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3,6-Dihydroxyphthalonitrile

    • Product Name 3,6-Dihydroxyphthalonitrile
    • Alias 3,6-Dihydroxy-1,2-benzenedicarbonitrile
    • Einecs 703-114-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    712267

    Product Name 3,6-Dihydroxyphthalonitrile
    CAS Number 33999-38-9
    Molecular Formula C8H4N2O2
    Molecular Weight 160.13 g/mol
    Appearance Off-white to light beige powder
    Melting Point 234-236°C
    Boiling Point Decomposes before boiling
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically ≥98%
    Storage Conditions Store in a cool, dry place, tightly closed
    SMILES C1=CC(=C(C(=C1O)C#N)O)C#N

    As an accredited 3,6-Dihydroxyphthalonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 25g of 3,6-Dihydroxyphthalonitrile is supplied in a sealed amber glass bottle with a tamper-evident screw cap.
    Shipping 3,6-Dihydroxyphthalonitrile is shipped in tightly sealed containers to prevent moisture absorption and contamination. Packages are labeled according to hazardous chemical regulations and handled with personal protective equipment. Transport is conducted via ground or air in compliance with local and international safety standards, ensuring a stable environment and temperature control.
    Storage 3,6-Dihydroxyphthalonitrile should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Store at room temperature and avoid excessive heat. Ensure that the storage area is labeled and has appropriate safety protocols in place to prevent unauthorized access and accidental exposure.
    Application of 3,6-Dihydroxyphthalonitrile

    Applications of 3,6-Dihydroxyphthalonitrile in Industrial Manufacturing

    3,6-Dihydroxyphthalonitrile serves as a critical intermediate in several high-value industrial sectors. Our manufacturing expertise supports global clients who require this specialty raw material for advanced synthesis processes, with strict attention to traceability, batch consistency, and regulatory adherence. We outline below the primary application scenarios confirmed by end-users within specialized industries.

    1. Phthalocyanine Pigment Synthesis for High-Performance Coatings

    Manufacturers employ 3,6-dihydroxyphthalonitrile as a key building block in the production of phthalocyanine pigments. This application supports advanced coatings for automotive, industrial, and marine sectors, where pigment purity directly influences product consistency. The synthesis stage incorporates the material into a multistep cyclization under high-temperature catalytic conditions, yielding pigments of superior chromatic performance and heat stability. Stringent raw material traceability and batch approval ensure pigments meet the exacting requirements of downstream coatings formulators.

    Industry compliance standards

    • DIN EN 13300 (Paints and varnishes – Classification of paints)
    • EU REACH Regulation (EC) No 1907/2006
    • ISO 9001:2015 (Quality management for pigment production)
    • ASTM D3722-05 (Standard Test Method for Pigment Characterization)

    Typical usage ratio

    • Ranges from 0.6 to 1.2 mole per mole of metal salt precursor, adjusted based on target pigment shade intensity and processing yield

    Downstream process integration

    • Charged at the cyclotetramerization stage during pigment synthesis
    • Enters reaction vessel pre-blended with nitrogen bases and selected catalysts
    • Batch QC protocols confirm conversion before isolation and purification

    Final product types

    • Automotive and industrial paints
    • Powder coatings for appliances and metalwork
    • High-solid marine paints
    • Color masterbatches for plastics

    2. Advanced Electronic Materials: Organic Semiconductor Precursor

    In the field of organic electronics, leading device makers use 3,6-dihydroxyphthalonitrile as a precursor for specialized phthalocyanine derivatives. These materials achieve high carrier mobility and stability in organic field effect transistors (OFETs) and photovoltaic cells. The compound’s defined substitution pattern enables straightforward functionalization, supporting tight molecular weight distribution needed for reliable thin-film deposition. Our strict analytical release ensures the active intermediate integrates across high-purity electronics manufacturing campaigns.

    Industry compliance standards

    • JEDEC Solid State Technology Association Guidelines
    • IEC 60747-1 (Semiconductor devices – General requirements)
    • ISO 14001:2015 (Environmental management in electronics manufacturing)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)

    Typical usage ratio

    • 0.95–1.1 equivalents relative to the anhydride/halide coupler, based on desired film thickness and electronic properties

    Downstream process integration

    • Dissolved into high-purity solvents for solution-phase polymerization
    • Introduced prior to the coupling step in organometallic synthesis reactors
    • Purified intermediate moves to thin-film deposition on silicon or flexible substrates

    Final product types

    • Organic field-effect transistors (OFETs)
    • Flexible printed solar cells
    • Photoactive layers for smart packaging
    • Semiconducting inks for sensor arrays

    3. Pharmaceutical API Intermediate for Macrocyclic Compounds

    Several pharmaceutical companies source 3,6-dihydroxyphthalonitrile to act as a regioselective intermediate in the production of macrocyclic drugs, especially those leveraging metal-phthalocyanine scaffolds for diagnostic imaging and targeted therapy. The controlled introduction of dihydroxy functionality supports high-yield routes and enhances downstream linker chemistry. Manufacturers demand full impurity profiling, enabling integration with validated cGMP-compliant API lines without risk of cross-contamination.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP–NF Monographs (Pharmaceutical Intermediates)
    • EU GMP Directive 2017/1572
    • 21 CFR Part 211 (cGMP for Finished Pharmaceuticals)

    Typical usage ratio

    • 0.8–1.05 mole per macrocyclic core, adjusted during route optimization based on reaction efficiency and regulatory batch yield

    Downstream process integration

    • Pre-loaded into the cyclization step of the API synthetic route
    • Intermediate isolated and further functionalized via selective metalation or ligand attachment
    • Full traceability batch documentation

    Final product types

    • Phthalocyanine-based MRI contrast agents
    • Photodynamic therapy (PDT) drug substances
    • Synthetic macrocycle APIs
    • Ligand precursors in targeted drug delivery systems

    4. Specialty Polymer Additives and Functional Polyimide Components

    Producers in the specialty polymer sector integrate 3,6-dihydroxyphthalonitrile to enhance the thermal and electrical properties of aromatic polyimides and related high-performance polymers. The dihydroxy substitution provides additional site functionality for ladder polymer formation, improving resistance to thermal degradation and electrical breakdown. Our material undergoes rigorous lot release with detailed impurity screens to ensure resin properties meet technical datasheet specifications for aerospace and defense applications.

    Industry compliance standards

    • ASTM D4066 (Standard Classification for Nylon and Polyimide Materials)
    • ISO 9001:2015 (Quality management for advanced polymers)
    • UL 94 (Flammability Testing for Plastics)
    • AS9100D (Aerospace Quality Management)

    Typical usage ratio

    • 5–12% by weight in amino acid–imidization blends, tailored based on molecular weight targets and heat deflection requirements

    Downstream process integration

    • Premixed into polycondensation batches with aromatic dianhydrides and diamines
    • Enters extrusion or casting process for film, fiber, or molded component manufacture
    • Added at the pre-polymer stage for thermal curing

    Final product types

    • Flexible printed circuit boards (FPCBs)
    • High-temperature wire insulation
    • Precision aerospace insulators
    • Dielectric films for capacitors and electronic devices
    Free Quote

    Competitive 3,6-Dihydroxyphthalonitrile prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 3,6-Dihydroxyphthalonitrile: Experience Rooted in Authentic Chemical Production

    Every Batch, Made with Care: What Sets Our 3,6-Dihydroxyphthalonitrile Apart

    Long hours in the plant have shown us the difference between theory and practice. 3,6-Dihydroxyphthalonitrile sits in that exact space—between an idea on a page and the real-world challenge of repeatable, reliable chemical synthesis. As manufacturers, we don’t just look at grams and purities on a certificate. We pay attention to how each granule dissolves in a solvent, how it reacts when subjected to heat, how it handles in day-to-day operations, and the subtleties that never show up on a spec sheet. Over decades, we have learned one thing: consistency is not a checkbox, it's a promise from our team to yours.

    Why Choose 3,6-Dihydroxyphthalonitrile? Manufacturing Wisdom Meets Chemical Precision

    Every kilogram of our 3,6-Dihydroxyphthalonitrile comes from controlled conditions that are born out of both experience and rigorous tracking. You never want variability creeping into your process, and neither do we. Purity levels regularly meet or exceed 98% when checked by HPLC—this is not just a number; it means fewer side reactions, smoother dissolving, and greater process control when used as a key building block.

    Over the years, we have found this molecule’s sweet spot as a core intermediate in phthalocyanine pigment synthesis. Dyes, organic semiconductors, and specialized photoresponsive coatings have all benefited from our refined batches. Our partners in R&D value a supplier who can deliver unwavering quality in both small tins for pilot studies and bulk drums for established production lines.

    Hands-On Manufacturing: What We’ve Learned About Scale, Purity, and Handling

    Grinding 3,6-Dihydroxyphthalonitrile with your own hands reveals the unique crystalline texture true to our process. The scales don’t flinch when measured, there’s no caustic dust in the air, and the powder flows freely from bags, free from unwelcome clumps or moisture. You see, process operators keep a sharp eye not just on the obvious—the dense, off-white color and fine consistency—but also the everyday details. There’s no shoddy caking, no discoloration, no remnant of unwanted solvent.

    Cutting corners never saved anyone time in the long run. In our operation, we’ve invested in direct air handling to minimize dust, stainless steel transfer lines for purity, and after decades, even seemingly small steps—like temperature ramping schedules in final crystallization—have proven to make or break lot-to-lot reproducibility. These steps mean actual savings for end-users: less downtime, easier cleanup, and tighter reaction profiles.

    Specs That Reflect Daily Realities

    Each lot of 3,6-Dihydroxyphthalonitrile is checked at the source, in-line and in the QC lab. The melting point measures sharply, reflecting the careful purification steps. Moisture content hovers near baseline, providing reliable results in moisture-sensitive steps such as phthalocyanine ring closures. From powder sieving to packing, real hands ensure real results.

    Different projects demand different mesh cuts, and because we run our own plant and not a warehouse mixer, custom cuts are always on the table. Vacuum-sealing bulk orders protects product during transit, side-stepping the degradation experienced with open-top packaging. Not many competitors can trace back every batch to a single reactor run, with digital logs and experienced eyes triple-checking key specs before any shipment leaves our gate.

    Field-Tested for Industry Applications

    Customers come to us for our product, but they stay for our understanding. A large pigment plant in the EU once faced issues with incomplete dissolution—their reactor loads clogged mid-stream, causing a shutdown. We visited on-site, analyzed residues, and verified that trace impurities in their other supplier’s batches caused agglomeration under high-pH conditions. With our material, particle distribution and clean conversion led to uniform color strength, higher yields, and, more importantly, fewer maintenance headaches.

    R&D teams in organic electronics tell a similar story. Impurity levels, even down into the ppm range, directly influence device performance. We support these sectors with documentation that doesn’t just read as paperwork—it comes straight from side-by-side runs with known standards, giving our customers the edge in competitive markets.

    Innovation in Every Order, Large or Small

    We never rest on old successes. Small-batch researchers receive the same attention as large-scale buyers. Years ago, a startup developing new photovoltaic materials requested tightly fractionated cuts of 3,6-Dihydroxyphthalonitrile, seeking a rare particle size distribution. Our plant team adjusted mill settings, tested the batch repeatedly, and delivered granules that matched the new process. That company now operates at scale, with their new line built on that foundation.

    Repeatedly, customers let us know how the right particle size reduces waste and delivers higher throughput in high-shear mixers. It may seem minor, but many plant managers recognize that these details add up to smoother operations and fewer headaches.

    How Our 3,6-Dihydroxyphthalonitrile Stands Apart

    Any chemical manufacturer can list purity, color, and particle size. Years on the job reveal meaningful differences. We do not ship untested or repackaged product. Each lot runs through dual-layer checks: in-process analytics using chromatography and spectroscopy, and final checks against industry benchmarks. Every operator in the plant knows these steps and how missed details can delay, or destabilize, downstream synthesis.

    Transport packaging cannot be overlooked. Lightweight, multi-layer bags, lined drums, and vacuum sealing keep both product and end-user safe. What we have learned is that moisture, once picked up during transit, can catalyze degradation—not just in storage rooms but inside reactors. Our tight packaging ensures this issue remains anecdotal, not routine.

    Feedback loops matter. We don’t simply hand off a shipment and walk away. Customers who share reaction notes or QA findings get direct answers from the teams who made their batch. This feedback sparks changes in both process and packaging—if someone reports a new downstream requirement, the lab revisits test protocols to reflect these real-world needs.

    Comparing Against Commodity, Repacked, or Third-Party Options

    Talking shop with buyers who have wrestled with off-spec batches, contamination, or late deliveries made one thing clear: not all 3,6-Dihydroxyphthalonitrile on the market is equal. Lab-grade, factory-sealed product from the source brings clear added value. Our samples undergo stability studies under accelerated conditions, so users receive actual, workable data, not speculation.

    We source raw materials directly from known suppliers we have audited ourselves. No unknown intermediates pass through our doors. This prevents foreign particle carryover and trace cross-contamination, which can derail sensitive work in fabrication of organic dyes or optical materials. Such “hidden” impurities often go unreported in articles or brochures, but production chemists see their impact: stuck filters, deactivated catalysts, or unplanned process downtime.

    Logistics operations rarely receive the spotlight, but we have seen production suffer from delayed or mishandled shipments. Keeping everything in-house—from synthesis to packaging to shipping—cuts down on uncertainty. Our warehouses operate climate-controlled spaces, and traceability never leaves a gray area. If a buyer requests historical analysis, the records track back through time-stamped entries maintained by the production team.

    Listening to Chemists and Operators: Practical Considerations

    We listen to plant chemists who prepare several liters of intermediate per week, not just lab managers overseeing one-time projects. Many share stories about competing products clumping in storage or leaving behind insoluble residues. Our operators engage in long-term storage tests because shelf life isn’t just a bullet point—it’s a question of dollars and lost hours when product is found unusable.

    How 3,6-Dihydroxyphthalonitrile behaves in the real world depends on these details. Transferring the product from bag to reactor should keep the floor clean and reduce airborne dust. Fresh shipments from our plant achieve this because care was taken at every step—to keep the particle size even, avoid static cling, and prevent the packaging from picking up odors from other warehouse goods.

    Working With You for Every Use Case: Customization and Flexibility

    Industrial purchasing does not follow a one-size-fits-all script. Sourcing managers want accurate scheduling and clarity on grades. Our depth of experience means we can blend small, high-purity research lots or scale up to multi-ton orders on short notice—all while maintaining full transparency on lead times.

    Some users require extremely fine powder for rapid dissolution, while others find larger granules ease dosing and piping. We work with customers to specify what works best—and we document these changes to preserve quality across repeat orders. In every case, real people answer technical questions and recommend options based on results, not theory.

    A Word About Sustainability and Compliance

    Responsible chemical manufacturing includes more than the final product. Waste management, solvent recovery, and reduction of fugitive emissions are built into our day-to-day operations, guided by the experience of operators who know how process choices affect the environment. Solvent residues and byproducts are monitored and recycled wherever possible, documented in internal reports and third-party audits.

    3,6-Dihydroxyphthalonitrile does not just require precise synthesis—it calls for safe handling and process integrity. Our site meets regional and global requirements, with routine internal training and process audits. These aren’t just regulatory checks—they are habits, practiced every week in the plant.

    Real-World Solutions for Real-World Challenges

    Customers sometimes hit unplanned roadblocks, such as unanticipated reactivity with batch additives, or issues scaling from bench to plant. Our technical staff, many of whom have decades in the same plant, regularly walk buyers through troubleshooting, offering insight from mistakes and successes alike. This gives our clients confidence to push R&D forward, knowing both product and support are stable and reliable.

    Unexpected problems have also led us to engineer bulk packaging designed to withstand long, hot sea journeys or storage in unventilated warehouses. We now monitor container integrity in real time, catching issues early. Through years of exchanges with downstream processors, we've incorporated these learnings into procedural standards that prevent most common pitfalls.

    Difference You Feel in the Final Product

    A chemical is more than the sum of its atoms when it passes through skilled hands. Our product’s real value becomes clear during use: fewer false starts, more reproducible yields, and an easy shift from the lab bench to scale. Customers who try our 3,6-Dihydroxyphthalonitrile often share that their conversion rates rise and process times shrink. Troubleshooting shrinks to small, manageable tweaks instead of root-and-branch overhauls.

    Our approach generates measurable returns. Years of strict screening ensure that nagging process issues, like sporadic yields or wasteful purification, rarely appear. By choosing a source built on knowledge, not just machinery, users experience the difference batch after batch.

    Looking to the Future: Ongoing Collaboration

    As new technologies demand stricter tolerances and cleaner reactions, we remain focused on the principles that only real manufacturing experience can bring. 3,6-Dihydroxyphthalonitrile remains at the core of a wide range of critical applications—from sustainable pigments to next-generation functional materials. Our role as a manufacturer goes beyond delivering a compound; it means constantly improving so your processes can, too.

    Continuing to listen, adapt, and innovate creates the kind of product that doesn’t just fill a line in a catalog. Instead, it powers the processes, discoveries, and businesses that shape tomorrow’s world. That’s always been our aim—and always will be.