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4,6-Dinitro-2-Aminophenol

    • Product Name 4,6-Dinitro-2-Aminophenol
    • Alias 2-Amino-4,6-dinitrophenol
    • Einecs 217-808-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    716154

    ChemicalName 4,6-Dinitro-2-aminophenol
    MolecularFormula C6H5N3O5
    MolecularWeight 199.12 g/mol
    CASNumber 6398-45-0
    Appearance Yellow to orange crystalline powder
    MeltingPoint 208-210°C
    SolubilityInWater Slightly soluble
    BoilingPoint Decomposes before boiling
    Density 1.77 g/cm³
    PubChemCID 13895645

    As an accredited 4,6-Dinitro-2-Aminophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed HDPE bottle containing 100 grams of 4,6-Dinitro-2-Aminophenol, labeled with hazard symbols, chemical name, and CAS number.
    Shipping 4,6-Dinitro-2-Aminophenol must be shipped as a hazardous chemical. It should be packed in tightly sealed containers, cushioned against shock, and clearly labeled with hazard information. Shipping must comply with local, national, and international regulations for transport of toxic and potentially explosive substances, ensuring safe handling and containment throughout transit.
    Storage 4,6-Dinitro-2-aminophenol should be stored in a tightly sealed container, away from light, heat, and sources of ignition. Store it in a cool, dry, and well-ventilated area, isolated from incompatible substances like strong oxidizers or reducing agents. Ensure all containers are clearly labeled, and handle with appropriate personal protective equipment to prevent exposure to dust or vapors.
    Application of 4,6-Dinitro-2-Aminophenol

    Applications of 4,6-Dinitro-2-Aminophenol in Industrial Manufacturing

    4,6-Dinitro-2-aminophenol is a specialized intermediate with defined value in colorant synthesis, pharmaceutical ingredient manufacturing, imaging chemicals, and functional material research. As a direct producer, we support key sectors that demand precise formulation, strict compliance, and reliable supply for advanced product performance and regulatory approvals.

    1. Azo Dye Intermediate Production for Textile Coloring

    This chemical is a crucial diazo component for synthesis of advanced azo dyes. Textile dye manufacturers use our material to achieve high reproducibility in shade and fastness. This intermediate reacts in controlled coupling steps converting into target dye structures under regulated conditions with sodium nitrite and couplers. Production follows rigorous wastewater management and batch validation to prevent cross-contamination and ensure spectral purity. Color development and fixation meet international textile standards for dye safety and performance.

    Industry compliance standards

    • OEKO-TEX® Standard 100 regulations (acceptable amine content and restricted substances)
    • REACH Annex XVII restrictions for aromatic amines in textiles
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • ISO 105 textile color fastness testing protocols

    Typical usage ratio

    • Ranges from 0.1–2.0% w/w of total dyestuff blend depending on target dye shade and molecular reactivity in batch synthesis
    • Adjust according to coupling component reactivity and desired shade intensity

    Downstream process integration

    • Introduced as a raw material at initial diazotization stage
    • Blended into the aqueous reaction system under temperature-controlled mixing
    • Subsequent coupling yields final azo dye product for textile printing or yarn dyeing

    Final product types

    • Disperse dyes for polyester fiber
    • Direct dyes for cellulosic fibers
    • Azoic colorants for textile printing paste
    • Reactive dye intermediates for wool and silk blends

    2. Synthesis of Pharmaceutical Intermediates

    Pharmaceutical API manufacturers use this intermediate for the production of certain nitroaromatic active ingredients and as a precursor in the creation of antibacterials and antitubercular agents. Each batch meets the fine purity and impurity limits required by pharmacopeial monographs. Our material enters the early synthetic route, supporting cost-effective route scouting and gram-to-kilogram scale process transfer under GMP conditions. Quality assurance includes detailed impurity profiling, audit trails, and stability assessment to guarantee traceability from starting material to finished formulation.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) requirements for intermediates
    • U.S. Pharmacopeia (USP) General Chapter 1086
    • Good Manufacturing Practice (ICH Q7)
    • FDA 21 CFR Part 210/211 for pharmaceutical ingredient manufacturing

    Typical usage ratio

    • Ranged per specific synthetic pathway; commonly 0.5–1.5 molar equivalents relative to target nitro compound in multi-step synthesis
    • Adjusted for reaction completeness and impurity threshold

    Downstream process integration

    • Charged in initial condensation or nitration steps of complex API assembly
    • Reacts with halogenated aromatics or carboxylated intermediates under controlled pH
    • QC tested for residual solvents and byproducts before upscaling

    Final product types

    • Nitrofuran-based antimicrobials
    • Antitubercular drugs
    • Research stage pharmaceutical leads with nitroaromatic core
    • Intermediates for sulfa drugs

    3. Imaging Chemicals for Thermal Paper and Color Formulation

    Thermal paper coaters and imaging chemical formulators use this compound as a developer precursor or functional additive to engineer color-forming systems. Its electron-donating and nitro substituent configuration enables tailored melt-point and image retention in thermal coatings. The substance is dissolved, blended, and co-deposited with phenolic resins and leuco dyes in multi-component microencapsulation processes. Quality assurance covers thermal stability and leachability, serving regulatory-compliant labels, tickets, and receipts with assured storage safety.

    Industry compliance standards

    • European Printing Ink Association (EuPIA) Guidelines for Packaging
    • REACH Registration dossier requirements for chemical safety
    • EN 646 determination for print image stability
    • ISO 18601 for documentation in paper chain-of-custody

    Typical usage ratio

    • Incorporated at 0.05–0.2% w/w in final thermal-sensitive coating formulation
    • Adjusted based on desired color intensity, background sharpness, and developer compatibility

    Downstream process integration

    • Blended into coating slurry at controlled temperature
    • Micronized for enhanced dispersion and rheology in coating head
    • Deposited onto paper web using reverse roll or blade coating systems

    Final product types

    • Thermal printer paper rolls
    • Self-adhesive thermal labelstock
    • POS (Point-of-Sale) ticket stock
    • Security-coded color imaging films

    4. Analytical Reagent Synthesis and Sample Derivatization

    Analytical laboratories and reagent manufacturers source this compound to synthesize colorimetric detection reagents that specifically interact with targeted ions and functional groups in trace analysis. Used as a starting material for chromogenic agent synthesis, the compound supports pharmaceutical QC, food safety monitoring, and heavy metal analysis protocols. Manufacturing employs purification and drying processes to achieve specification-grade batches compatible with sensitive instrumentation. Each lot ships with a certificate of analysis covering trace metals and residual solvents measured by validated methods.

    Industry compliance standards

    • ISO/IEC 17025 accreditation for laboratory reagents
    • Analytical Reagent (AR) quality requirements
    • European Commission Regulation No. 333/2007 for food contaminants analysis
    • FDA Laboratory Quality Assurance standards (21 CFR Part 58 GLP)

    Typical usage ratio

    • Prepared into working solutions at 10–250 µg/mL concentration depending on test method and matrix sensitivity
    • Adjusted for analyte concentration or to minimize matrix interference

    Downstream process integration

    • Converted into derivatizing agents via reduction or acylation reactions
    • Blended into mobile phases or extraction solvents
    • Employed in automated analyzers or manual batch test kits

    Final product types

    • Commercial colorimetric ion-binding reagents
    • Professional lab analysis kits for trace metal determination
    • Quality control reagents for pharmaceutical QC labs
    • Sample preparation chemicals in environmental monitoring

    5. Organic Electronics and Functional Material R&D

    Advanced R&D teams utilize this chemical as a building block for high-performance organic electronic materials and advanced polymers. Its unique substitution pattern enables integration into conjugated backbone structures and functional side chains. R&D departments develop small-batch pilot runs under inert conditions, optimizing purity, substitution pattern, and spectral qualities. Downstream blending and polymerization are monitored for molecular weight consistency and film uniformity. All shipments undergo batch tracking and stability studies according to documented supply chain protocols.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for R&D and pilot production
    • RoHS restrictions for electronics formulation substances
    • European Chemicals Agency (ECHA) notification for R&D use
    • Corporate Responsible Care® codes for laboratory safety

    Typical usage ratio

    • Used at 0.05–0.5 molar equivalents as an end-group or segment in oligomer and copolymer synthesis
    • Adjusted based on targeted conjugation length and polymer characteristics

    Downstream process integration

    • Dosed into polymerization reactors under controlled inert atmosphere
    • Integrated at polymer design stage as monomer or co-monomer
    • Processed into solution or film form for device testing and prototyping

    Final product types

    • Conjugated polymer films for electronic devices
    • Functional test materials for OLED and OPV research
    • Specialty coatings with dielectric and UV-absorbing performance
    • Organic semiconductors for academic or pilot device trials
    Free Quote

    Competitive 4,6-Dinitro-2-Aminophenol prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Looking Closer at 4,6-Dinitro-2-Aminophenol: Experience from the Production Floor

    Every Batch Starts with Raw Materials

    At the core of our work lies a commitment to start each synthesis from high-purity base chemicals. The precision in the selection of raw phenols and nitrating agents drives the outcome. What emerges from our reactors, 4,6-Dinitro-2-Aminophenol, showcases years of craftsmanship in controlling exothermic steps and ensuring correct substitution patterns on every molecule. Over time, we’ve refined procedures to avoid the harsh byproducts that can plague similar syntheses when shortcuts are taken.

    Understanding What Sets This Product Apart

    Production of 4,6-Dinitro-2-Aminophenol serves more than a checkmark on a chemical list—it factors directly into efficiency and reliability across multiple industries. We see requests from firms that make advanced dyes, specialty intermediates, or pharmaceuticals seeking purity and reproducibility. Not every process handles multiple nitro group attachments well; some related products don't maintain the same stability when exposed to certain conditions. Ours consistently meets purity levels specified by technical users, with a color and flow that simplify handling on automated dosing lines.

    Day-to-Day Chemistry: Run-Ins and Solutions

    From a manufacturer’s angle, little details matter. Crystallization temperature windows get narrow; managing particle size becomes more than an afterthought. Staff in our plant regularly check the filtration step, ensuring the bright yellow-orange crystals never include trapped solvents. This extra attention reduces the kind of residues that complicate downstream reactions. In the early days, we had batches where incomplete washing led to surprise spectral peaks—painful lessons that changed our protocols permanently.

    On the Line: Purity and Physical Form

    Users ask for 4,6-Dinitro-2-Aminophenol in powder or granule. Pharmacopeial-grade batches call for extra isolation steps and vacuum drying with careful monitoring for any signs of degradation. Technical-grade goes to pigment or dye manufacturing, while the more refined variant often lands in pharmaceutical intermediates. Our experience shows that moisture content can undermine stability, so we measure water constantly, adapting drying cycles to seasonal humidity.

    Why Consistent Color Matters

    Dye manufacturers in Europe and Asia have visited our sites wanting to see and touch our product before signing long-term deals. To their experts, shade and hue aren’t cosmetic—they indicate secondary impurities or the presence of iron. We combat that by using lined reactors and setting aside full days for line cleaning after each campaign. In one case, a switch in water source altered the end appearance, reminding us that the smallest shifts ripple across the process. It’s not just about numbers in a specification sheet; years of feedback from end-users shape how we tweak our equipment.

    Beyond a Simple Intermediate

    Comparing 4,6-Dinitro-2-Aminophenol to related chemicals such as 2,4-dinitrophenol or 2,6-dinitro-4-aminophenol reveals clear differences. Each nitro group positioning alters reactivity in coupling reactions. Our product slots into dye manufacturing processes needing a particular substitution pattern that no other compound imitates. The solubility profile and coupling efficiency set it apart from the more readily available mono-nitro or non-amino nitrophenols. This unique blend of properties allows certain colorfast dyes and intermediates to emerge that other compounds simply can’t deliver.

    Precision in Every Analysis

    Our laboratory staff prep each batch for TLC checks, HPLC profiles, and loss on drying measurements. Even with high-throughput demands, every shipment waits on lab sign-off. Over the years, we’ve upgraded analytical standards—not as a compliance matter, but because small aberrations translate directly to headaches at the customer’s end. Scenarios pop up where a dye manufacturer’s yield drops unexpectedly; our troubleshooting walks back to the purity and origin of every batch.

    On-site Handling: Hazards and Know-How

    Every worker here knows the sting of mishandling sensitized nitro compounds. Training and ventilation cut down dusting and risk, but nobody gets complacent. We’ve had to retrain staff through hands-on demonstrations after a spill left yellow residue in a pump housing. This isn’t just about ticking safety boxes; working daily with 4,6-Dinitro-2-Aminophenol teaches respect for energetic chemistry, prompting routine investments in PPE and spill control improvements. No process gets locked in—when industry standards or learning from near-misses calls for change, we act fast.

    Feedback from Dye and Pharma Sectors

    Over the last decade, feedback from multinational dye houses and local pharmaceutical manufacturers has shaped our operation. One large user in India reported faster filtration when using our material versus an overseas competitor's, traced to our tighter control on bulk density. Meanwhile, a pharma API producer flagged minute levels of residual catalyst that created regulatory headaches; now, we double-check catalyst removal at multiple stages. These stories keep our focus on end-use success, not just internal yield metrics.

    Distinct Needs Across Applications

    Many customers start their engagement by seeking an all-purpose product, only to learn over time that subtle tweaks make their processes run smoother. Influenced by repeated customer trials, we’ve separated two main models: one favoring dense, free-flowing granular material for automated feed, another offering fine powders to speed up dissolution where mixing time is critical, such as in batch dye tanks. This evolution stems directly from the plant floor—the intersection where chemistry meets application.

    Packaging: More Than a Container

    Bulk chemical bags and fiber drums look simple, but product stability hinges on more than just barriers. Water vapor, trace solvents, and temperature cause batches to cake or degrade. Our staff swapped out suppliers and even quadruple-tested liners after one summer’s string of complaints from customers in a tropical port city. By investing in foil-laminated bags and desiccant packs, we slashed the number of reshipments—direct savings for buyers who depend on clean, clump-free input each time. Here, packaging isn’t afterthought; it’s a factor in customer loyalty.

    Environmental Care in Nitro Chemistry

    Nobody in manufacturing avoids tough scrutiny over waste handling. Nitro aromatics demand extra vigilance. Wastewater management forms one pillar; we install in-line nitrogen destruction and activated carbon beds. Our plant revised scrubber systems recently to cut total organic carbon loads before outflow. Regulatory groups from multiple countries conduct regular audits here, and every visit becomes a chance to push for more effective containment—addressing concerns before they reach the headlines. Staff pride in environmental data transparency pays dividends well beyond compliance.

    Regulatory Landscape: Compliance with a Moving Target

    Our process chemists walk a tightrope between technical ambition and evolving regulation. Over the last five years, regulatory standards have tightened. As European REACH requirements changed, we had to document each precursor, insisting on traceability. Likewise, demand from certain countries for lower nitrosamine impurities forced rethinking of neutralization steps. Each shift in law means a feedback loop with production—never a hurdle we sidestep, but a cue to raise our own bar. This continuous dialogue with regulators laid the groundwork for our export track record and fosters customer trust.

    The Human Factor in Every Batch

    Sophisticated sensors and online controllers monitor reactions, yet behind every ton is a human judgment call. Senior operators here learned to spot out-of-norm hues, trace hydrolysis, and react long before a sample reaches the QC lab. These insights, drawn from shiftwork, prevention of fouling in kettles, and handling of high-throughput campaigns, fill gaps no software patch ever covered. Respect for the complexity of nitro- and amino-substituted phenols sets our operation apart from a site that runs on autopilot.

    Cost Drives, but Quality Persists

    Some industry buyers chase the lowest price per kilo. In this chemical, a cheaper deal can hide costs that show up as delayed deliveries or unusable material. Our experience with 4,6-Dinitro-2-Aminophenol is that process control, clean raw materials, and thorough final checks save time and trouble downstream. One missed impurity leads to full reactor cleanouts—costs that dwarf small savings at the sourcing stage. Repeat customers confirm this every year, as their plants experience fewer hiccups using our batches.

    Looking to the Next Generation

    Our plant brings in apprentices, training them directly on the quirks of making high-purity aminophenol derivatives. Rather than chase trend-based shortcuts, we invest in upgrades that deliver in the plant and the lab. Younger staff learn not just synthesis, but the picky art of color and trace moisture assessments. We track production variances, encourage open conversations when something works (or doesn’t), and replace assumptions with hands-on testing. These choices feed a cycle: better-trained operators turn out more reliable batches, and end-users reap the benefits.

    Every Plant Visit Teaches Something New

    Visitors from technical teams often ask to tour our facility. What they remember is the unusual way we sequence campaigns, never mixing precursor stocks across batches. These deliberate steps cut cross-contamination risks, something we learned after a single slip-up ran through an entire day's output years ago. Our supervisors developed checklists from these tough lessons, so new hires catch process variables before they become customer complaints. Tour groups leave not just with samples, but with direct answers born from hard experience, not PR lines.

    Pushing for the Future: Continuous Improvement

    Markets shift, and so does our recipe book for 4,6-Dinitro-2-Aminophenol. Small but regular investments in process analytics, pilot testing new drying cycles, and random batch audits all feed into a culture that values data from both plant and end-user. Behind every improvement lies feedback from those handling, dosing, or formulating with our product. Whether it’s tweaking a filtration angle or examining a residue spectrum picked up in a faraway customer’s lab, the cycle of making, listening, and refining never ends. This is what keeps a chemical plant relevant over decades—not just a well-printed specification, but a living record of problems solved and lessons learned.

    In Summary: Why Manufacturers Choose Our 4,6-Dinitro-2-Aminophenol

    For production staff at our site, 4,6-Dinitro-2-Aminophenol tells a story: adaptation, attention to detail, and resilience in the face of setbacks. Unlike generic or imported lots, our batches reflect an ongoing partnership between operator, laboratory, and end-user. Comparing notes across a decade, we see fewer disruptions and tighter performance bands compared to alternative sources. Each drum rolled out from our dock has passed not just paperwork checks, but the combined scrutiny of technicians, chemists, and customers who see value in each small calculation and clean-up.

    Manufacturing 4,6-Dinitro-2-Aminophenol isn’t glamorous chemistry, and surprises can appear without warning. Every challenge has cemented our view that process vigilance, honest customer engagement, and investment in human expertise deliver dividends well beyond an annual report. This mindset guides not just how we make chemicals, but how we sustain partnerships across continents and industries. Every kilogram shipped out connects the rigor of chemical manufacturing to the successful launch of a new color, a safe pharmaceutical intermediate, or a technical advance in industries that demand more than just the expected.