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3-Methylaniline

    • Product Name 3-Methylaniline
    • Alias m-Toluidine
    • Einecs 203-583-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    959091

    chemical_name 3-Methylaniline
    synonyms m-Toluidine
    molecular_formula C7H9N
    molar_mass 107.15 g/mol
    CAS_number 108-44-1
    appearance Colorless to yellow liquid
    boiling_point 199 °C
    melting_point -30 °C
    density 1.007 g/cm3
    solubility_in_water 6.3 g/L (20 °C)
    flash_point 82 °C
    odor Aromatic, amine-like
    refractive_index 1.580
    pubchem_cid 7922

    As an accredited 3-Methylaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Brown glass bottle containing 500 mL of 3-Methylaniline, tightly sealed with a screw cap, labeled with hazard and handling information.
    Shipping **3-Methylaniline** is shipped in tightly sealed containers, typically made of glass or chemical-resistant plastics, and labeled according to hazardous material regulations (UN 2213). Transport must comply with local and international regulations for flammable, toxic substances. Store and ship in a cool, well-ventilated area, away from incompatible materials and sources of ignition.
    Storage 3-Methylaniline should be stored in a tightly closed container in a cool, dry, well-ventilated area away from heat and direct sunlight. Keep it away from strong oxidizing agents and acids. Store separately from incompatible materials to prevent hazardous reactions. Ensure proper labeling and containment to avoid leaks or spills, and use secondary containment where appropriate. Handle with gloves and protective equipment.
    Application of 3-Methylaniline

    Applications of 3-Methylaniline in Industrial Manufacturing

    3-Methylaniline, also known as meta-toluidine, plays a crucial role as an intermediate in various specialized industrial manufacturing chains. Our production supplies consistent quality to support demanding formulations and accredited downstream processes in regulated environments. The following sections outline focused, real-world application scenarios, specifying regulatory frameworks, actual incorporation practices, technical integration points, and downstream finished goods.

    1. Synthesis of Agricultural Herbicides

    As a key aromatic amine intermediate, 3-Methylaniline enables the synthesis of selective herbicides targeting broadleaf weeds. Its chemical backbone supports subsequent diazotization and coupling steps to create active ingredients like metamitron. Major agrochemical plants use controlled formulation to comply with residue limits and formulation stability regulations, ensuring consistent batch quality for large-scale herbicide supplies to the agricultural sector.

    Industry compliance standards

    • FAO/WHO: Specifications for Plant Protection Products
    • EU Regulation (EC) No 1107/2009 on Plant Protection Products
    • US EPA: Requirements for Registration of Pesticides (40 CFR Parts 150-180)
    • China GB 20810-2006 for Pesticide Technical Material

    Typical usage ratio

    • 3–10% as a precursor in the total reaction mixture, adjusted for target yield of specific herbicide actives and to control byproduct formation

    Downstream process integration

    • Enters as a primary aromatic amine feedstock in batch and continuous synthesis for diazotization, followed by direct condensation with carboxylic derivatives under controlled pH and temperature

    Final product types

    • Metamitron technical concentrate
    • Formulated wettable powder (WP) and suspension concentrate (SC) herbicides
    • Customized herbicide blends for sugar beet and potato crops

    2. Manufacturing of Dye Intermediates (Azo and Anthraquinone Dyes)

    Leading synthetic dye producers incorporate 3-Methylaniline to introduce methyl substituents onto the aromatic ring, improving color fastness and light stability in the finished dye. It is an established raw material in the manufacture of azo coupling components and anthraquinone derivatives for textiles, leathers, and inks, demanding tight process controls and traceable lot testing per textile chemical standards.

    Industry compliance standards

    • OEKO-TEX® Standard 100
    • REACH Regulation (EC) No 1907/2006 for restricted substances
    • ZDHC MRSL (Manufacturing Restricted Substances List)
    • China GB/T 17592-2011 for Textile Dyes

    Typical usage ratio

    • Up to 8% of the total intermediate mixture depending on shade intensity and coupling efficiency requirements, with specific adjustment according to dyestuff yield

    Downstream process integration

    • Undergoes sulfonation or acylation, then used as a coupling agent in azo dye synthesis; added at controlled rates to maintain batch consistency during condensation or diazotization reactions

    Final product types

    • Acid and disperse dyes for polyester and nylon textiles
    • Anthraquinone dyes for plastics and leather treatment
    • Industrial and specialty inkjet colorants

    3. Production of Pharmaceutical Intermediates

    Chemical manufacturers use 3-Methylaniline to prepare intermediates essential in the synthesis of analgesics and antipyretic pharmaceuticals. The precise methyl positioning on the aromatic ring helps enhance pharmacological activity or improve metabolic stability. Production lines in this segment operate under enforced GMP with real-time monitoring to guarantee trace impurity levels throughout the synthesis of active pharmaceutical ingredients (APIs).

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Part II (ICH Q7) and Part III
    • US FDA 21 CFR Part 211
    • Chinese Pharmacopoeia (ChP) for process control

    Typical usage ratio

    • 2–6% in targeted syntheses of key intermediates, proportion adjusted according to specific API pathways and regulatory registered synthesis protocols

    Downstream process integration

    • Charged in as a starting amine for N-acylation or condensation with acid chlorides in multi-step synthesis routes for antipyretic APIs such as tolmetin and related analogues

    Final product types

    • Antipyretic/analgesic intermediates
    • Precursor blocks for non-steroidal anti-inflammatory drugs (NSAIDs)
    • API bulk powder (post refinement and purification)

    4. Specialized Polymer Additive Synthesis

    In polymer formulation, 3-Methylaniline functions as a functional amine for specialty monomer preparation, where methyl substitution gives tailored physical properties. It supports the production of end-use polymers with enhanced UV resistance and dyeability for high-performance resins and engineered plastics. Plant operators introduce the intermediate at tight, specification-driven ratios with full traceability from raw material batch to end product.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management in Chemical Manufacturing)
    • ISO 14001:2015 (Environmental Management)
    • EU REACH Regulation for polymer ingredients
    • ASTM D256 and D638 for plastics mechanical property testing

    Typical usage ratio

    • 1.5–5% in monomer blend, adjusted for targeted glass transition temperature or UV stability in the finished polymer

    Downstream process integration

    • Incorporated during solution or bulk polymerization as a functional co-monomer or crosslinker, entering at the monomer charging stage; monitored for complete reaction and residual amine clearance

    Final product types

    • Polyamide and polyester engineering plastics
    • UV-resistant film and fiber products
    • Industrial resin additives for automotive and electrical applications

    5. Rubber Chemical Accelerators

    Main tire and technical rubber manufacturers utilize 3-Methylaniline for synthesis of select accelerator compounds. By acting as a methyl-substituted aromatic amine, it contributes to accelerator molecule structures that enhance vulcanization kinetics, improve curing times, and impart specific mechanical properties to finished rubber goods. Rigorous process control ensures compliance with international tire and elastomer standards during batch production.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management for Rubber Additives)
    • ASTM D3182 for rubber compounding and batch curing
    • UN ECE Regulation No. 117 for wet grip and rolling resistance in tires
    • China GB/T 15340-2017 for Rubber Chemical Accelerators

    Typical usage ratio

    • 0.2–2% of compounding mix, calculating amount according to rubber matrix type and performance targets in the final accelerator formulation

    Downstream process integration

    • Entered as a precursor in the synthesis of thiazole and sulfenamide accelerators, followed by neutralization and granulation prior to blending into the rubber compounding line

    Final product types

    • Vulcanization accelerator chemicals
    • Passenger car and truck tire compounds
    • High-durability industrial conveyor belt rubbers

    6. Corrosion Inhibitor Intermediate

    In the metal processing and oilfield industries, 3-Methylaniline is used to synthesize aminic corrosion inhibitors for pipeline coatings and refinery process fluids. Its methyl group ensures tailored organic solubility and rheological characteristics. Quality assurance in its production and use focuses on performance in simulated corrosive environments, as well as compliance with environmental disposal requirements for industrial chemicals.

    Industry compliance standards

    • API RP 932-B: Design & Materials for Process Vessel Corrosion Control
    • ASTM G31: Laboratory Immersion Corrosion Testing of Metals
    • EPA TSCA (Toxic Substances Control Act) for chemical substances inventory
    • EU REACH Annex XVII environmental controls on use/disposal

    Typical usage ratio

    • 1–3% of total inhibitor formulation, varying with oil/water system, targeted inhibition efficiency, and operating temperature

    Downstream process integration

    • Introduced into batch synthesis reactors for the aminomethylation step, followed by formulation into concentrate and final blending as an oil-soluble inhibitor additive

    Final product types

    • Pigging and injection corrosion inhibitors for pipelines
    • Anti-corrosive coatings for storage tanks and equipment
    • Oilfield process chemicals for refinery and upstream asset protection
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    Certification & Compliance
    More Introduction

    Understanding 3-Methylaniline – Practical Insights from Years on the Production Line

    What Sets 3-Methylaniline Apart in Everyday Manufacturing

    The daily hum of our reactors brings certain chemicals into sharp focus because industry leans on them—not just for their chemistry but for their reliability and versatility. 3-Methylaniline has earned a regular spot in our batches for good reason. Known to most of us by its other name, meta-toluidine, this compound shows its value in production environments driven by real timelines and tight quality standards.

    Sitting just off the benzene ring, the methyl group in the “3” position changes the game compared to simple aniline or its ortho- and para-toluidine relatives. The way 3-Methylaniline reacts opens doors for manufacturers who can’t compromise on intermediate purity or consistency—especially those working with dyes, pesticides, pharmaceuticals, and rubber-processing additives.

    Model and Specifications – Real Numbers Behind Reliable Output

    We produce 3-Methylaniline under strict controls. Each drum or tank leaves our line clear to pale yellow, with aromatic amine notes that can seem sharp if you aren’t used to it. Typical material tests at ≥99.0% purity by GC. Impurities, like aniline and other isomeric toluidines, stay below 0.1%. Our GC runs dozens of times a shift, not because it’s required twice, but because variable feedstock can throw things out of balance without constant attention.

    There’s no shortcut for dryness—the happiest downstream reactions happen at less than 0.1% water content. This detail saves customers the pain of phase-separation issues and junk side reactions. With a boiling point right around 199°C and a melting point near -30°C, the liquid holds steady across a wide range of processes. A density just above 0.99 g/cm³ means transfer and blending calculations come easy, while the flash point above 80°C gives a practical safety window for ordinary handling and storage.

    How 3-Methylaniline Performs in Everyday Application

    Synthesizing dyes has taught us the quirks of anilines firsthand. 3-Methylaniline brings out certain colors and stabilities that difference makers in the textile and inks world lean on. Its meta substitution pattern limits where further substitutions happen when customers push for special azo dyes or tougher pigment chemistries. This means higher selectivity, less waste, and more precise shade control. Chemical plants integrating this intermediate end up with less downstream byproduct—no small thing in an industry fighting for every percent of yield.

    We also send regular shipments to agrochemical companies who depend on consistent 3-Methylaniline reactivity for their active ingredient syntheses. Compared to many para- or ortho-substituted isomers, the meta variant lines up for clean nucleophilic aromatic substitution, and forms the building block for a range of pesticides. These aren’t theoretical uses; they come as real purchase orders every month, followed by lab confirmations that tight purity specs hold up batch after batch.

    Pharmaceutical chemists appreciate how 3-Methylaniline’s steric environment makes it predictable in amide-forming reactions or functionalized to novel bioactive molecules. The typical feedback comes as repeat orders and direct calls to the production floor, where questions come quicker than formal documentation can. Being able to ship barrels with the precise amine content their route needs keeps timelines grounded in real world chemistry, not wishful thinking.

    The rubber industry is less publicized about the specifics, but feedback on antioxidant formulation has come in. 3-Methylaniline’s methyl group knocks down some oxidative sensitivity, which shows up in rugged performance specs in certain vulcanization accelerators and stabilizers. Hearing from line engineers who shave unplanned shutdowns by tweaking additive blends brings the chemistry full circle—we aren’t just shipping molecules, we’re helping processes run longer without interruptions.

    Why Meta Matters – Practical Thoughts on Isomer Choice

    Most new hires wonder: is 3-Methylaniline so different from ortho- or para- versions that it really demands this attention? The short answer from running full-scale production is yes. The different position of the methyl group changes how the molecule reacts—not just in glassware, but at the scale where thousands of liters move per shift.

    Take azo dye manufacture as the most common example. Ortho-toluidine’s proximity to the amine triggers unwanted secondary products and fouls filters far more often. Para-toluidine is less prone to caking but has different coupling characteristics, and forces more complicated purification. Meta position often offers the “sweet spot” for standard colorfast dyes or pharmaceutical precursors, with fewer surprises in the tailings tanks and less time lost in reworking off-color batches.

    The cost of straying from meta to other isomers isn’t just extra filtration or drying, it brings regulatory headaches too. Byproducts can trip up environmental discharge targets, especially for facilities treating their own effluent or managing strict local thresholds on aromatic amine content in water.

    Keeping an Eye on Supply – Consistency in the Age of Disrupted Logistics

    Operations managers have watched supply chains buckle over the last five years. Unusual demand cycles in pharmaceuticals, wild swings in dye consumption rates, and unforeseen logistic bottlenecks keep chemical plants guessing. 3-Methylaniline needs careful forward planning; it is never “business as usual” even when the process itself feels routine.

    In practice, scheduled shutdowns during upstream benzene price spikes mean plants run closer to the minimum safety stock. We keep buffer inventory, but rely on upstream partners to communicate changes in toluene supply. On our end, we check all incoming precursor batches for purity and stabilize them before pushing into the main reactors—variance in methylation efficiency from different precursor suppliers can eat into output if not caught early. There’s no gain in passing this downstream and risking a customer complaint or product recall.

    Reactors and staff handle each campaign with the anticipation that unplanned events cause the most quality problems. Experience says fresh catalyst or tweaked reflux temperatures resolve batch stuck-points more efficiently than launching new investigations or lengthy paperwork. Our biggest process improvements often come from operators and shift leads who see patterns before reports reach the office.

    There’s an old temptation to blame outside factors for short runs or rework, yet internal training and transparent feedback loops solve problems faster. As a chemical manufacturer, we train everyone—warehouse, operations, QC, shipping—to spot and act on off-spec drums or suspect odor shifts immediately. Nothing replaces on-the-ground vigilance.

    Addressing Evolving Regulatory and Customer Demands

    Manufacturing any aromatic amine means staying in step with regulatory shifts. Restrictions on aniline derivatives’ discharge to water and occupational exposure limits carry greater weight in European, North American, and some Asian markets. We invest in on-site waste treatment and air handling for good reason: keeping operational emissions well below threshold limits keeps both staff and surrounding communities safe.

    Customers increasingly ask for tighter impurity profiles, whether to meet new pharmaceutical development guidelines or textile Oeko-Tex compliance checks. We upgraded purification systems over the last decade, leaning on established crystallization and distillation methods but with more fine-grained process control. Batch histories follow every container—QC logs don’t just satisfy audits, they build trust when a customer’s formulation needs pinpoint consistency.

    All this adds cost, but end-users in any highly scrutinized sector know a few dollars extra per drum beats millions in recall risk, regulatory fines, or line fallout. We have learned that customers appreciate clear technical support, timely COAs, and no unexplained batch changes. Keeping the human element in support calls—the stories behind troublesome lots or the quick fix that got a run back on track—goes further than formal paperwork ever does.

    Opportunities and Challenges – What Comes Next for Our Industry

    Looking at long-term trends, the drive for greener chemistry and less hazardous waste continues to affect 3-Methylaniline use. Emerging dye and pigment chemistries experiment with alternative amine sources or push for new coupling chemistries. In agrochemicals, regulators closely watch for metabolites in food safety testing, which pushes compound development down less regulated paths.

    We see the change not as a threat, but a challenge to innovate. Our engineers follow new hydrogenation catalyst studies and green methylation methods, both aimed at shaving energy use and minimizing waste streams. If a mainstream commercial plant can run leaner while matching our current purity specs, it only improves our competitiveness.

    Pharma research shows rising interest in heterocyclic ring systems and bioactive building blocks that bend classic aromatic substitution rules. Still, few intermediates consistently hit the marks for cost, reactivity, and reliable transport the way 3-Methylaniline does. Customers with pilot plants in North America or Europe keep sharing feedback that supply security and straight answers matter more than branding—this feedback sticks with us on both good and bad days.

    Building on Experience – The Direct Line Between Manufacturing and End User Success

    Behind every drum or tote shipped sits a network of process experts, QC chemists, plant engineers, and operators—each piece fits to deliver the amine NMR peaks, water content, and odor profile our customers expect. Experience keeps us focused on checking every point of control, from bulk tankers’ seals to end-of-line packaging checks. As strange lots or unusual reaction time crops up, we can draw on a real backlog of what’s worked before to avoid widespread issues.

    We have seen well-meaning attempts at outsourcing or “one size fits all” programs cause more rework for downstream customers than anyone anticipated. Custom approach to process adjustments—more or less heat, tailored order of addition, tighter schedule on QC testing—remains the best defense against recurring headaches that disrupt both our plant and our customers’ operations.

    Our approach stays practical: keep safety, purity, and reliability front and center, share what we learn quickly, and remain open to feedback from users, not just spec sheets. Supplying 3-Methylaniline isn’t a routine—it’s supporting the flow of countless final goods, from dyed athletic clothes to specialty agro-products and medical compounds that keep end markets running.

    From Production Line Reality to End-User Value

    We work hard to put reliable 3-Methylaniline in every container. Each shift brings its own challenges: changing benzene prices, new customer needs, process tweaks, and export documentation quirks no one saw coming. Through everything, our experience shows that careful production, open lines between plant and customer, and keeping science honest drive success more than any press release or generic claims.

    For industries that depend on this amine to meet ever-rising demands—whether for brighter pigments, safer food supplies, or new pharmaceutical launches—the difference comes from up-front choices on the manufacturing floor. We recognize the risks, manage them together, and celebrate every batch that helps customers surpass their targets. That’s the story that matters, one delivery at a time.