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2-Nitrobenzenearsonic Acid

    • Product Name 2-Nitrobenzenearsonic Acid
    • Alias Arsanilic acid
    • Einecs 207-439-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    988446

    Chemical Name 2-Nitrobenzenearsonic Acid
    Cas Number 98-96-4
    Molecular Formula C6H6AsNO5
    Molecular Weight 247.04 g/mol
    Appearance Yellow solid
    Melting Point 199-201 °C
    Solubility Water Slightly soluble
    Density 1.85 g/cm³
    Inchi Key XLVGJMTXTAIGRJ-UHFFFAOYSA-N
    Pubchem Cid 77478
    Synonyms Ortho-nitrophenylarsonic acid
    Smiles C1=CC=C(C(=C1)[As](=O)(O)O)[N+](=O)[O-]
    Storage Conditions Store at 2-8°C, dry place
    Hazard Classification Harmful if swallowed; Irritant

    As an accredited 2-Nitrobenzenearsonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with a secure screw cap, clearly labeled for 100 grams of 2-Nitrobenzenearsonic Acid, including hazard warnings.
    Shipping 2-Nitrobenzenearsonic Acid should be shipped in tightly sealed, chemical-resistant containers, clearly labeled with hazard warnings. Protect from moisture, heat, and incompatible materials. Transport according to local, national, and international regulations (e.g., DOT, IATA), classifying as hazardous material. Include appropriate documentation and safety data sheets (SDS) with the shipment.
    Storage 2-Nitrobenzenearsonic acid should be stored in a cool, dry, well-ventilated area, away from sources of heat or ignition. Keep the container tightly closed and protected from direct sunlight and moisture. Store separately from incompatible materials such as strong oxidizers and bases. Proper chemical labeling and secure shelving are recommended to prevent leaks, spills, and accidental exposure.
    Application of 2-Nitrobenzenearsonic Acid

    Applications of 2-Nitrobenzenearsonic Acid in Industrial Manufacturing

    2-Nitrobenzenearsonic acid serves as a specialized intermediate in several tightly regulated industrial sectors. Our manufacturing process ensures high purity and compliance for consistency in downstream applications. Below, we detail specific industrial uses with corresponding regulatory, formulation, process, and end product information.

    1. Veterinary Feed Additives for Poultry Nutrition

    Feed manufacturers incorporate 2-nitrobenzenearsonic acid as a controlled organoarsenic source for enhancing weight gain and improving feed efficiency in poultry, particularly broiler chickens and turkeys. Regulatory frameworks strictly govern its use, requiring precise adherence to concentration limits during the premix blend stage. Dosing is closely monitored according to target species and production cycle. Finished feeds containing organoarsenic compounds undergo frequent residue and quality control checks as mandated by national livestock authorities.

    Industry compliance standards

    • U.S. FDA 21 CFR 573.35 regulations for arsenical feed additives
    • EU Regulation (EC) No 1831/2003 on additives for animal nutrition
    • China Feed Additive Standards GB 7300/GB 22254
    • ISO 22000 Feed Safety Management System

    Typical usage ratio

    • 5–45 g active compound per metric ton of complete poultry feed, adjusted for bird species and regional regulatory limits
    • Often introduced at the premix or concentrate preparation stage to ensure uniform distribution

    Downstream process integration

    • Dosed during formulation of vitamin-mineral premixes and incorporated via automated dosing units
    • Blended into finished feed using paddle mixers with strict batch segregation protocols to prevent cross-contamination
    • QC sampling at multiple production points, including post-mixing and post-pelleting

    Final product types

    • Medicated broiler grower feeds
    • Turkey starter and grower feeds
    • Poultry concentrate premixes

    2. Pharmaceutical Intermediate for Antiprotozoal Veterinary Drugs

    Veterinary pharmaceutical producers use 2-nitrobenzenearsonic acid as a critical chemical intermediate for synthesizing organoarsenical compounds deployed in the control of protozoal infections in livestock. These synthetic steps require defined reaction conditions, with purity and identity established by compendial analysis. Arsenical active pharmaceutical ingredients (APIs) are produced under cGMP with full traceability.

    Industry compliance standards

    • Chinese Veterinary Pharmacopoeia (2020 Edition)
    • FDA CVM Good Manufacturing Practices (21 CFR Part 211)
    • European Pharmacopoeia (Ph. Eur.) monographs related to veterinary APIs
    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients

    Typical usage ratio

    • Stoichiometric quantities based on target API synthesis—generally 100–130% of theoretical, depending on process yield
    • Batch-specific control to minimize unreacted starting material

    Downstream process integration

    • Added during the nitration or condensation step for API synthesis
    • Monitored by HPLC/GC during intermediate isolation and purification
    • Trace impurity and heavy metal testing in bulk API and finished pharmaceutical dosage form

    Final product types

    • Antiprotozoal oral suspensions for livestock
    • Injectable solutions for bovine and ovine coccidiosis
    • Drinking water medications for poultry and swine

    3. Dye and Pigment Intermediate Manufacturing

    Chemical processors utilize 2-nitrobenzenearsonic acid as a diazo coupling or condensing component in the synthesis of specialty organic pigments and metal-complex dyes. Its integration enables tailored molecular structures for color strength, shade, and fastness required by the textile and printing ink sectors. The process demands cleanroom handling and validated waste management in plant operations.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 (for chemical handling and registration)
    • Zero Discharge of Hazardous Chemicals (ZDHC) for textile chemical input
    • ISO 9001:2015 Quality Management for pigment and dye manufacturing
    • Oeko-Tex Standard 100 for final product safety conformity

    Typical usage ratio

    • 10–25% by weight in synthesis step, adjusted to influence chromophore structure or yield
    • Reaction scale based on downstream demand planning and color specification

    Downstream process integration

    • Reacted during initial azo or metallization synthesis procedures
    • Purification via multi-stage filtration, crystallization, and drying
    • Color properties tested in application trials on natural or synthetic fibers

    Final product types

    • Textile reactive dyes for natural fibers
    • Pigments for industrial coating formulations
    • Special effect inks for packaging and security applications

    4. Chemical Intermediate for Organic Arsenic Compounds in Analytical Reagents

    Producers of analytical reagents and laboratory testing kits employ 2-nitrobenzenearsonic acid in the manufacture of standard solutions and derivatization chemicals used for arsenic detection and quantification. Its inclusion provides high traceability and facilitates accurate calibration across a range of analytical methods for trace metal analysis in food, water, and biological samples.

    Industry compliance standards

    • ISO 17034:2016 for Reference Material Producers
    • USP General Chapter <11> for Reagents, Indicators, and Solutions
    • EN ISO/IEC 17025:2017 for laboratory process compliance
    • EPA SW-846 Test Methods for Evaluating Solid Waste

    Typical usage ratio

    • Prepared as standards in 0.01–100 mg/L solutions for calibration curves
    • Concentrations and handling protocols determined by analytical method sensitivity and matrix type

    Downstream process integration

    • Dissolved in ultrapure solvents during analytical reagent preparation
    • Aliquoted and sealed in certified ampoules within ISO-grade clean environments
    • Subject to batch release testing using mass spectrometry and titrimetry

    Final product types

    • Certified reference materials (CRMs) for arsenic calibration
    • Analytical grade test kits for trace arsenic quantification
    • High-purity derivatization reagents for laboratory and field testing
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    Certification & Compliance
    More Introduction

    2-Nitrobenzenearsonic Acid: Product Insights from the Factory Floor

    Producing 2-Nitrobenzenearsonic Acid over years at our facility has given us a pretty direct perspective on what this specialty chemical brings to the table. This compound comes with the CAS number 98-88-4, and our team recognizes its specific qualities—not just on the spec sheet but during the manufacturing process itself. Some people in the field call it ‘p-arsanilic acid’ or 'NBSA', but we always check context because that sometimes causes confusion with similar-sounding substances.

    Our Model and Approach to Manufacturing

    Making 2-Nitrobenzenearsonic Acid calls for a careful approach to raw materials and process design. Every batch starts with pure aniline derivatives, handled under tight controls to minimize batch-to-batch drift. Plant operators monitor temperature and pressure, especially during the diazotization and subsequent arsonation steps. Extreme care, in both safety and quality, stays essential on this line. Even a small deviation in acidity can lead to impurities the customer does not want to see.

    Our standard model features a fine, off-white to yellowish powder, typically around 99% purity by HPLC with low moisture content, matching what technical and industrial users have told us they need. We run regular NMR and elemental analyses, focusing on the arsonic content and organic purity, instead of trusting only legacy titration procedures. This lets us catch problematic byproducts before they reach drums or bags, keeping our downstream partners clear of unwanted surprises.

    Meeting Real-World Demands

    Users from dye synthesis to animal nutrition expect consistent performance, so our quality control team tracks not just assay numbers but physical handling properties—granulation, dust, and water solubility come up as routine talking points with bulk buyers. Our loading dock team doesn’t just see a commodity in a bag: In some cases, 2-Nitrobenzenearsonic Acid gets further processed into veterinary feed supplements, where the granule breakdown rate influences how evenly it disperses. Process engineers in textile intermediates check for color stability and compatibility with other aromatic nitro compounds—the fine margins make a difference.

    Unlike more basic arsonic acids or the widely used arsanilic acid, this nitro-functionalized variant supports very specific chemical transformations. Synthetic chemists count on its aromatic nitro group for reactivity, giving them an extra handle when building more advanced molecules. Our feedback loop with these customers has shown that substitution patterns, and stabilization of the arsonic acid group, can make or break a synthesis run. Nobody wants to explain a ruined lot or a failed step when an order is urgent.

    Why Process Details Matter

    We've refined filtration and washing procedures over the years for a reason: In some early runs, we found persistent inorganic salt contamination that kept popping up in certain applications. Drying at too high a temperature seemed to yellow the product, while too low left excess moisture that barely showed up on the “standard” tests but led to caking and difficult pouring for downstream users. This feedback came right from the lab—the kind you only get after a lot of hands-on work. These experiences convinced us that reproducible drying profiles deserve just as much focus as the front-end reaction yields.

    The choice of mother liquor recycling creates fewer waste issues and lets us recover arsonic intermediates that otherwise would have gone straight out the effluent line. Our environmental specialists monitor both the liquid and solid effluent, checking for any off-target organic load or heavy metal presence. Consider the arsonic group—a known environmental concern if not carefully handled. Facilities wrestling with aging treatment systems risk failing local discharge limits, so we design every production run to allow stand-by containment and real-time sampling points.

    Comparing 2-Nitrobenzenearsonic Acid with Similar Products

    Some new contacts approach this compound expecting the same behavior as plain arsanilic acid, but the difference between a nitro- and non-nitro-substituted ring goes far beyond what’s on paper. The nitro group doesn’t just change the basicity or acidity; it alters how the molecule engages with electrophilic aromatic substitution and with reduction chemistry. From a practical viewpoint, this means applications in dyestuff intermediates benefit from easier modification routes, especially when subsequent reductions or coupling reactions are on the agenda.

    On the physical side, granule firmness and hydroscopicity tend to differ from alternatives lacking the nitro group. This influences every handling step, especially bulk loading or pneumatic transfer. We've calibrated both manual and automated bagging lines to avoid dust generation, and our teams measure particle size distribution on each lot. Those granular differences show up in both simple assays and in how evenly feeders deliver product in continuous processing plants. Some competitive materials might boast a shinier powder, but end users report that those supposedly “superior” grades clog lines faster or pick up humidity in open hoppers.

    Putting Safety and Compliance Up Front

    Any factory handling arsonic acids takes workplace safety and regulatory compliance as foundational, not afterthoughts. The same electrified conveyor that boosts efficiency could become a static ignition source if protocols get lax. Our process safety reviews mapped out lightning protection and ensured all vessels and bagging stations carry antistatic grounding. We pressure test filtration units before every shift, and every worker receives practical training on safe transfer and spill containment—backed by regular drills that simulate equipment failure or sudden release.

    Globally, regulatory expectations for arsonic compounds have shifted—a lot. As producers, we keep our documentation up to date, focusing on actual use cases. This isn’t abstract; importers in some jurisdictions ask for full trace metal scans and documentation proving no illegal residues. Some feed producers conduct their own independent audits, sending staff to walk our lines and question our environmental systems. We welcome it, because their trust means more than any certification logo.

    Supporting the Chemistry Community

    We supply more than just a bagged product—we work with colleagues in academic and industrial settings, sharing technical observations on how minor handling differences yield major impacts during scale-up. During consultations, process chemists often note that their university teaching labs struggle to achieve the same level of purity as production grades. In those scenarios, our analytical team shares real exposure data and process logs, rather than generic instruction sheets, so that the handoff from benchtop to pilot plant grows smoother.

    In one collaboration, a research group encountered repeated batch failures due to trace copper pickup from antiquated glassware and stirrers. Our in-house validation team dug into the problem and found the solution rested on switching to inert-coated process equipment, a step that later improved both their yield and final color qualities. These small details—mundane as they seem—become the difference between experiment and production, and can only be learned by handling real product, repeatedly, at real scale.

    Environmental Considerations in Production and Use

    Modern chemical production cannot ignore the environmental footprint. With a compound like 2-Nitrobenzenearsonic Acid, environmental vigilance operates at several stages: raw materials, waste streams, and facility emissions. Arsenic-based substances draw close scrutiny from both regulators and public stakeholders. Our waste minimization strategies begin at the source: reusing filtered mother liquor wherever chemistry allows, neutralizing residual acid waste, and running post-reaction scrubbers during air discharge. Our environmental team maintains data logs not just for quarterly inspection—these records directly influence plant operating targets.

    We’ve had candid talks with local agencies and community representatives about the actual environmental impact, rather than negotiating over border-line values. They appreciate transparency. Over the years, we have invested in secondary containment, soil testing of storage areas, and tightening leak detection around liquid transfer stations. It’s more labor and capital upfront, but clean audits and risk-free operations offer a smoother path than cutting corners for a one-time cost saving.

    End-of-life fate of arsonic acid derivatives attracts mounting concern, especially in veterinary applications. Some scientific studies focus on how these substances pass through livestock and enter the soil ecosystem. Our staff reviews academic literature and tries to stay ahead of emerging research, offering customers suggestions on best practices and encouraging them to raise any data gaps they discover. Working collectively, rather than just as suppliers, helps mitigate systemic risks that could tarnish the industry’s reputation.

    Looking Ahead: Technical and Market Perspectives

    Every production cycle brings questions about scaling, cost management, and supply chain reliability. Raw material prices and transportation volatility force us to maintain inventory buffers, holding additional days of material on hand. Sourcing staff invest time building relationships with primary suppliers—raw aniline, acids, and solvents—since any logistical hiccup could idle a plant. This tight supply chain vigilance differentiates a manufacturer focused on reliability from a trader making opportunistic buys.

    Technical upgrades remain a constant focus. Several years back, we shifted to semi-continuous arsonation reaction vessels. Yield improved by several percent, but what really changed our output was lowered energy input per kilogram and a drop in off-spec waste that used to pile up in repack drums. These mid-scale equipment investments require confidence in customer demand stability, something earned through building long-term partnerships. We track international developments in both animal nutrition and specialty chemicals—knowing which regulatory windows open or close shapes our capital planning.

    On the user side, demand signals show operators in dye manufacture and veterinary premixes expect both purity and supply certainty. Their purchasing teams keep tabs on our historical on-time shipments. We’re obliged to share regular supply chain and production updates, which builds confidence for quarterly and annual contracts. Should a plant shutdown loom (whether for scheduled maintenance or unforeseen issues), we notify partners early, allowing their planners to secure buffer stocks from us and avoid last-minute scurrying.

    Improving Through Engagement and Honest Feedback

    Decades doing this have taught us that getting feedback from real users in the field—processing operators, research chemists, loading crew, even waste handlers—provides the information needed for continual product improvement. Sporadic batch inconsistency in color, even when below established limits, prompts us to trace back every upstream raw material and tighten storage conditions. Talking to users also reveals shifts in desired bag weights, package types, and preferred labeling details. One example: we used to offer only 50 kg drums until multiple downstream feeders lobbied for a 25 kg package that better suited their semi-automated dosing lines. Now, our plant offers both as standard options, and our traceability system lets us audit every lot by source and date.

    We make site visits to key users on a regular basis. While these calls sometimes uncover issues—such as traces of particulate forming on handling equipment, or batch segregation after shipping—they also give our quality assurance staff a real-world sense of how the product performs under tough, variable conditions. We take these observations back to our plant, holding cross-functional meetings with process, packaging, and transportation teams to translate user feedback into action.

    Challenges in the Broader Arsonic Acids Market

    Producers of compounds like 2-Nitrobenzenearsonic Acid operate in a complicated market. Broadly, public opinion about arsenic-based chemicals grows more cautious every year. Some customers ask about alternative synthetic routes or non-arsenic analogs, and a few governments have begun restricting use in traditional animal feeds. In these cases, the response involves a combination of R&D, regulatory engagement, and process transparency—not simply holding on to old product lines and hoping the market rebounds.

    We put research focus on safer alternatives and improved purification. Tighter environmental controls sometimes raise costs in the short term, but they lower risk and demonstrate commitment to both buyer needs and neighbor communities. In markets where restrictions narrow product scope, we provide full dossiers on use cases, risk management steps, and expected performance differences. This level of open technical support stems from our long-term confidence in chemistry as a profession—those who talk straight about real risk and performance last the longest.

    Final Reflections from the Production Team

    At the plant, 2-Nitrobenzenearsonic Acid is not just a specialty line item—it’s a product that demands both technical precision and hands-on skill every day. Handling arsonic compounds means everyone, from shift operators to quality controllers, commits to safety, compliance, and ongoing conversation with users near and far. The technical challenges keep us learning, from raw material selection right through to handling feedback from global users, and we see every batch as a continuation of a collective effort.

    Direct engagement with process improvements, a practical understanding of regulatory shifts, and an ongoing willingness to learn from the field account for the product’s ongoing place in modern manufacturing. Trust, reliability, and a commitment to shared success shape everything about how we make and supply 2-Nitrobenzenearsonic Acid.