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2-Chlorobenzotrifluoride

    • Product Name 2-Chlorobenzotrifluoride
    • Alias o-Chlorobenzotrifluoride
    • Einecs 202-396-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    356911

    Cas Number 88-16-4
    Molecular Formula C7H4ClF3
    Molecular Weight 180.56 g/mol
    Appearance Colorless to pale yellow liquid
    Density 1.34 g/cm³ at 25°C
    Melting Point -29°C
    Boiling Point 139°C
    Flash Point 43°C (closed cup)
    Solubility In Water Insoluble
    Vapor Pressure 7.2 mmHg at 25°C

    As an accredited 2-Chlorobenzotrifluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 25-liter blue HDPE drum, securely sealed, labeled "2-Chlorobenzotrifluoride," UN number, hazard symbols, and handling instructions.
    Shipping 2-Chlorobenzotrifluoride is shipped as a hazardous chemical, typically in sealed drums or approved containers. It must be labeled according to regulations, protected from heat, and stored upright. During transport, it requires proper documentation, handling to prevent leaks or emissions, and compliance with local and international shipping regulations for flammable liquids.
    Storage 2-Chlorobenzotrifluoride should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from heat, sparks, and open flames. Keep it separate from oxidizing agents, acids, and bases. Clearly label the storage area, protect from direct sunlight, and ensure proper grounding to avoid static discharge. Store away from incompatible substances to prevent chemical reactions.
    Application of 2-Chlorobenzotrifluoride

    Applications of 2-Chlorobenzotrifluoride in Industrial Manufacturing

    As a dedicated producer of 2-Chlorobenzotrifluoride, we supply this specialty intermediate to advanced manufacturers across several mature chemical industry segments. Below we highlight how this material delivers value in real-world downstream use, covering specific regulations, formulation parameters, process integration points, and final product examples.

    1. Agrochemical Synthesis: Herbicide and Fungicide Intermediates

    Producers in crop protection manufacturing employ 2-Chlorobenzotrifluoride as a halogenated aromatic intermediate for the preparation of selective herbicides and systemic fungicides. This compound enters targeted synthetic routes—such as etherification and nucleophilic substitution—to develop complex active ingredients designed for field application. Its use enables formulation of crop protection agents that conform to multi-region regulatory expectations throughout key export markets.

    Industry compliance standards

    • FAO/WHO Food and Agriculture Organization Pesticide Specifications
    • US EPA FIFRA compliance (active ingredient registration)
    • European Union Regulation (EC) No 1107/2009 for Plant Protection Products
    • Relevant national hazardous substance transportation and storage standards

    Typical usage ratio

    • Employed at 0.2–0.8 moles per mole of target active ingredient, adjusted for synthetic efficiency and step yield

    Downstream process integration

    • Charged as a raw material during the aromatic substitution or coupling stage following pre-neutralization
    • Followed by reaction monitoring and intermediate purification before final API formation

    Final product types

    • Selective herbicide actives for cereal and soybean crops
    • Triazole and strobilurin class fungicides used by post-harvest storage sector

    2. Pharmaceutical Intermediate Production (Active Pharmaceutical Ingredient Synthesis)

    API manufacturers select 2-Chlorobenzotrifluoride as a building block to introduce trifluoromethyl and chloroaromatic groups into target molecules for systemic anti-infectives and CNS drug families. The raw material undergoes controlled nucleophilic aromatic substitution, with strict reaction monitoring and traceability per GMP/ICH standards. Subsequent downstream processes convert the intermediate into the final regulated API, demanding high material purity and batch-to-batch reproducibility.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia and USP standards for chemical purity
    • FDA 21 CFR Part 211 (pharmaceutical manufacturing controls)
    • ISO 9001:2015 for documented quality systems

    Typical usage ratio

    • Average loading of 0.5–1.2 molar equivalents per key synthetic intermediate, determined by specific molecule structure and synthetic yield targets

    Downstream process integration

    • Added to multipurpose reactors during halogenation or etherification step as precursor for structural modification
    • Incorporated using weighed, high-purity grade with in-process analytics for trace component management

    Final product types

    • Intermediates for antiviral and anti-inflammatory APIs
    • Precursors for CNS therapeutics with trifluoromethylated rings

    3. Fine Chemical Intermediate for Dyes and Pigments

    Manufacturers in the colorant sector rely on this chlorinated benzotrifluoride derivative to synthesize specialty dyes and high-performance pigments, particularly where resistance to light, chemicals, and solvents is critical. The intermediate reacts via nucleophilic aromatic substitution or diazotization, enabling insertion of functional chromophores required for the desired optical properties. Chemical handling procedures focus on minimizing impurity carryover and achieving precise chromatic output.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for chemical safety in Europe
    • OEKO-TEX Standard 100 for textiles and leather applications
    • ISO 9001:2015 for traceable production and QC management
    • National Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) inventory

    Typical usage ratio

    • Used at 3–7% by mass in pigment or dye synthesis runs, calculated relative to total reaction charge and color concentration targets

    Downstream process integration

    • Introduced in the aromatic substitution step or as a coupling partner in complex diazo dye syntheses
    • Converted into color-active moieties during pigment lake preparation

    Final product types

    • High-stability pigments for coatings and plastics
    • Textile dyes with enhanced light fastness and solvent resistance

    4. Chemical Intermediate for Specialty Polymers and Fluorinated Materials

    Advanced polymer producers integrate this fluorinated aromatic as a reactive intermediate for engineering resins, specialty elastomers, and monomer synthesis. The compound participates in chain extension and functional group modification during copolymerization, imparting high chemical and thermal resilience to the resultant polymers. Process control emphasizes end-group fidelity and homogeneity of trifluoromethyl substitution.

    Industry compliance standards

    • UL 94 (Flammability Standard for Plastics Materials)
    • RoHS Directive 2011/65/EU (restriction of hazardous substances in electronics)
    • ASTM D257 (electrical insulation polymers)
    • ISO 14001:2015 for environmental management in the chemical sector

    Typical usage ratio

    • Ranges from 4–15% by mole, depending on target copolymer architecture and desired fluorine content

    Downstream process integration

    • Fed into reactor during pre-polymerization or copolymerization sequence with chain control agents
    • Blended with comonomers for in-situ property modification

    Final product types

    • Fluoropolymer-based insulation materials for electronic wires
    • Specialty elastomers used in aggressive chemical processing environments

    5. Intermediate for Fluorinated Aromatic Derivatives in Chemical Synthesis

    In advanced organic synthesis workflows, 2-Chlorobenzotrifluoride serves as a platform for the introduction of both chloro and trifluoromethyl functionalities, especially valued in custom synthesis houses and contract manufacturers producing building blocks for electronics and high-purity materials. The compound is processed through selective halogen-metal exchange and cross-coupling reactions, facilitating downstream modifications where fluorine content and positional specificity are required for advanced materials science applications.

    Industry compliance standards

    • ISO 9001:2015 for quality traceability in organic synthesis
    • REACH pre-registration or tonnage band notification for custom chemicals
    • GHS labeling for laboratory and industrial-scale operations
    • Applicable regional chemical handling statutes

    Typical usage ratio

    • Proportions set between 0.8–1.6 molar equivalents, determined by downstream functionalization efficiency and final derivative yield

    Downstream process integration

    • Undergoes halogen-metal exchange or Suzuki coupling in controlled glass-lined reactors
    • Material purity tracked from goods inwards through to final purification

    Final product types

    • Fluorinated building blocks for liquid crystal monomers and OLED chemicals
    • Precursors for specialty pharmaceutical or agrochemical intermediates
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    Certification & Compliance
    More Introduction

    2-Chlorobenzotrifluoride: Chemical Manufacturing Perspective

    Real-World Experience with 2-Chlorobenzotrifluoride

    Factories make chemicals for practical reasons, not just to fill out a product catalog. On the production floor, the difference between a successful batch and a costly rework often comes down to details that don’t make it onto spreadsheets. Years spent manufacturing 2-Chlorobenzotrifluoride have taught us plenty about its behavior under pressure—sometimes literally. This is not a lab curiosity, but a compound with a proven record in multiple industries, prized by people who understand how to get value from every drum.

    What Sets 2-Chlorobenzotrifluoride Apart

    Handling tons of aromatic compounds makes you value predictability. 2-Chlorobenzotrifluoride, sometimes called o-chlorobenzotrifluoride or OCBTF, has become a staple for more than one reason. Its molecular structure—chlorine at the ortho position on a benzene ring, three tightly bound fluorine atoms—offers unique chemical stability. This makes synthesis straightforward once you dial in the exothermic management. It boils at around 131°C, a sweet spot for solvent recovery setups and reactor design. Technicians appreciate its moderate volatility: easy to distill, not stubborn in separation, but not so volatile as to throw safety routines into chaos.

    Compared with regular benzotrifluoride, adding chlorine changes several things at once. Reactivity toward nucleophilic substitution opens doors for further transformation. Coatings producers who want to tweak polymer backbones pay attention. In contrast, straight benzotrifluoride won’t always react as readily. Certain downstream agro intermediates depend on this extra “hook” for attaching custom groups. Paint formulators like it for its role in specialty solvents, where it can balance solvency with resistance to environmental breakdown.

    Specifications, Grade, and Real-World Performance

    All quality starts with feedstock. Industrial 2-Chlorobenzotrifluoride generally targets a purity above 99 percent by GC analysis. Some users demand less than 0.1 percent of 2,6-dichlorobenzotrifluoride or related heavy ends, but the real challenge lies in moisture control. Trace water can catalyze side reactions during downstream synthesis. To avoid this, drying systems—like molecular sieves or azeotropic distillation—need tight calibration. Storage tanks with nitrogen blanketing fend off both water ingress and oxidation.

    Our output is clear, water-white, and free flowing. Every tank load comes with a full test report, but inspectors know what high-purity aromatics should smell like even before the GC gets to work. One leaky flange on a rotary valve, and the nose will spot contamination before instruments do. This is the human experience in a chemical plant that spec sheets can’t capture.

    Uses Across Industries

    The main outlet for 2-Chlorobenzotrifluoride is as a chemical intermediate. On the plant floor, we’ve seen the molecule head toward pharmaceuticals, agrochemicals, and advanced polymers. For example, one key route involves transforming it into 2-chloro-5-trifluoromethyl anilines, then on toward certain herbicides. That journey relies on the chlorine and trifluoromethyl groups for selectivity. Not every aromatic solvent can support such specificity—this is where OCBTF’s structure makes production feasible at scale.

    Paint and coatings manufacturers value its ability to dissolve stubborn resins. Unlike more routine aromatic solvents like toluene, it brings high chemical resistance to the finished film. Solubility parameters differ enough that blending opportunities open up: tough alkyds, silicone resins, or fluoroelastomers can be coaxed into solution more reliably with OCBTF. Trying to work with monochlorobenzenes, on the other hand, often gives less stability and more odor problems.

    Another customer, focused on fine electronics cleaning, once consulted us on switching from n-propyl bromide to an aromatic fluorinated solvent. Regulatory shifts steered them toward OCBTF, which proved effective at lifting oils without aggressive attack on sensitive plastics or circuit board finishes.

    Comparison with Related Products

    Experience in production keeps us cautious about “one size fits all” products. 2-Chlorobenzotrifluoride’s closest relatives in our line include mono-chlorobenzotrifluorides and methyl-chlorobenzotrifluorides. Each brings something distinct. For example, 3-chlorobenzotrifluoride (m-chloro) shifts physical and chemical properties just enough to favor other synthesis routes. Purification profiles differ—fractional distillation columns tuned for the ortho isomer have to adjust for boilup rates and column holdup.

    Comparing further afield, regular benzotrifluoride (BTF) lacks the reactive chlorine, making it less useful for coupling reactions and as a seed for stepwise aromatic substitutions. Dichlorobenzotrifluorides, meanwhile, can introduce steric hindrance, complicating catalytic hydrogenation reactions or sulfonation. OCBTF presents a reliable midpoint: enough reactivity for grabbing onto, but not so much bulk as to slow down processing.

    Some downstream users have looked at halogenated aromatics outside the benzotrifluoride family. Chloro-toluenes or difluorobenzenes pop up in product comparisons. OCBTF stands out for its balance of electron-withdrawing effect and manageable toxicity. Toluene derivatives can be more aggressive solvents but often flash off too quickly or run into VOC restrictions. OCBTF’s vapor pressure allows for cleaner application in spray systems, with less inhalation risk during manual usage.

    Handling and Storage: What Working with OCBTF Really Means

    Manufacturing staff care about more than just getting a drum out the door. Routine handling for 2-Chlorobenzotrifluoride involves monitoring for light exposure and tight vapor control. Unlike some monochlorobenzenes, OCBTF won’t darken in drums if kept free of oxygen. Nevertheless, excess heat in the tank farm during summer can pose pressure management headaches. Double-wall piping, lined pumps, and vapor balance lines keep leaks in check.

    Every fill line operator knows the scent and viscosity profile. On cold mornings, condensation on drum lids reminds you to keep those containers dry. Loaders hate dealing with sticky residues that sometimes form if the product sits too long in open air, so we flush lines after large truck fills. Years of practice show that the few extra minutes spent on line purging pay back in reduced contamination claims.

    The product isn’t considered especially hazardous or flammable by industrial solvent standards. Wearing gloves, splash goggles, and keeping the fill area ventilated works well. Overexposure risks in large-volume operations stay low under normal maintenance practices. Compared with the more notorious aromatic solvents such as nitrobenzene or trichlorobenzene, OCBTF presents an easier safety training scenario.

    Quality Consistency: Lab and Operator Know-How

    On-site QC teams keep product release tight. GC trace analysis picks up parts-per-million impurities that batch operators already suspect from process data. If distillation column pressures run higher, or the condenser water starts to cloud up, we check for potential contamination. There’s no substitute for a sharp operator with years of chemical nose. Near the batch house, people can trace subtle changes that might flag a mechanical seal failure or thermal imbalance. That hands-on engagement translates directly to more predictable product for our users.

    What we’ve learned is that “high-purity” in this business goes beyond a number on a sheet. Customers in crop protection synthesis used to call us out for haze in the product on cold delivery days. Addressing that meant fine-tuning our filtration, even if the lab said everything was still within spec. Real-world feedback loops like these shape every step on the plant.

    Downstream Processing Challenges

    Not every customer uses OCBTF in the same way. We’ve fielded support calls from technical teams fighting by-product formation in sulfonation or amination reactions. Sometimes the culprit is micro-trace impurities from upstream feedstock; other times, storage conditions introduce minor breakdowns. By working together with end-users, the process side can tailor distillation cut points or introduce extra drying steps if needed.

    Some research teams try to substitute cheaper mono-chlorinated solvents but run into poor yield or complicated waste streams. The way OCBTF holds up under both acidic and basic conditions on a real plant scale gives process engineers a wider processing window. This matters in continuous flow operations, where shutdowns cost tens of thousands in lost production. Technical support, drawn from our long-term operating data, helps customers adjust pH, temperature ramps, and residence times to match.

    Environmental and Regulatory Considerations

    Cleaner air and water standards keep changing, which pushes us to improve our own operation. 2-Chlorobenzotrifluoride falls well below the threshold for many regional airborne solvent restrictions, but no one can afford surprises from changed rules. Some of our biggest investments focus on emission scrubbing and wastewater reuse. By removing residual aromatics before effluent leaves the plant, we stay ahead of trouble—with the added benefit of reclaiming product from process rinsewater.

    A big shift in global regulations flagged halogenated aromatics for heightened scrutiny. Our plant invested in closed-loop sampling systems and vapor capture on drum filling operations to reduce fugitive emissions. Buyers ask for detailed trace-out reports, and our operations team keeps records going back years. This is about more than compliance; it’s about letting customers, and their own auditors, trust what they’re getting. On several occasions, we’ve supported clients during plant audits by providing in-depth tracking, from raw material intake to finished batch load.

    Shipping and Supply Chain Realities

    Moving OCBTF isn’t just a trucking operation. The liquid packs well into lined drums or stainless totes, but exposure to sunlight or extreme cold can degrade quality. Logistics coordinators account for warehouse turnover and delivery routes to minimize in-transit delays. In our region, freeze protection during winter becomes critical—one stuck valve on arrival and a customer’s whole batch schedule falls apart. On the other end, delivery appointments must factor in receiving dock capacity, short-term storage compatibility, and critical shutdown windows.

    Over the years, relationships built with reliable carriers and local hauliers keep disruptions rare. Every driver gets a product-specific handling sheet. Warehouse workers on both ends develop routines for drum rotation and first-in first-out stock. Talking with end-users, we find that minor schedule slips often trace back to logistics details that seem small—pallet stacking errors, slip-sheet tearing, or missed transfer paperwork. Taking responsibility for each load, from production line to the customer’s blending tank, makes the difference.

    Future of Chlorinated Aromatics: Where 2-Chlorobenzotrifluoride Fits

    Markets continue to shift. Electronics cleaning, specialty coatings, custom agricultural compounds—these segments want performance and safety. 2-Chlorobenzotrifluoride lands solidly in the intersection: strong enough for demanding chemistry, stable enough for regulated applications, with a safety profile that draws a clear line between it and more hazardous alternatives. Some of our customers look for “greener” substitutes, but after extensive trials, they keep coming back to OCBTF because of the reliability and consistency. It remains tough to find other compounds that combine chemical resistance, moderate solvency, and ease of handling in the same way.

    Production teams view innovation not as a matter of chasing every new molecule, but as a process of incremental improvement. Small tweaks in catalyst recovery, solvent purification, waste minimization—all feed back into the reliability of 2-Chlorobenzotrifluoride. Frequent technical visits with downstream users reveal changing requirements: sometimes a need for lower trace metals, other times for improved compatibility with automated blending systems. As partners in the supply chain, we stay alert to these changes, updating analytical standards and adjusting process set points where needed.

    Continuous Improvement and Shared Challenges

    Feedback from coatings manufacturers and fine chemical producers keeps our engineers busy. Requests for custom cuts, tighter specs, or non-standard packaging present challenges, but also drive process improvements. What sets the plant culture apart is the willingness to invite customers on site for tours or joint troubleshooting sessions. Real partnerships emerge from this openness, strengthening the collective understanding of OCBTF’s role in modern industry.

    As a manufacturer, there are days when the work feels routine: another batch in, another shipment out. But through every stage—distillation, storage, QC, logistics—attention to detail matters. QC complaints are learning moments. Production meetings that revisit yesterday’s near misses lead to safer, more consistent product. Trust develops over years and is built on the repeated experience of shipments arriving as promised, drums opening without surprises, and every usage scenario backed by real-world performance data.

    Working with 2-Chlorobenzotrifluoride: Practical Takeaways

    2-Chlorobenzotrifluoride continues carving out a role because its structure matches the needs of complex synthesis. The manufacturing process, tuned through years of experience, produces a consistent, clean product at commercial volumes. End-users, from electronics to advanced polymers, benefit from confidence in every tankload. Our plant runs on more than just technical routines; it runs on the experience and commitment of staff who see the bigger picture, linking feedstock to global progress in science and manufacturing. As demand for cleaner, more effective intermediates grows, the lessons learned here will shape the next era of chemical manufacturing.