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3-Chloroaniline

    • Product Name 3-Chloroaniline
    • Alias m-Chloroaniline
    • Einecs 203-109-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    135366

    Cas Number 108-42-9
    Iupac Name 3-chloroaniline
    Molecular Formula C6H6ClN
    Molar Mass 127.57 g/mol
    Appearance Colorless to pale yellow liquid
    Density 1.25 g/cm³
    Melting Point 32 °C
    Boiling Point 224 °C
    Solubility In Water Slightly soluble
    Flash Point 110 °C
    Vapor Pressure 0.033 mmHg (25 °C)
    Pka 4.61
    Refractive Index 1.589 (20 °C)
    Pubchem Cid 7924
    Smiles ClC1=CC=CC(N)=C1

    As an accredited 3-Chloroaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle, labeled "3-Chloroaniline," with hazard symbols, product details, and batch information for laboratory use.
    Shipping 3-Chloroaniline should be shipped in tightly sealed containers, clearly labeled and compliant with hazardous materials regulations. It must be protected from physical damage, moisture, and incompatible substances. During transport, ensure proper ventilation and temperature control, and include all required safety documentation and hazard symbols as per local and international shipping guidelines.
    Storage 3-Chloroaniline should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents and acids. It should be kept away from light and moisture. Store in a designated chemical storage area, preferably in a corrosive/poison cabinet, and clearly label containers to prevent accidental misuse.
    Application of 3-Chloroaniline

    Applications of 3-Chloroaniline in Industrial Manufacturing

    3-Chloroaniline serves as a foundational intermediate for several controlled and large-volume chemical synthesis applications. Our direct manufacturing involvement ensures material compatibility and regulatory conformity within distinct downstream sectors. Below, we detail primary industrial usage channels, with segment-specific considerations for compliance, processing methods, and end-user product types.

    1. Production of Agricultural Herbicide Intermediates

    Agrichemical formulators employ 3-chloroaniline as a critical amine source in synthesizing select anilide-based herbicides, particularly in the pre-emergence and selective weed control categories. Manufacturers introduce this compound during the condensation phase with acid chlorides, ensuring precise stoichiometry for active ingredient yield and isomer purity. In these processes, material quality directly affects the downstream product’s effectiveness and legal residue limits. Operators must verify up-to-date REACH registration and monitor for arylamine traces as mandated by agrochemical legislation.

    Industry compliance standards

    • EU REACH Regulation (EC) No 1907/2006
    • U.S. EPA FIFRA registration standards
    • China GB 2763 for agricultural chemicals
    • ISO 9001:2015 quality control for agrochemical intermediates

    Typical usage ratio

    • 22–28% by mass as a limiting reagent, balanced against acid chloride input based on targeted active ingredient synthesis

    Downstream process integration

    • Introduced during amide bond formation in batch or continuous reactors, followed by aqueous workup and solvent extraction steps prior to downstream chlorination or alkylation

    Final product types

    • Acetanilide-derived herbicide actives (e.g., pretilachlor, butachlor)
    • Blended herbicide suspensions and granules for commercial agriculture
    • Formulated agrochemical concentrates

    2. Pharmaceutical Intermediate Synthesis

    3-Chloroaniline functions as a building block for specialty APIs, specifically in the synthesis of various substituted aniline-derived pharmaceuticals. Its inclusion in multi-step synthesis is tightly regulated due to the need for high-purity intermediates and documentation for pharmacopeial conformity. Operations incorporate the material post-nitro reduction phases, optimising conditions to minimize residual impurities and halogenated byproducts, which must align with international drug manufacturing guidelines.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • U.S. Pharmacopeia USP-NF guidelines
    • EU GMP Part II for active substances
    • EDQM CEP documentation (where applicable)

    Typical usage ratio

    • 12–18% by mole relative to primary pharmaceutical precursor, adjusted according to reaction scale and yield requirements

    Downstream process integration

    • Added after initial core scaffold formation, within amidation or halogen substitution stages, followed by multiple purification and crystallization steps to ensure regulatory purity

    Final product types

    • Sulfonamide-based antibiotics
    • Pain management agents (aniline-derived)
    • Specialty anti-inflammatory actives used in secondary drug formulation

    3. Dye and Pigment Manufacturing

    The specialty colorant and pigment sector uses 3-chloroaniline for the diazotization and coupling stages of azo dye production. The strict control over input quantity and reaction temperature is key to achieving consistent chromophore development and avoiding unwanted secondary color shades. Plants must operate in compliance with environmental discharge regulations, given the risks associated with aromatic amine handling in dyehouse environments.

    Industry compliance standards

    • EU REACH restricted substance list for dyes
    • OEKO-TEX Standard 100 for input chemicals
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • ISO 14001:2015 Environmental Management

    Typical usage ratio

    • 14–25% by mass depending on target shade intensity and dye structure; may be further adjusted based on diazo component reactivity

    Downstream process integration

    • Fed into diazotization reactors under controlled cooling, followed by coupling with phenol or naphthol derivatives, then isolated prior to standardization and blending for textile or ink applications

    Final product types

    • Mono- and bisazo dyes for synthetic fiber coloring
    • Pigment dispersions for plastics and coatings
    • Water-based printing inks

    4. Rubber Chemical Additive Manufacturing

    In the rubber and elastomer industry, 3-chloroaniline acts as a key precursor for obtaining antioxidant and anti-degradant additives, ensuring longevity and performance under heat and UV exposure. Integration occurs in the initial synthesis of substituted amines, with process yields and additive characteristics dependent on controlled aniline feed ratios. Batch documentation and impurity profiling maintain compliance with automotive and consumer rubber standards.

    Industry compliance standards

    • ASTM D4678 for rubber compounding materials
    • EU Regulation (EC) 1907/2006 Candidate List for Substances of Very High Concern
    • ISO 9001:2015 for process and quality management
    • Global Automotive Declarable Substance List (GADSL)

    Typical usage ratio

    • 6–11% by mass in antioxidant synthesis, tailored to specific anti-degradation functions and polymer matrices

    Downstream process integration

    • Reacted during early-stage synthesis of arylamine antioxidants, followed by purification and isolation before blending with other functional additives for compound preparation

    Final product types

    • Anti-aging agents in tire and technical rubber manufacturing
    • High-temperature resistant elastomer compounds
    • Automotive weather-strip and seal materials
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    Certification & Compliance
    More Introduction

    3-Chloroaniline: A Manufacturer’s Perspective on Production, Purity, and Practical Application

    Introduction to 3-Chloroaniline

    At our production site, 3-chloroaniline goes beyond a simple chemical name or number. This compound, also known by its chemical formula C6H6ClN and CAS number 108-42-9, enters our plant as an aniline derivative and leaves after several precise steps as a robust intermediate for many chemical sectors. The process we use for manufacturing influences not only the consistency of the output but also the level of trace impurities and physical characteristics. Our team’s experience with every batch shapes the way we evaluate quality and the future applications for each shipment.

    Our Production Approach

    The importance of control in the reaction sequence cannot be overstated. Starting materials, chlorination conditions, and purification steps define the end result. We monitor every batch, paying attention to temperature, pressure, and catalyst loading, which translates into reliable consistency and minimal variance in byproducts. More impurity means less satisfaction for everyone along the supply line. Over the years, through investment in inline analytics, including GC-MS, we caught minor fluctuations and solved them before our customers experienced a single disruption.

    Experienced operators recognize that minor changes in input reactant composition or water content shift reaction rates and impact selectivity. We take pride in training staff to spot these subtle cues and respond quickly—whether adjusting the pH or tweaking agitation speed. Simple decisions at the plant floor impact the shelf life and downstream usability of our 3-chloroaniline. This attention to operational detail is rooted in years of iterative learning.

    Physical and Analytical Properties

    Every chemist or engineer working in downstream synthesis expects certain specifications. Our 3-chloroaniline comes as a pale yellow to light brown oily liquid, with a boiling point in the 232–234°C range and a melting point near -1°C. Purity, measured routinely by gas chromatography, sits at a minimum of 99.5%. Contaminants like moisture, aniline residue, or other chloroaniline isomers are typically less than 0.3%, because we run high-efficiency distillation and use high-integrity storage tanks that prevent re-contamination or hydrolysis. Storing in inert containers under nitrogen helps prevent oxidation, a lesson we learned the hard way back when metallic tanks introduced small but measurable increases in ferric ion content.

    Comparing batch-to-batch test data over the past five years, we notice less than 0.1% variance in halide impurities, which outperforms most industry standards. This performance doesn’t just land on certificates. It matters on the shop floor, in each vessel where a new dye or pharmaceutical intermediate starts from our material and each drum that arrives on our customers’ docks.

    End Uses: Dyes, Pigments, Pharmaceuticals, and Agrochemicals

    Practical value shows up in what customers create using our product. 3-chloroaniline serves as a core building block for making azo dyes, pigments, herbicides, fungicides, and pharmaceuticals. Textile dye houses rely on its aromatic amine structure, which incorporates easily into azo and anthraquinone classes of colorants. R&D chemists in the agrochemical field use it to assemble active molecules that crop scientists trust for yield enhancement or pest resistance. In pharmaceutical labs, its compatibility with standard coupling and substitution reactions allows rapid assembly of synthetic targets. From a production standpoint, flexible scheduling and tank cleaning routines enable us to satisfy fluctuating demand from diverse market sectors, without introducing carry-over or cross-contamination.

    Each application requires attention to slightly different physical properties. Dye manufacturers focus on color clarity and stability over long storage. Agrochemical formulators look for residues and solubility profiles. Drug R&D groups demand both high purity and strict inert packaging. We have set up our process so that we respond to these needs by altering cut points in distillation, tweaking dosage of stabilizers, or adjusting shipment logistics based on end user feedback.

    What Sets Our Product Apart

    For buyers new to sourcing, 3-chloroaniline might look interchangeable across global producers. We’ve learned that small operational differences pile up to affect the final application. Our production runs with validated procedures that prioritize consistent starting materials, minimize cross-batch contamination, and document every change—however minor—right down to cleaning protocol tweaks. Customers working on scale-up projects routinely share their analytical results. We collaborate openly to match our product to their anticipated reaction profiles, purity targets, or downstream approvals.

    Our in-house QA/QC laboratory runs both classic analytical tests and non-standard requests for customers. We provide full spectra and impurity profiles without delay, so downstream risk drops and new product launches don't stumble at the gate. By ensuring that trace levels of ortho- or meta-chloroaniline byproducts remain well below regulatory limits, we reduce rework and lower the long-term cost to formulators. We saw cases in past years where a single out-of-spec shipment led to thousands of dollars in lost work, so investing in robust quality systems made economic and professional sense in the long term.

    Maintaining Safety and Environmental Responsibility

    Handling chlorinated aromatic amines comes with risk both to the environment and the workforce. From our experience, improper containment, spills, or vapor release complicate compliance and public trust. Our facility operates with closed systems that limit operator exposure and vent vapors through multi-stage scrubbers. Contamination of water sources is strictly prevented with high-integrity pipelines and on-site treatment systems for liquid effluent. We regularly engage with local regulators for inspection and third-party audits, finding that clear records and proactive attitude toward upgrades keeps relationships strong.

    Overexposure hazards—from dermatitis to inhalation toxicity—mean we rotate staff, enforce PPE usage, and conduct regular training sessions. Years of operation proved that process discipline, not just safety manuals, prevents incidents and builds a safety-minded team. We log every exposure and near miss, using them as teaching moments for new and experienced staff alike. Our people know the molecular weight, boiling point, and reactivity of each intermediate, because understanding the chemistry translates directly into safer plant operation.

    Disposal of byproducts and waste from chlorination and neutralization is tightly controlled. Our incineration partners hold certifications recognized by leading chemical multinationals, and our documentation chain proves each step from drum to final ash. Neighbors and regulatory authorities appreciate transparency, and we avoid negative headlines by keeping not just to the letter, but to the spirit of environmental standards.

    Differences from Other Aromatic Amines

    Not all aromatic amines fit every application and differences matter downstream. 3-Chloroaniline stands apart from aniline or other chloroanilines such as 2-chloroaniline and 4-chloroaniline. Its regioisomeric placement impacts both reactivity and fate in chemical reactions. For example, nucleophilic aromatic substitution proceeds differently than with the ortho or para analogs. Many dye pathways favor the meta isomer, as it provides color hues or properties that customers specifically require.

    We see mixed use cases in the market: aniline forms the backbone for polyurethane production, while 2-chloroaniline and 4-chloroaniline crop up in certain agriculture and pharma processes. Some customers try substituting between these isomers, pursuing cheaper supply or adapting to local regulations, but we’ve seen outcomes where product performance drops or side reactions become uncontrollable. In our role as a direct producer, we help chemical companies compare isomeric performance in pilot runs before scaling up, rather than relying on theoretical compatibility.

    Besides isomer structure, minor contaminants play a huge role in downstream safety and regulatory approval. Certain isomers may be classified differently by environmental agencies. Our 3-chloroaniline meets relevant thresholds for persistent organic pollutants, and we constantly re-evaluate source material purity against changing international standards. This real-world approach prevents regulatory delays and steers clear of border bottlenecks or internal plant holds.

    Technical Support and Continuous Improvement

    No chemical plant operates in a vacuum. As a hands-on manufacturer, we work side-by-side with end users and researchers. Some of our closest working relationships started when a formulator called with a process problem—color fading, off-odors, or filter plugging—and together we tracked down the root cause back to trace impurities or unexpected stabilizer interactions. Projects like these led us to retrofit pumps, modify blend tank liners, or offer stabilized variants to keep storage properties unchanged despite summer heat or long journeys.

    Our technical team fields questions about reaction compatibility, analytical troubleshooting, and regulatory compliance. We document and share best practices for storing, sampling, and transferring chlorinated amines. Field experience taught us that shelf life stretches dramatically if drums stay sealed and shaded, that minor static buildup in transit can cause drum warp, and that certain gasket materials outperform others in real-world handling. Passing on our lived experience to customers cuts down on waste, lost time, and frustration all around.

    Customers experimenting with new formulations or pilot plants can request samples or analytical assistance. We provide full transparency into how we purify, stabilize, and transport each batch, allowing R&D teams to focus on innovation instead of troubleshooting upstream quality issues. Our history shows that this kind of open partnership builds credibility and supports new product launch milestones.

    Challenges in a Changing Regulatory Landscape

    The regulatory world for aromatic amines continues to evolve, especially where worker and environmental health draw added scrutiny. REACH, EPA, and other agency requirements push for ever lower thresholds of trace contaminants, and what passed muster last year might prompt new documentation or product reformulation this year. We deal directly with inquiries about batch traceability, impurity origin, and alternative pathways for synthesis. Our recordkeeping links raw material lots, operator records, and unit operation data, speeding up any regulatory reporting or corrective investigation.

    Downstream partners often ask for certifications or statements covering allergens, heavy metals, or SVHC status. We produce these directly from plant data and laboratory findings, with no generalizations or vague language. Years of compliance teach that clarity and specificity beat generic statements or copy-pasted legal boilerplate. Direct transparency saves everyone time, and in the end limits business disruption.

    As regulatory pressure ramps up, we invest in process upgrades and analytical technology. Onsite mass spectrometry, advanced chromatography, and digital archival of every run make recalls or disputes a rare occurrence. We welcome audits and encourage customer visits. Sharing how our processes meet and beat up-to-date standards helps both sides learn, adapt, and grow together.

    Supply Chain Considerations and Global Reach

    Shipping 3-chloroaniline safely and reliably demands tight coordination. We work directly with logistics partners to track drums, containers, and bulk tankers from our facility to users in every major market. Our experience with customs, hazmat laws, and paperwork means long delays or seized shipments stay off our ledger. Each export shipment pulls from a tested lot, and we document every chain of custody step. This level of control builds real trust with global customers, who face enough uncertainty from market fluctuations or competitor maneuvers without also worrying about late or out-of-spec deliveries.

    Market cycles influence demand for 3-chloroaniline; dye season peaks can squeeze supply, while raw material shortages can pinch output. We source starter chemicals from qualified and audited suppliers only, running secondary checks on every incoming drum or shipment. By reserving advance stock and scheduling production runs around both customer forecasts and spot demand, we buffer ourselves—and our partners—against sudden market swings. In tough years, this gave long-term customers predictable supply and the confidence to keep their commitments, even when competitors cut back.

    Recent global disruptions—pandemic, tariffs, or shipping logjams—taught us to rethink inventory management and look for local storage and distribution points when possible. Holding extra strategic inventory in key regions adds cost, but it prevents lost orders for partners downstream. These investments in supply security arose directly from experience, not theoretical planning, and we document savings from them in lower lost sales, expediting fees, and rescheduled launches.

    Commitment to Future Growth and Innovation

    Staying competitive with 3-chloroaniline takes more than steady production. We invest in continuous plant improvement, monitoring new catalysts for increased yield or lower power use, new methods for environmental abatement, and alternative synthetic routes that can push down cost or open up greener chemistry. Our R&D team partners with universities and industrial consortia to keep ahead of the curve on toxicity, process intensification, and sustainable feedstock options.

    We watch the marketplace, noting feedback not only from large volume buyers, but also from specialty formulators and startup labs. Some of the best incremental changes in our production came from outside voices suggesting different purification approaches or alternate stabilizer blends. Our team thrives on this back-and-forth, responding quickly to both opportunities and setbacks. It’s not uncommon for us to beta-test new analytical sensors or supply new pilot-plant samples on short turnaround, accelerating new product development cycles for us and our partners.

    Why 3-Chloroaniline Matters—A Manufacturer’s View

    To those working directly with our plant, the value of 3-chloroaniline starts not with packaging or spec sheets, but with trust built over batches, seasons, and technical challenges. Each drum or bulk shipment represents months of focused process optimization, operator vigilance, and careful listening to market and customer need. We do not see ourselves as simply filling orders but as working partners in the innovation chain, supplying a molecule that underpins industries as diverse as dyes, pharmaceuticals, and crop protection.

    Over time, every lesson—be it an improvement in water content control, an analytical discovery, or a field call about strange results—pushes us to produce a product that fits into complex workflows worldwide. The standards we set for ourselves, grounded in experience and data rather than marketing, help us avoid costly missteps and create sustained value.

    For users exploring new applications, scaling up a process, or meeting higher regulatory thresholds, our direct knowledge and willingness to adapt mean that 3-chloroaniline remains not just a commodity, but a partner—produced, tested, and shipped with the realities of real laboratories and manufacturing lines in mind.