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3-Chlorophenol

    • Product Name 3-Chlorophenol
    • Alias m-Chlorophenol
    • Einecs 202-613-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    635070

    Chemical Name 3-Chlorophenol
    Cas Number 108-43-0
    Molecular Formula C6H5ClO
    Molar Mass 128.56 g/mol
    Appearance Colorless to pale yellow liquid
    Melting Point 33 °C
    Boiling Point 214 °C
    Density 1.3 g/cm³
    Solubility In Water 25 g/L (20 °C)
    Flash Point 92 °C
    Pka 9.15
    Odor Phenolic
    Vapor Pressure 0.06 mmHg (25 °C)

    As an accredited 3-Chlorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with a secure screw cap, labeled "3-Chlorophenol, 500 mL," with hazard warnings and handling instructions.
    Shipping 3-Chlorophenol should be shipped in tightly sealed, clearly labeled containers made of compatible material. It must be transported as a hazardous chemical, in accordance with local and international regulations (e.g., DOT, IATA, IMDG). Shipping should ensure protection from heat, direct sunlight, and physical damage. Appropriate hazard labels and safety data must accompany the shipment.
    Storage 3-Chlorophenol should be stored in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers and acids. Keep the container tightly closed and clearly labeled. Store in corrosion-resistant containers, ideally under an inert atmosphere if possible, and avoid any contact with moisture to prevent decomposition. Use secondary containment to prevent leaks or spills.
    Application of 3-Chlorophenol

    Applications of 3-Chlorophenol in Industrial Manufacturing

    3-Chlorophenol finds critical utility as a functional intermediate and processing agent across multiple segments of the chemical industry. Our technical-grade material supports demanding production streams, meeting strict standards for purity, reactivity, and consistency specified by industrial formulators and end users.

    1. Pharmaceutical Intermediate Synthesis

    This raw material serves as a building block in the manufacture of active pharmaceutical ingredients, specifically in the synthetic route for agents such as antiseptics or intermediates for non-steroidal anti-inflammatory drugs. Process chemists introduce it during early-stage condensation or alkylation steps to enable selective substitution, which impacts the final molecule’s activity and regulatory profile. Quality audits focus on controlling trace impurities below pharmacopoeial thresholds to ensure reliability in downstream GMP environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF Monographs for relevant APIs
    • European Pharmacopoeia (Ph.Eur.) compliance for residual solvents
    • FDA 21 CFR Part 210/211 (as applicable for API plants)

    Typical usage ratio

    • 10–30% of reaction molarity in aromatic substitution; actual ratio determined by downstream API yield optimization and impurity control

    Downstream process integration

    • Added at the condensation, halogenation, or etherification step within multi-stage API synthesis trains
    • Subjected to in-process controls for residual precursor levels

    Final product types

    • Paracetamol intermediates
    • Antiseptic agents
    • Other chlorinated analgesic raw materials

    2. Agrochemical Active Ingredient Manufacturing

    Formulators in the crop protection industry employ 3-Chlorophenol as a controlled precursor in synthesizing herbicide actives and fungicides. Precision dosing at specific stages allows selective ring modification essential for target molecule bioactivity and environmental safety. Quality teams monitor for regulated aromatic residues and enforce traceability under international registration protocols for agrochemical registration.

    Industry compliance standards

    • ISO 9001 for agrochemical manufacturing
    • FAO/WHO Guidelines on Pesticide Specification
    • REACH (EC No 1907/2006) for raw material registration
    • OECD Principles of Good Laboratory Practice (GLP) for synthesis studies

    Typical usage ratio

    • 15–35% of the relevant reaction weight basis, fine-tuned depending on yield and crop-protection compound efficiency

    Downstream process integration

    • Dosed in the aromatic substitution and cyclization steps during the active compound synthesis
    • Monitored for carryover residue in technical grade crop protection active ingredients

    Final product types

    • Phenoxy herbicide actives
    • Pyraclostrobin fungicide intermediates
    • Other chlorinated agrochemical actives

    3. Industrial Dye Intermediate Production

    Specialty dye and pigment factories utilize 3-Chlorophenol in synthesizing azo, anthraquinone, or phthalein intermediates. Its reactive aromatic ring position enables controlled introduction of color chromophores, influencing lightfastness and heat stability demanded by the automotive, textile, and plastics sectors. Production batches undergo routine chromatographic verification of substitution patterns and trace aromatic contaminant limits as per downstream customer audits.

    Industry compliance standards

    • ISO 9001 for pigment and dye manufacturing
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) for azo and related dye chemicals
    • GOTS (Global Organic Textile Standard) prohibitions for restricted aromatic amines

    Typical usage ratio

    • 5–20% by batch mass for diazotization or coupling reactions; adjusted by chromophore intensity targets or synthesis scale-up needs

    Downstream process integration

    • Introduced in initial color base synthesis and during ring substitution events
    • Monitored and benchmarked via HPLC for final dye intermediate integrity

    Final product types

    • Azo dye intermediates for textile applications
    • Phthalein dye raw materials
    • High-performance pigment precursors

    4. Disinfectant and Preservative Formulation

    Producers of antiseptics and industrial biocides employ 3-Chlorophenol in blending surface disinfectants, wood preservatives, and cooling liquid additives. The material enters formulations at calibrated levels to ensure targeted microbial kill rates while aligning with permitted toxicological limits. Batch records highlight both efficacy and chemical stability performance in ready-to-use and concentrate forms.

    Industry compliance standards

    • EPA FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act) for U.S. formulations
    • EN 1276 (European test method for biocidal activity)
    • Biocidal Products Regulation (EU) No 528/2012
    • ISO 11930 Microbiological testing for preservative efficacy

    Typical usage ratio

    • 0.3–2% for disinfectants; up to 5% for wood preservatives depending on mandated log reduction or timber penetration depth

    Downstream process integration

    • Measured and mixed at emulsification or solubilization stages of biocide preparation
    • Subject to biocidal activity validation and stability testing

    Final product types

    • Hospital-grade disinfectants
    • Industrial wood preservation liquids
    • Chlorophenol-based cooling tower biocide concentrates

    5. Polymer and Resin Modifier Manufacturing

    Manufacturers of specialized resins and engineered polymers introduce 3-Chlorophenol at the modification or crosslinking stage to influence resin flexibility, solvent resistance, or adhesion properties. Its aromatic group offers strong electron distribution, supporting formation of high-performance thermosets and coatings. Quality systems oversee in-line monitoring and trace residual monomer for compliance with product safety and technical standards.

    Industry compliance standards

    • ISO 9001 and 14001 for resin manufacturing
    • ASTM D7767 for chemical resistance in epoxy and phenolic resins
    • RoHS Directive 2011/65/EU for restricted chemicals in electrical insulation
    • UL 94 Flammability Standard for end-use plastics

    Typical usage ratio

    • 1–10% w/w in resin modification or crosslinking reactions, based on desired performance metrics and compliance with end-user specifications

    Downstream process integration

    • Incorporated during resin backbone synthesis or post-polymerization functionalization
    • Controlled with in-process FTIR and GC-MS monitoring

    Final product types

    • Protective coating resins for electronics
    • Industrial adhesive bases
    • Specialty thermoset polymers for high-end applications
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    Certification & Compliance
    More Introduction

    Introducing 3-Chlorophenol: A Direct Manufacturer’s Perspective

    3-Chlorophenol in Our Production Line

    Producing 3-Chlorophenol requires both a careful eye for detail and a strong grasp of reliable chemical practices. As a team that's handled this compound from sourcing raw materials all the way through purification, packing, and dispatch, we’ve seen firsthand its strengths and challenges. Here, quality starts with pure monochlorobenzene and ends with a crystalline white to light tan solid, melting within a narrow controlled range. From each batch, we expect a direct reading above 99% assay by gas chromatography, and free from colored byproducts or residues. Unwanted water or iron compounds are unacceptable, not only to uphold our own standards, but because our users in downstream labs can trace even a hint of impurity.

    What Is 3-Chlorophenol

    In short, 3-Chlorophenol (C6H5ClO) stands apart as a monochlorinated phenol, specifically carrying its chlorine on the meta position of the aromatic ring. Its refined structure and reactivity have carried it from plant protection chemistry to dye intermediates, and into niche pharmaceutical synthesis. As a manufacturer, the unique character of the meta isomer has shaped our technical routines, since its reaction behavior differs from both its ortho and para relatives.

    Production Methods That Shape Quality

    We run our chlorination process in a closed system, where temperature, vapor pressure, and feedstock ratios see constant refinement by experienced hands, not just sensors or computers. Multiple crystallizations ensure consistency, especially for clients with analytical standards to meet. It’s not just about achieving the correct chlorination—removing side-products is equally central. After distillation, we offer both technical and high-purity grades, an option many of our customers rely on to balance performance with cost. We don’t skip on controls, running not just GC-MS, but also routine UV and IR scans for those rare non-standard requests.

    Physical and Chemical Properties That Matter to Industry

    In the drum or flask, 3-Chlorophenol has a persistent phenolic odor recognizable to anyone who’s worked a line of substituted phenols. Its melting point hovers between 32 and 36°C, with enough volatility at room temperature to require sealed packaging in lined drums or amber bottles. The compound dissolves well in ether, methanol, and hot water—a factor that continues to affect its handling from sample transfer to process scaling. Disposal and containment plans remain at the forefront of our operation; the toxicity profile calls for personal protection and workspace controls, and our packaging reflects both transport safety and lab practicality.

    Day-to-Day Uses and Applications

    Years of customer feedback have mapped the working life of 3-Chlorophenol. Agrochemical engineers value its role as a key intermediate in the synthesis of broad-spectrum pesticides and herbicides. Our colleagues in dye manufacturing depend on its meta structure, since it leads to distinct colorfast molecules compared to the ortho or para isomers, which follow different coupling routes. In the R&D sector, chemists reach for it to introduce specific halogenated functionalities in new small-molecule candidates. We get requests for both kilogram and multi-ton quantities, depending on the activity of these industries and global market swings—rarely predictable, but always with clear reasoning from our buyers who trust its established results.

    Why Our Batch Consistency Sets Us Apart

    We choose not to run on autopilot; process optimization comes from a blend of practical plant-floor know-how and continuous monitoring. Keeping each batch under narrow process windows drives consistency. When product leaves our facility, a certificate of analysis only tells part of the story. Lab staff, often with over a decade of specific experience, sign off after confirming the right melting point, color, and assay every time. Some buyers come to us after struggling with inconsistent material from unnamed upstream mixers or brokers—one batch with too much water, another with off-color or surplus iron. Our team’s commitment to eliminating those variables has established a loyal user base, especially among customers who themselves face strict regulatory or commercial end-use controls.

    What Sets 3-Chlorophenol Apart From Ortho and Para Isomers

    Chemists familiar with chlorophenol chemistry already know the difference between meta, ortho, and para-chlorophenol isomers is more than an academic detail. The meta isomer doesn’t just have a unique melting point or odor. Its reactivity patterns, suited for specific coupling and substitution reactions, enable synthesis routes unavailable to the others. In pesticide manufacture, the meta form leads to different activity profiles and selectivity in active ingredients. Dye-makers see alternate hues emerge when meta isomers serve as starting materials. We’ve studied both the physical behavior and the downstream chemistry under real operational constraints. Feedback from these users guides our own adjustments. In some cases, a batch of para-chlorophenol might pass the same purity threshold, but only the meta isomer proves viable in a customer’s proprietary reaction.

    Quality and Regulatory Oversight in Our Operation

    We operate under tightly-documented quality assurance protocols grounded in both local regulation and international standards. Internal teams carry out regular equipment validation and calibration. Every drum filled matches a logbook traceable to raw input lots. For those in need of compliance documents, we issue full analytical data and safety assessments, prepared by in-house chemists, not generic forms. Government audits continue to keep our handling and waste disposal transparent. From batch records to emission controls, each stage undergoes inspection—our customers have voiced their trust after following the paperwork down to the last signature. Transparency and traceability bring as much value to the market as the chemical itself.

    Customer Feedback: Beyond Technical Data Sheets

    By listening directly to end-users—formulators, plant engineers, and lab managers—we continually adjust production, packaging, and distribution. One recent project involved eliminating a recurrent off-odor worry by switching to a new grade of liners and boosting vacuum-level distillation. Customer reports from production lines have flagged even small shifts in thawing characteristics when storing through the winter, insights only possible after years sharing field experiences. Our approach, drawn from these relationships, delivers more than a number or a spec: it reflects ongoing learning on both sides of the supply chain.

    Shaping the Product for Today’s Markets

    Demand variances and emerging health trends force us to remain adaptable. Environmental scrutiny over halogenated aromatics calls for responsible sourcing and cradle-to-grave lifecycle analysis. Recent years have seen the market shift, with buyers asking for smaller, just-in-time shipments and global transit certificates covering bio-accumulative and toxicological endpoints. Working alongside regulatory consultants, we continually update our documentation as classification lists and handling requirements evolve. For multinational formulators, we provide both standard regulatory data and additional testing where standards diverge across trade zones. Changing market tides—seasonal pesticide demand spikes, new colorant launches—keep our planning agile, with inventory managed around actual use-patterns rather than projections alone.

    Environmental Responsibility and Safety

    Our environmental controls do not stop at the product’s exit gate. Vent scrubbers, spent process solvent recyclers, and hazardous waste segregation all play key roles on our site. Staff participate in regular chemical safety and emergency drills; personal protective equipment stands as a minimum rather than an afterthought. We work with accredited carriers for transport and share explicit disposal and spillage response protocols with customers on request. For sites with downstream waste treatment, we offer consultation on effluent treatment and air quality standards specific to chlorinated aromatics. Environmental responsibility, for us, means ongoing partnership between producer and user.

    Supporting Future Chemistry with Consistent Supply

    Lab chemists, quality managers, and plant engineers rely on materials they can trust to perform identically from year to year. We support R&D efforts by offering documented sample history, detailed analytical graphs, and direct access to senior chemists for troubleshooting. New product lines start with a single test batch—if the 3-Chlorophenol barely deviates from our published specifications, it becomes part of a broader synthesis plan. Long-standing synthetic routes depend on consistent input parameters—by keeping those stable, we lower risk for both new process launches and ongoing manufacturing.

    Differences from General Chlorophenol Sources

    Many organizations new to the field discover practical differences compared to bulk commodity traders or intermediates. Some brokers offer a non-specific “mixed chlorophenols” blend, sometimes with undefined isomer ratios and unknown side component concentrations. Labs requiring precise yields find unpredictable results from those blends. Our grade-specific, meta-selective process eliminates isomer impurities, a critical factor for specialty dyes and crop protection formulas. Customers value knowing exactly which positional isomer enters their process—not just for regulatory filings but also for optimizing downstream synthetic steps. By focusing on a single isomer, we remove variability and unexpected reaction byproducts, supporting predictable and high-yielding production.

    Handling, Storage, and Practical Daily Realities

    Our advice for day-to-day work with 3-Chlorophenol comes straight from the plant floor. Always keep drums in cool, well-ventilated rooms, away from easily oxidized feedstocks. Operators transferring material into reactors or holding tanks monitor exposure using vapor detectors, a practice we support with both equipment and training. Ease of weighing granulated or flaked solid depends on humidity control—our packaging uses industrial barrier liners that prevent caking even in humid transit or storage conditions. Spill kits with neutralizing agents remain close at hand; accidents in the drum hall get a rapid operator response before becoming clean-up issues.

    Real-World Challenges and Ongoing Problem Solving

    We face complex logistics every day. Shipping seasonally across regions means freeze-thaw cycles and tight delivery windows. Vessel containers sometimes sit in port for longer than scheduled, so our packaging stands up to shipping stress and variable temperatures. Container unique numbers tie back to production records; any anomaly or transit damage gets full documented investigation. Years of experience have taught us to never take short shortcuts in storage or labeling. Modern automation offers helpful checks, but direct human eyes and judgment remain irreplaceable. Feedback often draws attention to fine nuances—slight shifts in crystal appearance raised from a seasoned line foreman, or faint variance in odor profile highlighted by an experienced end-user.

    Driving Reliability for Research and Scale-Up

    Research teams seeking to launch a new synthetic route depend on reference data with clear lineage, not just generic “chlorophenol” labels. To help, we archive spectra, stability data, and past run logs. Clients scaling from grams to metric tons rely on receiving identical product at every order, removing the need to re-validate endless lots. Early engagement between our technical teams and project chemists helps foresee hurdles before they disrupt timelines. Our feedback loop includes tailored shipping, alternate lot splitting, and on-request minor grade modifications to account for unique process constraints without trampling overall process reproducibility.

    Distribution: Meeting Customers Where They Are

    Direct supply from manufacturing floor to customer bench brings flexibility. Our delivery blends bulk with small packs, anticipating both urgent research pilots and large continuous lines. We support both regular standing orders and sudden surges in consumption during peak seasons, a practice made possible by direct control over warehousing and real-time production data. Emergency response, although rare, operates through a 24-hour logistics calendar and trusted regional partners who understand our product’s sensitivity. We view logistics not as a back-end process, but as central to the customer’s experience.

    Collaborative Innovation and Industry Adaptation

    Colleagues in specialty industries sometimes present us with requirements beyond a simple catalog grade. Requests for higher purity, custom packaging, or tailored contamination limits prompt joint development. Our lab staff responds with trial runs, targeted purification tweaks, and new analytic methods calibrated against evolving process needs. We value these collaborations, recognizing that process improvement grows from open dialogue between the plant chemist and the end user. Many innovations arise as solutions to these routine challenges, shaping new standards for subsequent runs. Feedback often leads to incremental upgrades or even rethinking established protocols for storage, testing, or delivery.

    Commitment to Transparent Supply and Continuous Improvement

    Every order carries with it the visible legacy of our site’s experience—batch to batch, year to year. Our in-house chemists take pride in seeing customer projects through from proof-of-concept to scaled manufacturing. Regular technology upgrades, ongoing staff training, and steady improvement cycles keep our commitment focused on product consistency and reliability. The path from raw input to finished shipment remains direct and visible, with a single dedicated production group overseeing every detail. We welcome customer audits and routinely invite independent testing groups to review our operations, confident that our practices not only withstand scrutiny, but offer valuable learning for both sides.