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4-Amino-N,N-Dimethylaniline Sulfate

    • Product Name 4-Amino-N,N-Dimethylaniline Sulfate
    • Alias N,N-Dimethyl-p-phenylenediamine sulfate
    • Einecs 219-181-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    662300

    Chemical Name 4-Amino-N,N-Dimethylaniline Sulfate
    Cas Number 536-46-9
    Molecular Formula C8H12N2·H2SO4
    Molecular Weight 254.29 g/mol
    Appearance Off-white to beige powder
    Solubility In Water Soluble
    Melting Point 167-170°C (decomposes)
    Storage Temperature Room temperature
    Synonyms p-(Dimethylamino)aniline sulfate, N,N-Dimethyl-4-phenylenediamine sulfate
    Ec Number 208-627-9
    Hazard Class Harmful if swallowed
    Purity Usually ≥98%
    Odor Odorless

    As an accredited 4-Amino-N,N-Dimethylaniline Sulfate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g package of 4-Amino-N,N-Dimethylaniline Sulfate comes in a sealed amber glass bottle with chemical hazard labeling.
    Shipping 4-Amino-N,N-Dimethylaniline Sulfate ships as a solid chemical, typically packaged in sealed containers to prevent moisture exposure. It should be handled as a hazardous material, requiring appropriate labeling and documentation. Transport should comply with local regulations for chemicals, ensuring safe handling and minimizing risk of spillage or contamination during transit.
    Storage 4-Amino-N,N-Dimethylaniline Sulfate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect it from moisture and direct sunlight. Store at room temperature, ideally between 15–25°C (59–77°F). Handle using appropriate safety precautions, such as wearing gloves and eye protection.
    Application of 4-Amino-N,N-Dimethylaniline Sulfate

    Applications of 4-Amino-N,N-Dimethylaniline Sulfate in Industrial Manufacturing

    Used across several established industrial sectors, 4-Amino-N,N-Dimethylaniline Sulfate serves as a key intermediate in specialty synthesis workflows requiring stable paraphenylene derivatives. As a direct manufacturer, we supply this specialty amine salt to closely aligned customers in fine chemicals, dyes, imaging, and pharmaceutical manufacturing, each with demanding process parameters and industry-specific standards. Below, we present differentiated scenarios where this material plays a unique process role.

    1. Azo Dye Intermediates for Textile & Leather Manufacturing

    This compound enters dyehouses as a core intermediate for synthesizing stable azo dyes. Industry operators blend it with diazotized aromatic amines to generate high-chroma, acid-fast textile colorants and specialty black dyes for leather finishing. Facilities select this amine salt when targeting deep magenta, blue, or black color bases that withstand repeated wash and abrasion cycles per customer fastness specifications. Usage parameters vary by substrate dye class and shade depth requested by leading textile and leather brands.

    Industry compliance standards

    • Oeko-Tex® Standard 100 (dye residues for textiles)
    • REACH Annex XVII (restricted amines limits)
    • Eco Passport by OEKO-TEX® (chemical input audit)
    • ZDHC MRSL v3.0 (input chemical management)

    Typical usage ratio

    • Ranges from 0.2% to 2% of dye bath mass, adjusted for color depth and targeted chroma; higher end used in deep black formulations

    Downstream process integration

    • Added during coupling reaction phase to produce pre-dispersed azo pigment concentrates, which are then standardized and filtered before final formulation with other dye auxiliaries

    Final product types

    • Direct and acid azo textile dyes
    • Leather aniline and semi-aniline dyes
    • Resistant deep shade dye powders
    • Concentrated pigment pastes for yarn and garment coloration

    2. Photographic Developer Additives for Imaging Chemicals

    This specialty amine sulfate has a long-standing role in fine-tuning black-and-white and color photographic developer formulations, where it acts as both a primary and auxiliary developing agent. Chemists leverage it to enhance image density, gradation, and contrast during emulsion processing. Strict photographic standards require full traceability, low metallic impurity levels, and consistency in developer agent concentration to avoid batch-to-batch deviations in imaging results.

    Industry compliance standards

    • ISO 18902:2013 (Imaging materials – Processed films)
    • ANSI IT9.17-1993 (Photographic image stability)
    • RoHS (applicable if end-use in imaging electronics)

    Typical usage ratio

    • 0.05% – 0.15% w/v in developer concentrates, with adjustments based on targeted black density and film emulsion type

    Downstream process integration

    • Dissolved directly into developer concentrate tanks after water and alkali addition, prior to filtration and packaging as single-use or bulk developer solutions

    Final product types

    • Photographic development concentrates (liquids, powders)
    • On-site developer cartridges for photofinishing machines
    • Monochrome and color print developer kits
    • Chemical packs for medical X-ray film processing

    3. Redox Catalyst in Polymerization Reactions

    The compound enters advanced polymer synthesis as a redox co-catalyst that initiates or accelerates specific free radical reactions. Polymer chemists prefer this material when producing specialty polyacrylates, rubber latexes, and custom resins where controllable chain initiation is critical. It supports reaction efficiency and improves molecular weight distribution when working alongside peroxides or persulfates, reducing cycle times in batch and continuous reactors.

    Industry compliance standards

    • ISO 9001:2015 (process control within reaction plants)
    • ASTM D2563 (synthetic latex chemical analysis)
    • FDA 21 CFR 177 (for indirect food-contact polymers, requires end-use migration compliance)

    Typical usage ratio

    • 0.01% to 0.1% by monomer weight, calculated according to catalyst activity and desired polymer chain length

    Downstream process integration

    • Introduced to reactor vessels in tandem with aqueous monomer phase and oxidizers; dosing controlled by redox potential or feed-forward process sensors

    Final product types

    • Waterborne latexes for adhesives and coatings
    • Acrylic resins for pigment dispersions
    • SBR and NBR rubber intermediates for automotive/industrial applications
    • Specialty polymer dispersions

    4. Chemical Intermediate in Active Pharmaceutical Ingredient (API) Synthesis

    This material functions as a selectivity agent and building block within select pharmaceutical synthetic pathways, such as the construction of heterocyclic amines found in antihistamines and cardiovascular drugs. Pharmaceutical grade supply undergoes multistage purification and analytic release, supporting regulated production sites operating under cGMP protocols. Process chemists control charge-in and monitoring for every batch to avoid carryover of amine-related side products which can affect impurity profiles of APIs.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP-NF Monographs (applicable APIs)
    • EU EudraLex Volume 4 (GMP for Pharmaceuticals)
    • FDA 21 CFR 210/211 (manufacturing, processing, packaging, and holding of drugs)

    Typical usage ratio

    • 1% to 5% molar equivalence relative to the limiting reactant, set by process-specific stoichiometry and impurity control requirements

    Downstream process integration

    • Metered into multi-stage synthesis reactors or added during targeted amination and ring closure steps, followed by aqueous work-up and chromatographic purification

    Final product types

    • Pharmaceutical intermediates (e.g., substituted anilines)
    • Bulk active pharmaceutical ingredients (APIs) for generic and branded drugs
    • Finished dosage formulations after further processing

    5. Analytical Chemistry Reagents for Water Quality Testing

    Laboratory supply chains utilize this material as a colorimetric agent in spectrophotometric protocols for trace-level detection of nitrates, nitrites, and certain metal ions in environmental samples. The unique electron-donating structure produces stable colored complexes when reacted with specific analytes, enabling high-sensitivity visual or instrument-based quantification in accordance with regional water testing regulations.

    Industry compliance standards

    • ISO 7027-1 (water quality– determination of turbidity)
    • EPA 300.0/300.1 (nitrate/nitrite method for drinking and waste water)
    • Standard Methods for the Examination of Water and Wastewater, APHA-AWWA-WEF

    Typical usage ratio

    • Reagent concentrations from 0.01% to 0.05% w/v in sample cuvette or testing solution, with amounts optimized for analyte and sensitivity required

    Downstream process integration

    • Formulated into ready-to-use reagent kits or added to aqueous samples during standardized test workflows; sometimes dried onto test strip matrices for field use

    Final product types

    • Water analysis reagent kits
    • Pre-packed colorimetry test tubes
    • Portable test strips for environmental and municipal water laboratories
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    Certification & Compliance
    More Introduction

    Introducing Our 4-Amino-N,N-Dimethylaniline Sulfate: Insights from the Manufacturing Floor

    Real-World Experience Behind Every Batch

    Every time we process a new batch of 4-Amino-N,N-Dimethylaniline Sulfate, we see more than just numbers and ratios; we see decades of trial, observation, and conversation with customers across specialty chemicals, dyes, and pharmaceutical intermediates. Our team, from technicians to plant supervisors, brings hands-on experience into each production step. We value the difference it makes when a chemist can trust the material that arrives at their door.

    The product has a distinct chemical structure, with both an amino group and two methyl groups attached to the aniline ring, and it's precisely the sulfate salt we manufacture. The sulfate form brings water solubility and stability, which has established it as a mainstay for various synthesis applications. Every run in our reactors combines precise raw materials with operational discipline, because even minor deviations can lead to impurities that compromise downstream performance. Instead of hiding behind certificates, our open dialogue with colleagues in dyehouses, research labs, and processing facilities has taught us what matters most—consistency, reproducibility, and material clarity.

    Specifications Rooted in Industry Practice

    The standard model we prepare stays within tight tolerance limits for active content, color index, and controlled moisture. There’s a reason we don’t just chase higher yields for the sake of internal numbers. Early in our journey, a customer demonstrated that a spectacular yield, if obtained at the expense of color purity, ended up causing headaches in their chromatographic analysis. So we maintain strict controls at every filtration, drying, and sieving stage. Typical active content remains above 98%. Color and moisture content undergo batch-specific monitoring. Our operators—many of whom have processed thousands of metric tons over the years—test both with machines and with their own experience to judge when something looks off. A deep yellow hue or a trace impurity by HPLC leads to investigation, not quick shipment.

    Unlike dry commodity chemicals, the sulfate salt must meet more than just a checkbox; it needs to support precision applications like dye and pigment synthesis, DNA research, and as a coupling reagent for analytical chemistry. Shelf life depends heavily on moisture protection and packaging standards, which we enforce with modern sealing technologies. Instead of “tailored to requirements,” we have long recognized that sloppy packaging or trivial defects in crystal morphology can disrupt an entire production run downstream.

    Usage in Dye and Pigment Manufacturing

    Every manufacturer of dyes knows the frustration of variable shade intensity or unpredictable reactivity. 4-Amino-N,N-Dimethylaniline Sulfate handles these inconsistencies better than many comparable aromatic amines, due in large part to its stability in storage and its reaction predictability during diazotization and coupling. For textile dyeing, precise batch-to-batch color reproduction holds tremendous value. Our chemists have spent years working alongside textile groups, helping solve color drift and controlling undesirable side products by revising filtration and washing sequences.

    During pigment synthesis, demand surges often push us to the limit, but we never shortcut the reaction completion or post-synthesis purification to meet a date. End-users confirm that a crystalline sulfate salt free from phenolic or nitro impurities prevents the off-coloration seen in mass colorant production. The difference between a reliable intermediate and a troublesome one lies in the margin of process control at every stage, right from the initial feedstock to final vacuum drying.

    Compounding and Research Applications

    In pharmaceutical research, our 4-Amino-N,N-Dimethylaniline Sulfate enters reaction schemes as a building block for advanced organic syntheses. Laboratories trust the material when it provides documented, repeatable profiles in both pilot and scale batches. Over time, we’ve learned which variables affect product reproducibility: exposure to air, choice of anti-caking agent, and sequence of recrystallization. On lab benches, customers running hundreds of parallel reactions require clean, well-identified crystalline sulfate to avoid costly retesting or cleanups. The sulfate salt’s solubility profile allows easy integration into water-based reaction systems, making it an asset for teams already operating within tighter environmental regimes and stricter process limits.

    Several research teams have reported that minor by-products from poorly controlled syntheses disrupt biological activity and analytical tracing. That insight led us to adopt double-recrystallization with a solvent system designed for maximum byproduct removal and minimal waste. We’ve worked directly with research chemists who provide candid feedback when something in the batch doesn’t behave as expected—and we improve based on that. Our analytical team supports customers by offering guidance on spotting subtle impurity peaks, because those small details make a difference in high-stakes experiments.

    Reliability Through Process Discipline

    It’s not theory that drives process change in our plant; it’s the problems we’ve solved shoulder-to-shoulder with users who depend on every metric ton. Early on, product caking in transit or delays due to residue in filling lines prompted us to overhaul dryer temperatures and optimize de-dusting systems. Today, the sulfate powder exits our controlled drying environment at low residual moisture, packaged for long shelf life and transfer safety. We adjust sieve mesh based on customer mixing preferences for liquid dye formulations or pharmaceutical intermediates, understanding that one-size-fits-all barely serves anyone well.

    How Our Product Differs from Alternatives

    Some plants produce the free base of 4-Amino-N,N-dimethylaniline, which lacks the solubility and long-term stability offered by the sulfate form. We have seen repeated complaints from industry partners that the free base, while easy to handle in some processes, introduces extra steps for stabilization and often picks up atmospheric moisture. The sulfate salt resists this and allows direct addition to aqueous systems without delay.

    Compared to similar amino-aniline derivatives, our product distinguishes itself through purity and by the absence of common byproducts like nitrosamines, which we keep below trace levels strictly through in-process testing and operator oversight. Decades ago, stray contamination in the amine line caused enough trouble in pigment manufacture that we made it a plant-wide rule to test each lot with cross-methods: HPLC, GC-MS, and spot tests. Most commodity producers don’t go this far, but our hands-on experience tells us that catching a problem in the lab is less costly than fielding customer complaints after shipment.

    Other salts like hydrochlorides accompany the amine line, yet sulfate consistently outperforms them in terms of handling safety and shelf stability. We observed that hydrochloride salts, while easier to dry, often introduced corrosive dust in handling rooms and required more robust ventilation—an overlooked hazard for smaller customers. The sulfate salt avoids this, as simulation studies and customer audits confirmed.

    Supporting Customers Through Sharing Experience

    Quality assurance isn’t only a matter of testing; it’s grounded in years of responding to quality questions, troubleshooting end-use issues, and carrying back solutions into plant operations. Our team has updated purification steps not because of theoretical gains but as a result of direct customer feedback showing where side reactions and unwanted impurities appeared in complex syntheses. Whether used by a large-scale dye manufacturer or a research chemist handling grams at a time, product trust builds batch by batch.

    We encourage customer site visits, not only to showcase our follow-through but also to exchange lessons on safe handling, storage, and batch adaptation. Our technical staff keeps in touch with partner labs who push for tighter impurity windows or test for new byproducts. Through joint troubleshooting, we’ve tailored packaging methods to simplify weighing and minimize operator exposure, which became a concern among users in smaller, less-automated environments.

    Responsibility in Supply and Continual Learning

    As global demand for specialty amines grows, industry pressures for cost cutting sometimes tempt shortcuts in handling or raw material selection. Our experience from supply chain disruptions and customer side rejections reinforces the need for transparency, even when it occasionally slows output. We remain committed to full material traceability; no drum leaves the facility without full documentation back to raw supplier, batch record, and in-house assay.

    Routine audits and continuous reevaluation of plant SOPs make all the difference. A few years ago, an unexpected impurity trend forced a review of our sulfonation step; our technical group worked around the clock with both suppliers and plant engineers to isolate the issue and adapt new filtration media. The lesson stuck: robust process change comes from real-world feedback, not theoretical documentation alone. Packaging upgrades, such as double-sealed PE liners and stackable fiber drums, began as a response to logistics issues experienced by customers running multi-site operations, not from deskbound risk assessments.

    Environmental and Safety Practices

    We actively manage waste streams from the amine process line, minimizing the risk of nitrogenous runoff into municipal water. We’ve invested in closed-loop water handling systems and on-site treatment, a step that might seem excessive but grew out of direct experience with local environmental audits and community expectations. Every change we make, from solvent selection to packing material alternatives, gets stress tested in our plant before being released to the market. Over the years, this approach has contributed to cleaner production and fewer rejected batches, which serves both our operators and end-users.

    Safe handling of 4-Amino-N,N-Dimethylaniline Sulfate — especially in bulk or in sensitive research labs — requires grounded training, not just listing precautions on an MSDS. We share practical handling guides informed by incidents and near-misses from across our own plant and customers’ facilities. Storage recommendations stem not from theoretical shelf-life windows but from conversations with partners in less temperate climates, who face seasonal spikes in humidity and temperature.

    Storage, Distribution, and Quality Commitment

    Efficient supply starts with stable storage. Our warehouse team brings years of hands-on knowledge in stacking, rotation, and protection against cross-contamination. We learned early that inconsistent temperature swings affect not only the appearance but also the performance of the sulfate salt in key formulations. Maintaining ambient humidity under control, using robust bag-in-drum packaging, and training staff in warehouse hygiene— these aren’t procedures we take lightly, but lessons earned from adverse customer feedback.

    Distribution relies on reliability, not promises. Over time, we’ve set up direct routes and established backup contract carriers to minimize transit times and avoid unnecessary handling. Customers who depend on ‘just-in-time’ deliveries get more than a shipment; they get the assurance that we’re managing expiry risk and transit damage proactively.

    Building Trust with Every Lot

    Our operation has long been shaped by the lessons we pick up from industry partners, researchers, and operators. Manufacturing 4-Amino-N,N-Dimethylaniline Sulfate isn’t merely about reaching theoretical purity. It’s about understanding the realities and constraints of downstream processing, and about testing small but critical changes that prevent “mystery” failures in application. We believe in direct, clear communication—precisely because we’ve seen avoidable surprises when these conversations don’t happen.

    As new applications arise—whether in advanced material synthesis, assay development, or industrial-scale pigment production—we adapt our plant in real-world conditions, stress-testing improvements before scaling them up. That’s why our product has built reputation among both traditional and emerging users. Instead of generic assurances, we anchor trust in shared experience, transparency, and a willingness to keep learning.

    Looking Ahead: Innovation Driven by End-User Needs

    Innovation, in our view, doesn’t only grow from technology; it comes from the push and pull of everyday problem-solving. Customers navigating regulatory shifts or scaling up to new synthetic pathways shape our priorities. We invest in modest but impactful upgrades to reactor control, packaging integrity, and post-shipment support. The confidence researchers and manufacturers find in our 4-Amino-N,N-Dimethylaniline Sulfate reflects a real engagement between the plant and the people who rely on the final product.

    Our plant, like any living system, evolves as we gather more data, but our foundation remains the same: produce quality through discipline, solve problems with transparency, and share lessons honestly, so every user—large or small—benefits from what we’ve learned. As we see new uses and tighter specifications emerge, we’ll continue shaping our process around the realities faced by all our partners in the field.