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2-Chloroaniline

    • Product Name 2-Chloroaniline
    • Alias o-Chloroaniline
    • Einecs EINECS 202-425-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    805352

    Cas Number 95-51-2
    Iupac Name 2-Chloroaniline
    Molecular Formula C6H6ClN
    Molar Mass 127.57 g/mol
    Appearance Colorless to pale yellow liquid
    Melting Point -1 °C
    Boiling Point 208 °C
    Density 1.22 g/cm³
    Solubility In Water 1.8 g/L (at 20 °C)
    Flash Point 98 °C
    Vapor Pressure 0.22 mmHg (25 °C)
    Odor Aromatic, amine-like
    Refractive Index 1.587 (20 °C)

    As an accredited 2-Chloroaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Dark amber glass bottle containing 500 mL of 2-Chloroaniline, labeled with hazard warnings and tightly sealed with a screw cap.
    Shipping 2-Chloroaniline should be shipped in tightly sealed, chemically resistant containers, kept upright and clearly labeled. Transport must comply with local, national, and international regulations for hazardous substances, as it is toxic and harmful by inhalation or skin contact. Avoid exposure to heat, direct sunlight, and incompatible materials during shipping.
    Storage 2-Chloroaniline should be stored in a tightly sealed container in a cool, dry, well-ventilated area away from sources of ignition, incompatible substances (such as strong oxidizers and acids), and direct sunlight. The storage area must be equipped with spill containment and suitable ventilation to prevent accumulation of vapors. Properly label all containers and restrict access to authorized personnel.
    Application of 2-Chloroaniline

    Applications of 2-Chloroaniline in Industrial Manufacturing

    2-Chloroaniline plays a critical upstream role in several sectors of the fine chemicals and materials industries, where it serves as a key intermediate for synthesis and formulation processes. Below we outline the main industrial segments where this compound finds established, consistent use, with clear details on compliance, formulation practice, integration into downstream operations, and the resulting final products.

    1. Agricultural Chemicals: Phenylurea Herbicide Synthesis

    As an aromatic amine intermediate, 2-Chloroaniline is essential in the large-scale manufacture of certain urea-structured herbicides. Its role enables formation of core molecular structures in products intended for selective weed control in cereal, rice, and cotton crops, with strict oversight from national agrochemical regulators.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS) purity and impurity profiles
    • China NY/T 1107-2006 specification for technical materials
    • EU Regulation (EC) No 1107/2009 authorization for plant protection products
    • ISO 8657 for technical-grade herbicides

    Typical usage ratio

    • 0.85–1.1 molar equivalents in relation to isocyanate co-reactant, adjusted based on target herbicide synthesis yield and byproduct minimization

    Downstream process integration

    • Reacts in the initial condensation stage with isocyanate derivatives under controlled temperature and pressure, ensuring efficient conversion before further substituent modification and formulation into active ingredients

    Final product types

    • Phenylurea herbicides (e.g., chlorotoluron, diuron, linuron)
    • Formulated wettable powders and suspension concentrates for field application

    2. Dyestuffs: Chloroaniline-Derived Azo and Anthraquinone Dyes

    Downstream dye manufacturers incorporate 2-Chloroaniline as a diazo component or coupling partner for specialty colorant synthesis. This usage enables production of high-precision dyes with selective color fastness, essential in fibers and printing sectors regulated for safety and consistency across international markets.

    Industry compliance standards

    • REACH Annex XVII (Restrictions on hazardous amines in azo dyes)
    • OEKO-TEX Standard 100 for restricted substances in textile colorants
    • Chinese GB/T 22863 for dye intermediates
    • ZDHC (Zero Discharge of Hazardous Chemicals) Manufacturing Restricted Substances List

    Typical usage ratio

    • 0.9–1.2 mol equivalents relative to diazotizable substrate, ratio determined by desired shade depth and chromophore efficiency in batch or continuous operations

    Downstream process integration

    • Diazotization of 2-Chloroaniline under aqueous acidic conditions, followed by coupling with naphthols or other acceptors to build the dye molecule prior to purification and drying

    Final product types

    • Azo dyes for textile and leather finishing
    • Anthraquinone dyes for polyester and polyamide fibers
    • Specialty pigment dispersions used in inkjet and flexographic printing

    3. Pharmaceutical Synthesis Intermediates

    API producers employ 2-Chloroaniline as a precursor in the multi-step synthesis of certain antihypertensive and antitumor agents. Its amine group and chloro functionality support targeted aromatic substitutions prescribed in international pharmacopeial monographs, with strict impurity and trace contaminant thresholds.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practices (APIs)
    • USP/NF monographs for pharmaceutical intermediates
    • EDQM CEP (Certificate of Suitability) dossier submission
    • Chinese Pharmacopoeia (ChP) Appendix for raw material assays

    Typical usage ratio

    • Frequently 1.0 mol equivalent in relation to acylating or alkylating agents, adjusted to limit byproduct formation and meet specified intermediate purity

    Downstream process integration

    • Enter synthesis as the initial aromatic amine, supporting core scaffold construction through nucleophilic aromatic substitution, subsequent cyclization or condensation, and protection/deprotection strategies in cGMP environments

    Final product types

    • Bulk pharmaceutical intermediates for antihypertensive drugs (e.g., chlorthalidone synthons)
    • Starting units for targeted antineoplastic agents (e.g., aniline-derived kinase inhibitors)

    4. Rubber Chemicals: Antioxidant and Accelerator Precursors

    Companies producing process aids and specialty rubber additives use 2-Chloroaniline to develop key antioxidants and vulcanization accelerators. This practice has a sustained industrial history, especially in regions with established tire, belt, and industrial rubber product lines requiring process chemicals regulated for performance and occupational safety.

    Industry compliance standards

    • ASTM D4671 standard for rubber processing chemicals
    • EN 2001:2013 for safety-relevant elastomer auxiliary substances
    • ISO 9001 quality management for chemical auxiliaries
    • OSHA 29 CFR 1910.1200 (Hazard Communication)

    Typical usage ratio

    • Ranges from 0.2–0.6 weight% at the precursor preparation stage, with fine-tuning based on batch scale and intended physical attributes of the final rubber compound

    Downstream process integration

    • Condensed with carbon disulfide and secondary amines to form sulfenamide or thiazole accelerators; involved in antioxidant manufacture by further derivatization, then supplied for direct compounding with natural and synthetic rubbers

    Final product types

    • Thiuram and sulfenamide accelerators (e.g., CBS, TBBS)
    • Special purpose antioxidants for heavy-duty elastomers
    • Industrial rubber goods including tires, conveyor belts, and sealing systems

    5. Specialty Fine Chemicals: Corrosion Inhibitor Manufacturing

    Producers of process water additives and industrial lubricants integrate 2-Chloroaniline into the synthesis of arylamine-based corrosion inhibitors. Its performance is valued in harsh environments such as oilfield water circuits and recirculating cooling systems, subject to chemical control and disposal regulations.

    Industry compliance standards

    • ASTM D665 for testing of rust-preventive characteristics
    • REACH registration for inhibitor substances under EC No 1907/2006
    • API RP 936 for materials selection in refinery systems
    • EPA TSCA Section 5 for new chemical notification

    Typical usage ratio

    • Concentration between 0.5–2.5 wt% in the synthetic feed, depending on system throughput and inhibitor loading requirements

    Downstream process integration

    • Initial condensation or alkylation with aldehydes or carboxylic acids, followed by formulation into emulsifiable or water-dispersible concentrates for industrial scale-up and blending

    Final product types

    • Circuit water corrosion inhibitors for petrochemical and refinery plants
    • Concentrated additive packages for metalworking and hydraulic fluids
    • Custom blend inhibitor systems for power station cooling towers
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    Certification & Compliance
    More Introduction

    2-Chloroaniline: A Foundation Chemical Built on Experience

    Introduction to the Product

    In the world of aromatic amines, 2-chloroaniline stands as a compound that plays a discreet but vital role in the backbone of chemical manufacturing. Drawing from years of hands-on manufacturing, our plant has focused on delivering this fundamental intermediate with a strong understanding of quality expectations, meticulous process control, and respect for downstream applications. We recognize the direct impact that purity, consistency, and packaging integrity have on the success of every customer’s process, from the largest batch reactors to small R&D labs.

    What 2-Chloroaniline Offers

    Customers turning to 2-chloroaniline require more than just a CAS number or a technical label. This mono-chlorinated aniline derivative carries a lot of weight in industrial synthesis, especially as a building block for dyes, agrochemicals, drug precursors, and performance polymers. Our production line crafts 2-chloroaniline in accordance with methods honed not just for output but for reproducible results that make real-world scaling easier. Whether serving established multinational operations or supporting specialty synthesis, we keep our focus squarely on operational transparency and measurable control.

    Our standard grade typically delivers assay values consistently above 99.5% as determined by validated GC analysis. That’s not a marketing claim—it’s an achievement driven by a proven reaction path, careful temperature management, and robust handling protocols from the reactor through purification. Impurities like polychloroanilines, dichloroaniline isomers, or residual aniline present a risk when they fall outside industry-accepted tolerances. Our in-process quality checkpoints target these specifically with continuous monitoring, so you can calculate yields and side reactions with real confidence.

    Manufacturing Approach: Lessons Learned in Practice

    Aromatic amination and chlorination are anything but forgiving. Factory-floor experience shows that minor deviations at the chlorination step—whether in reactant ratios, agitation, or solvent choice—trigger unwanted by-products or color bodies in your final product. Early in our own plant’s timeline, we faced hard lessons about water management post-reaction, recognizing how even trace moisture influences both color and stability during storage and shipment. These process details become obvious only after living through real troubleshooting cycles—laboratory analysis alone can’t completely substitute for what operators learn hands-on during scale-up.

    We chose to refine our process using continuous-flow methods over older batch standards. Constant flow rates, tight residence time control, and custom-designed filtration allowed us to lower the risk of runaway reactions or incomplete chlorination. This practical change reduced both waste and batch variability, and also built safer working conditions, which matter deeply to us after years of line operation. Each lot still receives characterization by both GC and NMR to verify the absence of halogen exchange and off-position substitution. It’s not just about ticking off regulatory boxes; our technical staff knows how tiny shifts in impurity profiles can disrupt customer processes, particularly for pharmaceutical and pigment uses.

    Product Appearance and Packaging Insights

    Typical 2-chloroaniline production yields a pale yellow to pale brown liquid under ambient conditions. Small color shifts often trace back to impurities or improper handling—so every drum and container comes with a tamper-evident seal and lot traceability. We’ve seen customers struggle when suppliers shipped in contaminated or corroded containers and have made double-walled steel drums our standard for bulk shipments. Smaller quantities are packaged in HDPE safety jugs to balance chemical compatibility with safe manual handling.

    Some of our clients have unique requirements—small-scale pharma operators may need inert atmosphere filling, while larger paint and dye makers ask for higher volume ISO tanks. We learned it’s never one-size-fits-all by speaking directly with their technical teams and adjusting our filling protocols. It’s the unexpected details—outgassing from closure caps, unnoticed surface irregularities, or residues from previous fills—that can cause headaches at your plant door. Our own shipping management team tracks every lot to understand how temperature and transit time alter physical properties during the journey.

    Key Uses in Industry—Insights Gained on the Production Floor

    The majority of our output moves into dye manufacturing, where 2-chloroaniline forms the backbone of azo dye coupling agents and optical brighteners. Years of collaborating with dye shops taught us how even minuscule trace chlorinated byproducts distort tint or alter true shade. Manufacturers of agricultural chemicals lean heavily on our product as a precursor in the synthesis of certain herbicides and pesticides, such as those targeting broadleaf weeds. Our relationship with formulation chemists in this sector showed us the domino effects of inconsistent feedstock—yield losses, inconsistent crystalline properties, and even process shutdowns from off-spec lots. Close relationships forged during field audits and customer returns reshaped how we monitor residual aniline and dial in our purification steps.

    Beyond dyes and agrochemicals, 2-chloroaniline quietly fuels pharmaceutical intermediate synthesis and specific polymer lines. From our experience, the pharma sector’s analytical scrutiny leaves no room for error—trace contaminants amplify in subsequent reaction steps, so our lot certification now couples routine chromatographic analysis with selective melting point and color index reporting. We’ve also addressed safety directly by boosting onsite ventilation and staff training in response to learnings from process near-miss reports—a commitment you only develop through years in direct production.

    Technical grade and higher-purity selections are also available to R&D labs, where chemists appreciate transparent GC trace data and actual impurity breakdown across the batch. Requests for “non-standard” packaging—argon blanket, custom volumes—usually start from real-world problems shared during direct calls or visits, not from marketing fads. We accommodate these because we know that agile development work sets the stage for scaled-up success down the line.

    Comparisons to Related Products: Insights from Direct Batch Experience

    Customers often compare 2-chloroaniline to its close relatives—monochloroanilines at alternate ring positions or substituted analogs like 4-chloroaniline and 2-bromoaniline. Having produced these variants onsite, side-by-side, we recognize the subtle differences in reactivity and byproduct risk. For instance, while 4-chloroaniline offers similar molecular weight, the ortho position of the chloro group in 2-chloroaniline drives different nucleophilicity, affecting downstream electrophilic substitution or condensation reactions in dye or pharma synthesis.

    2-Chloroaniline’s handling profile shares similarities with its isomers, yet long-term drum storage behavior and chemical stability can diverge. We’ve seen 4-chloroaniline resist discoloration better under poorly controlled storage, due mainly to the para position decreasing ring activation. The ortho-substituted 2-chloroaniline shows a slightly greater tendency to darken over time if shipping extends into high-heat seasons or delays at customs, so we’ve adapted storage recommendations appropriately. Direct batch experience also allowed us to tweak antioxidant or stabilizer additions when shipping overseas.

    Compared to non-halogenated anilines, 2-chloroaniline resists certain oxidative degradations, which our process chemists exploit when scheduling long-haul bulk container shipments. Still, it requires more attention during cleanup and handling—volatile fumes can be more intense under high mixing shear, which older facilities sometimes overlook. We modified our drum dispensing lines to include vapor scrubbers, based on feedback from real-world incidents, so the smell never builds to disruptive levels for plant personnel or handlers.

    Real-World Challenges and Solutions Developed in the Field

    Manufacturing and supplying 2-chloroaniline confronts practical hurdles every day. Back when we started bulk operations, inconsistent raw material purity—especially aniline and chlorinating agents—often forced us to pause or reprocess entire lots. Strong supplier relationships and lot-level authentication of every incoming drum changed that pattern for the better. Tight specifications on chlorinating agent content, water inclusions, and metal catalyst residues became part of our standard purchasing contracts, reducing operational headaches downstream. On the plant line, employee training emphasizes real-time sensory and chromatographic monitoring, a system evolved by necessity from dealing with past runaway reactions and off-color drums rejected at customer gates.

    Shipping 2-chloroaniline brings another set of challenges. We have dealt with trucks stuck at national borders in hot climates, where internal drum temperature spiked above optimal storage conditions. In response, we now apply heat-sensitive indicator strips to containers and train logistics personnel on quick temperature checks upon unloading. Sometimes, long transit times expose containers to vibration and excess motion, which can loosen seals and promote minor leakage. Inspection checkpoints and changed drum crimping protocols directly addressed this. Customers with highly sensitive batch processes benefit when these less obvious steps eliminate ruined raw material and waste, because production lines run on reliability and trust.

    Quality Assurance—Earning Trust Beyond Certificates

    It’s easy to promise certificates of analysis, but sustaining technical trust only happens through close feedback and accountability. Regular audits by customer quality teams taught us where to strengthen our records and exactly where to focus lot testing. During past recalls by other suppliers, our own historical control records and retained sample library enabled us to prove product stability and resolve disputes without weeks of delay. We’re committed to full transparency about how we blend, sample, and test—frequency, method, and range included in every certificate to satisfy even the most detail-oriented QA departments.

    Occasionally, users need deeper analysis—tracking trace polychlorinated impurities or employing exhaustive NMR and IR for downstream patent mapping. Our technical staff consults directly and offers side-by-side analytics, so customers can calibrate their own in-process controls. We have discovered that open collaboration always yields better outcomes than treating these issues as one-off complaints or warranty cases. Our investments in better lab instrumentation arose directly from these technical partnerships.

    Environmental and Safety Considerations Learned Firsthand

    Chlorinated anilines bring both opportunity and environmental responsibility. Wastewater generated during purification or reaction often contains low levels of aromatic amines and halogenated byproducts. Prior in-plant spills and effluent brown-outs showed us how small missteps can cascade into regulatory trouble or ecological impact. We engineered scrubbers and on-site water treatment with this hard-won knowledge. Operator vigilance throughout drum packing and transfer always matters, and ongoing hands-on training in spill management comes not just from policy but from lived experience handling this class of materials.

    Handling 2-chloroaniline also demands respect for personal safety—its vapors carry a strong odor and moderate toxicity. Respiratory protection, skin barrier gloves, and cross-department safety drills became non-negotiable parts of daily operation after incidents earlier in our history. Newer employees work alongside seasoned team members to learn effective cleanup, first-aid, and safe transfer, blending practical knowledge with evolving best practices. We view these lessons as much a part of our chemical stewardship as any specification or regulatory control.

    Responding to Industry Shifts and Regulatory Demands

    Markets and regulations move quickly, and staying relevant means staying informed. Recent shifts in global toxics regulations around chlorinated aromatics impacted our reporting requirements and, in some regions, driven batch-level registration or even requalification. Instead of taking chances, we actively track major regulatory updates and relay those impacts into revised documentation, labeling, and SDS management. Open dialogue with regulatory consultants, customer compliance teams, and industry associations shapes how we interpret evolving guidance and fit them into everyday plant operation.

    Concerns around trace impurities have sharpened with stricter rules from authorities in developed markets—both for workplace exposure and for final end-product safety. We see genuine opportunities amid tighter rules, as each new compliance step has expanded our analytical capabilities and customer trust. We watch for global supply chain disruptions too, adjusting inventory strategy in response to world events, labor markets, and raw material shortages. Transparency about fluctuations is as important to our customers as shipping notice or technical specs.

    Innovation Through Partnership, Not Guesswork

    True advances in chemical manufacturing come from listening, not just innovating in a vacuum. Several of our most productive process improvements resulted from on-site exchanges with technical users—people who see the practical snags that bench chemists might gloss over. For instance, feedback about spent drum disposal led us to revisit packaging design and recover more drums for safe return and recycling. Some large-scale clients suggested line-side purity checks using direct in-line FTIR, which we then adapted to benefit smaller users as well.

    Our plant continues to invest in better process automation, real-time contamination monitoring, and safer transfer technologies. We track customer feedback, not just as a satisfaction metric, but as a central tool for tweaking reaction timing, flushing protocols, and environmental monitoring. The cycle of learning, adapting, and sharing became our core workflow.

    Summary of Experience-Informed Delivery

    Working directly with 2-chloroaniline for years shapes our sense of responsibility. It’s not enough to meet minimum standards; each batch carries the reputation of all the labor and care poured into its creation. The science behind the molecule is only part of the story—experience with raw material selection, reaction troubleshooting, and hands-on safety forms the rest. Our team stands ready to support exacting customers who value practical expertise over generic assurances. By maintaining open channels and continuous improvement, we build the reliability that customers have come to expect, grounded not just in certificates but in years of real-world results.