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2-Aminophenol Hydrochloride

    • Product Name 2-Aminophenol Hydrochloride
    • Alias 2-Hydroxyaniline hydrochloride
    • Einecs 226-388-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    956111

    Productname 2-Aminophenol Hydrochloride
    Casnumber 600-23-7
    Molecularformula C6H8ClNO
    Molecularweight 145.59 g/mol
    Appearance White to off-white crystalline powder
    Meltingpoint 174-178°C
    Solubility Soluble in water
    Purity Typically ≥98%
    Odor Odorless
    Storagetemperature Store at 2-8°C
    Ph Acidic in water solution
    Synonyms o-Aminophenol hydrochloride
    Boilingpoint Decomposes before boiling
    Stability Stable under recommended storage conditions
    Hazardclass Irritant

    As an accredited 2-Aminophenol Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Aminophenol Hydrochloride, 100g: Supplied in a sealed amber glass bottle with tamper-evident cap and clear hazard labeling.
    Shipping 2-Aminophenol Hydrochloride is shipped in tightly sealed containers to prevent moisture absorption and contamination. The packaging complies with hazardous materials regulations, including appropriate labeling and cushioning to avoid breakage. It is transported in cool, dry conditions and handled by trained personnel, ensuring safety during storage and transit.
    Storage 2-Aminophenol Hydrochloride should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from moisture and incompatible substances such as strong oxidizers. Protect it from light and avoid prolonged exposure to air. Store at room temperature and ensure the storage area is clearly labeled and compliant with relevant chemical safety guidelines.
    Application of 2-Aminophenol Hydrochloride

    Applications of 2-Aminophenol Hydrochloride in Industrial Manufacturing

    As a chemical raw material producer, we supply 2-Aminophenol Hydrochloride to manufacturers operating in demanding industrial fields. Below, we detail key downstream applications, compliance standards, manufacturing ratios, integration steps, and typical finished products in each sector.

    1. Dye and Pigment Intermediates in Fine Chemicals

    Leading dye and pigment manufacturers use 2-Aminophenol Hydrochloride as an essential intermediate for synthesizing azo and sulfur dyestuffs, specially targeted for textiles, leather, and paper coloration. The compound enters dye synthesis via nucleophilic substitution or coupling processes, enabling the controlled development of custom chromophores and precision-shaded dyes. Quality control requires traceability for each batch entering multipurpose fine chemical facilities.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for Chemicals
    • REACH Registration (EC No. 1907/2006) for European market formulation
    • Zhejiang Dye Industry Association Testing Protocols
    • OEKO-TEX® Standard 100 for textile safety (when used in textile dyes)

    Typical usage ratio

    • Relative dosage: 0.08–0.20 mol per mole of main dye coupling component, precisely adjusted for target color yield and chromatic fastness. Optimization depends on desired shade intensity, reaction pathway, and substrate affinity.

    Downstream process integration

    • Charged into dye intermediate reactor after initial mixing and pH adjustment
    • Blended with aromatic compounds in stepwise addition to regulate exothermicity
    • Integrated with sulfonation or diazotization units for final pigment formation
    • On-line in-process quality check for color indices and residual impurities prior to downstream blending

    Final product types

    • Azo dyes for cotton and polyester fibers
    • Sulfur dyes for cellulosic textile processing
    • Specialty pigments for food packaging inks (where permitted)
    • High-performance paper dyes and colorants

    2. Pharmaceutical Intermediate for Paracetamol Synthesis

    Pharmaceutical companies source 2-Aminophenol Hydrochloride for use as a key intermediate in paracetamol (acetaminophen) production via acetylation processes. Controlled conversion ensures purity and yield, with trace impurity analyses carried out at each stage to comply with global pharmacopoeias. Batch records and GMP-compliant documentation are mandatory throughout the active ingredient manufacturing chain.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) as per ICH Q7A
    • Ph. Eur., USP, and JP monographs for intermediates and APIs
    • FDA 21 CFR Part 211 for finished dosage form facilities
    • Drug Master File (DMF) submission for regulatory approval

    Typical usage ratio

    • Usually 1 mol per mol of acetic anhydride in the acetylation step; actual ratio subject to in-process stoichiometric optimization, depending on target batch size and limiting reagent strategy.

    Downstream process integration

    • Dosed into primary acetylation reactors after pre-assay of moisture and impurity content
    • Reaction progress tracked via HPLC for intermediate and byproduct analysis
    • Purified intermediate routed to crystallization and tablet synthesis units
    • Full traceability and chain of custody records kept for all intermediates supplied

    Final product types

    • Pharmaceutical-grade paracetamol active ingredient (API)
    • Pain relief and fever-reducing tablets, capsules, and suspensions
    • Paediatric and extended release paracetamol formulations
    • Combination analgesic medications

    3. Antioxidant Additive in Industrial Lubricant Formulation

    Producers of industrial lubricants and metalworking fluids utilize 2-Aminophenol Hydrochloride as a functional antioxidant to suppress oxidative degradation at elevated temperatures and in harsh environments. Process engineers incorporate this additive at precise concentrations following solvent blending or base oil pre-treatment to ensure long-term stability and metal compatibility, validated through accelerated aging and corrosion resistance tests.

    Industry compliance standards

    • ASTM D4951 for additive content determination
    • ISO 14001:2015 for environmental controls in blending facilities
    • RoHS Directive 2011/65/EU, when used in machinery lubricants for electronics
    • API Base Oil Standards (API 1509) for finished lubricants

    Typical usage ratio

    • 0.05%–0.3% by weight in finished lubricant formulations; fine-tuned to meet required oxidation stability and pour point characteristics, depending on base oil type and application

    Downstream process integration

    • Added post-refining to solvent-neutral or hydrocracked base stocks
    • Dissolved under nitrogen blanketing to prevent premature oxidation during blending
    • Product stored and dispatched in lined tanks to minimize contamination risk
    • Routine batch testing performed for deposit formation and volatility parameters

    Final product types

    • Heavy-duty industrial gear oils
    • Metal rolling and cutting fluids
    • Compressor and transformer oil blends
    • Hydraulic system lubricants

    4. Developer Component in Photographic Chemical Processing

    Photographic and imaging industry manufacturers use 2-Aminophenol Hydrochloride as a developer agent for black-and-white photo processing, contributing its reductive properties in silver halide reduction. It is formulated in proprietary mixtures after dissolution in aqueous or buffered solutions to achieve uniform image contrast and tonal quality. Handling and processing align with environmental and occupational safety standards for darkroom chemicals.

    Industry compliance standards

    • ISO 18902 for imaging chemical storage and handling
    • ANSI/NAPM IT9.2 for photographic processing solutions
    • Local authority regulations on waste silver effluent disposal
    • Occupational exposure limits as per ACGIH TLVs for chemical handling

    Typical usage ratio

    • 1–6 g/L concentration in developer working solutions; concentration refined based on film sensitivity, developer temperature, and desired contrast profile for professional and industrial photographic workflows.

    Downstream process integration

    • Dissolved in pre-measured developer concentrate solutions
    • Combined with alkali buffers and sulfite preservatives before use
    • Sequential addition to automated or manual processing tanks
    • Spent solutions passed through silver recovery systems prior to disposal

    Final product types

    • High-contrast industrial X-ray and technical films
    • Archival black-and-white prints for documentation and legal records
    • Photographic papers for specialized laboratory imaging
    • Photolithography developer solutions for printed circuit board manufacturing

    5. Corrosion Inhibitor Synthesis for Water Treatment Chemicals

    Manufacturers of corrosion inhibition products for industrial water treatment utilize 2-Aminophenol Hydrochloride as a precursor in the synthesis of anti-corrosive agents targeting steel and copper systems. In these formulations, precise molecular modification enables the production of water-soluble inhibitors that extend asset life in boilers, cooling towers, and heat exchangers, under strict monitoring of amine residuals and treatment compatibility.

    Industry compliance standards

    • ANSI/AWWA B603 standards for water treatment chemicals
    • ASTM D2688 for corrosion performance evaluation methods
    • National Sanitation Foundation (NSF) International certification, where required
    • ISO 9001 certification for specialty chemical manufacturing

    Typical usage ratio

    • Precursor concentration: 0.1–1.5 mol/L in reaction mixtures depending on targeted molecular weight and intended performance. Formulator adjusts proportion to reach required corrosion rate reduction and solubility levels.

    Downstream process integration

    • Introduced to amination or alkylation reactors under controlled temperature
    • Reaction intermediates pH-monitored and sampled for amine analysis
    • Product neutralized and filtered prior to drum or IBC filling
    • Final inhibitor solutions dosed directly into client water circulation systems

    Final product types

    • Closed system corrosion inhibitors
    • Boiler and steam system additive blends
    • Chilled water treatment packages
    • Copper pipe and heat exchanger protection chemicals
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    Certification & Compliance
    More Introduction

    2-Aminophenol Hydrochloride: Reliable Consistency from the Source

    An Insider’s Look at 2-Aminophenol Hydrochloride

    Across decades of hands-on manufacturing, we’ve seen the difference that well-controlled 2-Aminophenol Hydrochloride (model: APH-HCl, CAS 137-08-6) brings to chemical processes. In our production lines, APH-HCl stands out for its purity and batch-to-batch consistency. Our engineers focus on minimizing metallic contaminants and adjusting particle size to fit processes in dyes, pharmaceuticals, and specialty chemicals. It doesn’t just fill a spot on a shelf — real value lies in how it supports reliable yields and fewer headaches down the line.

    Clarity on Specifications Backed by Practical Production

    We don’t stop at purity figures. We monitor residual water content and keep chloride levels tightly controlled, as even minor fluctuations can throw off sensitive downstream reactions. In the dye industry, for example, APH-HCl remains in demand for its role in making azo dyes and developing color-forming intermediates. Product stability, especially during transit and storage, matters most to our clients. Our dedicated storage procedures and moisture-proof packaging keep the product free from caking or chemical degradation—problems that often show up with lower-grade sources.

    What Makes APH-HCl Tick for End Users

    From years in the business, we’ve learned that 2-Aminophenol Hydrochloride solves process headaches chemists face with oxidations, couplings, and condensations. In pharma synthesis, APH-HCl helps build essential intermediates for analgesics, antipyretics, and even hair dye ingredients. By keeping our pH targets strict and controlling the color index, we reduce the risk of batch failures, particularly during scale-up.

    Compared with other starting amines, APH-HCl offers better solubility in water and lower dusting, which cuts down both respiratory hazards and clean-up time. We get fewer calls about clogged pipelines or material bridging during feed—reality-based advantages that stem from manufacturing choices at our facility. For custom projects, we can modify the particle size or supply the material in granulated form, based on hands-on experience with various reactor configurations.

    How APH-HCl Sets Itself Apart

    Buyers often weigh 2-Aminophenol base against the hydrochloride salt. The salt form brings distinct advantages. It handles humidity better, which means no sudden clumping during humid shipping conditions. The hydrochloride version also mixes easily with aqueous systems, saving time during formulation steps. We’ve known customers in the pigment sector who switched to APH-HCl and reported a noticeable reduction in filtration time and product loss.

    Unlike generic offerings sourced through layered resale channels, our APH-HCl ties back to controlled internal QA, and we give attention to every detail, from neutralization pH to final drying cycle. This discipline not only enhances reproducibility but limits unwanted side-products, which can cause regulatory or performance issues. Our product rarely triggers complaints about off-odors, which crop up in less refined batches.

    Applications Shaped by Hands-On Insights

    Over years of running kilo to multi-ton batches, we’ve seen APH-HCl slot into a surprising range of chemistries. In dye manufacture, it stands as a building block for both basic and advanced colorants. Textile labs lean on it for diazo coupling reactions, while downstream veterinary pharmaceutical plants use it in antipyretic formulations. We’ve delivered shipments to labs developing antimalarial intermediates, where moisture stability kept rejections near zero. It’s also found a place in photo developers, antioxidants, rubber accelerators, and niche research settings.

    End users reach out for help when troubleshooting unanticipated side-reactions. With direct manufacturing under one roof, we draw from real case experience, not just textbook examples. For instance, when a customer’s azo dye yield dropped unexpectedly, close scrutiny of trace metal content in our APH-HCl revealed a slight batch variation. Tweaking our recrystallization step restored their process yield. This sort of feedback loop between producer and user makes a deeper, practical difference.

    Batch Quality: Beyond the Data Sheet

    Our internal specs cover color, content, and impurity profile. Yet, the truer story surfaces in user labs: high reproducibility means fewer do-overs and less waste. Returning customers often cite the "non-hygroscopic" property, a direct result of our drying process and dedicated packing line. Over time, we’ve tweaked our manufacturing to limit the aromatic amine impurity fraction, aiming at requirements well below what industry specs set as minimums.

    This difference defines why some manufacturers attract steady, long-term partnerships while others chase spot price. Consistency of APH-HCl links directly to reduced rejects in dye coupling tanks and more reliable yields in pharmaceutical intermediates. Hard-won knowledge guides each production change—something not gained by brokers handling only paperwork.

    Sustainable Manufacturing with Real Results

    Environmental responsibility isn’t just a slogan. Our approach focuses on solvent recycling and using closed systems for acidification and crystallization. These steps reduce waste acid discharge—a real challenge in aminophenol chemistry. Over the years, these improvements have also benefited product purity, as tighter controls on internal recycling limit cross-contamination and stabilize output.

    Clients dealing with strict regulatory requirements, especially in pharma and veterinary sectors, often quiz us on traceability. Our lot tracking allows backward investigation down to raw material batches, removing the guesswork common among traders or contract packagers. These systems didn’t develop overnight. They evolved from real-world audits and supplier qualification cycles, where gaps in traceability cost everyone time and effort.

    Comparisons That Matter for Chemical Users

    Not all 2-Aminophenol hydrochlorides are equal. Variations in production routes—reduction of nitrophenol in batch versus continuous lines—leave hard-to-predict fingerprints on purity and side product pattern. We've compared our output with commercial lots from both domestic and global suppliers. Some showed inconsistent moisture content, and others failed at stability during long sea journeys.

    Through holding direct control over reduction, neutralization, and filtration, we hold responsibility in-house. If an issue does come up, we resolve it ourselves, not through a web of emails to upstream providers. That’s a difference many downstream processors appreciate, especially those that can’t afford batch failures caused by incoming material drift.

    Serving Large Volumes and Small Batches Alike

    We’re equipped for both bulk tanker loading and custom-packed laboratory lots. After client feedback, we shortened lead times and offer buffer storage for repeat contracts. That way, urgent lines never stall due to raw material gaps. Bulk customers who switched to us from fragmented resellers report sharper production scheduling and lower holding costs, since our lot-to-lot uniformity reduces surge ordering for blends or rechecks for quality.

    Supporting R&D means more than just small deliveries. We've answered direct technical questions—about downstream color reactions, solubility in non-aqueous solvents, and even pilot plant troubleshooting. Our team draws from first-hand manufacturing and application backgrounds so conversation isn’t just sales talk.

    Challenges and Solutions: Boots-on-the-Ground Experience

    No product line stays free from issues. In APH-HCl production, atmospheric oxidation control, filter efficiency, and consistent acidification levels top our list. Years ago, we faced shipment returns due to excessive chlorine odor. That wake-up call led us to update our ventilation and neutralization protocols. Now, chlorine volatilization sits far below actionable limits by international guidelines.

    Clients processing APH-HCl into advanced intermediates sometimes face filtration slowdowns during rainy seasons. Early batches would cake inside drums from unplanned humidity spikes. We overhauled our storage and drying operations, and we added humidity indicators in each drum. It cut off complaints and reduced time spent breaking up material at customer sites.

    Waste minimization matters both for cost and community acceptance. Closed-loop filtration and investment in acid recovery tanks came from practical problem solving—government fines and rising effluent costs provided the push. Over a few years, we dropped our waste output by nearly half, making operations more stable and projects easier to sustain.

    Backed by Hands-On Testing and Market Feedback

    Year-round, we run application tests using our current-lot APH-HCl in real chemical formulations. These go beyond mere compliance checks—they show if small-scale adjustments on the line made a difference in color strength, solution clarity, or reaction time compared to competitor products. This loop, connecting plant engineers, lab chemists, and technical sales, keeps us close to user realities and pins down what buyers actually find valuable, instead of just quoting out-of-context specs.

    We see some labs using the base form and converting it in-house to the hydrochloride. That route looks cheaper on paper. Direct use of APH-HCl, though, eliminates an extra neutralization and drying cycle, saving overhead and lowering exposure in plant rooms that struggle with aromatic amine odors. That’s not theory—we’ve seen clients realize both safer workspaces and tighter material controls.

    Future Possibilities and Continuing Evolution

    As synthesis and regulatory rules evolve, APH-HCl faces new demands. Some buyers now specify even lower levels of trace metal contamination. We invest in high-sensitivity detection—atomic absorption, ion chromatography—so our output meets tomorrow’s standards. These upgrades don’t just satisfy inspectors; they stem from long-term feedback cycles with researchers who regularly stretch chemical performance limits.

    Moving forward, reduction in process solvents, greener acids, and even bio-based synthesis options come under discussion at our facility. Some of these changes need more research to match the quality of current routes, but we pursue these directions not as PR, but out of genuine necessity to keep production both safe and competitive.

    APh-HCl: More Than a Commodity

    People in the chemical business know products like 2-Aminophenol Hydrochloride can get treated as simple raw material lines. Our approach comes from knowing that process failures, operator concerns, or regulatory surprises crop up not from a lack of data but from unseen differences in how materials are made, handled, and delivered. Through every shipment, we build in lessons learned, whether about improved filtration, longer shelf life, or reduced hazardous waste.

    Chemical users in dyes, pharma, or specialty intermediates rely on producers who stand behind their batches. Years of staying close to the shop floor and listening to user struggles helps us deliver material that minimizes trouble where it actually occurs. That’s the story of our APH-HCl—not just another amine salt, but a product kept reliable through real-world experience, process tuning, and ongoing investment in the small details technical teams count on.