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2,6-Dimethylaniline

    • Product Name 2,6-Dimethylaniline
    • Alias 2,6-Xylidine
    • Einecs 203-583-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    211999

    ChemicalName 2,6-Dimethylaniline
    CASNumber 87-62-7
    MolecularFormula C8H11N
    MolarMass 121.18 g/mol
    Appearance Colorless to pale yellow liquid
    MeltingPoint 8.4 °C
    BoilingPoint 210 °C
    Density 0.99 g/cm3
    SolubilityInWater Slightly soluble
    FlashPoint 88 °C
    VaporPressure 0.21 mmHg (25°C)
    RefractiveIndex 1.560 (20 °C)
    Synonyms 2,6-Xylidine
    Odor Aromatic amine odor
    PubChemCID 7047

    As an accredited 2,6-Dimethylaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle labeled "2,6-Dimethylaniline," tightly sealed, with hazard warnings, manufacturer's details, and safety instructions.
    Shipping 2,6-Dimethylaniline should be shipped in tightly sealed containers, clearly labeled, and compliant with relevant regulations for hazardous chemicals. It must be kept away from ignition sources and transported with proper documentation. Use secondary containment to prevent leaks or spills, and handle with appropriate personal protective equipment (PPE) during loading and unloading.
    Storage 2,6-Dimethylaniline should be stored in a cool, dry, well-ventilated area, away from sources of ignition, heat, and incompatible substances such as oxidizing agents and acids. Keep the container tightly closed and clearly labeled. Store in an approved chemical storage cabinet, preferably for flammable or toxic substances, and protect from moisture and light. Use proper secondary containment to prevent spills.
    Application of 2,6-Dimethylaniline

    Applications of 2,6-Dimethylaniline in Industrial Manufacturing

    2,6-Dimethylaniline plays a significant role in the production of specialty chemicals. As a specialized aromatic amine, it serves as a core building block for a range of downstream manufacturing sectors. The following sections present authentic industrial applications, with detailed information on compliance, formulation, integration methods, and final product types.

    1. Agrochemical Intermediate Synthesis

    2,6-Dimethylaniline functions as a go-to intermediate for selective synthesis of crop protection agents, especially certain herbicide and pesticide actives. It reacts efficiently through diazotization, acylation, and condensation pathways. The input ratio and reaction steps depend on the final desired bioactive’s structure and regulatory needs. Agrochemical production companies select this compound for its favorable reactivity and minimal trace impurity risk in active ingredient manufacture.

    Industry compliance standards

    • FAO/WHO Specifications on pesticide active ingredients
    • EU Regulation (EC) No. 1107/2009 for Plant Protection Products
    • China GB2763 MRLs for pesticide residues
    • ISO 9001:2015 Quality Management System

    Typical usage ratio

    • 0.8–1.2 molar equivalents per target intermediate, with ratio adjusted for complete conversion and impurity control

    Downstream process integration

    • Added at initial stage in amide or carbamate herbicide synthesis
    • Used in acylation or coupling steps to construct active base structure
    • Purified before final bioactive formulation
    • Subjected to multi-stage QC for trace impurity analysis

    Final product types

    • Acetanilide and phenylcarbamate herbicides
    • Substituted aniline-based insecticidal actives
    • Integrated plant growth regulator intermediates

    2. Dyestuff and Pigment Manufacturing

    Specialty dye and pigment makers incorporate 2,6-Dimethylaniline as a diazo component for producing azo dyes and metal complex pigments. Its symmetrical methyl groups help achieve color stability and specific shades required in premium textile, leather, and plastic colorants. The compound offers tight control of chromophore formation and is selected for its consistent performance in large-scale couplings and pigment dispersions.

    Industry compliance standards

    • REACH Regulation (EC) No. 1907/2006 (Annex XVII: Azo Dye Restrictions)
    • OEKO-TEX Standard 100 – chemical restrictions in textile applications
    • ZDHC Manufacturing Restricted Substances List for apparel dyes
    • ISO 9001:2015 Dye & Pigment Manufacturing QMS

    Typical usage ratio

    • 0.9–1.1 molar equivalents per diazotization or coupling batch, with margin set according to desired color yield and minimized unreacted amine

    Downstream process integration

    • Introduced during the diazotization to form diazonium salts
    • Combined with specific coupling components under controlled pH and temperature
    • Washed and filtered before pigment isolation or liquid dye concentration
    • Color strength and tone standardized via QC batch sampling

    Final product types

    • Azo and metal-complex dyes for polyester and nylon textiles
    • Disperse pigment powders for plastics manufacturing
    • Leather colorants and printing ink pigments
    • High-stability pigment dispersions for industrial coatings

    3. Pharmaceutical Intermediate Production

    The pharmaceutical sector uses 2,6-Dimethylaniline as a critical building block in the multi-step synthesis of APIs and advanced intermediates. Its reactivity profile enables selective amide and urea formation needed in certain antihypertensive, antiviral, and central nervous system drugs. Manufacturers apply precise molar ratios and follow current Good Manufacturing Practice (cGMP) protocols to ensure high-purity output meeting regional pharmacopeial standards.

    Industry compliance standards

    • ICH Q7 – Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) and European Pharmacopeia (Ph.Eur) monographs for intermediates
    • 21 CFR Part 211 – US cGMP for Pharmaceutical Manufacturing
    • ISO 9001:2015 for Pharmaceutical Intermediates

    Typical usage ratio

    • 1.0–1.15 equivalents per downstream pharmaceutical precursor, adjusted for stoichiometry and minimal byproduct generation

    Downstream process integration

    • Dosed in amidation or cyclization step under strictly monitored conditions
    • Often subjected to recrystallization and chromatographic purification
    • Tested for residual solvent and amine content per pharmacopeial limits
    • Integrated into multi-stage synthesis leading to API blend or salt formation

    Final product types

    • Antihypertensive drug intermediates (e.g., selective sartans)
    • Central nervous system modulator intermediates
    • Anti-infective and antiviral precursor compounds

    4. Antioxidant Additive Synthesis for Polymer Industry

    Polymer manufacturers utilize 2,6-Dimethylaniline to synthesize hindered phenol and amine-based antioxidants. Its ortho-methyl substitutions provide enhanced stability during further derivatization. These antioxidants, once incorporated, extend shelf life and resist thermal degradation in plastics, synthetic rubbers, and lubricating oils. Each application demands strict moisture and trace metal limits to prevent fouling or polymer yellowing.

    Industry compliance standards

    • US FDA 21 CFR 178.2010 (Antioxidants and stabilizers for polymers)
    • EU Regulation (EU) No. 10/2011 – Plastic Materials and Articles
    • ISO 14001:2015 for Environmental Management in Additives Manufacturing
    • ASTM D4676 Standard for Polyolefin Additive Performance

    Typical usage ratio

    • 0.7–1.0 equivalents per antioxidant reaction batch, tailored to functional group conversion and downstream blending strength

    Downstream process integration

    • Reacted with ketones or phenols in antioxidant core synthesis
    • Purified additive blended directly into resin pellets, masterbatches, or base oil blends
    • QC for oxidation induction time and extraction residue compliance
    • Performance verified by accelerated aging and migration tests

    Final product types

    • Hindered phenolic antioxidants for polyethylene and polypropylene
    • Amine-based antioxidant concentrates for synthetic rubber compounds
    • Stabilizer blends for lubricating and cooling oils

    5. High-Performance Polyimide Monomer Sourcing

    Advanced polymer producers incorporate 2,6-Dimethylaniline-derived diamines as functional monomers in high-performance polyimide synthesis. The compound’s symmetrical structure supports fabrication of flexible films and heat-resistant coatings used across electronics and aerospace. Manufacturers implement rigorous input QC and tailored condensation parameters to ensure polymer chain integrity and dielectric performance.

    Industry compliance standards

    • UL 94 V-0 Flammability Standard for Polyimide Materials
    • RoHS Directive 2011/65/EU for hazardous substance limits in electronics
    • ISO 9001:2015 Certified Specialty Polymer Manufacturing
    • IEC 60216 for Polyimide Thermal Endurance Testing

    Typical usage ratio

    • 1.0 equivalent per dianhydride monomer ratio, with fine adjustment for polymer molecular weight targeting

    Downstream process integration

    • Enters polycondensation reactor as aromatic amine monomer
    • Subjected to precise stoichiometry and solvent removal cycles
    • Polyimide films cast, cured, and QC tested for electrical properties and tensile strength
    • Residue analysis for amine byproducts performed on polymer batch completion

    Final product types

    • Flexible polyimide films for electronics insulation
    • High-heat-resistant industrial coatings
    • Laminates for advanced circuitry and aerospace composites
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    Certification & Compliance
    More Introduction

    2,6-Dimethylaniline: A Closer Look from the Producer’s Perspective

    Recognizing the Value of 2,6-Dimethylaniline in Chemical Manufacturing

    On production floors that have seen generations of progress, 2,6-Dimethylaniline stands out as a backbone for many downstream chemical processes. We work long shifts to refine its synthesis, knowing that purity and performance aren’t abstract targets—they’re the difference between an entire batch making it out the door or landing in rework. The chemical structure—two methyl groups at the 2 and 6 positions on the benzene ring tied to an amino group—gives this molecule just the right reactivity that specialty chemical users rely on. The formula, C8H11N, seems simple. The real value comes from knowing how subtle production choices affect everything that follows.

    Our Model: Consistency in Quality and Delivery

    Our approach goes beyond just filling drums. In every shift, our operators carefully adjust the methylation step parameters. Temperatures hover between 180-210°C, and the timing of reactant addition means the difference between produce a clean product or dealing with tars and side-products that cost time and money to remove. Raw feedstocks pass through multiple quality checks before they ever hit the reactors.

    Each shipment comes from monitored, controlled syntheses where we measure free aniline content, water content, and methyl group placement. We use gas chromatography and mass spectrometry to guarantee consistent outcome. If you walk past our blending area, you’ll see techs checking for residues and contaminants number well below the high-performance liquid chromatography detection threshold. The end result feels like a high-precision process, but it’s the human judgment of our frontline crew that speeds up troubleshooting much faster than any automated alarm ever could.

    Key Differences from Standard Aniline Derivatives

    Many chemical plants use aniline salts or toluidines for dyes, rubber ingredients, or pharmaceutical intermediates. 2,6-Dimethylaniline stands apart in three key ways. Its methyl groups block some side reactions, leading to better selectivity in follow-up syntheses, especially where steric hindrance helps guide reactivity. Where ortho positions stay open in aniline, our product’s structure steers the chemistry down a path that other derivates can’t follow, nudging molecules into final forms that laboratories and finished-goods manufacturers seek. Some customers report yields in certain dyes and antioxidants that are consistently higher than with 2,5- or 3,5-dimethylaniline.

    This structural difference changes the boiling point, solubility, and even color reactions during downstream use. You get a faint to light yellow liquid—no bright orange or heavy brown impurities that would throw off critical formulations. Shelf stability also improves, even in summer months when storage spaces heat up. Plants that rely on reproducible color, like manufacturers of azo pigment or polyurethane curing agents, see less batch variability and less need for pigment correction.

    Why Specification Matters for 2,6-Dimethylaniline

    The technical grade we manufacture targets a purity above 99%, verified batch by batch. These numbers come out of real-world pressure to support dye makers, rubber chemical producers, and pharmaceutical companies who cannot afford to take risks on mislabelled material. Quality slips show up fast, usually in the form of off-odor or colored byproducts. Every lot we send out is tied directly to the process operator who ran the batch, reinforcing accountability at every stage. Traceability is not a slogan; it runs through our shift logs, test reports, and drum tags.

    Moisture changes not just the weight of the product, but also ruins some downstream Grignard and Friedel-Crafts reactions. Our production line removes water traces through vacuum distillation and nitrogen purging—steps that cost more, but pay back because our customers don’t call up complaining about stuck reactions or fouled catalysts. This attention to detail comes from years of hard-won experience fixing problems after the fact, and it’s become a routine part of our craft.

    Usage: The Everyday Reality in Plant Operations

    The main role for 2,6-Dimethylaniline lies in the synthesis of dyes, especially azo and anthraquinone classes. On dye benches, the right choice of aniline derivative shapes the hue, vibrancy, and longevity of the color. Batch-makers have called in after long nights troubleshooting dye precipitation, only to find that the smoother performance from our material made their lives easier.

    Pharmaceutical plants look for specific isomers to build drug intermediates. The methyl positions in our product mean more precise bond formation and less risk of unwanted side products that would take time and solvents to remove. In antioxidants for rubber, 2,6-Dimethylaniline structures ensure heat and UV stability in finished tires, hoses, and belts. Whether it’s Japanese, European, or North American standards, customers count on the details being right so they can skip secondary checks or reprocessing.

    We field questions from R&D teams who ask about alternative feedstocks, or if they can swap this chemical for cheaper ones like para-toluidine. We’ve learned from decades of trial runs and failed experiments that those swaps mean lower yields and more time spent cleaning reactors. Our 2,6-Dimethylaniline provides proven performance—less headache in maintaining product lines, less waste sent for disposal.

    Process Know-How: Not All 2,6-Dimethylaniline Is Created Equal

    Producers face safety, yield, and regulatory concerns almost on a daily basis. Takes one spill or poorly handled reaction to know how dangerous aniline derivatives can become. We analyzed incident logs from various plants and saw the direct correlation between poorly purified aniline derivatives and plant upsets—everything from vapor leaks to batch discoloration and unplanned shutdowns. Using genuine precursor streams and refining consistently saves time, cuts insurance costs, and prevents environmental releases.

    Global sourcing pressures have led to a flood of materials with unclear origins. Our method doesn’t tolerate uncontrolled recycling or repurposing from unknown sources. We refine our own process streams, control every reagent, and stand behind each drum that leaves the truck dock. Customers come back, not because we're the lowest price, but because months down the line, their operators still say, “No surprises.”

    Regulatory Aspects and Responsible Manufacturing

    Regulatory agencies in major markets now scrutinize aromatic amines like 2,6-Dimethylaniline for potential environmental and health effects. We engage with these rules directly—storing, handling, and documenting every shipment. We track emissions, scrubbing vent streams, and reclaiming spills with proven engineering controls. Waste streams are managed to prevent ground or water contamination, and we invest in staff training because frontline experience prevents most incidents before they escalate beyond the loading dock.

    Labeling, documentation, and traceability run deep. Most customers receive not only purity and water analysis, but also full documentation showing batch genealogy. This helps meet Good Manufacturing Practice requirements—especially important for end users in pharmaceuticals, but a standard for all our production.

    Working with R&D Partners and End Users

    Many breakthroughs in dyes or drug intermediates started in labs that demanded different methylation patterns. Over the years, we’ve hosted chemists from customer labs, opening up our production records to their teams. Sometimes, the request is for slightly altered impurity profiles that help a very specific downstream synthetic pathway; other times, the question is about scaling up a pilot batch that started with glassware in a lab. We rarely say “no” outright; instead, we work through trial runs, tweaking column setups and distillation parameters. Sometimes that means running 10,000-liter reactors at odd hours, knowing full well we won’t ship until everyone on the line signs off on quality.

    Fielding questions at technical conferences and plant visits, we hear about the challenges producers face with supply chain disruptions, fluctuating raw material prices, and regulatory changes. Our team includes operators who started on the lines, chemists who’ve published papers, and production managers who’ve put in decades scaling bench chemistry to full tons. Listening to their stories, we keep learning new ways to tweak synthesis and improve operator training—two things that ultimately strengthen the entire value chain.

    Tackling Common Challenges and Innovations

    Oxidation is a constant concern. Even trace air leaks into storage tanks can lead to discoloration or build-up of unwanted byproducts. Our plant keeps storage under nitrogen, and we test for peroxides as a routine check before shipping. Thermal runaway in the methylation or distillation stages can ruin days’ worth of batches. Lessons learned from early setbacks now guide our investment in real-time analytics and continuous temperature monitoring. Safety data may look straightforward; implementing a culture where no one bypasses alarms—that’s still a matter of day-to-day commitment.

    Renewable feedstocks won’t easily match the quality or yield of petro-derived precursors yet, but research continues. We’ve tried pilots mixing bio-derived toluene streams into the reactor. Results show potential, with similar conversion rates in early stages, but with more side products that take longer to remove. The industry isn’t there yet, but plant investments in recycling and waste minimization still pay off—spending up front reduces clean-up costs and avoids headaches with local regulators.

    Looking Ahead: Trends Shaping Production and Use

    Clients want both sustainable sourcing and predictable quality. Shift after shift, we’ve learned customers decide on a supplier not only by paperwork but also by how quickly and clearly we respond to issues. Transitioning to more automated quality checks frees up operators for troubleshooting and innovation. As regulations tighten, documented accountability and environmental responsibility become the default expectation.

    A few years back, several large end users reorganized their purchasing to focus only on suppliers able to pass not just basic quality audits, but deeper systems checks on traceability, emissions, and supply security. Our team keeps up by bringing in outside auditors and running trial batches under simulated “worst-case” conditions. It isn’t the cheapest or the simplest path, but avoiding costly recalls and helping clients protect their brand reputation pays off for everyone in the chain.

    Understanding the practical needs of dye manufacturers, pharmaceutical firms, and specialty chemical plants keeps driving our process improvements. For all the talk of digital transformation or Industry 4.0, most lessons about what works and what fails come from crews who’ve stood in front of distillation towers at 4 am or operators who spotted a near miss before an alarm tripped. Their hands-on experience shapes which upgrades we implement, which process tweaks truly matter, and how well we serve long-term partners.

    Summary: Experience Above Standardization

    2,6-Dimethylaniline isn’t just a line in a product brochure for us—it’s a substance shaped by real-world needs, technical details, and constant adaptation. Its differences from other anilines show up every day in production lines, batch records, and customer complaints avoided. Consistency is no accident. It arrives through generations of plant know-how, a solution-driven mindset, and continuous improvement throughout the entire operation. From chemistry and engineering to customer conversations, the lessons learned from hands-on production help keep our shipments on spec, our relationships strong, and our customers a step ahead.