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2,6-Dinitroaniline

    • Product Name 2,6-Dinitroaniline
    • Alias 1-amino-2,6-dinitrobenzene
    • Einecs 202-811-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    257357

    CAS_Number 601-42-1
    Molecular_Formula C6H5N3O4
    Molecular_Weight 183.12 g/mol
    Appearance Yellow crystalline solid
    Melting_Point 91-94 °C
    Boiling_Point Decomposes before boiling
    Density 1.55 g/cm³
    Solubility_in_Water Slightly soluble
    Storage_Temperature Store at room temperature, away from light
    Synonyms 2,6-Dinitroanilin, Dinitroaniline, NSC 4201

    As an accredited 2,6-Dinitroaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2,6-Dinitroaniline is packaged in a 100-gram amber glass bottle, clearly labeled with hazard warnings and chemical identification details.
    Shipping 2,6-Dinitroaniline should be shipped in tightly sealed containers, protected from physical damage, heat, and incompatible substances. It must be labeled as a hazardous material, including Class 6.1 (toxic substances) and possibly Class 9 (miscellaneous dangerous substances). Proper documentation and compliance with relevant shipping regulations (DOT, IATA, IMDG) are essential.
    Storage 2,6-Dinitroaniline should be stored in a tightly closed, labeled container, kept in a cool, dry, and well-ventilated area away from sources of heat, ignition, and incompatible materials such as strong oxidizing agents. It should be protected from light and moisture. The storage area must be secure and access restricted to authorized personnel with appropriate safety training.
    Application of 2,6-Dinitroaniline

    Applications of 2,6-Dinitroaniline in Industrial Manufacturing

    As a direct manufacturer of 2,6-Dinitroaniline, we supply this specialty nitroaromatic intermediate to key industrial sectors with established, compliant downstream applications. Below, we detail specific scenarios where 2,6-Dinitroaniline demonstrates critical value throughout the chemical supply chain, highlighting real regulatory adherence, formulation strategies, integration into manufacturing processes, and the resulting finished goods produced by our customers worldwide.

    1. Azo Pigment Intermediate for High-Performance Colorants

    2,6-Dinitroaniline functions as a primary coupling component in the synthesis of certain yellow and orange azo pigments, mainly for the plastics, coatings, and inks sectors. Its nitro-substituted aromatic structure ensures high tinctorial strength and weather-fastness in resultant pigment molecules. Manufacturers employ 2,6-Dinitroaniline in both batch and continuous diazotization-coupling systems, producing colorants used in applications demanding strict light- and solvent-fastness, such as automotive coatings and engineering thermoplastics.

    Industry compliance standards

    • EN 71-3:2019 (Safety of toys – Migration of certain elements, relevant for pigments in toys and plastics)
    • REACH Regulation (EC) No 1907/2006 – registration and authorization for use in colorant manufacturing
    • ETAD Code of Practice – safety evaluations specific to colorant raw materials
    • ISO 18451-1:2015 (Terminology for pigments and extenders)

    Typical usage ratio

    • 5–18% by mass in pigment synthesis; ratio adjusted to colorimetric requirements and desired pigment yield

    Downstream process integration

    • Added to azo coupling reactors after diazotization step, under controlled pH and temperature, prior to pigment precipitation and milling

    Final product types

    • Azo pigments for plastics (e.g., PE, PP, PVC masterbatches)
    • Industrial coatings and paints for automotive and architectural surfaces
    • Printing ink concentrates
    • High-grade dispersions for fiber and engineering resins

    2. Synthesis of Agricultural Herbicide Intermediates

    Within the agrochemical sector, 2,6-Dinitroaniline serves as a key intermediate in the manufacture of certain dinitroaniline-based herbicides, notably used for pre-emergent weed control in crop management. Industrial producers employ it in multi-step synthesis routes, beginning with nucleophilic substitution and reduction processes to achieve the desired active ingredient structures. The robust nitro-substitution on the aniline ring confers selectivity and persistence required by modern agronomic standards.

    Industry compliance standards

    • FAO/WHO Specifications and evaluations for agricultural pesticides
    • ISO 9001:2015 (Quality management systems for agrochemical manufacturing)
    • European Directive 91/414/EEC – Plant Protection Products Regulation
    • US EPA registration requirements for active herbicidal substances

    Typical usage ratio

    • 15–25% as a starting intermediate in the total batch weight for herbicide active ingredient synthesis; precise percentage dependent on specified molecular conversion rates

    Downstream process integration

    • Charged during initial reaction stage for nucleophilic aromatic substitution, followed by reduction/alkylation sequences under inert atmosphere

    Final product types

    • Dinitroaniline-class pre-emergent herbicides such as trifluralin and pendimethalin intermediates
    • Technical-grade agrochemical actives for formulation plants
    • Herbicide microcapsules and granules
    • Bulk concentrate technicals supplied for liquid dispersions

    3. Key Intermediate in Specialty Dye Manufacture

    In the dye industry, 2,6-Dinitroaniline participates as a crucial building block for synthesizing select acid and metal-complex dyes. Its unique electron-withdrawing groups facilitate precise color shade control and high substrate affinity, particularly for polyamide and wool dyeing applications. Companies integrate this compound into multi-stage synthesis routes, often engaging in reduction and condensation processes prior to sulfonation and metal complexation, resulting in high-stability textile dyes.

    Industry compliance standards

    • Oeko-Tex Standard 100 (limitations on certain aromatic amines and nitro compounds in textiles)
    • ZDHC MRSL v3.1 (Manufacturing Restricted Substances List for dye chemicals)
    • ISO 14001:2015 (Environmental management for dye production plants)
    • REACH Annex XVII (authorizations and restrictions for aromatic intermediates)

    Typical usage ratio

    • 10–22% relative to total starting materials in dye coupling reactions; optimized based on required tinctorial value and shade intensity of the target dye group

    Downstream process integration

    • Introduced at the condensation or reduction step, often combined with sulfonating agents and complexation salts, prior to filtration and spray drying of the dye product

    Final product types

    • Acid dyes for nylon and silk
    • Metal-complex dyes for wool and leather applications
    • Industrial textile dyes for apparel, carpet, and upholstery sectors
    • Color concentrates for fiber and film coloration processes

    4. Precursor in Fine Chemical Synthesis for Pharmaceuticals R&D

    Research-driven pharmaceutical producers use 2,6-Dinitroaniline as a starting point in the multi-step synthesis of advanced intermediates explored during drug discovery and development. The presence of dual nitro functionalities supports regiospecific reduction and further derivatization, allowing medicinal chemists to tailor aromatic substitution patterns for structure-activity relationship studies and pilot API synthesis. Control over raw material origin and traceability meets stringent laboratory and GMP requirements.

    Industry compliance standards

    • ICH Q7 – Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 – US FDA cGMP for finished pharmaceuticals
    • Ph. Eur. (European Pharmacopoeia) raw material screening guidelines
    • USP <1045> Bulk Pharmaceutical Excipients (where used in R&D support)

    Typical usage ratio

    • 1–8% of total input mass in pilot-stage syntheses, with adjustment based on yield optimisation and downstream conversion requirements in medicinal chemistry routes

    Downstream process integration

    • Employed as a core aromatic precursor in the initial synthetic step, followed by selective reduction and functional group interconversions in controlled laboratory or kilo-lab settings

    Final product types

    • Pharmaceutical research intermediates
    • Patent-registered API scaffolds for clinical candidates
    • Reference standards for analytical laboratories
    • Specialty fine chemicals supporting early-stage process development
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    Certification & Compliance
    More Introduction

    2,6-Dinitroaniline: Straightforward Chemistry, Reliable Performance

    Introduction to 2,6-Dinitroaniline

    Our work with 2,6-dinitroaniline began as a response to the precise needs of pigment and chemical intermediate manufacturers. This compound draws attention for its reliable performance in challenging environments and adaptable chemistry. Over the years, our production team has become thoroughly acquainted with its structure and properties, tuning every batch to suit the realities of plant-scale usage rather than abstract technical ideals. Chemists look for consistency, and this molecule provides it, giving downstream users fewer headaches and steady results.

    Understanding Its Structure and Specifications

    2,6-Dinitroaniline carries the molecular formula C6H5N3O4, featuring an aniline core with nitro groups at the 2 and 6 positions. This configuration sets it apart from isomers such as 2,4-dinitroaniline, where nitro groups change position and shift the way the molecule behaves in synthesis. Our latest output typically arrives as a yellow to orange crystalline powder, usually in a technical grade suited for industrial processes. Purity can reach upwards of 98 percent by weight when required, depending on the target application and specific requirements specified by the customer.

    Working from a chemical manufacturer’s perspective, we have learned to keep a close eye on melting point and solubility. 2,6-Dinitroaniline generally offers a melting point in the range of 110–115°C, a factor that directly influences drying, formulation, and storage practices at the user’s site. Solubility in common solvents tends to follow predictable patterns, with increased uptake in organic solvents and lower water solubility. This affects how formulators plan their process workflows, influencing equipment cleaning and solvent recovery strategies. Over time, these details trim operational costs and shape the way customers handle material on a day-to-day basis.

    Production Realities and Practical Choices

    Producing 2,6-dinitroaniline involves steps that require real attention to safety, reagent quality, and process efficiency. Our operators closely monitor reaction temperatures and exotherms, as careless handling or insufficient mixing can result in unwanted byproduct formation such as ortho- or para-substituted isomers. During purification, crystallization becomes a balancing act between efficient yield collection and removal of off-color impurities. Direct feedback from customers has taught us that color variations can disrupt pigment performance, so we control iron content and other trace metals prior to shipment.

    Each lot runs through a set of analytical checks—HPLC, GC-MS, and targeted wet chemistry tests. The feedback loop between production and quality control means our chemical parameters don’t just sit on a certificate, they translate into smoother blending for formulators and more predictable yields for synthesis teams.

    Practical Applications: Where 2,6-Dinitroaniline Performs Best

    Most of our output finds its way into specialty dyes, pigment intermediates, and the synthesis of complex organic molecules. Dye manufacturers trust 2,6-dinitroaniline for its consistent chromophoric backbone; experienced hands know that deviation in precursor quality quickly throws shade and lightfastness off target. In agricultural chemistry, it acts as a starting material for certain herbicides, giving compounders the flexibility to move between product generations with minor process tweaks. The compound’s chemical stability allows storage in standard warehouse environments without demanding special atmospheric controls or strictly inert conditions.

    Some clients rely on its nitroaromatic moiety to drive nitration or reduction steps, seeking high conversion without excessive byproduct formation. We have seen 2,6-dinitroaniline outperform related products such as 2,4-dinitroaniline in applications where selective reactivity is needed. For instance, reactivity at the para position is blocked, which plays a role in the formation of downstream target molecules without competitive side reactions at unwanted positions.

    Distinct Features Over Similar Compounds

    Comparing 2,6-dinitroaniline with related nitroanilines, structural differences drive distinct behaviors in synthesis. Our clients working in azo dye manufacture often remark on the difference in color hue and purity achieved with 2,6- versus 2,4-dinitroaniline. The dual ortho positioning of nitro groups reduces unwanted coupling during diazotization, improving the reliability of subsequent reactions. Formulators targeting high-performance pigments benefit from improved light and thermal stability in end products. Technicians in pilot plants regularly mention that crystallization and recovery step adjustments remain manageable, even when scaling up new processes with this molecule.

    Some manufacturers still use 2,4-dinitroaniline for certain dye routes, yet our experience has found 2,6-dinitroaniline’s lower byproduct tendencies provide better yield management and reduce the time lost during purification. In material science applications, these characteristics translate to fewer filter changes and less downtime for cleaning, a daily reality that matters more than any broad marketing promise.

    Handling Challenges and Solutions: Lessons Learned on the Shop Floor

    2,6-Dinitroaniline comes with its own set of handling requirements. Anyone who has worked with this compound knows that it dusts more easily than some heavier aromatic intermediates. To avoid material losses and keep workplace air clear, we invested in closed-system charging equipment and vacuum transfer lines. The payoff shows in cleaner working environments, improved worker safety, and more precise batch results.

    During colder months, crystallization control faces a greater challenge, as the product can become prone to caking and bridging in bins. Our team refined our drying and packaging technique to keep cake formation low, so downstream manufacturing lines avoid stoppages and material wastage. Temperature fluctuations can also speed up minor oxidative changes, so we tie our product flow to a just-in-time delivery schedule when customers request higher sensitivity.

    For users unfamiliar with handling nitroaromatics, proper PPE and dust collection become essential. Our shipments include technical usage guidance—not just generic MSDS sheets, but operating tips tuned to large-scale plant realities. Customers have told us this helps their training teams onboard new staff faster and cuts batch-to-batch variability. We offer practical feedback in real terms based on our test runs and in-house closed-loop feedback.

    Environmental Responsibility and Continuous Improvement

    Our plant has shifted toward greener nitration technologies to reduce the impact of waste acid and offgassing. During purification, we recycle rinse solvents through multi-stage recovery, slashing the total solvent volume required per ton of product. We pay close attention to wastewater treatment, using in-line sensors to monitor contaminant loads and adjust pH in real time. From our side, efficiency is a daily target, not a one-off claim.

    By reducing our reaction batch sizes and adopting modular mixing systems, we cut the energy footprint of every kilogram shipped. These investments improve competitiveness by lowering cost structure while keeping product quality stable, and also reflect the expectations of regulators and customers alike. We've found customers increasingly ask about the environmental impact of their intermediates. Sharing details about process improvements, waste minimization, and small-batch process development helps us earn their trust, going beyond the paperwork that comes with compliance.

    Customer Partnerships: Addressing Real-World Needs

    Our relationship with end users often starts at the technical level. A formulator calls with an upcoming color match challenge, or a newly commissioned plant needs advice on optimizing their reduction step. Our technical group dives into practical recommendations—sometimes suggesting dilution, sometimes direct charging, based on years of bench testing and firsthand production knowledge. We keep communication channels open, swapping process feedback for insights into shifting market needs or potential quality failures.

    Periodic onsite visits often highlight the realities customers face—powder flow issues, unexpected color drifts, solvent compatibility snags. We walk through these problems shoulder-to-shoulder, adjusting our QA focus or packaging standards in response. For example, one pigment manufacturer flagged that trace iron in a single batch created yield and color performance fluctuations. Our QA team pinpointed the source to an upstream raw material drum and reengineered filtration on the main process line. Lessons like this carry forward. The next season, a new customer avoided the same pain, thanks to process data we already had on file.

    Over time, customers press us for shorter lead times and more flexibility. Instead of building up inventory, we tighten our planning and increase batch frequency to supply fresh product on demand. This shift gives smaller companies room to call off material as needed, without locking up capital in a warehouse.

    Staying Ahead With Technological Progress

    Process control remains at the root of quality and safety when scaling up hazardous chemical manufacturing. Our plant adopted digital monitoring for every critical parameter, including explosion potential around nitroaromatics, as well as advanced temperature and pH controls. Whenever our analytics team identifies a new benchmark for impurity reduction or yield improvement, those changes go straight onto the production floor. Real data shapes our daily operations and keeps output where it should be—meeting spec for our customers and minimizing unforeseen adjustments.

    Raw material fluctuations in global markets prompt operators everywhere to reevaluate supply chain risk. We qualify secondary suppliers for reagents and solvents, keeping consistency high to avoid disruptions down the line. Our team values longstanding supplier relationships, which often tip the balance when material shortages hit the wider industry. These links help us keep customer orders on schedule, no matter the upstream volatility.

    Future Prospects: Keeping Quality Front and Center

    Demand for higher-purity intermediates only grows as pigment requirements and chemical legislation tighten worldwide. We continue to refine our process to cut trace residuals and streamline analysis. Customers push for more detailed certificates of analysis, including batch traceability and contaminant screening, because audits grow more thorough every year. Our approach answers these calls through practical experience—backed up by test data, production logs, and hands-on support.

    As green chemistry advances, alternative synthesis paths will emerge. Some groups experiment with bio-derived feedstocks or more selective reduction catalysts. Our research team evaluates these technologies for scalability, stability, and cost. We believe innovation starts at the plant floor, where improvements become visible in yield calculations, solvent consumption, and waste generation, not only in glossy presentations.

    Conclusion: Practical Value in Every Batch

    The story of 2,6-dinitroaniline production is one of hands-on problem solving, ongoing teamwork, and continual learning. It doesn’t fit neatly into a generic product sheet; it takes shape in daily production decisions, shared process improvements, and the evolving requirements of the companies that rely on it. We take pride in delivering results that support chemical manufacturers, pigment formulating labs, and research teams alike—not just in the numbers reported but in the smoothness of their daily workflow and the reliability of their production lines. Each batch we ship draws on this shared history, shaped by both challenge and opportunity over many years in the chemical industry.