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2-Methyl-1-Propanethiol

    • Product Name 2-Methyl-1-Propanethiol
    • Alias isobutyl mercaptan
    • Einecs 201-179-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    294762

    CAS_Number 513-44-0
    Molecular_Formula C4H10S
    Molecular_Weight 90.19 g/mol
    IUPAC_Name 2-Methyl-1-propanethiol
    Synonyms Isobutyl mercaptan
    Appearance Colorless liquid
    Odor Strong, unpleasant, skunk-like
    Melting_Point -120°C
    Boiling_Point 89-90°C
    Density 0.818 g/mL at 20°C
    Solubility_in_Water Insoluble
    Flash_Point -7°C (closed cup)
    Refractive_Index 1.432
    Vapor_Pressure 185 mmHg at 25°C
    PubChem_CID 10470

    As an accredited 2-Methyl-1-Propanethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical 2-Methyl-1-Propanethiol is packaged in a 100 mL amber glass bottle with a tightly sealed screw cap for safety.
    Shipping 2-Methyl-1-Propanethiol is shipped as a hazardous chemical, typically in sealed, corrosion-resistant containers due to its flammability and strong odor. Transport complies with relevant regulations (DOT, IATA, IMDG), often under UN2026. Proper labeling, ventilation, and segregation from incompatible substances are essential to ensure safety during handling and transit.
    Storage 2-Methyl-1-Propanethiol should be stored in a cool, dry, well-ventilated area away from sources of ignition, heat, and incompatible materials such as strong oxidizers. Containers must be tightly closed and clearly labeled. Due to its strong odor and flammability, storage should be in corrosion-resistant containers, preferably in a flammable liquids cabinet, with appropriate spill containment measures in place.
    Application of 2-Methyl-1-Propanethiol

    Applications of 2-Methyl-1-Propanethiol in Industrial Manufacturing

    2-Methyl-1-Propanethiol offers distinct performance as a sulfur source and odorant across several chemical manufacturing sectors. The following sections detail its established uses, technical requirements, dosage conditions, integration into downstream processes, and the types of end-products where it plays a critical role.

    1. Gas Odorization for Industrial Safety

    Major gas utilities and industrial energy providers use 2-Methyl-1-Propanethiol to clearly identify and detect natural gas leaks by incorporating it as an odorizing agent. The substance’s persistent sulfurous scent serves as an early warning signal, directly addressing regulatory public safety mandates. Formulation teams select composition levels based on pipeline length, local regulations, and prevailing atmospheric conditions. Production facilities make product additions at gas terminal or injection points, maintaining continuous quality controls to ensure safety signals remain distinct and stable during distribution under varied flow rates and system pressures.

    Industry compliance standards

    • EN 437 (Test gases for appliances), Europe
    • 49 CFR 192.625 (U.S. DOT Natural Gas Odorization Requirements)
    • ISO 13734 (Specification for odorants in natural gas)
    • GB 50028 (China Design Code for City Gas Transportation)

    Typical usage ratio

    • 3–8 mg per cubic meter of natural gas; adjusted based on odorant fade risk, seasonal volatility, and end-user detection thresholds

    Downstream process integration

    • Metered injection at odorizer stations at main gas pipelines or distribution hubs
    • Continuous real-time monitoring of concentration by in-line sensors
    • Mixing into pressurized gas flow during or after gas cleaning stages
    • Periodic recalibration in response to system throughput or maintenance cycles

    Final product types

    • Odorized utility-grade natural gas supplied to residential, commercial, and industrial consumers
    • Compressed and liquefied petroleum gas (C/LPG) for transportation or energy storage
    • Custom-odorized specialty gases for laboratory and analytical supply
    • Training simulators for gas emergency response drills

    2. Synthesis of Pharmaceutical Intermediates

    Pharmaceutical manufacturers employ 2-Methyl-1-Propanethiol as a key thiolating agent to introduce sulfur-containing functional moieties in active pharmaceutical ingredient (API) precursors. Reaction specificity and yield rely on accurate dosing, consistent purity, and thorough control of thiol incorporation steps within GMP-regulated synthesis environments. Typical use occurs in batch or semi-continuous reactors under controlled temperature and inert conditions to minimize by-product formation. Personnel oversee weighing, charging, and transfer within segregated suites, with batch documentation and analytical verification following pharmacopoeial monographs and audit trails.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 (U.S. FDA cGMP for Finished Pharmaceuticals)
    • EU GMP Volume 4 Part II (APIs)
    • Relevant USP/EP monographs referencing specific APIs

    Typical usage ratio

    • 0.8–2.0 equivalents relative to limiting API precursor, adjusted per R&D scale-up or route optimization

    Downstream process integration

    • Direct addition to heterocycle formation, alkylation, or thiolation steps
    • Charge via closed-loop transfer into jacketed glass-lined or stainless reactors
    • Residence time and thermal ramp controlled to minimize residual by-products
    • Purification of crude intermediates by extraction or crystallization post-reaction

    Final product types

    • Sulfur-modified pharmaceutical intermediates (e.g., penicillins, cephalosporins, ACE inhibitors)
    • Custom building blocks for orphan drug synthesis
    • Chiral resolving agents for specialty APIs
    • Reference standards for analytical laboratories

    3. Agrochemical Active Ingredient Manufacturing

    Chemical plants producing crop protection agents utilize 2-Methyl-1-Propanethiol during the synthesis of thiolated herbicide and fungicide actives. Its controlled reactivity enables precise formation of thiomethyl and tertiary-thio groups, which directly impact the mode of action of several patented molecules. Application engineers monitor purity and dosage per in-house route validation. Additions typically occur through closed system reactors lined for chemical compatibility, often in multi-step runs with in-line monitoring and periodic sampling to meet specifications aligned with agricultural residue limits and regulatory approvals.

    Industry compliance standards

    • FAO/WHO Specifications and Evaluations for Plant Protection Products
    • ISO 9001:2015 for agrochemical manufacturing quality management
    • REACH Annex XVII restrictions (if in the EU supply chain)
    • China’s GB 2763 Maximum Residue Limits for Pesticides in Food

    Typical usage ratio

    • Varies from 1.0–2.5 equivalents to the specific synthesis step; adjusted for molecule structure and yield targets

    Downstream process integration

    • Dosed in stepwise addition during precursor conversion to enhance selectivity
    • Applied after solvent swap or dehydration to maximize pure product output
    • Integrated with solvent recovery systems for emission minimization
    • QC sampling at defined timepoints for traceability

    Final product types

    • Thiolated triazole fungicides
    • Modified sulfonylurea herbicides
    • Custom crop protection intermediates
    • Seed treatment compound bases

    4. Manufacture of Lubricant Additives

    Specialty lubricant formulators deploy 2-Methyl-1-Propanethiol to graft advanced thioester and sulfonate groups onto base oil-soluble antioxidant and antiwear chemistries. This enhances oxidative and thermal resistance in severe-duty lubricants. Accurate ratio of the thiol to reactive intermediates prevents over-sulfurization or unwanted decomposition. Feed is introduced under nitrogen and moderate agitation, with temperature profiles optimized to minimize side reactions. On-line FTIR and sulfur analysis verify end-point completion before downstream blending and final additive package formulation.

    Industry compliance standards

    • ASTM D4951 (Determination of Additive Elements in Lubricating Oils)
    • API Engine Oil Standards
    • ISO 14001 Environmental Management
    • SAE J183 for Engine Oil Performance

    Typical usage ratio

    • 1.2–3.0% w/w of total additive concentrate; fine-tuned according to base oil compatibility and finished oil performance targets

    Downstream process integration

    • Reacted during additive manufacture with overbased sulfonates or antioxidant intermediates
    • Mixed in a closed reactor with continuous agitation and in-line cooling
    • Monitored batchwise for sulfur incorporation and color
    • Blended post-reaction into multi-functional packages for downstream oil blenders

    Final product types

    • Engine oil additive packages
    • Gear and transmission fluid additives
    • Industrial hydraulic and turbine oil packages
    • Heat transfer oil protection blends

    5. Polymerization Chain Transfer Agent

    Polymer manufacturers incorporate 2-Methyl-1-Propanethiol as a chain transfer agent during the free-radical polymerization of certain acrylics, styrenics, and specialty resins. The thiol controls molecular weight and branching structure by terminating growing chains at defined intervals. R&D formulators set dosages via pilot line runs to match target physical properties and processing windows, with regular sampling to assess polymerization kinetics and conversion rates. Addition occurs at initial monomer charging or split between initial and mid-reaction doses for multi-stage reactors. Material is stored and handled under controlled temperature to prevent pre-reaction or odor issues.

    Industry compliance standards

    • ISO 9001:2015 QMS for chemical production
    • Regulatory limits for residual monomer (e.g., EU Plastics Regulation 10/2011)
    • REACH Annex XVII (Industrial monomer and polymer compliance)
    • Customer-specific purity requirements and food-contact testing if applicable

    Typical usage ratio

    • 0.1–1.0% by weight of total monomer feed; tuned to batch size, molecular weight specification, and intended resin properties

    Downstream process integration

    • Charged to monomer solution prior to thermal or initiator activation
    • Feed split for staged additions in semi-batch or continuous reactors
    • Residue removal by vacuum stripping or solvent washing
    • Post-polymerization QA for residual odor and chain transfer byproducts

    Final product types

    • Acrylic elastomers, sealants, or PSAs
    • Specialty copolymers for coatings and adhesives
    • Styrenic resins with controlled polydispersity
    • Low-odor building and packaging polymers
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    Certification & Compliance
    More Introduction

    2-Methyl-1-Propanethiol: A Closer Look from the Manufacturer’s Perspective

    Understanding 2-Methyl-1-Propanethiol in Our Daily Process

    As a chemical manufacturer who works long hours in production, technical teams here know the distinct scent of 2-Methyl-1-Propanethiol before we see it. This compound, with the formula C4H10S, often triggers quick and careful handling from our crew. Our experience goes back decades producing this organosulfur compound for customers in various sectors. You might hear it called isobutyl mercaptan around the industry. Seeing thousands of kilograms flow from tank to drum has taught us a few things beyond what's printed on a basic chemical data sheet.

    Model and Purity from the Production Floor

    Every batch starts with a focus on purity—our current standard process achieves 98 percent minimum purity, which means customers get material with almost no interfering byproducts. We monitor isobutyl aldehyde and other trace volatiles through gas chromatography after every distillation run. Our team adjusts rectification columns daily to hold impurities below 1.5 percent, usually closer to 1 percent. The liquid rolls out crystal clear with a sharply pungent odor—any sign of haze or yellowing triggers a process review. From pilot batches to full railcar loads, we look for low moisture and absence of corrosive residues.

    We produce it in both bulk and smaller sealed packaging, with stainless steel containers as our mainstay. Stainless doesn’t just keep the odor contained; it prevents the product from picking up iron or other metals from the packaging, which could show up in sensitive end-uses. Some customers request added care, asking for nitrogen blanketing during filling to cut down oxygen exposure even further. Our process lines clean with alkali wash after every run. This keeps both the tank and the transfer lines free of evening residues, which translates into better purity and fewer headaches for everyone handling the product downstream.

    Special Properties: More Than Just a Strong Odor

    The first thing that hits newcomers in the plant is that strong, almost skunky smell. For most of our staff, proper PPE is non-negotiable — this compound lingers. Unlike regular propane thiols, the methyl branch at the second carbon introduces a shade of volatility and an unmistakable olfactory note. Our own QC officers can pick out 2-Methyl-1-Propanethiol from other thiols by scent. This property finds commercial relevance in odorant applications. Gas leak warning systems frequently rely on our product because humans sense these molecules long before concentrations reach dangerous levels. No sensor on the market rivals the sensitivity of a human nose to this category of molecules.

    Our analytical teams measure boiling point (close to 68°C at atmospheric pressure) every week, ensuring batch results align with the product’s expectations for purity and consistency. For some applications, the sharp threshold between vapor and liquid phase is a benefit, making it easy to capture and recycle emissions in closed systems. The density and refractive index also come up during blending sessions, especially for clients in flavors or specialty intermediates where compatibility matters.

    Context and Uses: What Sets 2-Methyl-1-Propanethiol Apart

    Drawing from years of sales and technical talks, three main customer segments drive our output for this product. The largest group includes energy companies and municipal safety systems. They rely on 2-Methyl-1-Propanethiol as an odorant for natural gas detection. The compound’s odor threshold sits well below hazardous concentrations—just a trace alerts people to leaks, saving lives and property. We stock data showing how fast our product disperses through pipeline grids, comparing favorably to more linear mercaptans which sometimes lag due to weaker odor characteristics.

    Another segment comes from the flavors and fragrance world. They employ the compound as a building block for more complex molecules, occasionally using it at extremely low concentrations to impart “savory” or “umami” notes in some flavor profiles, or as a precursor in organic synthesis. Only the highest-purity grades leave our plant for these buyers. Every additional impurity can cause off-notes in end products. Our reactor teams follow separate cleaning protocols for these flavor runs, and we maintain glycol traps to catch stray contaminants that might slip through.

    Some technical professionals use 2-Methyl-1-Propanethiol as a specialty intermediate for custom syntheses. Its branched structure adds reaction sites that differ from n-butanethiol or methanethiol. Our R&D team has published measurements showing faster reaction kinetics during certain alkylations and oxidative couplings with tertiary thiols compared to their unbranched relatives. We get requests every month for small-lot runs with tailored sulfur profiles for experimental uses. These clients often ask for test data from our NMR and IR runs, seeking assurance that the product will behave consistently.

    Working With This Compound: Hazards and Hands-On Handling

    Many who visit our facility are surprised by the elaborate ventilation and odor control systems around the 2-Methyl-1-Propanethiol lines. Our crew knows from past experience just how persistent the smell can be—once a spill happens, it lingers for days unless handled quickly. We route product lines with secondary containment. Operators who spend hours near the storage tanks trust in air monitoring systems because even small fugitive emissions stretch miles downwind.

    The health and safety regimen has evolved. In earlier decades, open-barrel transfer led to off-gassing and headache complaints in the plant. We switched to closed transfer systems and double-sealed pumps. Weekly training covers both routine care and incident response so mistakes don’t turn into costly downtime. Our emergency response team insists on redundant PPE and personal vapor detectors. We use activated carbon scrubbers on vent lines, aiming to keep airborne concentrations well below government exposure limits. The procedures change after audit reviews and real-world learning, not just on paper.

    Differences From Other Thiols: Insights From Operations

    Some colleagues who have worked tank washes with multiple thiols note subtle but important differences. The n-butanethiol or propanethiol lines tend to clean out with fewer rinse cycles, largely due to lower vapor persistence. 2-Methyl-1-Propanethiol ‘sticks’ in valves and pump gaskets unless you use hotter water and longer soak periods. The methyl group causes a modest increase in both vapor pressure and solubility behavior compared to linear analogs.

    Our technical group has analyzed reactivity differences using side-by-side tests. The branched chain of 2-Methyl-1-Propanethiol resists certain oxidation reactions, compared to straight-chain butanethiol, which can create issues in synthesis if not planned for. On the other hand, this extra stability extends shelf life, minimizing auto-oxidation concerns during months of storage under typical warehouse conditions. Our storage log has shown that this product maintains its profile longer than some of our more reactive linear thiols, especially if drums are kept cool and tightly sealed.

    Gas odorizing teams prefer this product because of the balance between intensity and longevity. Methanethiol gives an even more pungent hit, but customers say it fades too fast from treated natural gas during prolonged storage or transport. Iso-butanethiol offers an extended alert window—the human nose detects its presence even at low levels, and the “signal” remains unchanged for hours as it disperses. Natural gas utilities share feedback about fewer “false positive” odor fade incidents following a switch to our grade.

    We’ve also seen growing interest from research labs exploring new uses for sulfur compounds. The branched architecture of 2-Methyl-1-Propanethiol opens up differentiated reaction paths compared to more common thiols. Working shoulder-to-shoulder with these researchers shows us just how many surprises a small molecule can hold. A little hands-on use often reveals quirks and benefits that raw molecular diagrams miss.

    Quality, Consistency, and What Really Matters to Manufacturers

    On our end, field complaints about off-odors or inconsistent performance push us to examine every step of production. It’s easy for a spec sheet to claim “high quality” — proving it each run is a daily task. Our team meets weekly to review customer feedback. If a shipment arrives at the client with even a trace more impurity than expected, we go back to the logs and the instruments. Analysts re-run gas chromatograms, checking retention times against in-house standards stored in temperature-controlled memory. Only after matching both odor strength and analytical output do we release the next tank for shipment. Customers from oil & gas or flavors rely on this degree of vigilance because product failures down the line cost every party much more than careful batch review upfront.

    Packaging standards make a difference over the product’s journey from site to site. Stale or permeable drums allow trace oxygen and moisture, damaging performance, and if the product is headed overseas, extra care during container loading becomes critical. Our warehouse team tracks every batch and container—knowing what leaves the dock and how it’s sealed matters as much as what goes in at the start.

    Facing Market and Regulatory Challenges

    Recent years brought a wave of tighter environmental and transport restrictions for sulfur compounds. Our compliance team keeps tabs on national and international shipping laws that affect how we label, store, and transport this product. Documentation now needs more detail—full hazard communication, spill control procedures, and tracking of every kilogram. We work with regulators during plant audits, not just to meet rules but to learn where shifting standards might impact process tweaks. The need to limit fugitive emissions shaped redesigns in our loading bays and tank farms. Our maintenance specialists recalibrate containment sensors frequently, using lessons from unexpected pressure bumps or temperature swings.

    Our purchasing partners look for assurance that every liter is produced with minimal environmental footprint. Investing in more efficient scrubbers and leak-prevention systems cost us up front but reduced community complaints and waste disposal rates over time. Beyond compliance, the best manufacturers remain vigilant for process drift—small excesses turn into regulatory headaches and extra expense, especially as local air quality standards keep tightening.

    Raw Materials, Energy Efficiency, and Production Insights

    Years ago, our synthesis route for 2-Methyl-1-Propanethiol leaned heavily on older catalyst packages that left more inorganic byproducts. Over time, incremental improvements to catalyst beds, heat exchangers, and vapor recovery lowered energy use and waste. Every efficiency gain during distillation—whether by heat integration or improved pressure regulation—cuts both greenhouse gas output and utility bills. Plant operators ride that line between maximizing throughput and cutting losses.

    Some years, raw material volatility makes planning a challenge. Dual-source strategies for isobutyl alcohol, for instance, help us keep the supply flowing even during market spikes or transportation delays. Few customers see that side of the business, but those of us at the plant know how close we sail to disruption during global hiccups. Our procurement and logistics groups keep reserves of key feedstocks and work with nearby suppliers to keep contracts flexible. This flexibility means we can deliver on time and avoid delays, even if a shipment gets caught in customs or faces weather setbacks.

    Environmental Stewardship: Lessons Learned

    Manufacturing sulfur-based compounds has always brought scrutiny from environmental groups. Our plant built a stronger relationship with the surrounding community through transparency. Publishing annual air quality and waste data made the difference in how neighbors perceive us. We added recovery units for vapor emissions—a decision that was time-consuming to implement but paid dividends in lower community impact and regulatory peace of mind.

    Our water treatment protocols filter wash effluents before discharge, targeting low sulfur targets to protect receiving waterways. Auditors no longer just look at product leaving; their checklists dig into how every waste stream is managed. With demand rising for greener performance, we fund R&D programs on next-generation catalysts and energy-saving synthesis steps. Every bit of solvent and sulfur we recover for reuse sharpens our competitive edge and reduces total impact.

    Customer Collaboration and Tailored Solutions

    The people who purchase 2-Methyl-1-Propanethiol rarely settle for off-the-shelf answers. Technical teams from customer sites fly in, bringing real-world problems: equipment fouling, off-odors, incompatibility with existing blends. We sit down, run split-batch experiments, and follow up with joint testing at their pilot plants. Out of these conversations, solutions emerge—sometimes as simple as an extra filtration step, on other occasions, it takes a tweak to our upstream process.

    Repeat business builds on trust earned with consistency and technical expertise. We keep records not just for compliance, but so we can compare, year over year, which process tweaks led to fewer complaints. One client improved process yield by shifting to our high-purity specification following a six-month joint review. These collaborations foster innovation and steady improvement.

    Continuous Improvement and Looking Forward

    Our manufacturing team doesn’t coast—each new production run brings its own learning. As the market for odorants, intermediates, and custom synthesis grows, so does the need for ever cleaner, more traceable product. The pressure to balance tight cost controls with reliable, high-quality output stretches team skills. Over the last few years, entering new energy markets and flavors applications added even more requirements. Each year we overhaul QA protocols and invest in the next round of plant upgrades, always seeking fewer emissions, better worker safety, and more efficient batches.

    Every kilo of 2-Methyl-1-Propanethiol leaving the plant carries with it the effort of dozens of hands and decades of combined know-how. The path from synthesis to sealed drum means more than just chemical equations—it comes alive through the judgment, skill, and practical problem-solving of teams committed to responsible production. What customers receive isn’t just a chemical, but a blend of reliability, quality, and all the lessons that come from working with such a uniquely challenging molecule.