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3-Methyl-2-Butanol

    • Product Name 3-Methyl-2-Butanol
    • Alias isoamyl alcohol
    • Einecs 201-234-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    191079

    CAS_Number 598-75-4
    Molecular_Formula C5H12O
    Molecular_Weight 88.15 g/mol
    IUPAC_Name 3-Methyl-2-butanol
    Appearance Colorless liquid
    Boiling_Point 102-104 °C
    Melting_Point -96 °C
    Density 0.81 g/cm3 at 20 °C
    Flash_Point 29 °C (closed cup)
    Solubility_in_Water Moderate (16 g/L at 20 °C)
    Refractive_Index 1.404 at 20 °C
    Vapor_Pressure 36 mmHg at 25 °C
    Synonyms 2-Hydroxy-3-methylbutane
    Odor Alcohol-like
    PubChem_CID 11541

    As an accredited 3-Methyl-2-Butanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Brown glass bottle, 500 mL, with tamper-evident cap, hazard labeling for flammability and toxicity, and clear chemical identification.
    Shipping 3-Methyl-2-Butanol is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. It should be stored and transported in a cool, well-ventilated area away from heat, ignition sources, and incompatible materials. Shipping must comply with relevant regulations for flammable liquids, including proper labeling and documentation.
    Storage **3-Methyl-2-butanol** should be stored in a cool, dry, well-ventilated area, away from heat, ignition sources, and incompatible substances such as strong oxidizers. Keep the container tightly closed and protected from physical damage. Store in a flammable liquids cabinet if available. Avoid exposure to direct sunlight and moisture, and ensure proper labeling and segregation from acids or corrosives.
    Application of 3-Methyl-2-Butanol

    Applications of 3-Methyl-2-Butanol in Industrial Manufacturing

    As a direct manufacturer, we supply 3-Methyl-2-Butanol for multiple specialized industrial processes. The following sections detail its integration and value in principal downstream sectors, highlighting regulatory compliance, correct handling ratios, process positioning, and resulting finished goods within each application area.

    1. Pharmaceutical Synthesis – Solvent for Active Ingredient Production

    Pharmaceutical manufacturers incorporate 3-Methyl-2-Butanol as a process solvent in synthesizing select active pharmaceutical ingredients (APIs), especially in reactions requiring moderate polarity and controlled volatility. Its defined purity and chemical stability allow for repeated recapture and reuse in reaction steps such as Grignard and reductive amination protocols. Producers implement rigorous in-process monitoring, removal via controlled distillation, and validated cleaning protocols aligned with each product’s regulatory pathway.

    Industry compliance standards

    • Good Manufacturing Practices (GMP) – ICH Q7A
    • Relevant sections of USP <795>, EP, and JP monographs where applicable
    • FDA Process Residual Solvent Guidance (ICH Q3C)
    • Internal validated cleaning and impurity control procedures

    Typical usage ratio

    • 10–25% by volume of total reaction media, adjustable per substrate solubility and process step
    • Ratio tailored for API yield optimization and solvent recoverability

    Downstream process integration

    • Charged during reagent dissolution and reaction initiation stages
    • Phase separation and removal via distillation before crystallization or API isolation
    • Residue content monitored before batch release

    Final product types

    • Active pharmaceutical ingredients for cardiovascular and antipyretic drugs
    • Specialty intermediates for contract manufacturing organizations (CMOs)
    • Regulated bulk pharmaceuticals for export licenses

    2. Agrochemical Formulation – Intermediate and Co-solvent in Herbicide Manufacture

    Leading agrochemical companies apply 3-Methyl-2-Butanol both as an intermediate and a co-solvent in the production of selective herbicides and pesticide active substances. Its defined reactivity contributes in alkoxylation and esterification reactions to yield functional herbicidal analogues. In finished formulations, it supports targeted solubilization and field stability. Application protocols demand adherence to environmental and chemical safety controls specific to agricultural inputs.

    Industry compliance standards

    • FAO/WHO Specification for Pesticides (JMPS)
    • REACH Registration, Evaluation, Authorization and Restriction (for use within EEA)
    • OECD Good Laboratory Practices (GLP) for field trial and residue analysis
    • National agrochemical industry emission and hazard management laws (e.g., EPA regulations, CLP)

    Typical usage ratio

    • 5–15% by weight in pre-emergent liquid herbicide solutions
    • Adjusted for temperature resilience, tank mix compatibility, and regulatory limits

    Downstream process integration

    • Introduced as a reaction partner during intermediate synthesis steps (e.g., alkylation)
    • Stabilizer and co-solvent in final product blending before packaging
    • Monitored in retention sample testing for registration dossiers

    Final product types

    • Water-dispersible, emulsifiable, and microencapsulated herbicide concentrates
    • Active ingredient intermediates for seasonal crop protection markets
    • Bulk technicals supplied to downstream formulators

    3. Fragrance Ingredient – Component in Fine Aroma Chemical Synthesis

    In the production of luxury perfumes and personal care aromas, 3-Methyl-2-Butanol participates as a key building block in the molecular design of complex floral and fruity notes. Fragrance houses use it in controlled esterification reactions yielding signature esters and as a supportive diluent in high-end perfumery concentrates. Its volatile profile and mild odor support regulatory-mandated impurity thresholds while enabling formulation differentiation in international fragrance portfolios.

    Industry compliance standards

    • International Fragrance Association (IFRA) standards and use guidelines
    • EU Regulation (EC) No 1223/2009 for cosmetic ingredients
    • IFRA/IOFI Labelling Manual for raw materials
    • ISO 9235:2013 (Aromatic natural raw materials – Vocabulary)

    Typical usage ratio

    • 0.5–5% in perfume concentrate mass depending on target intensity and stability window
    • Purity specification: typically ≥99.5% for aroma applications

    Downstream process integration

    • Reacted with organic acids for ester manufacture during perfume base compounding
    • Dosed in monitored micro-litre increments for olfactory stability control
    • Content verification using GC-FID and compliance with restricted substances lists

    Final product types

    • High-value perfume oils and aromatics
    • Personal care and cosmetic scents in premium product ranges
    • Flavor and fragrance intermediates for global trade

    4. Specialty Coatings & Resins – Modifying Alcohol in Polyvinyl Systems

    Major coatings manufacturers leverage 3-Methyl-2-Butanol as a modifying alcohol in polyvinyl butyral (PVB) resin and specialty lacquer production. Its presence tunes polymer flexibility and film formation, enhancing adhesion and impact performance in applications such as automotive interlayers and high-clarity architectural coatings. Resins made with this material feature precise flow and leveling characteristics demanded in advanced surface finishing sectors.

    Industry compliance standards

    • RoHS 2011/65/EU and amendments (for electronics coatings)
    • ISO 9001:2015 Certified Quality Control for resin formulation
    • ASTM D3029 (Polyvinyl Butyral Sheeting Properties)
    • Regulation (EC) No 1907/2006 (REACH) Safety Data and Submission

    Typical usage ratio

    • 2–8 parts per hundred resin solids (phr) for flexible and anti-migration properties
    • Final dosage determined using pilot scale physical-chemical testing

    Downstream process integration

    • Blended during resinification process, typically post-polymerization
    • Included as a flow modifier in coating pre-mixes before solvent removal
    • Assayed in QC for migration and volatilization during curing

    Final product types

    • PVB films for laminated safety glass in automotive and building sectors
    • Gloss and matt finish clear coatings for consumer electronics
    • Specialty adhesives and optical-grade varnishes

    5. Fine Chemical Synthesis – Intermediate for Plasticizer Manufacturing

    Chemical plants use 3-Methyl-2-Butanol as a synthesis intermediate during the manufacture of niche plasticizer esters, finding use in high-performance packaging and wiring applications. Reactivity with phthalic or adipic anhydrides produces branded ester derivatives with tailored migration and plasticity standards. Integration demands strict batch traceability, impurity tracking, and performance validation aligned with global compounder specifications.

    Industry compliance standards

    • EN 71-3:2019 (for plasticizers in toys and packaging)
    • UL 94 Flammability Rating for wire coatings
    • EU 10/2011 (Plastics Food Contact Legislation) if used in FCMs
    • ANSI/ASQC Z1.4 Statistical Sampling for batch release

    Typical usage ratio

    • 30–60% of alcohol charge in esterification reactors, based on desired molecular weight and performance grade
    • Adjusted by reactivity and catalyst selection

    Downstream process integration

    • Added to substrates with controlled heat and catalysts for selective esterification
    • By-product recovery and purification before downstream blending
    • Monitored for low-odor requirements in packaging films

    Final product types

    • Specialty plasticizers for wire and cable compounds
    • Food contact flexible packaging materials (where permitted)
    • Low-migration PVC compounds

    6. Analytical Chemistry – Reference Material and Extraction Solvent

    Certified analytical laboratories specify 3-Methyl-2-Butanol as a reference and extraction solvent in regulated sample preparation workflows, such as headspace gas chromatography (GC) analyses, particularly for volatiles quantification in environmental, food, and pharmaceutical matrices. Consistent purity supports generation of reliable calibration standards, while its defined volatility assists in reproducible recoveries and method validations, critical for accredited QC operations.

    Industry compliance standards

    • ISO/IEC 17025:2017 Laboratory Accreditation
    • FDA 21 CFR Part 211 (for drug product QC)
    • EPA SW-846 Test Methods for Evaluating Solid Waste
    • AOAC Official Methods in food and beverage analysis

    Typical usage ratio

    • 1–10% in sample extraction media, calibrated based on matrix and analyte
    • Reference level determined by certified internal standards

    Downstream process integration

    • Used during liquid-liquid or solid-phase extractions to isolate volatile analytes
    • Dosed in accurate volumes for headspace and direct injection analyses
    • Handled in contamination-controlled environments with batch-to-batch certification

    Final product types

    • QC-tested sample extracts
    • Calibration and system suitability standards for regulated methods
    • Proficiency testing kits for laboratory audits
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    Certification & Compliance
    More Introduction

    Understanding 3-Methyl-2-Butanol: Experience from the Manufacturing Floor

    From Process to Product: Our Perspective as Manufacturers

    The daily rhythm of chemical manufacturing carves a clear line between textbook knowledge and the hands-on world of the plant. 3-Methyl-2-butanol stands as a molecule we've come to know inside and out—not just because of its chemical structure, but because we see the difference it makes through direct interaction and practical application. Every batch we craft has to meet exacting requirements, yet what sets this compound apart is rooted deeper than technical sheets allow.

    Technical Identity: What 3-Methyl-2-Butanol Is—and Isn’t

    3-Methyl-2-butanol, known in our lab as a tertiary alcohol with a branched five-carbon chain, offers a distinct character. Unlike straight-chained alcohols, this molecule bears a branching at the second carbon, introducing new facets in both reactivity and handling. We typically supply it in liquid form, with a clear to slightly yellow appearance, carrying its characteristic mild odor. You will see it described chemically as C5H12O, and at room temperature it remains stable, with boiling and melting points that fit nicely into applications that require moderate volatility and good solubility in a range of organic solvents.

    From a practical standpoint, handling 3-methyl-2-butanol calls for deliberate care. Its flash point, vapor pressure, and comparatively lower toxicity (relative to certain stronger alcohols) mean staff still follow focused training and robust procedures through every stage—from drum filling to final purification. These are not just lab metrics; these shape every routine check in our plant and determine the design of our venting, storage, and emergency plans.

    Applications Driven by Real-World Experience

    End-users rarely just purchase a chemical—they depend on its performance. Among our regular orders, most shipments of 3-methyl-2-butanol support the synthesis of pharmaceuticals or specialty intermediates. Chemists often reach for this alcohol when they need a non-linear backbone, which can alter reactivity or solubility in final formulations. In our experience, it steps past simple solvent duty, becoming a valued building block where selectivity and branching make a tangible impact on reaction yields.

    In the world of flavors and fragrances, its subtle aroma and flavoring potential land it in products that demand mildness without blandness. As manufacturers, we're often asked to guarantee the absence of off-notes and to prove consistency through every barrel. This is where our batch records and traceability pay off—each lot must mirror the one before, with no room for shortcuts or variability, because customers downstream notice the slightest drift.

    Small research setups order it for reference standards and as a reaction medium, banking on the stability we guarantee by monitoring every distillation cut and verifying purity with GC analysis. There is also recurring demand in fine chemical production, where branched alcohols help manipulate molecular complexity. Our team sees firsthand how quality concerns from customers almost always trace back to inconsistencies in raw materials, highlighting the critical role of our precise manufacturing protocols.

    Setting 3-Methyl-2-Butanol Apart: What We See on the Factory Floor

    Manufacturing alcohols as a broad group reveals just how much even a small chemical shift alters everything—from processing steps to end-use potential. Many procurement teams start by asking why they might use 3-methyl-2-butanol rather than more common alcohols like 2-butanol or isopropanol. Here, the difference is concrete.

    The branching at the third carbon changes its miscibility, boiling behavior, and metabolic fate compared to less substituted cousins. It resists oxidation more than primary alcohols; we notice this in both storage stability and in the reactivity profiles during downstream use in synthesis. Where a linear alcohol might undergo certain reactions rapidly, the tertiary structure in this molecule dampens those changes, leading to more predictable outputs when producing fine chemicals that need stability under pressure or moderate heat.

    In solvent applications, users benefit from a slower evaporation rate and a mild, less aggressive odor. This creates opportunities where a fast-evaporating or pungent alternative would disrupt, such as in sensitive coatings or in flavor preparations that must not overpower the rest of the matrix. Process engineers request this compound specifically for these reasons—often after trial and error with more traditional alcohols highlight their limitations.

    As manufacturers, it makes a difference to supply a product that solves specific technical headaches. With 3-methyl-2-butanol, the talk is not just about purity in abstract numbers, but about how a side-chain changes the whole game of solubility, reactivity, and downstream compatibility. Colleagues from R&D remind us that no two alcohols behave alike in a real-world synthesis, even if the lab catalog lumps them close together.

    Quality Standards: Learning from Every Batch

    Our product line sticks to quality controls shaped by years of feedback and a string of performance audits. Each drum must pass GC purity benchmarks, moisture tests, and checks for related impurities. We operate closed systems for both filling and transfer, targeting low exposure risk and strong trackability.

    Over time, we've invested in better purification columns and automated monitoring, not because it reads well on a specification sheet, but due to real issues flagged by our customers and plant staff. A decade ago, trace butanone contamination led to odor issues downstream—a lesson in how a minor lapse can cascade through a customer's entire process and reputation. This drives us toward constant improvement, not just compliance.

    Product consistency comes from more than just the latest technology or a new certificate. It is born out of a habit—logging small observations, tracing the root of odd results, correcting batch sizes when slight deviations arise, and staying in regular touch with our customer labs. Our staff knows that the moment we relax these habits, the first call will not come from management but from an experienced chemist working late who notices something is off.

    Environmental Responsibility and Safe Handling Experience

    Handling organic solvents responsibly is a lesson our crew learns not just from manuals but from constant vigilance. We recognize that even lower-toxicity alcohols need full containment, vapor controls, and careful waste management. Our effluent and air emissions teams review every shipment and implement recovery processes to reduce environmental release and reclaim valuable residues.

    Safe storage and transport mean tank inspections, double wall containment, and ongoing training. Our record shows fewer incidents than the industry average, a result of treating each transfer as critical. Everyone here learns early: complacency breeds mistakes, so we put routine checklists ahead of convenience. You can read about safety requirements on paper, but the lived experience—smelling a minor leak, noting the temperature rise in the tank, catching an odd reading on the refractometer—builds the muscle memory that stops problems before they escalate.

    We work with neighboring facilities, discussing mutual aid plans and sharing learnings at industry roundtables. Regulatory compliance goes beyond paperwork; field inspectors value open records, real-time monitoring, and a willingness to share findings. Our own plant culture evolved from hard lessons, including near-misses with overfilled tanks or pump malfunctions traced back to neglected preventive maintenance. Each review cycle, we invest in better process automation and responsive sensor networks, lowering risk not just for us but for the entire supply chain.

    Meeting Industry Needs: Listening and Responding

    Market trends shift, but a recurring theme is the need for tailored chemical solutions—rooted in real-world use, not just catalog promises. Researchers ask for tighter specification ranges as their processes evolve. Coatings manufacturers trial new binder systems, chasing better compatibility with less hazardous profiles. Pharmaceutical partners feed back their yield data, pointing to where a seemingly minor impurity reduced crystallization or slowed a reaction. Every piece of feedback loops into our next production schedule.

    Adjusting our process lines to tighter purity specifications or different container sizes comes from these ongoing conversations. It isn’t uncommon for a single, well-documented customer claim to justify a permanent shift in our filtration regime or a recalibration of analytical methods. Years of supplying a product like 3-methyl-2-butanol reinforce that the market values a manufacturer who solves problems quickly and stays reachable, not just a distant supplier behind generic labels.

    Some competitors cut corners by blending across batches or softening reporting standards, but this sort of shortcut shows up sooner or later when a downstream process falls short. We set our quality outputs not by minimum compliance but by the performance reported by process engineers using every drum in their own lines.

    Why the Difference Matters

    Scientifically, only small adjustments in molecular structure separate one alcohol from another, but on the plant floor, the outcome is far from academic. With 3-methyl-2-butanol, project chemists note its value in selective addition and elimination reactions, processes where bulkier or linear alcohols fall short. Over several years, we’ve seen growth in demand from both classic organic synthesis and from newer applications in regulated flavors, where traceability and food safety demand extra vigilance.

    By maintaining direct control over our production—from choice of feedstocks through shutdown procedures—we prevent cross-contamination, guarantee consistent performance, and back every container with batch traceability. As experts in scaling up from lab experiments to ton-scale runs, we know which process signals to trust, which parameters demand closer watch, and how to adjust for seasonal or supplier variability.

    This expertise enables us to take on more specialized orders, where purity matters at the decimal point, or where a single contaminant can shift a whole product line’s outcome. The background we’ve built enables fast troubleshooting, candid communication, and a level of transparency that our long-term customers have come to rely on. In our field, reputation is earned not through slogans but through reliability, correction of mistakes, and visible improvement over time.

    Innovation on the Shop Floor: Real-World Solutions

    Opportunities and challenges arise side by side. Regulatory pressure, shifts toward greener chemistry, and customer demand for greater transparency all press us toward improvements. Over the years, new catalytic systems, cleaner reactors, and better in-process controls have become routine rather than exception. For instance, solvent recovery initiatives reduced our waste load while also distilling valuable side products—both profit and responsibility in one cycle.

    Our development staff works directly with customers to expand applications, such as exploring more environmentally benign synthesis routes that leverage the unique properties of 3-methyl-2-butanol. Some pharmaceutical innovators rely on our alcohol for chirally selective steps, and new coatings agents depend on consistent evaporation profiles that only this structure can provide. Each technical challenge from the marketplace drives our own research, often leading to tweaks in distillation cuts or the introduction of new removal methods for problematic trace impurities.

    We also benefit from equipment upgrades borne out of necessity. More precise temperature control, better mixing systems, and integrated quality tracking have all made the move from pilot trials to daily practice. It’s seldom headline news, but steady technical progress defines our path—measured not just by smoother operations but by reduced downtime, fewer rejects, and happier downstream customers reporting cleaner, more predictable results.

    Transparency and Trust in Supply Chain Interactions

    In today’s chemical landscape, traceability isn’t a luxury—it’s a requirement driven by both regulation and customer expectation. We stitch traceability into every lot, recording raw material batches, process temperatures, and operator signoffs. Our documentation is accessible and direct, reflecting both regulatory demand and the practical reality that a problem from weeks or months ago may surface only after customers have already integrated a product into their own processes.

    Customers benefit not just from clean data sheets but from responsive service when questions arise. We share analytical methods, collaborate on solutions when off-spec product appears, and follow up to track downstream performance. This openness flows both ways; our own teams learn from the real challenges buyers face, feeding that practical intelligence back into the next run or process tweak.

    Stringent regulations frequently redraw the map for both manufacture and application of specialty chemicals. By staying involved in industry groups and embracing pre-emptive compliance, we adapt plant operations rapidly. These are not theoretical moves; each adjustment directly ties into better performance, lower complaint rates, and smoother audits.

    Future Outlines: Collaboration and Continued Progress

    Looking ahead, demand for 3-methyl-2-butanol will likely track with broader trends toward tighter purity controls, expanded application in high-value synthesis, and ongoing environmental improvements. Our role as a chemical manufacturer focuses on production, true, but equally on partnership with those who depend on our materials. We focus not just on the molecule itself, but on how each process step, safety habit, and technical improvement supports practical results for all users down the line.

    We invest in ongoing operator training, tailored to the actual risks and opportunities seen over years, not just the minimum checklists or external pressure. Our improvement journey continues through collaboration—plant engineers work with formulation specialists, customer chemists flag application concerns, and quality auditors drill into records to spot patterns early.

    Continued evolution in our production of 3-methyl-2-butanol comes from this network of shared expertise. As an experienced manufacturer, our role is to blend process rigor, open communication, and continuous learning, ensuring every liter shipped stands up not just to analytical scrutiny but also to the expectations of those building the next set of industry solutions.

    The technical and practical story of 3-methyl-2-butanol is more than structure, grade, or simple supply—it is the ongoing, lived outcome of process knowledge, systematic care, and relational trust. As shifts in industry and application continue, the partnership between producer and user remains at the core of reliable, responsible chemical solutions.