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3-Bromophenol

    • Product Name 3-Bromophenol
    • Alias m-Bromophenol
    • Einecs 210-092-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    364934

    Chemicalname 3-Bromophenol
    Casnumber 591-20-8
    Molecularformula C6H5BrO
    Molarmass 173.01 g/mol
    Appearance White to off-white solid
    Meltingpoint 36-40 °C
    Boilingpoint 210-212 °C
    Density 1.78 g/cm³
    Solubilityinwater Moderately soluble
    Flashpoint 99 °C
    Refractiveindex 1.598
    Pubchemcid 11837

    As an accredited 3-Bromophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g amber glass bottle with a white screw cap, labeled "3-Bromophenol," hazard symbols, lot number, and safety instructions.
    Shipping **3-Bromophenol** should be shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. It must be properly labeled and accompanied by the necessary safety documentation. The package should be handled and transported according to regulations for hazardous materials, avoiding extreme temperatures and incompatible substances during transit to ensure safe delivery.
    Storage 3-Bromophenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Protect it from light and moisture. Store in a chemical storage area designated for hazardous organic compounds, and ensure proper labeling to avoid accidental misuse. Keep the container sealed when not in use.
    Application of 3-Bromophenol

    Applications of 3-Bromophenol in Industrial Manufacturing

    As a direct manufacturer specializing in fine chemicals, we supply 3-Bromophenol with consistent quality for precise downstream production. This compound features prominently as an intermediate in several highly regulated sectors. Below, we outline established industrial applications supported by process experience, including regulatory compliance, standardized dosage approaches, integration into complex processing chains, and the resulting finished products.

    1. Pharmaceutical Intermediate Synthesis

    Manufacturers use 3-Bromophenol as an essential intermediate during the synthesis of active pharmaceutical ingredients (APIs), notably in the preparation of certain tyrosine kinase inhibitors and nonsteroidal anti-inflammatory drugs. The aromatic bromide moiety enables regioselective coupling and further derivatization under GMP-controlled conditions, supporting batch traceability and impurity profiling as part of regulated drug substance production. Reaction conditions and molar ratios are tailored for optimal conversion based on targeted pathways such as Suzuki coupling or nucleophilic substitutions.

    Industry compliance standards

    • cGMP (Current Good Manufacturing Practice)
    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP/EP/JP relevant monographs for final APIs
    • REACH (for import/export operations with the EU)

    Typical usage ratio

    • 0.85 – 1.15 molar equivalents, adjusted to target intermediate step and desired throughput per batch sizing; ratio determined by reaction stoichiometry of the respective synthetic route.

    Downstream process integration

    • Charged during the early or mid-stage organic synthesis reactors, typically following initial halogen-lithium exchange or before cross-coupling steps; process monitored for purity, residual halides, and side product control assays.

    Final product types

    • Pharmaceutical intermediates and building blocks for APIs (e.g., kinase inhibitors, analgesics, specialized anti-infectives)
    • Regulated drug substances containing phenolic or brominated motifs

    2. Agrochemical Intermediate Manufacturing

    The agrochemical industry utilizes 3-Bromophenol in synthesizing select fungicide and herbicide molecules where the bromophenyl group imparts target selectivity and facilitates downstream chlorination or etherification. Controlled addition into multi-step organic synthesis ensures compliance with both product-specific and environmental standards, with process safety managed through in-situ quenching and closed reactor systems.

    Industry compliance standards

    • FAO/WHO specifications on pesticide quality
    • ISO 9001 (Quality Management for chemical production)
    • REACH and GHS labeling regulations
    • Regional agrochemical registration protocols (e.g., EPA FIFRA for the US market, GB/T standards for China)

    Typical usage ratio

    • 1.0 – 1.2 molar equivalents, fine-tuned based on the crop protection molecule’s synthetic pathway and the efficiency of downstream conversion steps.

    Downstream process integration

    • Introduced at the phenol functionalization stage or during halide exchange steps prior to condensation, often within semi-batch reactors equipped with real-time analytical monitoring.

    Final product types

    • Intermediates for triazole or strobilurin fungicides
    • Precursors for phenoxy herbicides
    • Finished brominated agrocompound solutions

    3. Dye and Pigment Precursor Formulation

    3-Bromophenol functions as a functionalized starting material for the synthesis of specific diazo and triarylmethane dyes, where the bromine atom contributes to unique coloration or fluorescence properties. Stringent control of addition and purification is mandatory to minimize trace halide contamination in colorant-grade products, aligning with both technical and eco-label standards.

    Industry compliance standards

    • EN 71-3 (Migration of certain elements, for dyes used in toys)
    • OEKO-TEX® Standard 100 (Textile chemical safety)
    • EU REACH Annex XVII (Restrictions on colors and additives)
    • ISO 9001-certified dye manufacturing protocols

    Typical usage ratio

    • 0.6 – 1.0 weight percent relative to total reactants, optimized for targeted chromophore yield and downstream coupling efficiency.

    Downstream process integration

    • Employed during the pre-condensation stage for diazotization or as a coupling agent in aromatic ring modifications; purification by recrystallization and solvent extraction is used to ensure dye purity.

    Final product types

    • Azo, anthraquinone, and triarylmethane dye intermediates
    • Specialty pigments for inks, plastics, and textile fibers
    • Colorant concentrates for high-performance applications

    4. Synthesis of Specialty Chemical Monomers

    Within the specialty polymers and resins sector, 3-Bromophenol offers a phenolic building block for monomer production utilized in high-temperature plastics, photoresists, and composite adhesives. Incorporation at the oligomer precursor stage allows downstream users to design molecular weight and resin functionality while maintaining compliance with polymer-grade purity requirements and sector-specific emission control regulations.

    Industry compliance standards

    • ISO 14001 (Environmental management for chemical production)
    • FDA 21 CFR Part 177 (Indirect food additive polymers, where applicable)
    • UL 94 and RoHS (for polymer flame retardancy and hazardous substance limits)
    • REACH and polymer-specific registration

    Typical usage ratio

    • 1.2 – 1.8 molar equivalents, calculated according to targeted resin chain length and functional end groups as specified by customer formulation or ASTM process guidelines.

    Downstream process integration

    • Dosed during initial monomer formation by nucleophilic substitution or catalyzed coupling, preceding polycondensation or polymerization steps under controlled temperature and inert atmosphere conditions.

    Final product types

    • Epoxy and phenolic resin monomers
    • Specialty photoresist materials for microelectronics
    • Engineered adhesive and coating compounds with enhanced thermal or chemical resistance
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    Certification & Compliance
    More Introduction

    3-Bromophenol: Focused Performance for Purposeful Production

    Our Experience Manufacturing 3-Bromophenol

    Manufacturing 3-Bromophenol calls for a well-orchestrated approach from the very beginning. Over years spent refining our production, we realized that the quality of the final product depends just as much on the reliability of starting materials as on the wisdom built into every process step. We source crude phenol and bromine that consistently meet our strict internal standards, since anything less eventually surfaces as an issue during final purification or in the properties of the product made downstream. In our plants, we track each batch from raw materials to the glass bottle, because people who work with this compound downstream deserve consistency in every order.

    The reaction process is controlled closely to steer the bromination precisely to the meta position. A small deviation here can give rise to isomeric impurities or cause the reaction to stall before completion. Even after years developing this product, minor tweaks to temperature ramps or solvent ratios still make a noticeable difference in yield and purity. Only a manufacturer with long-term hands-on production can speak to these challenges or shape process controls tightly enough to keep the finished product within narrow analytical bands. At scale, too many shortcuts eventually compromise outcomes—nobody wants to discover this through a failed run or a rejected customer shipment.

    What Makes Our 3-Bromophenol Distinct

    Finished 3-Bromophenol comes off our lines as a crystalline solid, white to pale beige, with a sharply chemical, phenolic odor. Our experience shows that subtle process differences affect both color and odor—signs that trace impurities remain. We prioritize controls that avoid exposure to high temperatures or air at sensitive process stages. By using multi-stage distillation and crystallization, we reach higher purity on a consistent basis, so less post-processing is needed by end users who rely on the material for complex syntheses.

    We provide 3-Bromophenol with purity exceeding 99% as determined by gas chromatography. Any residual isomers or starting materials are tracked closely. Analysts in-house run multiple methods to rule out contamination, since even trace halogenated impurities can disrupt follow-on reactions or affect product color downstream—especially in pharmaceutical and agrochemical syntheses built on this key intermediate. End users often report fewer downstream side products and higher overall yields when they switch to our grades, a trend backed by their data and our own quality reports.

    Model and Specifications That Matter on the Floor

    The model most commonly requested by large chemical producers and R&D groups is our granular or crystalline product, packed in sealed containers designed for straightforward handling in labs and plants. We keep particle size distribution tight to aid precise Weighing and rapid dissolution. Consistent melting range, maintained from batch to batch, gives confidence to technicians monitoring each run. In our experience, color and melting point variation signal process deviations, so we track them in every unit produced.

    Moisture matters just as much. 3-Bromophenol is hygroscopic; it picks up water from the air, especially in humid months. Water has a way of sneaking into glassware and reactors, subtly affecting yields, reactivity, and downstream purification. For this reason, we ship all product in airtight packaging with robust seals; for critical users, we fill each bottle in a nitrogen-flushed, low-humidity environment. Failing to control moisture shows itself in erratic performance and the presence of tiny droplets on long-term storage. Years ago, an autocatalytic degradation issue taught us the hard way that skipping the triple-sealing process to save time is never worth the risk.

    Why Direct Manufacturer Supply Pays Off

    Direct sourcing from our manufacturing floor ends the chain of questionable repacks or improperly labeled product. End customers avoid surprises that sometimes occur with intermediaries who mix products from different origins or bulk and repack without the right equipment. We track the lineage of every drum, each labeled to allow for real-time traceability if a quality question arises.

    Having command over each production stage means we can respond to custom requests in particle size, packaging, or documentation—changes that resellers rarely accommodate effectively. For instance, our team once worked with a specialty pigment maker who needed 3-Bromophenol in a non-standard mesh size so they could avoid clumping during a blend. By adjusting the crystallization protocol and screening at a finer mesh during drying, we met their request without sacrificing batch-to-batch consistency. Their colorists saw immediate benefit in mixing behavior and hue of the finished pigment, a result confirmed in their quality control logs.

    Our role goes beyond just supplying a drum or bottle. Technical support and troubleshooting make a real difference for users tackling new synthetic routes or scaling proven recipes. Over the last decade, our staff fielded dozens of calls every year from researchers confronted by unexpected outcomes—a haze in solution, slower-than-expected reaction speeds, or unexplained side reactions. Because we run the reactors ourselves and solution-test each batch, our team helps troubleshoot whether the root cause stems from the bromophenol or an unrelated variable upstream. On occasion, deeper testing even inside the customer’s own process uncovers pitfalls that generic suppliers tend to overlook, from inappropriate solvent choices to residual acid contamination.

    3-Bromophenol in Practice: What Users Achieve

    On the synthetic bench, 3-Bromophenol plays a pivotal role for pharmaceutical and specialty chemical development. The phenolic ring, functionalized with a bromine substituent in the meta position, opens a unique window for cross-coupling, etherification, and substitution reactions. Medicinal chemists choose this compound as an entry point for creating more complex aryl bromides, anilines, and phenol derivatives with specific bioactivity. Agrochemical developers rely on 3-Bromophenol’s structure to introduce halogenated and protected motifs, building molecules that withstand tough environmental stressors or target specific pest pathways.

    In dye chemistry, our customers apply this product as a precursor for more sophisticated aromatic intermediates. The controlled reactivity of the bromine handle steers selectivity in multi-step syntheses. Some custom colorant producers have leaned on 3-Bromophenol as a base to achieve shades that remain color-fast in textiles or plastics. Close control over each impurity matters here, as trace metals or alternative halogens muddy the color palette, or even sabotage the stability required by demanding applications.

    Across uses, our best feedback comes from customers who need guaranteed reproducibility. Each kilogram of our 3-Bromophenol supports streamlined process validation, especially when developing regulatory dossiers or scaling up new syntheses. Consistency in analytical profiles noticeably reduces the need to chase down root causes for strange baseline spikes or product contamination. The confidence that arises from this stability enables users to focus on innovation, quality control, and rapid commercialization, instead of firefighting raw material uncertainty.

    Differences and Decisions: 3-Bromophenol vs. Similar Products

    In the broader landscape of halogenated phenols, timing and placement matter. 3-Bromophenol’s meta-relation between bromine and hydroxyl groups creates different electronic and steric properties than its ortho- or para-substituted cousins. Researchers working with aryl coupling or nucleophilic aromatic substitution reactions report that their outcomes shift dramatically when using the meta product, compared to 2- or 4-isomers. The reactivity and orientation allow synthesis designers to fine-tune routes toward more complex compounds without introducing unwanted side-reactions or misdirected functionalization.

    Compared to simple phenol, brominated derivatives offer a launching pad for a suite of downstream modifications. The meta-bromine directs further substitutions to the right sites on the aromatic ring, while also activating or deactivating key intermediates in a way that pure phenol cannot. For applications requiring multi-step transformations or secondary functionalizations, users report that choosing 3-Bromophenol often saves steps down the line, avoiding harsh conditions or the need to protect and deprotect functional groups repeatedly—a revelation only apparent after careful benchwork.

    Within the family of aryl bromides, the choice between 3-Bromophenol and its close relatives depends on both the electronic effects and the specific synthesis goals. Switch to 2-Bromophenol or 4-Bromophenol and different steric interactions and reactivity patterns begin to dominate. These differences rarely show up in textbooks, but from our conversations with experienced synthetic chemists, they often uncover themselves in stubbornly low yields or mysterious byproducts. Laboratories intent on discovering or refining new active ingredients usually experiment with each isomer side by side; our records show that precision in isomer identity reduces bench time and cost—especially in larger campaigns.

    Risk Management: Purity, Safety, and Sustainability in Practice

    3-Bromophenol, though not as notorious as some heavier halogenated aromatics, presents its own set of handling and regulatory challenges. Over the years, we’ve invested in plant infrastructure that keeps exposure to a minimum. Strict handling protocols minimize inhalation and cutaneous contact, and dedicated lines prevent cross-contamination with other hazardous materials. Security of supply only works when safety is part of every batch cycle, not a once-a-year exercise for auditors.

    Environmental controls, often overlooked in smaller operations, predict whether minor spills or emissions morph into compliance issues. As discharge limits and regulatory expectations tightens globally, we focus on capturing fugitive emissions and managing effluent load in every campaign. Our water treatment systems, which have been upgraded several times, specifically target phenolic and halogenated compounds prior to discharge. Some years ago, investing in improved solvent recovery reduced our hazardous waste footprint, convincing not just our own management but also our local communities of the value embedded in sustainable production.

    Disposal, while often a last thought for traders, stretches deep into a manufacturer’s operations. Unwanted off-spec material, process residues, and expired inventory require careful collection and tracking, since lingering just a few drums too long can create unnecessary risks. Our protocols require thorough documentation and neutralization before disposal, and long-term partnerships with licensed disposal providers ensure that finished and process waste leaves our site as intended.

    Continuous Improvement and Partnership in Production

    Practicing continuous improvement raises the bar in each campaign. Over the past two decades, we have adjusted distillation endpoints, improved solvent recycling, and re-trained staff on the changing regulatory landscape. Even when 3-Bromophenol production appears routine, lessons emerge from every shift—a crystallizer behaving differently on a hot summer day, a slight yellowing after an unusually long hold, or a discovery that a new filter media slices hours off a laborious cleanup. By listening to experienced operators and not just the lab’s spreadsheets, we close the loop on process drift before it hits the customer’s hands.

    Real partnerships develop not through volume business but by keeping eyes open to long-term risk and growth. Some of our clients have entrusted us for over a decade, bringing their toughest raw material challenges and product launches to our plant for advice and support. Often, we collaborate on improvements—trialing lower-dust products, developing custom labeling, or tackling trace impurity issues together. These conversations steer product upgrades that would be missed by those disconnected from the tough questions faced by real-world chemists under real deadlines.

    Conclusion: What Counts Today and Tomorrow

    Offering high-purity 3-Bromophenol brings technical responsibilities and rewards. As the manufacturing world evolves, expectations on traceability, environmental stewardship, and technical guidance increase in lockstep. Those producing this compound without full process control or awareness of downstream impacts often introduce risk and inefficiency that show up late in the supply chain. Based on direct experience—across maintenance calls, late-night troubleshooting sessions, and years of steady customer relationships—we see that a genuine manufacturing approach rooted in detail, improvement, and customer dialog stands apart.

    In a world where so much chemistry depends on reliability and openness, the more we share about the realities, surprises, and lessons of producing 3-Bromophenol, the better those downstream can plan, innovate, and succeed. Each drum, bottle, and kilogram produced carries not just a molecular standard, but an understanding built from patience, rigor, and respect for the complexity of modern synthesis. Those seeking dependable inputs for real-world outcomes know that choosing manufacturer-direct means more than just price or specification—it means partnering with those who live the challenges, know the answers, and invest in getting both product and process right.