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3-Methyl-1-Butanol

    • Product Name 3-Methyl-1-Butanol
    • Alias Isoamyl alcohol
    • Einecs 203-745-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    732353

    CAS_Number 123-51-3
    Molecular_Formula C5H12O
    Molecular_Weight 88.15 g/mol
    IUPAC_Name 3-Methylbutan-1-ol
    Synonyms Isoamyl alcohol
    Appearance Colorless liquid
    Odor Faint alcoholic odor
    Boiling_Point 131.2 °C
    Melting_Point -117 °C
    Density 0.812 g/cm³ at 20 °C
    Solubility_in_Water 14 g/L at 20 °C
    Flash_Point 43 °C (closed cup)
    Refractive_Index 1.4050 at 20 °C
    Vapor_Pressure 4 mmHg at 20 °C
    LogP 1.2

    As an accredited 3-Methyl-1-Butanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 500 mL of 3-Methyl-1-Butanol, tightly sealed with a screw cap, labeled with safety and hazard information.
    Shipping 3-Methyl-1-butanol is typically shipped in tightly sealed containers, such as drums or bottles, made from compatible materials to prevent leaks or contamination. It should be kept in a cool, well-ventilated area, away from sources of ignition, and clearly labeled as flammable. Ensure all relevant transportation regulations are followed.
    Storage 3-Methyl-1-Butanol should be stored in a tightly closed container in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. Keep away from heat, sparks, and open flames. Store at room temperature, preferably in a flammable liquids storage cabinet. Ensure containers are properly labeled and protected from physical damage.
    Application of 3-Methyl-1-Butanol

    Applications of 3-Methyl-1-Butanol in Industrial Manufacturing

    3-Methyl-1-Butanol serves as a specialized intermediate and formulation component across several targeted industrial sectors due to its well-characterized solvency, reactivity in esterification, and distinctive alcohol properties. We ensure every batch meets strict regulatory and quality requirements for downstream production. Below, we detail real-world application modes, including sector-specific standards, processing integration, and performance in commercial manufacturing environments.

    1. Synthetic Flavor and Fragrance Industry

    Manufacturers employ 3-Methyl-1-Butanol to synthesize esters that impart fruity and malty notes for compounded flavors and fragrances. The alcohol acts both as a precursor and solubilizer in processes that prioritize sensory profile consistency, stability, and high-purity feedstocks, meeting elevated food and cosmetic safety requirements in globally traded products.

    Industry compliance standards

    • FCC (Food Chemicals Codex)
    • EU Regulation (EC) No 1334/2008 on flavorings
    • IFRA (International Fragrance Association) Standards
    • US FDA 21 CFR 172.515

    Typical usage ratio

    • As ester precursor: typically 0.2–2% of total batch, adjusting based on the target ester concentration
    • In compounded mixtures: 0.01–0.3% direct addition, depending on flavor or fragrance strength required

    Downstream process integration

    • Introduced at the esterification stage with organic acids to form esters, followed by rectification
    • Homogenized into perfume and flavor compositions during bulk blending or compounding

    Final product types

    • Artificial fruit and malty flavor formulations for beverages and confectionery
    • Compounded fragrance bases for personal care and household products
    • Ready-to-use flavor additives compliant with food industry regulations

    2. Pharmaceutical Intermediate Manufacturing

    Active pharmaceutical ingredient (API) producers utilize 3-Methyl-1-Butanol as a reaction intermediate in the synthesis of certain medications and as a process solvent due to its controlled volatility and compatibility with GMP guidelines. Its use under strictly monitored conditions ensures reproducibility and batch traceability in high-value pharmaceutical syntheses.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF Monograph (where applicable as an excipient or process solvent)
    • 21 CFR Part 210/211 (US current Good Manufacturing Practice)
    • European Pharmacopoeia (section on solvents and intermediates)

    Typical usage ratio

    • As a solvent in API synthesis: 10–30% v/v of total reaction mass, ratio determined by process route and yield optimization requirements
    • Intermediate reactant: stoichiometric amounts as per target synthetic route, typically less than 10% w/w relative to starting materials

    Downstream process integration

    • Charged during stagewise organic synthesis or esterification within closed reactors
    • Subsequent removal via distillation or washed out following the completion of the transformation

    Final product types

    • API intermediates such as esters, amides, or substituted alcohol derivatives
    • Semi-synthetic pharmaceutical substances requiring alcohol condensation steps

    3. Industrial Coatings and Resins

    Industrial coating and resin manufacturers select 3-Methyl-1-Butanol as a reactive diluent and as a chain-modifier in alkyd and acrylic resin synthesis, leveraging its branched structure to influence drying speed, plasticity, and viscosity control. The integration demands robust quality oversight to prevent impurities affecting final film integrity and regulatory adherence across coatings markets.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • ISO 9001:2015-certified process controls
    • US EPA TSCA Inventory Listing
    • China GB/T 23985-2009 (Coating Materials—General Rules for Safety Assessment)

    Typical usage ratio

    • As resin modifier: incorporated at 1–5% of total polymer mass, ratio depends on molecular weight targets and flexibility adjustment needs
    • As a solvent during blending: 5–15% by weight of total volatile content in enamel or lacquer systems

    Downstream process integration

    • Added during the resinification step or co-polymerization, acting as a branching agent in reactor vessels
    • Used during pigment dispersion and final viscosity tuning prior to canning

    Final product types

    • Industrial wood finishes and synthetic alkyd paints
    • Acrylic-based architectural coatings
    • Corrosion-resistant metal primers and protective lacquers

    4. Plasticizer and Additive Formulation

    Producers of flexible plastics and specialty rubbers use 3-Methyl-1-Butanol in plasticizer synthesis, especially for phthalate and non-phthalate plasticizers required in high-performance vinyls. The alcohol’s chain structure modifies migration, cold flexibility, and processability parameters for compliant finished articles under strict migration and residual solvent controls.

    Industry compliance standards

    • EU Regulation (EU) No 10/2011 on food contact materials
    • EN 71-3:2019 (Safety of Toys—Migration of Certain Elements)
    • OEKO-TEX Standard 100 (for textile-related additives)
    • RoHS Directive (2011/65/EU) for electronic plastics

    Typical usage ratio

    • Primary alcohol input for esterification: 2–10% of overall batch, ratio optimized for targeted migration limits and plasticizer compatibility
    • Direct additive for specialty blends: up to 0.5% in masterbatch formulations

    Downstream process integration

    • Esterified with phthalic anhydride or organic acids in heated reactors for base plasticizer synthesis
    • Blended into polymer melt during compounding for secondary property modification

    Final product types

    • PVC films and sheets for packaging or industrial flooring
    • Flexible wire and cable insulation
    • BPA-free polyurethane articles
    • Elastomer modifiers for specialty footwear and coatings

    5. Specialty Solvent in Analytical and Biotechnological Preparations

    Laboratory and diagnostic reagent producers utilize 3-Methyl-1-Butanol as a specialty solvent for selective extraction, purification, and sample preparation steps where conventional alcohols risk interference or lack sufficient solubility for critical analytes. These production flows demand rigorous analytical validation, cleanroom handling, and solvent traceability to international metrological standards.

    Industry compliance standards

    • ISO 17025:2017 Laboratory Accreditation
    • USP Reagent Grade specifications
    • CLSI (Clinical & Laboratory Standards Institute) applicable protocols
    • FDA 21 CFR Part 11 for electronic records and data integrity

    Typical usage ratio

    • Solvent for sample extraction: 1–10% of extraction volume, ratio tuned for target analyte partitioning
    • Diluent in diagnostic reagent kits: 0.05–1% by solution mass, based on assay validation

    Downstream process integration

    • Added in liquid-liquid extraction or phase separation protocols during analyte isolation
    • Formulated into chromogenic or immunoassay kits during bulk reagent preparation

    Final product types

    • Analytical grade extraction solvents
    • In vitro diagnostic reagent sets for clinical chemistry
    • Biotechnological purification intermediates
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    Certification & Compliance
    More Introduction

    Introducing 3-Methyl-1-Butanol: Quality From the Source

    3-Methyl-1-Butanol stands out across specialty chemicals thanks to its distinct molecular structure and reliability in performance. As manufacturers who oversee the full cycle from raw material selection through purification and packaging, we place a premium on the consistency and traceability that industries demand. Years on the production floor have taught us that the right isomer and the smallest margins of impurity carry a real-world impact across applications in flavors, fragrances, and industrial solvents.

    What Defines 3-Methyl-1-Butanol?

    In this business, structure makes all the difference. 3-Methyl-1-Butanol, sometimes known as isoamyl alcohol, is a colorless liquid with a faint, peculiar odor reminiscent of ripe pears. Its chemical identity, C5H12O, puts it among the higher alcohols, and the branched structure introduces both volatility and the solvency chemists need for niche formulations. We focus on the isoamyl isomer due to its favored properties in reaction profiles and end-use compatibility.

    We produce this alcohol in batches tailored for bulk and specialty use, using fractionation and distillation to control both purity and odor profile. No two applications are alike, which means separating off low-boiling and high-boiling components is not a simple numbers game. It takes experience to anticipate how small traces of n-butanol, other amyl alcohols, or fusel oils will affect everything from esterification yields in flavors to volatility in industrial processes. Each drum passing out of our gates has been checked—not only for content but also for performance in actual end-use tests.

    Specifications That Matter in Real-World Use

    Our product runs at 98% minimum purity by GC, with water levels held below 0.2% in standard grades. We don’t choose these thresholds at random; they reflect real feedback from compounding rooms and blending lines where inconsistent purity can mean ruined batches or off-spec odors. In food and fragrance, anything off in the impurity profile will alter the consistency of ester products, especially for banana-pear top notes in artificial flavors.

    Physical constants are well-documented—boiling point at 131-133°C and a density of about 0.81 g/cm³. What rarely gets highlighted in standard specs is the practical side: at this boiling point, 3-Methyl-1-Butanol allows safe, low-pressure distillation, which translates to fewer safety incidents in our partners’ operations. We’ve built in extra drying at the end of our line, drawing water out of the final product in response to persistent complaints from esterification plants about hydrolysis during reactivity.

    Container choice sounds like a logistics detail, but it matters. We supply both drums and IBC totes treated for moisture and oxygen barrier performance. Too many industry recalls result from drums picking up water in humid warehouses—so we run accelerated storage trials to verify that claim before each new packaging line rolls out. Experience here tells us that sacrificing on packaging undermines even the finest production work.

    Why Manufacturers Value This Alcohol

    Across sectors, 3-Methyl-1-Butanol earns its place as more than a solvent or blending component. It goes through esterification to yield isoamyl acetate, known for its intense banana flavor. In our years of supplying the flavor industry, we’ve seen even slight impurities shift the aroma from fruity to harsh. Every customer synthesizing flavor compounds from our alcohol expects not only chemical compliance, but also reproducibility in aroma. Poor grade or misidentified isomers end up wasted down the drain.

    In the world of fragrances, this material finds use as a fixative and as part of the top note constructor set. For those in industrial cleaners and extraction, its solvency outperforms straighter-chain alcohols in extracting specific organics. 3-Methyl-1-Butanol outpaces alternatives like n-butanol in certain saponification and dissolution applications. The branch point on the third carbon introduces both steric hindrance and unique solvation behavior—handing formulators new variability in dissolving hydrophobic compounds that n-butanol just cannot match.

    Producers constantly search for stability, especially in EM-sensitive and pharmaceutical sectors. They turn to 3-Methyl-1-Butanol because it brings both chemical stability and predictable volatility. It forms esters and amides without forming significant side products, and our chromatographs back up that claim with real, batch-to-batch data.

    Differences from Other Alcohols: Lessons from the Shop Floor

    From experience, even minor alcohols can cause headaches. Regular n-amyl alcohol, 2-methyl-1-butanol, and other branched pentanols show up as by-products when using biological fermentation as a source. What we’ve learned from running both synthetic and fermentation routes is that the downstream effect of isomer choice is much bigger than standards documents suggest.

    3-Methyl-1-Butanol has a lower freezing point than its straight-chain cousin. That means fewer winterization issues during storage and transport—valuable in colder climates or unheated warehouses. In flavor blending, baking applications, and natural aromas, alternative isomers may impart off-odors or reduced solvency. We’ve run side-by-side esterification at industrial scale; the yields with 3-Methyl-1-Butanol consistently hit higher marks, with fewer oligomerization side reactions.

    Customers moving to more sustainable production methods have examined fermentation-based supplies, which often struggle with inconsistent isomer ratios and higher fusel oil content. We address that head-on with an extra post-distillation purification step. Chemical synthesis (via acetaldehyde condensation or Guerbet reactions) yields a cleaner product but introduces trace aldehydes that need targeted removal. Over years of monitoring, we’ve optimized our process to minimize each route’s unique contaminant profile. When flavor or fragrance applications require ultra-low odor, we can push secondary processing further—though that raises a candid discussion about price versus purity that we always keep transparent.

    Challenges in Production and Industry Trends

    Manufacturing 3-Methyl-1-Butanol at scale is far from trivial, especially under tightening purity requirements. Fermentation yields alcohols in a complex mix—requiring fractional distillation and tailored adsorbents to reach high purity. The synthetic pathway takes a different route, using catalysts that must be renewed and monitored for metal or polymer residue. We invest in both routes to balance costs, supply risk, and environmental impact. Over the last decade, pushback against petrochemicals has increased demand for renewable-source products, driving us to source more from corn and other biomass.

    Sustainability isn’t only a matter of renewable feedstocks. Handling and emissions now drive customer decisions just as much as origin, especially in food and pharma. We’ve retrofitted our emission recovery and vapor abatement lines after customer audits consistently flagged this area for improvement. New closed-loop loading systems cut down fugitive losses, while staff training emphasizes real accountability at each tank transfer. We’ve found that genuine openness helps overcome skepticism when explaining trade-offs between environmental and purity goals.

    The future for 3-Methyl-1-Butanol will likely involve even stricter residue monitoring, full traceability, and dual-sourcing flexibility. End-users increasingly want analytics on non-target residues, including phthalates and heavy metals from production equipment. We learned early that transparency—sharing independent third-party GC-MS and ICP-MS data—wins more long-term partners than hiding behind generic claims.

    Supporting Reliable Supply: Logistics and Risk Management

    The best chemistry means little without reliable delivery. Supply interruptions and contamination events have taught us never to accept claims of “untouchable” purity or infallible transportation. From staged stock in regional warehouses to real-time order tracking, we invest heavily in making sure each load stays compliant through land and sea transit. Once, a container shipment to a food flavor customer in Asia got held due to an off-smelling drum. Investigating root causes, we found that the storage yard sat upwind from an agricultural chemical warehouse, and vapor transfer during a hot spell had tainted the lot. Addressing these issues required both repackaging and changing our warehouse partners—lessons paid for in time and customer relationship capital.

    Precaution against cross-contamination guides our selection of bulk haulers and cleaning procedures between loads. Maintaining specialized, dedicated equipment costs more, but skipping these steps risks losing business with strict audit requirements. Food, fragrance, and pharma buyers routinely inspect our cleaning regimens, and we have real, working solutions—such as disposable drum liners or tamper-evident seals—that go beyond minimal regulatory standards. Over the long haul, these steps have paid off in reduced rejected loads and closer relationships with our top-tier clients.

    Beyond Chemistry: Supporting Our Partners

    What sets manufacturers apart isn’t only process control, but a readiness to partner in problem-solving. Our technical team doesn’t stop at batch release analysis; we’ve spent countless hours in client labs troubleshooting everything from reverse reactions in flavor compounding to yield drops triggered by impurities hard to detect in routine assays. We openly share process improvements and routinely adjust fractions or distillation cut points in response to feedback. This kind of problem-solving has built our reputation across segments relying on 3-Methyl-1-Butanol, from artisan perfumers to agrochemical giants.

    Quality doesn’t happen automatically. Every new customer brings a unique set of requirements, especially as applications diversify into new flavor profiles, advanced solvents, and performance chemicals. Sometimes, that means giving honest guidance about which alcohol grade fits a customer’s purpose, even if it means steering them to a less expensive or differently-processed product. We value long-term trust above quick sales and back up claims with real sampling and technical support at each stage—from development through commercialization.

    Conclusions From Years at the Bench

    Every day on the production line shows that 3-Methyl-1-Butanol is more than just another solvent or flavor-building block. Its performance depends on tight process control and honest communication about what each grade can and cannot deliver. If you need reliability, safety, and a partner committed to continuous improvement, this material earns its place in every serious plant chemist’s toolkit. We’ve earned our edges not by keeping to minimum standards, but by understanding real industry requirements and staying one step ahead of evolving customer needs.

    In the end, manufacturing excellence with 3-Methyl-1-Butanol rests not on promises, but on the results we deliver. Each customer challenge sharpens our focus, driving us to pursue purity, compliance, and transparency as non-negotiable standards. The journey isn’t without its headaches, but the reputation built on decades of honest, hands-on work means more than the flashiest brochure. Every batch tells the story of a product crafted with know-how and pride in the manufacturing process.