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2-Chlorobenzoyl Chloride

    • Product Name 2-Chlorobenzoyl Chloride
    • Alias o-Chlorobenzoyl chloride
    • Einecs 208-937-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    670187

    Cas Number 609-65-4
    Molecular Formula C7H4Cl2O
    Molar Mass 175.02 g/mol
    Appearance Colorless to pale yellow liquid
    Melting Point -5 °C
    Boiling Point 228 °C
    Density 1.39 g/cm³
    Solubility In Water Decomposes
    Refractive Index 1.579
    Flash Point 104 °C
    Purity Typically ≥98%
    Synonyms 2-Chlorobenzoyl chloride, o-Chlorobenzoyl chloride
    Odor Pungent
    Storage Temperature Store below +30 °C
    Ec Number 210-199-8

    As an accredited 2-Chlorobenzoyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle with a secure screw cap, labeled "2-Chlorobenzoyl Chloride" and appropriate hazard and handling warnings.
    Shipping 2-Chlorobenzoyl chloride should be shipped in tightly sealed, corrosion-resistant containers under dry, cool conditions. It must be clearly labeled as a hazardous material, require UN 1759 (corrosive solid, organic), and be handled by trained personnel. Protection from moisture and incompatible substances during transport is essential to prevent hazardous reactions.
    Storage 2-Chlorobenzoyl chloride should be stored in a cool, dry, well-ventilated area away from heat, moisture, and incompatible substances such as water, alcohols, and strong bases. Store in tightly sealed, corrosion-resistant containers and protect from light. Use secondary containment and ensure proper labeling. Access should be restricted to trained personnel, and emergency spill procedures should be in place.
    Application of 2-Chlorobenzoyl Chloride

    Applications of 2-Chlorobenzoyl Chloride in Industrial Manufacturing

    2-Chlorobenzoyl Chloride is a critical intermediate for a variety of chemical transformations across high-value manufacturing sectors. As the producer, we supply this raw material to specialized downstream industries where process design and quality controls require well-documented performance and traceability. The following sections present focused, real-world application cases demonstrating formula role, regulatory adherence, integration point, and finished goods types for each scenario.

    1. Pharmaceutical Synthesis: Non-Steroidal Anti-Inflammatory Drug (NSAID) Intermediates

    Our material is a key acylation agent for the synthesis of NSAID intermediates, specifically in routes leading to diclofenac and structurally related compounds. Its chlorinated aromatic functionality allows for selective introduction in controlled coupling steps under anhydrous conditions. Production chemists configure reaction sequences to ensure minimal residual acid chlorides, satisfying stringent impurity profiles. Formulation teams closely monitor traceability for use in regulated API synthesis pipelines where batch records and reproducibility are scrutinized throughout pre-GMP and GMP scale operations.

    Industry compliance standards

    • International Council for Harmonisation (ICH) Q7 GMP for Active Pharmaceutical Ingredients
    • US Pharmacopeia and European Pharmacopeia for API/intermediate quality standards
    • FDA 21 CFR 210/211 for pharmaceutical manufacturing controls
    • REACH Annex XVII for controlled precursors within the EU

    Typical usage ratio

    • 1.05–1.15 molar equivalents relative to the amine component, adjusted for conversion yield and minimization of byproducts

    Downstream process integration

    • Material enters during the acylation/benzoylation step in API intermediate assembly, often in chlorinated solvent under Schotten–Baumann conditions, followed by in situ quenching and phase separation

    Final product types

    • Non-sterile pharmaceutical intermediates for diclofenac sodium and potassium
    • Contract-manufactured active building blocks for specialty pharmaceuticals

    2. Agrochemical Intermediate Manufacturing: Herbicide Active Ingredient Synthesis

    Producers in the crop protection industry utilize our raw material as a specialty benzoylation reagent in several synthetic steps leading to selective phenylcarbamate and anilide herbicides. These applications demand reliable material purity to control residue chemistry, facilitating validatory assessments for downstream registration dossiers. Strict stewardship of process documentation supports traceability from input batch to technical active ingredient output for global crop protection portfolios.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • OECD Guidelines for Testing of Chemicals
    • ISO 9001:2015 for quality management in fine chemicals manufacturing
    • GHS (Globally Harmonized System) labeling and transport compliance for precursor substances

    Typical usage ratio

    • 1.0–1.2 molar equivalents relative to aromatic precursor, varied to match process scale and downstream hydrolysis profiles

    Downstream process integration

    • Material charged post-nitration or amination, initiating benzoylation on functionalized aromatic moieties in solvent-mediated condensation, followed by neutralization/extraction

    Final product types

    • Herbicide technical concentrates (e.g., phenylcarbamate products)
    • Custom intermediates for R&D in new molecule discovery

    3. Dye and Pigment Manufacturing: Acid and Reactive Dye Intermediate Production

    The colorant industry specifies our raw material for the introduction of chlorobenzoyl groups in intermediates designed for high-color-strength acid and reactive dyes. Its reactivity profile allows for selective acyl modifications that define fastness properties and dye fiber affinity, especially for wool, nylon, and silk substrates. Quality teams in downstream plants document critical material identity and batch purity for broader regulatory reporting, as dye ingredients face regulatory registration both locally and for export markets.

    Industry compliance standards

    • REACH Regulation (EC) No. 1907/2006 for dye intermediates in the EU
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List) compliance
    • ISO 14001:2015 for environmental management
    • Azo dye exclusion standards (EU, Japan) for regulated amines

    Typical usage ratio

    • 0.95–1.10 molar equivalents versus parent amine or phenol, tuned by dye type and fiber specification targets

    Downstream process integration

    • Material added during aromatic acylation to modify chromophore properties in multi-step dye synthesis, followed by aqueous work-up and filtration steps

    Final product types

    • Acid dye intermediates for textile and leather coloration
    • Reactive dye components for high-fastness product lines

    4. Specialty Chemical Manufacturing: Benzoyl-Substituted Polymers and UV Absorbers

    Chemical plants focused on polymers and performance additives employ this reagent for site-selective benzoylation in specialty monomers and UV stabilizer precursors. Process engineers select exact reagent charge and sequence placement to reduce run-off and improve isolation of target functionalities. Consistent material traceability supports compliance, especially for downstream products entering regulated plastics and coatings supply chains.

    Industry compliance standards

    • ISO 9001 for quality assurance
    • EU Regulation (EU) No 10/2011 regarding plastic materials and articles intended to come into contact with food for polymer additives
    • GHS, SDS, and technical dossier requirements for handling and labeling
    • RoHS Directive (2011/65/EU) for electronics-compatible compounds

    Typical usage ratio

    • 1.0–1.3 molar equivalents relative to monomer/polymer backbone; process chemists optimize for full conversion without excess hydrolysis

    Downstream process integration

    • Charged during copolymerization or additive synthesis prior to polymerization, facilitating covalent attachment of benzoyl functionality in one-pot or staged reactions

    Final product types

    • Polymeric UV absorbers for plastics and coatings
    • Benzoyl-functionalized resins for specialty adhesives and films
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    Certification & Compliance
    More Introduction

    2-Chlorobenzoyl Chloride: Experienced Manufacturing, Reliable Supply

    Real-World Manufacturing Insight into 2-Chlorobenzoyl Chloride

    As a company that has spent many years refining the chlorination and acylation processes, we’ve learned that subtle differences in molecular structure can mean a world of difference for end users. 2-Chlorobenzoyl chloride is a prime example: it’s not just another benzoyl chloride derivative. Through hands-on work with this key intermediate, we’ve seen its unique reactivity shape the success of clients in pharmaceuticals, agrochemicals, dyes, and specialty polymers.

    On our line, we start with ortho-chlorinated benzoic acid. The process routes out minimal by-product, keeping technical performance high and cost pressures lower for our partners. Material exits at purity levels that support demanding synthesis requirements, backed by analytic controls that make batch-to-batch differences negligible. Every drum we fill echoes this careful approach, whether ordered in modest quantities or bulk.

    Product Profile and Specifications as Proven in Practice

    2-Chlorobenzoyl chloride comes as a colorless to pale yellow liquid with a biting, strong odorous character typical of acyl chlorides. The molecular formula is C7H4Cl2O, with a CAS number that gives traceability all the way back to the earliest reference syntheses. Years on the production floor tell us the best runs consistently deliver an assay above 99%. Moisture, iron, or residual acid can spoil catalytic cascades in customer processes, so we’ve implemented effective washing and distillation steps.

    Our process yields product with a boiling range that falls right in line with the literature, but the acid value and free chlorine content stay well below the thresholds set by major pharmacopeias. What leaves our facility represents the culmination of methodical design and actual experience responding to customer feedback for purity improvements. Quality here is not aspirational — it’s measured, achieved, and guaranteed by experienced chemists and lab technicians who run checks at every step.

    Applications Shaped by Real Industry Needs

    Ask a manufacturer where this compound enters the stream, and several patterns emerge. Pharmaceutical developers reach for 2-chlorobenzoyl chloride in the construction of active intermediates for anti-inflammatory, antipyretic, and anti-fungal compounds. Its selective reactivity with amines, alcohols, and phenols is valued for constructing tailor-made amide and ester bonds — often forming the pharmacophore in finished active ingredients. In our past collaborations with life science firms, every percent of purity has become magnified when forming structures designed for clinical trial scale-up.

    Outside pharma, its presence looms large in herbicidal and fungicidal molecules, where the ortho-chloro substituent provides enhanced metabolic stability upon application in the field. The result for formulators and growers is often a product that persists just long enough to provide crop protection, then degrades in a managed window. We routinely work with agrochemical synthesizers who demand not only reactivity, but documentation and supply chain predictability — both of which matter just as much as purity these days.

    Dye and pigment chemistry leans on 2-chlorobenzoyl chloride for its ability to introduce the needed acyl groups onto aromatic platforms. Applied in the hands of a skilled color chemist, this modification leads to vivid, lasting shades with improved chemical resistance. The polymer industry uses this chemical to fine-tune the properties of specialty resins, fibers, and high-performance plastics that see service in harsh environments. In fiber spinning and in functional coatings, the reliability of our process prevents off-spec batches from creeping into downstream processing, which saves both time and reputation for processors.

    Why Not Just Any Benzoyl Chloride Will Do

    Some ask about the differences between this product and standard benzoyl chloride or its meta- and para-chloro analogues. From a synthetic standpoint, the ortho-chlorine changes everything — the electron-withdrawing effect influences reaction rates, positional selectivity, and the overall stability of the target molecule. Years of handling and shipping have taught us that positional isomers behave differently, not just in the test tube but in large-scale reactors. The ortho-chloro substitution sometimes slows hydrolysis, which proves critical when precise control in esterification or amidation is required.

    For procurement, there’s an operational difference as well. Regular benzoyl chloride usually comes with more commodity pricing and less attention to impurity profiles. By contrast, 2-chlorobenzoyl chloride serves customers who can’t afford uncertainty — a trace impurity can lead to lost yield or the formation of side-products. Our supply experience has shown that practitioners in strict pharmaceutical or crop protection markets will perform incoming QC on every lot. We match this scrutiny with in-depth reporting, documentation, and a readiness to trace single-origin raw materials if concerns arise post-delivery.

    Manufacturing Consistency and Environmental Responsibility

    Scaling up for commercial volumes always introduces variables. We’ve found that close monitoring at each stage — from chlorination to phosgene substitution — is crucial to weed out incomplete reactions or hazardous by-products. The direct communication channels between our engineering group and QC lab ensure that issues arising in a single production run never multiply across subsequent batches. Our team benefits from decades spent troubleshooting and improving every aspect of the plant’s operational window.

    Disposal and sustainability carry real stakes in acyl chloride manufacturing. In the early days, vent gases and acid effluent caused headaches and regulatory scrutiny. Stepwise upgrades have replaced vent-and-scrub approaches with integrated recycling systems for HCl offgas and internal neutralization loops. Every shift technician learns waste-minimizing protocols the first week. Independent audits now pass without delays — a hard-won change from a time when small oversights could lead to pileups in waste storage or added costs. We’re mindful that customers are not just buying a drum of chemical, but must answer to their own environmental and safety commitments.

    Supporting Customer Process Goals

    Many buyers look for ready answers when they call about a new project involving 2-chlorobenzoyl chloride. We don’t just ship product; we support method development, analytical troubleshooting, and scale-up planning. Whether it’s a pharmaceutical firm running pilot batches or a dye house confronting solubility issues, our technical staff has probably encountered a similar problem. Time and again, our partners rely on knowledge that comes from real troubleshooting with actual equipment, not just a list of specs.

    Shipping this compound is never an afterthought. Failures in containment, exposure to moisture, or improper sealing mean more than just nuisance — they put entire projects at risk. Dedicated storage and packaging (such as drum liners selected for resistance to hydrolysis and corrosion) keep loss rates far below industry averages. We train our logistics teams to coordinate carefully with hazmat handlers and end-user facilities, ensuring that receipt is documented and complaints are tracked for root-cause resolution. Our records show incidents have dropped year over year, as refinements in packaging and shipping controls have paid off.

    Why Professional Manufacturers Make a Difference

    A trend in the global chemical market is the growing list of intermediaries and traders inserting themselves between user and producer. While traders provide reach, their knowledge of actual process chemistry and impurity control seldom matches what a direct manufacturer offers. We remain closely involved from raw material sourcing to finished product, so customer questions never have to bounce between layers of bureaucracy. The people answering queries about 2-chlorobenzoyl chloride are the same ones who helped draw up the batch sheet or resolve a mid-run anomaly.

    Direct sourcing from experienced producers means customers can verify the consistency of the lot, request tailored documentation for regulatory filings, or adjust specifications based on their specific downstream processes. Over the years, we’ve learned to bridge the gap between research required for patent filings and the hands-on adjustments needed for kilo-lab or commercial output. In one instance, a pharmaceutical partner faced new regulatory requirements for nitrosamine impurities — we worked jointly to trace, reduce, and document any possible routes for such contaminants, leading to a clean bill of health for their filing and ongoing production campaign.

    Building Value Relationships Beyond the Molecule

    Relationships with buyers and users never stay at the transactional level for long. Our team fields requests ranging from alternative packaging (needed to fit into restricted loading docks) to custom blending services when a customer faces on-site restrictions for handling acid chlorides. We view our role as a partner — not just a vendor. By listening to user needs on the ground, suggestions and complaints turn into actual changes in production, sometimes within a matter of weeks. Overwhelmingly, it's these refinements, not one-time sales, that ensure both sides grow.

    A few years ago, a new regulation threatened to block export of our 2-chlorobenzoyl chloride. Early notification and an open line with our compliance group allowed a major customer to adjust their production window and avoid costly idle time. Transparent communication (and a documented history of regulatory engagement) translates to reliability. By integrating these lessons learned into daily management, we deliver not just product, but confidence in our supply.

    Ongoing Challenges and How We Address Them

    Every year brings shifts in demand forecasts, transportation bottlenecks, and occasionally raw material shortages. No batch at commercial scale is immune from process drift: unexpected color changes, small spikes in impurity concentrations, or delayed output can all threaten customer timelines. We’ve mitigated these issues by building in excess capacity, qualifying more than one upstream supplier for every critical input, and maintaining in-stock reserves. Our labs operate extended hours to ensure that urgent quality rechecks don’t hold up the outbound flow. These steps cost time and money, but the alternative is instability for both us and the client.

    Information flow matters as much as physical stocks. Chemical handling requirements continue to evolve, with increased scrutiny on worker safety, shipping manifest accuracy, and trace impurity risk. Our compliance team monitors regulatory developments in key target regions. Empowered with real-time data, they identify early signs that a customer might run into trouble with local regulators — sometimes before the customer becomes aware. This proactive approach has turned difficult conversations into collaborative planning sessions, keeping clears paths for shipments that might otherwise be hampered by border issues or additional documentation demands.

    Commitment to Quality, Safety, and Transparency

    Years spent in batch production, process troubleshooting, and ongoing improvement drive home a simple point: quality is constructed, checked, and maintained by real people, through routines that are tested by daily use. Instrument calibration can slip, or batches can temporarily fall out of spec — it’s the habit of checking, adjusting, and updating protocols that keeps final product consistent. Everyone on our team, from plant operator to delivery scheduler, has direct accountability to review and correct issues as soon as they’re found.

    Safety forms the backbone of every shift in our plant. Our operators wear personal air monitors, receive annual training in handling hazardous materials, and participate in regular drills for spill or leak containment. We track near-misses as closely as full incident reports — all to ensure that improvements never pause. For customers, this attention means more than a line in a brochure; it serves as an assurance that their teams will never receive a shipment compromised by unsafe handling or incomplete hazard labeling.

    Transparency forms the third leg of trust. We make outgoing records available for every batch, including impurity profiles, traceable input lots, and compliance documentation relevant to the user’s own regulatory landscape. If an issue emerges — whether an unintended color, odor difference, or reactivity blip — we open up our logs, share findings, and collaborate on root-cause elimination.

    Future Directions for 2-Chlorobenzoyl Chloride Production

    Technical possibilities continue to evolve. New catalyst systems and greener processing steps catch our attention. A few pilot-scale projects currently underway are investigating alternatives to traditional phosgene routes, aiming to retain product quality while further cutting down on hazardous by-products. The ultimate goal is to make key building blocks like 2-chlorobenzoyl chloride even more reliable, less resource-intensive, and safer for both production teams and end users.

    Long-term supplier relationships with research consortia, universities, and R&D arms for major producers drive our innovation cycle. We’ve seen a growing interest from small biotech and fine-chemical firms seeking precisely defined, impurity-controlled batches for new molecular designs. These partnerships accelerate test runs, process optimization, and commercial launches for new candidates in pharma and materials science. Multiple feedback loops — from analytical chemists, formulation scientists, and QA auditors — inform small but significant changes that ripple through our manufacturing plans.

    The Bottom Line for 2-Chlorobenzoyl Chloride Users

    For everyone in the value chain — R&D chemists, manufacturing managers, EH&S leads, procurement heads — the choice of supplier has measurable consequences for operational stability, regulatory confidence, and finished product reliability. Drawing on years of actual manufacturing experience, we supply a 2-chlorobenzoyl chloride product proven in real industrial settings, tested by rigorous procedures, and reinforced by responsive support. Our commitment to clients means not just competitive pricing, but a technical partnership built on experience, transparency, and a problem-solving mindset.

    More than mere molecules, what we deliver with every shipment is the result of hard-earned manufacturing knowledge, up-close customer engagement, and a drive to evolve with the industries we serve. As the future brings new challenges and tighter requirements, we remain ready to adapt in ways that a catalogue or third-party broker never could. We hold ourselves accountable to our customers — and to the industries and communities tied to every shipment that rolls out our gates.