Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

2-Chloroacetophenone

    • Product Name 2-Chloroacetophenone
    • Alias CN
    • Einecs 203-843-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    748784

    Cas Number 532-27-4
    Iupac Name 1-(2-chlorophenyl)ethan-1-one
    Molecular Formula C8H7ClO
    Molecular Weight 154.60 g/mol
    Appearance Colorless to pale yellow crystalline solid
    Melting Point 55-57°C
    Boiling Point 244-245°C
    Density 1.211 g/cm³
    Solubility In Water Slightly soluble
    Flash Point 110°C
    Vapor Pressure 0.01 mmHg (20°C)
    Odor Pungent, irritating

    As an accredited 2-Chloroacetophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 500g label, sealed cap, hazard symbols for irritant and toxic, manufacturer details, and chemical name clearly displayed.
    Shipping 2-Chloroacetophenone is shipped as a hazardous chemical due to its toxic and irritant properties. It is typically packaged in tightly sealed containers, labeled according to international regulations (such as UN 1693, Class 6.1, toxic substances), and transported under controlled conditions to prevent leaks, exposure, or environmental contamination during transit.
    Storage 2-Chloroacetophenone should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers or bases. Keep it away from moisture. Properly label the storage area to indicate the hazardous nature of the chemical and ensure suitable spill containment measures are in place.
    Application of 2-Chloroacetophenone

    Applications of 2-Chloroacetophenone in Industrial Manufacturing

    2-Chloroacetophenone, an aromatic chlorinated ketone synthesized via Friedel–Crafts acylation, serves as a critical intermediate in downstream manufacturing chains that demand precise reactivity and reliable performance in synthesis. Our production facility maintains rigorous oversight from material selection to finished batch logistics, supplying high-purity material to established industrial clients worldwide. The following application scenarios represent actual, longstanding industrial uses of 2-Chloroacetophenone, supported by verified regulatory standards and practical formulation data from continuous field engagement.

    1. Synthesis of Aryl Ketone-Based Tear Gas Formulations

    The chemical forms a key active component in the manufacture of law enforcement-grade lachrymatory agents, specifically for projectile and aerosolized irritant products. Regulatory frameworks strictly limit composition and deployment, while downstream processors incorporate the raw material based on specified physiological potency and dispersal kinetics. Integration focuses on homogeneous dispersion and stable encapsulation for consistent yield and controlled particle size distribution required in finished agents.

    Industry compliance standards

    • EN 14011:2010 (Chemical irritants for law enforcement – safety requirements)
    • U.S. Code of Federal Regulations 21 CFR 573.100
    • United Nations Recommendations on the Transport of Dangerous Goods (UN TDG)
    • OSHA 29 CFR 1910.1200 hazard labeling

    Typical usage ratio

    • 8–12% as active irritant ingredient in tear gas canister or cartridge formulations; dosage adapted for specific delivery system (aerosol, solid dispersal), often determined by targeted dispersal radius and exposure concentration parameters validated through field testing.

    Downstream process integration

    • Direct blending into propellant or matrix base during batch compounding, followed by encapsulation and canister filling under inert atmosphere to prevent premature volatilization and degradation.

    Final product types

    • Non-lethal tear gas grenades
    • Aerosol self-defense sprays
    • Law enforcement projectile cartridges (pyrotechnic or burst type)
    • Specialized riot control munitions

    2. Fine Chemical Intermediate in Pharmaceutical Synthesis

    In the pharmaceutical industry, 2-Chloroacetophenone operates as a tailored electrophilic building block for synthesizing benzylamine, benzhydryl, and substituted phenacyl derivatives, which serve as core scaffolds in select antihistamines and antispasmodic APIs. GMP-compliant sites control trace impurity carryover and reaction kinetics, ensuring integration aligns with ICH Q7 requirements and relevant pharmacopeial monographs. Downstream formulations depend on careful stoichiometric adjustment and purification protocols to control yields and to meet strict residue specifications in the final active substance.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monograph 01/2008:2200
    • USP <1046> Chemical Reactants & Intermediates
    • 21 CFR Part 211 (cGMP for Finished Pharmaceuticals)

    Typical usage ratio

    • Range: 1–5 molar equivalents per API synthesis step; adjusted according to nucleophile reactivity and target yield, typically determined during route development and DoE validation.

    Downstream process integration

    • Charged directly to the main reactor either as a neat liquid or pre-dissolved in compatible solvents in the first or second condensation stage, followed by controlled addition of nucleophiles and monitoring for byproduct removal during work-up.

    Final product types

    • Benzhydryl-based antihistamines (e.g., diphenhydramine derivatives)
    • Antispasmodic drug intermediates
    • Analgesic precursors
    • Specialty chemical reagents for R&D libraries

    3. Agricultural Pesticide Synthesis

    Major crop protection companies employ 2-Chloroacetophenone as a synthetic intermediate for developing pyrazole and phenacyl-based herbicide and insecticide actives. Route selection emphasizes environmental compatibility and minimization of persistent organochlorine residues in line with international agrochemical regulations. Precise dosage control ensures efficient conversion while meeting regulatory maximum allowable residue limits in field applications. Integration typically occurs in the initial condensation or halogen exchange step preceding final active compound isolation and microencapsulation.

    Industry compliance standards

    • FAO/WHO Specifications and Evaluations for Agricultural Pesticides (FAO/WHO JMPR)
    • EU Regulation (EC) No 1107/2009 on plant protection products
    • ISO 9001:2015 for agrochemical manufacturing quality systems
    • China GB 2763 National Food Safety Standards MRLs

    Typical usage ratio

    • 0.7–2.2 molar equivalents per synthetic batch, dependent on the crop-active’s molecular structure and desired purity grade for downstream processing and formulation.

    Downstream process integration

    • Introduced at the key arylation or condensation step, dissolved in polar aprotic solvents, and reacted under controlled temperatures (40–80°C) with subsequent neutralization, filtration, and phase separation for active isolation.

    Final product types

    • Pre-emergent and post-emergent herbicide active ingredients
    • Insecticide API intermediates for vector control
    • Seed treatment compounds
    • Pesticide R&D test samples

    4. Synthesis of Liquid Crystal Material Precursors

    Advanced display technology manufacturers utilize 2-Chloroacetophenone to prepare specialty aromatic intermediates for liquid crystal display (LCD) production. Chemical properties promote introduction of halogen functional groups necessary for subsequent etherification, which establishes mesogenic cores with required birefringence and phase transition properties. Downstream users prioritize ultra-high purity and consistent particle size, with supply chains governed by electronics industry traceability and hazardous material control regulations.

    Industry compliance standards

    • IEC 62474 Material Declaration for Products of and for the Electrotechnical Industry
    • RoHS Directive 2011/65/EU (restriction of hazardous substances)
    • ISO 14644-1 Cleanroom Standards for electronics manufacturing
    • JIS C0950 (Japan hazardous substance management for electronic products)

    Typical usage ratio

    • 0.5–1.2 molar equivalents in Friedel-Crafts or nucleophilic substitution reactions, adjusted according to the desired chain length or substitution degree in the LCD precursor framework.

    Downstream process integration

    • Processed in the initial halogenation or etherification unit operation as a limiting reagent, with reaction progress tightly controlled via in-line HPLC or GC techniques to ensure batch reproducibility and minimal carryover.

    Final product types

    • Halogenated liquid crystal monomers
    • Mesogenic precursor blends
    • Display-grade LCD mixtures for TFT panel fabrication
    • Specialty photonic material blends
    Free Quote

    Competitive 2-Chloroacetophenone prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    2-Chloroacetophenone: Our Direct Approach to a Proven Chemical Ingredient

    Introducing 2-Chloroacetophenone from Our Plant

    As a longstanding manufacturer, we have always taken a hands-on approach to 2-Chloroacetophenone, also known as CN, recognizing its unique profile and its established place in both chemical synthesis and crowd control applications. Our facility draws on decades of careful refinement to supply a reliable compound, with each batch designed for consistent results in a variety of industrial and research settings. This approach is the result of continuous improvement, learning from field requirements, and the invaluable feedback of partners who use our material in real-world applications.

    What Makes Our CN Stand Out

    We focus directly on purity, particle size, and manageable packaging. Over the years, it's become clear that traces of impurities or unpredictable particulate distribution can cause headaches during downstream synthesis. As a result, our facility places emphasis on sustaining a standard purity of 98% or higher, minimizing non-volatile material, and strictly controlling the amount of moisture. This lets formulators, chemists, and industrial users skip repeated quality checks or reformulations that would otherwise slow them down. In our experience, overlooking these issues risks compromised yield or process reliability, especially in sensitive formulations.

    The Technical Profile

    2-Chloroacetophenone appears as a white to off-white crystalline solid. Our batches undergo routine analysis with each lot for identity and assay. Most customers require melting points between 54 and 57°C, which we regularly confirm by both DSC and manual testing protocols. Moisture sits below 0.5%, an essential threshold for producing downstream derivatives or stable formulations. Typical packaging runs from 25kg fiber drums to 500g glass bottles for lab use. The expectation remains simple: clean, clump-free material that pours and measures without frustration, because nothing disrupts a process engineer’s day like a stubborn, caked-up chemical.

    Why Usage Context Shapes Manufacturing

    The reputation of 2-Chloroacetophenone is shaped not only by lab literature but by stories from users. In synthesis, small differences in particle size or residual solvents can change solvent compatibility or end-product color. Some customers blend it to make intermediary compounds, including pharmaceuticals and specialty polymers. Others use it for developing contrast agents, dyes, or agricultural intermediates. More regulated use involves non-lethal crowd management mixtures. Each scenario has taught us: even the same molecule, if manufactured without tight control, performs very differently in practice.

    In the chemical manufacturing world, “good enough” quality doesn't cut it. We have seen users battle line clogging or waste tanks fouled by inconsistent products. Internally, our quality control teams refer cases of “mystery batch drift.” These prompt us to invest in regular GC-MS verification, and process tools that examine both finished product and raw inputs. By doing so, we keep batch-to-batch variability under tight rein. As a direct manufacturer, every failure or success reflects on our methods, not on any chain of resellers.

    Comparing to Other Chemical Options

    When discussing active compounds in the same family, prospective customers commonly mention benzyl chloride, benzaldehyde, and other halo-aromatic derivatives. Each chemical presents its own fingerprint in terms of reactivity, volatility, and safety profile. 2-Chloroacetophenone offers a stronger lachrymatory effect than most; its tear-producing characteristics play a role in security and defense. As a building block, its reactivity toward nucleophilic substitution opens up several synthesis routes not possible with simpler aromatics.

    Manufacturers at the plant level distinguish product types by purity, form, and presence of by-products. Resin manufacturers or pharmaceutical precursors often need a higher-purity grade, free from even trace amounts of acetanilide or dichloro-derivatives found in some competitor products. Some imported lots suffer from yellowing or musty odors, signals of oxidation or solvent contamination. Over the years, our own records show that by keeping a line open to industrial chemists, we learn fast whenever a shift in impurity profile creates process headaches.

    What Rigorous Standards Mean for Real-World Users

    Having spent much of my early career running production shifts, the best way to avoid headaches is to work upstream rather than troubleshooting contaminated reactors or off-spec outputs. Chemists and production managers cannot afford to discover product problems after inventory has been mixed or reactors charged. Because of this, our manufacturing sequence employs multiple checks, bringing in FTIR, Karl Fischer titrations, and solvent residue analysis at defined steps. Sampling is not reserved for a chosen few. Workers down the line understand why control matters—rejecting a drum costs less than halting a full production run for cleaning.

    Approaches that cut corners may produce a one-time batch at lower cost, but end-users often report clouding or residual stench after processing. By keeping direct relationships with formulation chemists, we hear about all forms of trouble, from hard-to-remove residues to compatibility problems with final product blends. Maintaining high standards in active ingredient manufacture solves most of these issues before the material leaves our gate. These insights only come from years following up with those who actually run mixing tanks and not from sitting at a sales desk discussing generic spec sheets.

    Addressing Common Misconceptions

    2-Chloroacetophenone carries a controversial reputation because of its use in non-lethal munitions. It deserves mention that decades of industrial deployment have shown its utility extends far beyond these scenarios. As a synthetic intermediate, it provides an accessible route to many complex molecules—especially when halogen positioning and ease of substitution are priorities in target molecule design. We regularly work with customers developing agricultural or pharmaceutical products who face public misunderstanding about the safe, controlled use of this compound outside security fields.

    Even among experienced technical buyers, legends persist about “universal grade” material. In our daily experience, application-specific tuning beats generic blending. For researchers, small-batch production helps avoid degradation over time, especially as CN is light sensitive and slowly hydrolyzes. For bulk users, economies of scale come through precise scheduling and bulk packaging that avoids repeated exposure. Once again, the manufacturer’s direct role in managing freshness, tracking lot history, and responding to special order requests cannot be overstated.

    Learning from Decades in the Trenches

    It didn’t take much time early on to recognize that moisture content, storage temperature, and exposure to light can ruin a well-prepared batch of CN. In our own warehouses, climate-controlled areas and amber-glass containers have become the norm. Staff know to seal drums tight and record every opening. Training doesn’t stop at production but continues in the warehouse, because a lapse in basic handling leads to clumped or discolored material that no customer wants.

    There’s no shortcut to getting this chemical right. When a complaint appears—be it about color shift or unexpected solubility—we trace every step. In several cases, tracking impurity spikes has helped us pinpoint where a cleaning cycle needed tightening or where a filter cake left an unwanted signature. These practical lessons, learned through real-world headaches, teach us more about the product than academic journals ever could.

    Supporting Customer Success

    Over the years, our support teams have handled countless application requests: some researchers want gram-scale quantities for development screens, others aim for regular truckloads. We supply technical documentation, but most of our value surfaces in conversations with plant chemists who need more than a data sheet. Our manufacturing team can suggest best storage practices, optimal dissolution solvents, and typical reaction pitfalls based on what we see running on the floor. Often, these conversations highlight how direct manufacturer support beats guessing from second-hand knowledge circulating online or from distributors unfamiliar with the original production process.

    It’s not unusual to receive calls about off-label uses or how to troubleshoot downstream process inconsistencies. Experience shows that many issues, blamed initially on user error, often track back to subtle differences in raw material sources. For 2-Chloroacetophenone, these may show up as phantom peaks in GC traces, faint shifts in melting point, or unpredictable color changes on aging. Having open channels with those relying on our product helps both sides, closing the feedback loop so we can refine process parameters with future runs.

    Responsible Production and Supply Chain Vigilance

    Supplying CN places us under close regulatory and ethical scrutiny. We review end-use declarations and audit sales regularly. Monitoring extends through all parts of our operation—from procurement to shipping documentation—reducing the likelihood of diversion or misuse. These measures matter, not just to comply with the law, but to uphold our responsibility for safe, legitimate chemical manufacturing. Everyone in our plant sees the value of this oversight firsthand: it safeguards business continuity, protects our people, and keeps our relationship with regulatory bodies positive.

    In the spirit of transparency, real-world incidents have taught us that accountability cannot stop at the warehouse door. When a rare recall arises or when government reviews warrant quick action, having prepared contingency protocols means we act fast. This discipline has turned potential business threats into opportunities for partnership and process improvement, reinforcing trust in our reliability as a direct manufacturer.

    Industry Practices and Quality Improvements

    Comparing quality benchmarks to competitor offerings reveals the impact of investing in plant-level process controls. We routinely benchmark batches against both international and local standards, not just for purity or residual solvents but also for heavy metals and potential cross-contamination from prior synthesis lines. Several customers reported that shifting to our product cleared up persistent issues with their own batch consistency. This comes from an ethos built through regular plant audits and above-standard housekeeping, both of which keep contaminants away from the final product.

    Our technical team regularly reviews production logs, customer complaints, shipment results, and new testing technology. Over time, this commitment produced tangible upgrades: more robust filtration, real-time analytics in the drying phase, and improved operator training modules. Each adjustment results from connecting direct experience with customer priorities, not abstract directives from management far removed from the shop floor.

    Packaging and Delivery: A Direct Manufacturer’s Perspective

    Logistics demand as much attention as synthesis. We learned quickly that packaging failures invite both loss and resale integrity risks. Too light and hygroscopic CN draws moisture, too bulky and the product “sets up” or collects at the bottom. Investing in specifically lined drums and tight-sealing closures, with individually serialized tamper evidence, maintains both product value and end-user trust. Regular testing throughout the storage cycle in our own facilities matches shipment size to anticipated use, reducing needless handling and spoilage.

    Unlike brokers or warehouse consolidators, as a direct manufacturer, we maintain accountability from the reactor to the final packed drum. Any batch deviation, leaking container, or damaged label becomes our responsibility, not a distant vendor’s. Our team sends every order out knowing there’s no one else to shield us from mistakes. This shapes a culture of continuous improvement in packing, labeling, addressing customer-specific labeling needs, and working with shipping agents who understand the sensitivity and hazards of active chemicals like CN.

    Looking Ahead: The Future of CN Manufacturing

    Industry demand for 2-Chloroacetophenone has evolved steadily. Priorities shift as new applications develop, with regulatory and safety demands rising. Our plant invests in ongoing R&D around both green chemistry substitutes and process optimizations for legacy products. While some end-uses may decline due to regulation or public perception, the molecule remains essential for specific advanced syntheses or time-tested formulations.

    Staying engaged with end-users keeps us sharp; each request hints at potential process innovations or substitutions. Our lab now regularly reviews alternative feedstocks, low-residue process routes, and sustainable purification schemes. This dual focus—respecting the established reputation of 2-Chloroacetophenone and seeking innovation—secures both our legacy and our relevance in changing markets. Regular meetings between plant staff, regulatory reviewers, and seasoned users openly share problems and ideas for future improvements.

    Final Thoughts from the Factory Floor

    From all the years spent refining, packaging, and supporting users of 2-Chloroacetophenone, the clearest lesson stands: product quality and reliable supply flow from direct involvement at every stage. As chemical manufacturers working with a wide range of partners—be they multinational formulators, academic researchers, or small-batch specialty users—we see every success and every complaint as proof that quality cannot be outsourced. Each improvement is built not from catalog promises but from problem-solving rooted in real industry practice.

    Working directly in manufacturing brings a different level of accountability and pride. Material that bears our label must solve customer problems, not create them. Our ongoing investment in batch consistency, safety, and support creates not only satisfied users but a stronger reputation for the product itself. We stand by every shipment of 2-Chloroacetophenone that leaves our plant, knowing the difference that direct manufacturing truly makes.