approximate)
    pKa 5.1 (arsonic acid group)

    As an accredited 4-Aminophenylarsonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic bottle labeled "4-Aminophenylarsonic Acid, 100 grams," with hazard symbols, lot number, and manufacturer’s details, securely sealed.
    Shipping 4-Aminophenylarsonic Acid is shipped in sealed, labeled containers to prevent contamination and moisture exposure. It is classified as a hazardous material and must be transported according to applicable regulations. Appropriate safety documentation (SDS) and handling instructions accompany the shipment to ensure safe storage, handling, and compliance during transit.
    Storage 4-Aminophenylarsonic acid should be stored in a tightly sealed container, away from moisture, light, and incompatible substances such as strong oxidizers or bases. Keep it in a cool, dry, well-ventilated area with clearly labeled containers. Always store it in accordance with local regulations, and restrict access to trained personnel to ensure safety and prevent contamination.
    Application of 4-Aminophenylarsonic Acid

    Applications of 4-Aminophenylarsonic Acid in Industrial Manufacturing

    4-Aminophenylarsonic acid serves as an important functional compound in multiple industrial sectors, including animal pharmaceuticals, pigment manufacturing, specialty intermediate synthesis, and certain analytical reagent formulations. As the original manufacturer, we maintain direct process knowledge and compliance with all relevant downstream application requirements.

    1. Veterinary Feed Additives Production

    In regulated animal nutrition, this material acts as a key intermediate for producing arsonic acid-based growth promoters. Formulators incorporate it in complex blending stages to manage conversion to active pharmaceutical ingredients under designated protocols. All raw material handling and dosing must comply with veterinary regulations concerning residual arsenic levels. The downstream mixing process mixes the acid with solvents, carriers, and stabilizers in staged reactors prior to granulation or liquid dosing.

    Industry compliance standards

    • US FDA 21 CFR 558.530 and 558.360 (limit uses and residue tolerances)
    • European Regulation (EC) No 1831/2003 (feed additive approval and monitoring)
    • Chinese Veterinary Pharmacopoeia (2020 Edition, arsonic acid derivatives)
    • ISO 22000:2018 (feed production quality systems)

    Typical usage ratio

    • For premix: 5–15% of total arsonic acid intermediate batch, depending on intended concentration in complete premix or formulation target strength
    • Adjustments depend on species-specific feeding rates and maximum residue limit (MRL) regulations

    Downstream process integration

    • Conversion during synthesis of roxarsone or analogous arsonic derivatives in reactor vessels
    • Microdosing and blending with active and inert excipients in continuous-feed mixers
    • Final product granulation, followed by QA/QC analytical testing for arsenic content
    • Packing in compliance with GMP and hazard labeling regulations

    Final product types

    • Growth promoter feed additives (e.g., finished roxarsone or 3-nitro mixtures)
    • Premixed feed grade arsonic acid supplements
    • Microgranulated animal feed preparations
    • Veterinary pharmaceutical bulks for further processing

    2. Organic Pigment and Dye Intermediate Manufacturing

    Specialty pigment and dye manufacturers employ 4-aminophenylarsonic acid as a coupling component for select azo and aryl-arsenic pigment systems. The compound enters as a diazotization agent or oligomerization intermediate, supporting color-fastness and insolubility in finished product matrices. Synthesis lines dose precise quantities at controlled temperatures to ensure uniform particle size and prevent unwanted by-products.

    Industry compliance standards

    • GHS/CLP (EC No 1272/2008) for hazardous substance management
    • REACH Regulation EC No 1907/2006 (chemical registration in the EU)
    • ISO 9001:2015 for pigment and colorant manufacturing processes
    • ASTM D476 (specifications for pigment quality assurance)

    Typical usage ratio

    • 0.5–4% w/w of total dry pigment batch, depending on intended shade intensity and arsonic pigmentation content, typically adjusted by batch size and target chroma

    Downstream process integration

    • Direct addition during diazotization process for azo pigment preps
    • Use in closed-system reactors for oligomerization and coupling purposes
    • Follow-up washing, filter pressing, and drying of pigment cakes containing bound arsonic groups
    • Internal continuous monitoring for particle size and residual free arsenic species

    Final product types

    • Specialty yellow and orange azo pigments for plastics and coatings
    • Arsonic-based dye intermediates for textile coloring
    • Water-insoluble pigment dispersions for industrial paints
    • High-durability colorants for inks

    3. Pharmaceutical Synthesis of Antiprotozoal Agents

    Several major pharmaceutical manufacturing lines use the acid as a registered intermediate in producing antiprotozoal APIs for veterinary and limited human health markets. The compound forms a core precursor for downstream condensation and substitution steps, requiring GMP-compliant handling, traceability, and final product validation for active ingredient registration. All process stages require full impurity profile documentation and analytical QA sampling before release.

    Industry compliance standards

    • US Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.) monographs for relevant APIs
    • cGMP (ICH Q7 & 21 CFR 210/211) regulations for active pharmaceutical ingredient manufacturing
    • Chinese GMP (2010 revision) for veterinary drug intermediates
    • ISO 17025 for QC testing laboratories

    Typical usage ratio

    • 0.8–2.5 molar equivalents per synthesis batch, calculated based on process-specific yield and downstream coupling requirements

    Downstream process integration

    • Controlled input during stepwise condensation reactions for API intermediate creation
    • On-stream purification and waste removal via solid-liquid separation
    • Integration with hydrogenation, alkylation, or acylation units as required by formulation
    • Final yield monitoring and batchwise traceability as per GMP

    Final product types

    • API intermediates for veterinary antiprotozoal compounds
    • Bulk active ingredients (e.g., arsonic acid-based antiprotozoals)
    • Pharmaceutical grade reference standards
    • Registered veterinary medicinal product bulks

    4. Analytical Reagent Formulation for Metal Detection

    Analytical laboratories utilize 4-aminophenylarsonic acid in the formulation of colorimetric and chromatographic reagents designed for detection of heavy metals, especially arsenic and phosphate ions, in environmental and food matrices. Production follows ISO/IEC standards on traceability and purity, and all batch records document precise blending ratios and solubilization dynamics to ensure performance stability.

    Industry compliance standards

    • ISO/IEC 17025:2017 (laboratory competence, traceability, and calibration)
    • EPA Method 7062 for arsenic determination in soil/metals testing
    • Chinese GB/T standards for food and water testing reagents
    • EN ISO 11969 for laboratory chemical reagents

    Typical usage ratio

    • 0.1–1.2 g/L, adjusted according to detection limit requirements and target matrix complexity per analytical method

    Downstream process integration

    • Direct incorporation into ready-to-use analytical reagent kits
    • Blending with buffer agents, stabilizers, and chromogenic agents in sterile packaging
    • Filtration and microbottle dosing for consistent kit quality
    • Final batch calibration using standard reference samples

    Final product types

    • Colorimetric test kits for arsenic detection in water and food
    • Chromatography reagents for environmental analysis
    • Reference solutions for laboratory QA/QC programs
    • Trace metal screening kits
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    Certification & Compliance
    More Introduction

    4-Aminophenylarsonic Acid: Product Introduction and Manufacturer’s Perspective

    Bringing Over a Decade of Experience to 4-Aminophenylarsonic Acid Production

    As a chemical manufacturer, our journey with 4-Aminophenylarsonic Acid (APAA) extends beyond technical formulations and batch logs. Each fine white crystal we produce marks a point of pride in maintaining purity, reliability, and consistency for applications that demand more than abstract promises. APAA, known for its unique molecular structure with the formula C6H8AsNO3, stands apart among organoarsenic compounds. In our view, its value comes from both its chemical functionality and its long history of controlled, purposeful application—especially in animal nutrition and research.

    A Close Look at Our APAA Model and Specifications

    We manufacture APAA to meet a rigorous purity standard of at least 98.5%, measured by HPLC and arsenic content analysis. Customers expect consistent texture, manageable particle size, and steady solubility—factors that might sound simple, until you strive to deliver them in every metric ton. The moisture content rarely creeps above 0.5%. Most of our output possesses a uniform crystalline appearance, easy to recognize by handlers who have used competitors’ offerings. Our specification sheets provide clarity on each batch, but this level of control comes from hard-earned experience: tight reaction parameters, filtration checks, and feedback from end-users.

    We store our APAA in low-humidity, temperature-controlled facilities to preserve its shelf life. Packaging is designed to prevent contamination from dust or mechanical agitation, because the best chemical doesn’t improve a process if it arrives compromised. We supply this product as a fine, stable powder to suit large-scale mixers or automated dispensers. The unique blend of physical and chemical stability stems from both careful raw material selection and repeated process validation.

    Intended Applications: What Sets APAA Apart in Real-World Use

    APAA has played a significant role in feed additives—primarily in poultry and swine nutrition. Our customers rely on it for its well-defined effect on growth rates and feed efficiency. Over the last 20 years, shifts in regulatory priorities have reduced reliance on certain arsenic-based additives, but in jurisdictions where use remains permitted, APAA still delivers dependability in daily feed manufacturing lines. The material dissolves easily in water at controlled pH levels, so it integrates smoothly into existing feed premix facilities. In smaller research institutes or laboratories, few compounds offer the same precision for experimental work involving arsenic labeling or biochemical tracing.

    Manufacturers like us face increasing scrutiny regarding the traceability and transparency of each incoming and outgoing shipment. We’ve adapted by investing in trace element analytics, tracking the arsenic profile of each lot so researchers precisely control dosing and exposure levels. This reduces the risk of cross-contamination and supports compliance documentation, a welcomed shift for research chemists who prefer predictable data over uncertainty.

    Practical Differences From Other Organoarsenic and Aminophenyl Compounds

    Customers regularly ask about the difference between APAA and other compounds like arsanilic acid or phenylarsonic acid. Outwardly, these molecules might seem closely related. The key distinction lies in APAA’s para positioning of the amino group on the aromatic ring. This structural factor impacts solubility, reactivity, and metabolic fate in ways that downstream users appreciate only after practical experience. Arsanilic acid lacks the amino group at the same ring position, changing its suitability for specific feed and research protocols.

    In actual production lines, we see APAA outperform other additives when consistency, simple mixing, and precise dosing become priorities. Some customers set up lateral studies, testing our APAA against legacy arsenic compounds tracked for decades in published literature. They find better batch-to-batch purity and a more predictable response curve with APAA—something that statistics, not brochures, confirm over time. On a practical level, it handles with less “caking” in humid climates because of our post-processing and packaging routines.

    Challenges We Have Seen—and How We Solve Them

    We didn’t start as experts. A decade ago, we fielded complaints about lengthier dissolving times and minor, stubborn impurities. Each complaint forced us to adjust crystallization rates, rethink filtration media, and tune pH swings. Many of our insights come from laboratory observations directly tied into our manufacturing floor: a sample tube that won’t dissolve, a bag that spews too much dust in transit, a change in hue noticed by a sharp-eyed technician. These real-world signals led us to prioritize operator training and real-time feedback over simple cost-cutting.

    Supply chain interruptions test rigor as much as chemistry. We weathered raw material price spikes by qualifying dual sources and maintaining minimum inventory buffers, not just-in-time trickery. Because APAA’s legal status varies between countries and changes faster than most chemical regulations, we designed adaptable documentation processes for customs and regulatory inspections. That way, a client in one country doesn’t have to endure delays just because another has shifted its import policy.

    Supporting Scientific Advancements and Regulatory Evolution

    If there’s a single quality that matters for modern chemical manufacturing, it’s openness. We routinely support trial runs for universities validating new methods for arsenic detection. This means providing batch samples with detailed impurity breakdowns and responding candidly about trace elements—even potential contaminants below the quantitation limit. We’ve partnered with labs to establish stringent method suitability testing (such as ICP-MS for arsenic speciation), so feed safety authorities can verify each lot independently.

    As industry consensus shifts toward reducing arsenic additives in animal feeds, our production team shifted toward serving the research and analytical sectors. The need for high-purity APAA remains present in various diagnostic kits, metal speciation standards, and pharmaceutical experimentation. There’s a difference between a chemical tailored for mass volume feed application and one designed for chromatographic reference use; we cater to both by adjusting our purification stages and packaging types. Each lot’s impurity profile gets submitted alongside the bulk product, which helps customers clear internal audits and satisfy increasingly tough stakeholders.

    Quality Assurance: What We Do, Not Just What We Promise

    Many suppliers rely on off-the-shelf QA routines; we developed ours in response to specific customer demands. Each batch faces multi-step analysis for organic impurities, metallic contaminants, and arsenic speciation. We archive this data for traceability on every shipment, so end-users can pull historical records on request. We have learned that transparency earns repeat business: over 60% of project-scale APAA users return for subsequent orders after comparing our documentation with competitor products.

    Product handling also matters. APAA arrives in sealed liners inside industrial-grade drums, reducing airborne dust and limiting exposure to moisture. Field technicians regularly conduct spot checks at customer sites for sample verification. In the event of any deviation, our technical team confers directly with the user—not through intermediaries—to resolve questions at the point of application.

    From Factory to Customer: How We Manage Consistency

    No automated process replaces the last check by a trained chemical operator. That holds true for every lot of APAA that leaves our facility. Operators monitor color, particulate phenomena, and solution clarity with straightforward in-process tests—often using test plots updated from decades of production data. No algorithm predicts contamination or outlier results better than experience accrued on the shop floor. Stability testing covers not just regulatory requirements, but also field reports from sites storing APAA in less-than-ideal conditions.

    Some customers need smaller, research-grade batches with customized QC analytics; others want ton-scale production for ongoing operations. In both cases, we adjust batch size, purification protocol, and packaging features so customers don’t pay for excess specification or compromise with underperformance. Handling and logistics teams maintain close schedules to minimize holding times at distribution hubs, preserving freshness and accuracy between production and delivery.

    Environmental and Safety Considerations from a Manufacturer’s View

    Responsible production of APAA isn’t just about chemical know-how. We routinely inspect process effluents for arsenic content and operate neutralization facilities for wastewater streams. Facility design incorporates closed-loop systems and spent filter recovery, aiming to limit any release of undesirable by-products. Because of the nature of APAA’s active elements, our team goes beyond compliance training—internal audits cover both process safety and environmental stewardship.

    Workers receive routine health screenings and PPE upgrades every year, based on actual handling observations rather than theoretical risk tables. We share process safety notes with peers and regulatory bodies to reduce incidents industry-wide. Feedback from incident reports—no matter how minor—feeds into ongoing operator retraining and process re-evaluation.

    Safe transport also gets attention. Our APAA ships in drums with secondary containment, and shipments include hazard labeling per destination requirements. This not only helps keep the surrounding community safe but provides peace of mind for clients who have faced supply interruptions due to improper shipping practices.

    Reliability and Reputation: Industry Relationships Built Over Time

    Earning real trust from repeat buyers takes more than periodic quality surveys. Over multiple product cycles, we receive and engage with detailed user feedback, whether from an on-site mixing manager, research chemist, or project manager overseeing QA for a global feed company. This dialogue informs future batches; a small suggestion on crystal handling or moisture content can feed into plant-level process improvements by the next production run.

    Technical staff share field application notes—not just sales bulletins—highlighting how APAA supported process control, bioassay repeatability, or minimized downtime. These shared stories reinforce internal pride and encourage practical innovation. We maintain open channels to regulatory agencies as laws continue to change on arsenic additives or handling. Our aim is not just to comply but to stay ahead, through documentation, ongoing education, and laboratory partnerships.

    The Human Side of Specialty Chemical Production

    Making chemicals like APAA involves more than reactors and chromatographs. People—both on our team and among our customers—choose to rely on us based on trust earned over years of open communication, unwavering quality, and consistent on-time delivery. The market has shifted, regulations have become stricter, yet the essential value of high-purity APAA remains recognized by those who need it for responsible applications.

    Adapting to those changes, not only do we refine formulas or invest in better reactors; we make sure each team member understands both the customer perspective and the broader impact of each drum leaving our gate. This means celebrating employee ideas that help reduce environmental impact, and working with users to evolve application methods as needs change.

    A View Into the Future of APAA Manufacturing

    Looking forward, we see opportunity both in niche feed operations and in the growing sector of analytical reference chemicals. Research continues to highlight unexpected roles for APAA analogs in tracking arsenic movement in biological and geological systems—a field where traceability and certified purity remain essential. By teaming up with university-based researchers and multinational partners, we continuously update our own standards to anchor ourselves as reliable specialists, whether for an animal feed producer or a research scientist exploring novel arsenic chemistry.

    No two shipments are exactly alike in their challenges. One season, humidity spikes push us to improve our packaging. Another, evolving documentation demands call for extending our traceability records. Meeting evolving regulations keeps us nimble—adapting not just batch records but facility systems and training, aiming always to anticipate what’s next instead of waiting for mandates. From our vantage in the factory, we see every lot of APAA as both a finished product and a promise—to deliver quality rooted in hands-on care, honesty in data sharing, and readiness to meet today’s needs with tomorrow’s solutions.

    Summary of 4-Aminophenylarsonic Acid’s Unique Place in Industry

    Through the years, 4-Aminophenylarsonic Acid has earned its standing for its dependable performance and flexible application across fast-changing industrial, research, and regulatory contexts. Each step of our process—from sourcing raw materials, through synthesis, purification, packaging, logistics, and user support—draws on first-hand feedback and a legacy of lessons learned from real-world use. Customers approach us for quality, transparency, and support that do not stop at delivery. In a marketplace where regulations, application needs, and user expectations evolve daily, we continue to see the value of careful manufacturing, open communication, and direct engagement with scientific and regulatory communities.

    That perspective sets our approach apart. We make and refine 4-Aminophenylarsonic Acid in direct response to both customer feedback and scientific progress. By keeping quality, safety, and proactive innovation at the core, we meet today’s challenges and set the bar higher for the future of specialty chemical manufacturing.