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2,6-Dimethylmorpholine

    • Product Name 2,6-Dimethylmorpholine
    • Alias N,N-Dimethyl-2,6-morpholinediamine
    • Einecs 216-452-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    666417

    Chemical Name 2,6-Dimethylmorpholine
    CAS Number 6368-00-5
    Molecular Formula C6H13NO
    Molar Mass 115.17 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 148-150 °C
    Melting Point -17 °C
    Density 0.913 g/cm³
    Solubility in Water Miscible
    Refractive Index 1.436
    Flash Point 46 °C
    Vapor Pressure 2 mmHg (25 °C)
    Synonyms 2,6-Dimethyl-1-morpholine
    Structural Formula C1CN(COCC1)(C)C
    SMILES CC1CN(CCO1)C

    As an accredited 2,6-Dimethylmorpholine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2,6-Dimethylmorpholine is supplied in a 500 mL amber glass bottle with a secure screw cap and detailed hazard labeling.
    Shipping **Shipping Description:** 2,6-Dimethylmorpholine should be shipped in tightly sealed containers made from compatible materials, protected from physical damage, and clearly labeled. Store in a cool, dry, well-ventilated area away from incompatible substances. Comply with all local, national, and international transport regulations, including appropriate hazard identification if classified as hazardous.
    Storage 2,6-Dimethylmorpholine should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers and acids. Protect from moisture and direct sunlight. Proper labeling and secondary containment are recommended to prevent leaks and spills. Store at room temperature and follow all relevant safety guidelines.
    Application of 2,6-Dimethylmorpholine

    Applications of 2,6-Dimethylmorpholine in Industrial Manufacturing

    2,6-Dimethylmorpholine supports specialized chemical synthesis and formulation in multiple mature sectors. As a direct manufacturer, we supply high-purity grades to downstream partners with precise technical specifications. The following application scenarios illustrate its established industrial integration.

    1. Polyurethane Catalyst for Flexible Foam Production

    Flexible polyurethane foam manufacturers use 2,6-Dimethylmorpholine as a tertiary amine catalyst, accelerating the polymerization and urea formation steps. This additive improves cell structure, foam rise speed, and physical uniformity in block and slabstock foam lines. Technicians adjust the content according to reactivity profile, polyol composition, ambient temperature, and target density in automotive, furniture, and bedding applications.

    Industry compliance standards

    • ISO 9001:2015 Quality Management in chemical processing
    • REACH Regulation (EC) No 1907/2006 (Europe)
    • GB/T 29418-2012 (China, PU foam industrial standard)
    • OEKO-TEX Standard 100 (contact foams for restricted substances)

    Typical usage ratio

    • 0.08%–0.15% by total foam formulation weight
    • Adjusted based on isocyanate index, amine balance, and end-use foam properties

    Downstream process integration

    • Add directly to polyol blend before metering
    • Continuous and batch foam lines; pre-mixed in catalyst packages to ensure even distribution

    Final product types

    • Flexible polyurethane foam rolls and sheets for bedding
    • Automotive interior seating and headrests
    • Furniture cushioning and upholstery
    • Textile laminates and technical foams

    2. Intermediate in Macrocyclic Lactam Synthesis (Nylon-6 and Nylon-12)

    In advanced polyamide manufacturing routes, 2,6-Dimethylmorpholine functions as an effective base for aminolysis and cyclization catalysis. Downstream users employ it in the controlled ring-cleavage and polymerization of lactams. It aids precise molecular weight control, influences end-group distribution, and benefits surface quality of spun and extruded fiber products.

    Industry compliance standards

    • ISO 9001:2015 and ISO 14001:2015 (environmental management for nylon plants)
    • EU Regulation 10/2011 (Plastic materials for food contact, for relevant fiber applications)
    • REACH

    Typical usage ratio

    • 0.5–1.2 mol% relative to lactam feed
    • Adjusted for polymerization kinetics and target viscosity

    Downstream process integration

    • Introduced in reactor prior to thermal cyclization
    • Acts in liquid-phase or melt-phase production lines for nylon prepolymers

    Final product types

    • Nylon-6 and Nylon-12 fibers for engineering textiles
    • Filament yarn for tire cord and conveyor belting
    • Engineering resin pellets and monofilaments
    • High-durability molded nylon parts

    3. pH Regulator in Industrial Waterborne Coatings and Paints

    Paint and coating formulators use 2,6-Dimethylmorpholine as a neutralizer and co-dispersant in waterborne systems to stabilize pH and maintain emulsion quality. Its volatility ensures minimal residue in cured films. Adjusting the dosage allows finished coatings to comply with major international standards on VOC and amine emissions, safeguarding final product usability in architectural, automotive, and packaging end markets.

    Industry compliance standards

    • US EPA 40 CFR Part 59 (VOC limits in coatings)
    • EN 13300 (European interior coatings standard)
    • GB 18582-2020 (mandatory Chinese standard for architectural coatings)
    • SCAQMD Rule 1113 (Southern California VOC control for architectural coatings)

    Typical usage ratio

    • 0.05%–0.3% by total paint formulation
    • Optimized by resin type, pigment loading, and target gloss/sheen level

    Downstream process integration

    • Dosed directly into the pigment grind or final letdown stage
    • Inline pH monitoring enables real-time adjustment during batch production

    Final product types

    • Waterborne acrylic wall paint
    • Industrial primers and adhesives
    • Automotive refinish coatings
    • Metal packaging internal coatings

    4. Catalytic Promoter in Epoxy Resin Curing Systems

    In advanced epoxy formulation, processors add 2,6-Dimethylmorpholine as a co-catalyst for amine-epoxy and anhydride-epoxy reaction pathways. It enhances gel time control, glass transition temperature, and final tensile strength in electrical potting, composite prepregs, and civil engineering adhesives. Our high-purity material enables repeatable performance and reactivity where low ionic content is required for sensitive end uses.

    Industry compliance standards

    • UL 94 (flame retardancy for electrical encapsulants)
    • RoHS 2011/65/EU (for circuit/electronics)
    • ASTM D1763-12 (Epoxy resin manufacturing)
    • ISO 9001:2015 for composite intermediates

    Typical usage ratio

    • 0.03–0.12 phr (parts per hundred resin) in epoxy systems
    • Ratio fine-tuned according to hardener structure, working time window, and final cure temperature

    Downstream process integration

    • Dissolved in resin or hardener blend prior to mixing and casting
    • Used in ambient and hot-cure production for bulk resins or prepreg manufacture

    Final product types

    • Structural adhesive films for aerospace and automotive
    • Electrical potting masses and PCB encapsulants
    • High-strength composite sheets
    • Infrastructure repair mortars

    5. Auxiliary Base in Pharmaceutical Intermediate Synthesis

    2,6-Dimethylmorpholine finds controlled use by pharmaceutical API and intermediate manufacturers as a sterically hindered base and phase-transfer agent. It facilitates selective alkylation, acylation, and ring-forming reactions when low nucleophilicity is essential. Process chemists select this material for syntheses demanding high purity, defined impurity profiles, and reliable performance under cGMP validation protocols.

    Industry compliance standards

    • ICH Q7 (GMP for active pharmaceutical ingredients)
    • USP/NF Monographs (where applicable for intermediates)
    • EU GMP Directive 2003/94/EC
    • ISO 9001:2015 (chemical manufacturing quality systems)

    Typical usage ratio

    • 0.2–1.8 equivalents relative to key reactant
    • Adjusted per route-specific stoichiometry and process constraints

    Downstream process integration

    • Added to reaction batch following solvent charge, under nitrogen atmosphere
    • Used in single-step or multi-step syntheses at pilot and commercial scale

    Final product types

    • Macrocyclic or heterocyclic pharmaceutical intermediates
    • APIs for anti-infective, CNS, or cardiovascular drug classes
    • Chiral synthons for advanced pharmaceutical ingredients
    • Non-GMP intermediates for new chemical entities (NCEs) in R&D
    Free Quote

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    Certification & Compliance
    More Introduction

    2,6-Dimethylmorpholine: Quality From Our Own Workshop

    Real Manufacturing Knowledge for Modern Chemistry

    Every batch of 2,6-dimethylmorpholine that leaves our plant reflects years of hands-on work in heterocyclic synthesis. Our chemists work at the reactors, manage the purification, and maintain the strict controls that create product consistency batch after batch. 2,6-dimethylmorpholine (2,6-DMM) stands out as a versatile intermediate and performance additive. While many chemical companies promote their catalog without knowing the actual process, we design, monitor, and scale the reaction ourselves—from raw amines and diols to finished, quality-controlled drums ready for real-world use. Only direct experience in production gives us clarity on practical performance, batch reliability, and the small details that separate routine goods from reliable, trusted materials.

    Rooted in Application: Shape and Structure Matter

    Through our own downstream work with customers and in our labs, we notice that 2,6-dimethylmorpholine fills a unique space among morpholine derivatives. The methyl groups positioned at the 2 and 6 carbon atoms on the morpholine ring impart steric hindrance and adjust the compound’s reactivity in downstream chemistry. This impacts both the selectivity in alkylation reactions and stability under various operating conditions. Technical grade 2,6-DMM, colorless liquid with a mild amine odor, will resist unexpected oxidation or polymerization that sometimes plagues less pure grades. As manufacturers, we see how this translates directly: polymers remain consistent, catalysts hold up longer, and downstream reactions generate higher yields with fewer byproducts.

    Specifications Backed by Day-to-Day Controls

    We do not rely on paperwork alone; our own team runs every step. Most end-users require a purity above 99.0%, water content under 0.5%, and low color for their syntheses. We stick with a model that provides product in standard iron drums, custom-sealed to avoid moisture uptake. We constantly monitor GC, NMR, and Karl Fischer titration during and after production. Years ago, before we implemented in-line moisture removal, customers reported shifts in reaction times. By pushing water specification even lower and using closed-system transfers, we improved downstream epoxide ring-opening and polyurethane chain extension, giving partners tighter processing control.

    Practical Differences from Other Morpholines

    Out in the field, customers sometimes struggle to choose between morpholine, N-methylmorpholine, 2,6-lutidine, and our 2,6-dimethylmorpholine. It pays to know the real differences. Regular morpholine goes into rubber, antioxidants, and corrosion inhibitors, but tends to react too broadly where selectivity matters. By placing methyls at the 2 and 6 positions, we cut down on Brønsted basicity and give bulk to the ring, limiting unwanted side reactions in finely-tuned steps. As a manufacturer, working with bulk blends and specialty reactions, we notice that 2,6-dimethylmorpholine offers greater oxidative stability and a lower tendency to nitrosate or form colored byproducts. Customers in high-performance coatings and pharmaceuticals can see real improvements in stability and purity profiles when they switch.

    Supporting Downstream Innovators

    Some additives sound good on paper but fail to deliver in tough conditions. We run our own pilot tanks to reproduce polyurethane and epoxy systems using both generic and our own 2,6-dimethylmorpholine. The difference shows up in reaction kinetics: shorter, more manageable gel times that keep production lines running smoothly rather than leading to costly downtime from blockages or inconsistent polymer growth. Customers working on waterborne urethanes or sensitive API syntheses see consistent throughput and fewer batch failures using our high-purity material. Not all plants or end markets need the same purity, and sometimes customers want custom blends for particular formulations or pH control. Our in-house application team links those needs to actual process adjustments, not just paperwork.

    Why Purity and Handling Matter for Real Operations

    Over years of feedback, we noticed that small impurities in low-end material—even at fractions of a percent—create macroscale impact in continuous reactors. A little trace of water reduces the lifespan of catalysts by speeding side reactions, or triggers polymer haze that takes hours to clean. Our plant’s closed transfer system, and in-line monitoring, help us keep headache problems out before a drum gets into customer hands. We’ve stood by lines where a drum from our competitor led to color drift in advanced coatings, showing how quality imparts measurable change in process efficiency as much as in product outcome.

    Direct Experience With Scale-up Challenges

    Scaling from grams in the lab to metric tonnes in production brings real surprises, not always pleasant. We hit unexpected issues with polymer plug formation when methyl placement wasn’t controlled tightly enough during one of our upgrades. That led us to rethink our temperature ramp profiles during the ring closure step, resulting in a more robust intermediate that converts to 2,6-DMM efficiently on large scale, cut our waste, and ultimately made higher-purity output repeatable. Lessons like these underscore that data sheets don’t tell the core story; hands-on familiarity with the molecule’s tendencies, reactivity, and final use cases does.

    Supporting Advanced Synthesis and Emerging Applications

    Our research partners work at the leading edge—needing morpholine derivatives stable enough for specialty pharma and electronics. The unique steric profile of 2,6-dimethylmorpholine means you can introduce it into complex syntheses without over-reactivity or unwanted cation formation. Battery technology teams look for amine stabilizers with low water and byproduct levels; we supply material that stands up through long hours of electrochemical testing. We have watched our product improve shelf life and storage stability for high-performance resins, academic labs, and railcar-scale polymer producers. Many of these improvements only came to light after years of iterative troubleshooting—testing new batch sequences, altering distillation columns, and revising our handling protocols on the actual factory floor.

    Why Source Direct From the Manufacturer?

    As a real, plant-based manufacturer, we own every stage from raw chemical arrival to outbound shipment. No third parties involved, so if there’s a query or troubleshooting need, we pull records from the actual run and speak with the engineers and operators who produced the lot. Decades of experience show that direct manufacturer oversight reduces risk for customers: batch-to-batch consistency is real, and tailored support means no mystery if any issue arises. For high-specification pharmaceutical or industrial applications, knowing precise batch origin, storage conditions, and full analytical history protects customer operations.

    Safety, Packaging, and Real-World Handling

    We learned early that small packaging shortcuts cause costly spills and moisture ingress. Good chemical handling starts in our own warehouse, where teams use lined drums with gasket seals to block contaminants. We ship under inert atmospheres for especially moisture-sensitive orders. Our in-house logistics team runs routine checks with real drum samples. Delivery schedules often mean timed unloading at large plants; irregularities waste hours or halt lines. By syncing our own schedules to downstream needs, we keep product fresh, dry, and process-ready, even for users who empty containers via automated pump lines and closed-loop systems.

    Challenges We’ve Tackled Directly

    Long-haul shipments in humid climates used to pose a recurring risk. Moisture pickup inside drums led to performance drops until we introduced real-time container tracking sensors and improved our drum interior liners. We restructured our inventory management to enable smaller, fresher batches, rather than bulk storage that ages material in unpredictable ways. Each time, problem-solving draws on both production know-how and close customer contacts who give field reports or raise challenges. This ongoing cycle of feedback and improvement anchors our understanding of what constitutes real-world quality.

    Quality Assurance: How We Build Confidence

    We operate our own analytical laboratories adjacent to production, not outsourced or offsite. Batch-by-batch, we track purity, GC-MS fingerprints, and physical properties. Once, an impurity drifted upward on a critical run; analytical flagged it, halted release, and sent a direct report for production review. We trace every lot number to reactor, operator, and even the raw chemical supplier. So, if ever a question arises, nothing is hidden—traceability is built in because operations management and quality assurance work on the same floor. End-users who must comply with stringent regulations appreciate this transparency, since clear records back up compliance and audit work.

    Continuous Process Improvement—Not Just Paperwork

    Safety and performance audits drive how we upgrade both equipment and standard operating procedures. Not every specification change on paper matches reality. We learned by trial that higher-temperature storage jeopardizes color quality and raises impurity risk, so we invested in climate-controlled warehouses, improved our cleaning schedules, and stopped minor leaks before they become major losses. We update procedures in response to real incidents and gather process engineers with frontline operators to review procedures and adapt workflows for both safety and consistency, not just cost.

    Knowledge Shared Means Better Outcomes

    We notice most knowledge transfer happens during real technical discussions, not just through marketing material. Customers who call get hands-on advice: if a downstream reaction stalls, we send our lab team to run test series, compare N-methylmorpholine to 2,6-dimethyl, and sometimes blend samples side by side. We track these case studies over years, building a library of real outcomes. That’s knowledge rooted in experience, not theory.

    Trends Shaping Next-Generation Chemistry

    Growth in specialty polyurethanes, battery electrolytes, and advanced pharmaceutical intermediates keeps morpholine derivatives in demand. Two decades back, only a handful of users sought high-purity 2,6-dimethylmorpholine. Today, we ship to users who rely on microgram-level accuracy for synthesis or who demand extended storage times in harsh climates. Processes evolve, but so do contaminant risks and performance requirements. We keep R&D and production teams talking daily, watching incoming trends, and updating both purity targets and process controls as needs move.

    How Our Product Strengthens End User Value

    The extra effort to maintain purity, manage logistics, and track every outgoing drum builds resilience into users’ supply chains. One large coatings producer cut downtime in half after switching to our material, attributing it to fewer off-spec batches and consistent color performance. Pharmaceutical development teams reported higher repeatability during scale-up studies. These outcomes don’t stem from chance. They follow from our everyday insistence on process precision, hands-on review, and continuous adaptation.

    Supporting Compliance and Risk Reduction

    Auditors look for more than specifications—they investigate record traceability, incident reports, and supply chain integrity. We prepare for this with complete, accessible documentation on each batch and raw material. Large users face more regulatory checks, so our partnership model keeps compliance support available on short notice. Any product complaint or incident triggers a review, with root cause analysis and corrective action, drawn from shipping, production, and analytical staff.

    Customer-Focused Adaptation Drives Our Future

    Years of direct conversations with chemists, engineers, operators, and R&D leads show us that every application has its own hurdles. No single product fits every downstream process. For one user, water content below 0.2% held the key to success; another needed custom drum fill levels for automated pumps. Our adaptation never rests only on market demand—it relies on the feedback loop formed between our factory and the end user’s plant floor. That connection keeps both innovation and reliability moving forward.

    Looking Ahead: Reliability Reaches Beyond the Drum

    By making every batch ourselves and iterating based on real user challenges, we treat 2,6-dimethylmorpholine production as a daily, evolving responsibility. End-user value depends on attention to detail from synthesis through storage to delivery. Trends in sustainable chemistry, automation, and advanced synthesis expand the product’s future, but the anchor remains hands-on knowledge, practical quality control, and a willingness to stand by every drum we ship. Our team’s aim stays the same every day—to ensure the material our customers receive opens new possibilities, not new problems, for the next steps in advanced manufacturing.