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3-Chlorobenzotrifluoride

    • Product Name 3-Chlorobenzotrifluoride
    • Alias m-Chlorobenzotrifluoride
    • Einecs 202-609-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    882069

    Cas Number 98-16-8
    Molecular Formula C7H4ClF3
    Molar Mass 180.55 g/mol
    Appearance Colorless to pale yellow liquid
    Melting Point -31°C
    Boiling Point 139-142°C
    Density 1.36 g/cm³ at 20°C
    Flash Point 47°C (closed cup)
    Solubility In Water Insoluble
    Refractive Index 1.505 at 20°C

    As an accredited 3-Chlorobenzotrifluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 3-chlorobenzotrifluoride 500 mL amber glass bottle with a secure screw cap, labeled with hazard warnings and batch information.
    Shipping 3-Chlorobenzotrifluoride is typically shipped in tightly sealed drums, bottles, or containers, compliant with international and local hazardous material transport regulations. Proper labeling, appropriate hazard warnings, and secure handling are required due to its flammable and potentially harmful nature. Shipping should follow UN identification, ensure safety measures, and prevent leaks or exposure.
    Storage 3-Chlorobenzotrifluoride should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from direct sunlight, heat, and incompatible substances such as strong oxidizers. Keep away from sources of ignition, as it is flammable. Ensure that storage containers are clearly labeled and made of materials compatible with aromatic halogenated hydrocarbons to prevent leaks or reactions.
    Application of 3-Chlorobenzotrifluoride

    Applications of 3-Chlorobenzotrifluoride in Industrial Manufacturing

    3-Chlorobenzotrifluoride serves as a key intermediate for several high-value downstream manufacturing sectors. Our advanced production capabilities ensure consistent purity and supply reliability for industrial clients worldwide. Below, we detail how downstream industries incorporate this material into their specific manufacturing processes.

    1. Agrochemical Active Ingredient Synthesis

    This raw material forms an essential building block in the synthesis of certain agricultural pesticides, including herbicides and fungicides. Major agrochemical manufacturers employ 3-chlorobenzotrifluoride to introduce trifluoromethyl and chlorinated aromatic moieties in active molecules, enhancing biological activity and field stability. Dedicated facilities use established chlorination and substitution processes, followed by conversion to downstream intermediates for crop protection formulations.

    Industry compliance standards

    • EPA 40 CFR Part 180 (US Maximum Residue Levels for Pesticide Chemicals)
    • EU Regulation (EC) No 1107/2009 (Placing Plant Protection Products on the Market)
    • OECD Guidelines for the Testing of Chemicals
    • ISO 9001:2015 Quality Management Systems for API supply chain

    Typical usage ratio

    • 10–35% by weight in multi-step synthesis, depending on target active ingredient structure and conversion pathway

    Downstream process integration

    • Introduced in the halogenation and trifluoromethylation step, prior to coupling or cyclization reactions in active ingredient synthesis
    • Handled in closed reactor systems under controlled temperature to limit byproducts

    Final product types

    • Selective herbicides (e.g., substituted benzotrifluorides)
    • Fungicidal active molecule intermediates
    • Crop protection end-user formulations

    2. Pharmaceutical Intermediate Manufacturing

    Pharma sector specialists deploy 3-chlorobenzotrifluoride as a strategic intermediate for synthesis of complex fluorinated aromatic drugs, where it is valued for building lipophilic cores. Use cases include production of anti-inflammatory, CNS, and oncology APIs. The material enters via nucleophilic aromatic substitution or is subjected to further halogenation and cross-coupling for fine-tuned ring structure creation under cGMP-controlled environments.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF and Ph. Eur. guidelines for raw material purity
    • 21 CFR Part 211 (US FDA GMP for Finished Pharmaceuticals)
    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (EU)

    Typical usage ratio

    • Typically 5–20% of total batch weight during core intermediate synthesis; final ratio determined by target API molecular structure

    Downstream process integration

    • Charged into stirred reactors for aromatic substitution, hydrogenation, or coupling, typically early in the multi-step route
    • Monitored for residual levels in subsequent purification steps

    Final product types

    • Pharmaceutical intermediates for non-steroidal anti-inflammatory drugs
    • CNS active ingredient precursors
    • Drug substance intermediates used in custom synthesis

    3. Polymer and Specialty Resin Modification

    The electronics and coatings industries incorporate this material as a functional monomer or modifier to introduce electron-withdrawing groups into high-performance polymers and specialty resins. This directly influences chemical resistance, hydrophobicity, and dielectric properties in end products such as circuit board coatings and specialty fluoropolymers. Producers carry out co-polymerization or chain-end modification under strictly controlled temperature and initiator dosing in batch reactors.

    Industry compliance standards

    • UL 94 (Flammability rating for plastic materials)
    • IEC 61249-2-21 (Materials for PCB baseboards)
    • ISO 14001:2015 for environmental management in resin manufacture
    • RoHS Directive (EU Restriction of Hazardous Substances)

    Typical usage ratio

    • Normally 2–12% by weight as a functional modifier in polymer blends; exact ratio based on target property enhancement

    Downstream process integration

    • Blended into reaction kettle during co-monomer dosing or as chain transfer agent in specialty resin polymerization
    • Integrated upstream of final compounding or extrusion stages

    Final product types

    • High-performance PCB substrate coatings
    • Specialty fluoropolymer resins
    • Industrial anti-corrosive paints and coatings

    4. Dye and Pigment Intermediate Sourcing

    Colorant manufacturers select 3-chlorobenzotrifluoride for targeted introduction of trifluoromethyl and chloro functional groups in high-stability pigment molecules. This confers enhanced fastness in pigments used in plastics, textiles, and inks. The process often involves controlled aromatic substitution and further refinement through sulfonation or diazotization, delivering specialized dye intermediates on a consistent production scale.

    Industry compliance standards

    • EN 71-3 (Migration of certain elements, relevant for pigments in toys and textiles)
    • REACH Annex XVII for colorant safety in Europe
    • GB 18582-2020 (China VOC limits in coatings)
    • ISO 9001:2015 for batch traceability

    Typical usage ratio

    • 5–18% by weight as a key intermediate; usage fine-tuned by the required chromatic strength and solubility profile

    Downstream process integration

    • Fed into primary aromatic substitution and activated position reactions at pigment plant reactors
    • Purified through crystallization ahead of finishing and blending with dispersants

    Final product types

    • High lightfastness pigments for plastics
    • Reactive dye intermediates for synthetic textile fibers
    • Specialty ink pigment dispersions

    5. Fluorinated Fine Chemical Synthesis

    Producers in the fine chemical sector use this material to construct highly fluorinated aromatics, which serve as building blocks for specialty surfactants, high-purity solvents, and advanced materials. Multi-step synthesis in this context involves stringent moisture control, precision dosing, and specialized safety monitoring to manage reagent reactivity and batch consistency.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for chemical synthesis operations
    • Responsible Care Global Charter (ICCA chemicals management)
    • Globally Harmonized System (GHS) classification for safe storage and handling
    • National: TSCA (US) and REACH (EU) volume tracking

    Typical usage ratio

    • 6–25% by weight as initial aromatic source; adjusted for conversion efficiency and downstream specificity

    Downstream process integration

    • Injected at the start of aromatic ring construction and halogen exchange steps in fine chemical plants
    • Followed by fractional distillation and product isolation for purity assurance

    Final product types

    • Fluorinated surfactant precursors
    • Electronic-grade solvent intermediates
    • Building blocks for specialty materials (e.g., fluorinated lubricants)
    Free Quote

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    Certification & Compliance
    More Introduction

    3-Chlorobenzotrifluoride: A Practical Perspective from Our Manufacturing Floor

    What 3-Chlorobenzotrifluoride Means for Modern Industry

    Every day on our production lines, we see the real value that 3-Chlorobenzotrifluoride brings to industries as diverse as agrochemicals, pharmaceuticals, and specialty coatings. The benefits aren’t abstract or theoretical—they show up in the way our teams streamline complex syntheses and control quality from raw input through finished product. Manufactured under tightly monitored conditions, our 3-Chlorobenzotrifluoride delivers the consistency that process engineers and chemists demand in large-scale operations. Old hands on the floor appreciate its stable nature and ease of handling, part of what makes this compound so reliable for ongoing supply contracts and day-to-day production.

    Let’s break down what makes this compound such a staple. We manufacture 3-Chlorobenzotrifluoride—chemical structure C7H4ClF3—as a clear, high-purity liquid, typically offered at a minimum assay of 99.5% by gas chromatography. The knowledge gained over years of real-world demand has set our quality specs: maximum moisture under 0.05%, stringent color requirements, and packaging designed for both bulk and mid-scale consumption. Teams at our site know how important it is to ship material safely and keep it from moisture and direct sunlight, which helps prevent degradation and batch-to-batch variability.

    Production Experience Shapes Quality

    We have spent years honing the reaction conditions that give our product its uniform character. Chlorination of benzotrifluoride calls for precision: careful temperature control, reagent handling, and tight monitoring of the reaction profile. Skipping a checkpoint risks impurities, so our operators run regular sampling during each batch. Our laboratories run HPLC and GC-MS analysis before any shipment leaves our site. These steps may seem routine to industry veterans, but they are where human eyes and practical judgment catch potential problems early—long before our process reaches downstream customers who rely on flawless chemistry.

    From a technical standpoint, it’s the combination of a robust manufacturing method and an experienced team that lets us consistently meet tight impurity limits. Direct feedback from customers in dye and pigment manufacture, for instance, has helped us tailor our finishing protocols and kept our lot-to-lot variation under strict limits. It takes more than just a recipe to deliver fluent supply; it takes the collective know-how of people who have handled the product during every shift and season.

    Natural Fit for Complex Applications

    Chemists who visit our plant often comment on how 3-Chlorobenzotrifluoride fills a gap left by other aromatic solvents and intermediates. Its halogenated aromatic backbone makes it much more than a volatile carrier or a passive participant. In custom synthesis, it often serves as a key building block where three points of fluorination deliver both stability and chemical reactivity, depending on conditions applied. This dual role makes it especially valuable for those working in advanced agrochemical and pharmaceutical research, where a molecule’s performance under scale-up matters as much as textbook reactivity.

    During pilot runs, our technical teams join customer chemists to adjust process flows and minimize losses. The low boiling point—around 139-140°C—allows for streamlined recovery and recycling, important for both environmental management and cost efficiency. We often integrate cryogenic chilling or fractionating columns to optimize recovery, based on the specific needs of each customer’s flow diagram. It’s this in-the-field problem-solving, rather than any fixed protocol, that lets us assist in meeting increasingly strict sustainability targets among our buyers.

    How 3-Chlorobenzotrifluoride Stands Apart

    No chemical intermediate gets selected in isolation, and we encourage buyers to look beyond raw price or generic specifications. Compared to other chlorinated aromatics—like chlorobenzene or dichlorotoluene—3-Chlorobenzotrifluoride earns its place though a unique mix of chemical properties and process compatibility. The trifluoromethyl group in the para position brings notable resistance to oxidative degradation and offers strong electron-withdrawing effect, qualities that help it outperform simpler halogenated benzenes in tough oxidative or nucleophilic conditions.

    On our floor, it’s not uncommon to run side-by-side tests replacing older aromatics with 3-Chlorobenzotrifluoride in cross-coupling and substitution reactions. The difference shows up in cleaner reactions and more predictable yields—results that enable tighter process control, especially in pharma and specialty polymer applications where purity targets keep rising. Our histories of routine maintenance show that equipment wear from our product remains minimal, a point plant managers value when reviewing long-term operating costs.

    Supporting Fine Chemical Synthesis

    In real-world settings, research teams and production chemists come to us looking for reliability with a compound that helps unlock advanced molecular design. The stable para-chlorine and electron-withdrawing trifluoromethyl grouping mean 3-Chlorobenzotrifluoride becomes a starting point for Suzuki coupling, nucleophilic substitution, and Grignard-type transformations. These routes feed downstream production of herbicides, fungicides, or active pharmaceutical ingredients. Our engagement doesn’t stop at the factory door; we help formulators adjust their methods as raw material norms shift through regulatory or market pressure.

    Those who make the jump from traditional halobenzenes discover both higher selectivity and fewer by-products using our product. As environmental constraints tighten, the ease of by-product separation from 3-Chlorobenzotrifluoride intermediates delivers a real advantage in effluent management and overall capex planning. We have direct experience helping teams recalibrate solvent recovery and distillation assets—not only improving margin but reducing the headaches associated with off-spec disposal or regulatory reporting.

    Key Differences from Similar Aromatic Chemicals

    It’s not only the chemistry but the total process impact where 3-Chlorobenzotrifluoride marks its distinction. While both chlorobenzene and certain mixed halogenated solvents compete in the same general field, our product’s trifluoromethyl group brings unique performance: greater hydrophobicity means lower water solubility and less risk of hydrolytic decomposition under storage or use, even in humid environments. This trait has allowed customers in coatings and performance materials to extend product shelf-life and cut down the waste from off-spec material—outcomes that matter on the balance sheet and in regulatory reviews.

    Some buyers have questions about flammability and volatility. Our manufacturing records show that, compared with lower molecular weight aromatics, 3-Chlorobenzotrifluoride offers a more favorable combination of flash point and evaporation profile. It gives plant managers a safer handling window for process and storage, provided normal containment practices are observed. That’s not simply a theoretical perk; for warehouses and shipping operations, it reduces compliance headaches and risk assessments associated with high-hazard substances.

    There’s no universal substitute for hands-on experience in this field. From discussing requisitions with procurement teams to troubleshooting pump sizing with plant engineers, our aim remains to keep lines running with minimum downtime. In our experience, downstream conversions such as direct amination, metal catalyzed cross-coupling, or functionalization through nucleophilic aromatic substitution all benefit from the reproducibility of our 3-Chlorobenzotrifluoride supply. These are the untold stories that often differentiate a successful campaign from a costly rerun.

    Addressing Market Trends and Regulatory Pressures

    Industry trends don’t stand still. As national and international controls tighten around halogenated chemistry, manufacturers like us have worked alongside regulatory bodies to keep products compliant with the latest environmental and worker safety guidelines. We’ve invested heavily in closed-system handling, automated leak detection, and real-time quality tracking. This means our product continues to earn approvals where others fall short, particularly in jurisdictions where discharge thresholds and occupational exposure limits grow stricter every year.

    We’ve seen a movement in recent years toward green chemistry and sustainable sourcing, even for intermediates in commodity sectors. By collaborating with both academic researchers and industrial partners, we’ve managed to lower the environmental footprint of our 3-Chlorobenzotrifluoride operation. This has included working with alternative feedstocks for upstream processes and improving thermal recovery efficiency in the distillation stages of our plant. Direct input from our customers pushed us to develop returnable drum systems and simplified container disposal practices—saving both time and cost on shipping and waste management.

    Our investment doesn’t end at hardware. We run annual cross-training and certification for our plant workers, ensuring that safety management and product stewardship are more than just box-checking exercises. Building expertise into every level of our operation pays off not only in fewer incidents but also in sharper troubleshooting and faster response in the rare event issues crop up. We view transparency and participation as critical to upholding the trust placed in us by global partners and regulators alike.

    Real-World Applications and Customer Solutions

    Over the past decade, the range of applications for 3-Chlorobenzotrifluoride has only expanded. Major agrochemical producers rely on our material as a precursor for established and novel crop protection chemicals, where the robust electron-withdrawing capacity of the trifluoromethyl group supports synthesis of actives with prolonged field half-lives and improved selectivity. We’ve worked with pharmaceutical partners to navigate scale-up issues, where the predictability of our product prevented costly development setbacks during regulatory submission.

    Paint and coatings manufacturers have also turned to this compound for specialty applications, especially where regulatory or performance concerns limit the use of more volatile or reactive solvents. Our teams frequently collaborate on trial runs, providing feedback on fluid handling and long-term stability in novel formulations. In the pigment and dye sector, our product’s clean conversion profile suits the demand for high-purity, low-residue intermediates essential for achieving consistent coloration and brightness at scale.

    We never overlook the importance of field support. When customers face bottlenecks or quality questions, we prioritize fast communication between technical teams. One long-term project with an agrochemical plant led to a mutually beneficial change in order volumes and packaging, aligning batch cycles to seasonal requirement changes and eliminating both shortage-related downtime and excessive warehousing costs.

    Expertise in Handling and Logistics

    There’s a world of difference between lab-bench supply and full-scale commercial delivery. Our experience across global and domestic supply chains supports reliable and adaptable logistics. Materials leave our plant in sealed, nitrogen-protected drums and isocontainers, with detailed batch records and chain-of-custody data. On rare occasions, we’ve had to troubleshoot a temperature-controlled shipment or adjust for local storage constraints. Direct communication with on-site logistics coordinators means our product shows up ready to use, not in need of remedial reprocessing.

    We hold that clear documentation and real-world guidance go further than theoretical risk assessments. Our technical service staff don’t just supply paperwork—they assist buyers in environmental permitting, workplace exposure assessments, and regulatory consultation. This partnership approach helps companies new to 3-Chlorobenzotrifluoride avoid pitfalls and align practices with both operational reality and regulatory targets.

    The Road Ahead

    Industry won’t ever stand still, and neither will we. Emerging applications in electronics, energy storage, and advanced materials are opening new horizons for high-purity 3-Chlorobenzotrifluoride. Ongoing feedback from field users continues to shape the way we operate and deliver. From continuous quality improvement to tailored packaging solutions, our focus remains on practical results. Peer feedback, technical collaboration, and honest discussion with end users help us stay ahead in a sector where regulatory and technical challenges evolve rapidly.

    Trust built on decades of handling hazardous intermediates, a record of operational safety, and a willingness to learn from end users gives us confidence looking forward. 3-Chlorobenzotrifluoride will keep earning its place in modern chemical synthesis, not through generic specification compliance but through hands-on expertise and solutions rooted in the day-to-day reality of chemical manufacturing. We welcome every opportunity to work with partners ready to move industry forward—one batch, one conversation, or one innovation at a time.