Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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2,5-Xylenol

    • Product Name 2,5-Xylenol
    • Alias 2,5-Dimethylphenol
    • Einecs 200-579-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    130176

    ChemicalName 2,5-Xylenol
    CASNumber 95-87-4
    MolecularFormula C8H10O
    MolecularWeight 122.16 g/mol
    Appearance White to pale yellow crystalline solid
    MeltingPoint 57-59°C
    BoilingPoint 210-212°C
    Density 1.04 g/cm3
    SolubilityInWater 1.38 g/L at 25°C
    FlashPoint 87°C (closed cup)
    Odor Phenolic
    pKa 10.22
    VaporPressure 0.15 mmHg at 25°C

    As an accredited 2,5-Xylenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2,5-Xylenol is packaged in a 500 mL amber glass bottle, sealed with a screw cap, and labeled with safety and hazard information.
    Shipping 2,5-Xylenol should be shipped in tightly sealed containers, protected from physical damage and moisture. Transport in compliance with local, national, and international regulations for hazardous chemicals. Label containers clearly with hazard information. Store upright, away from incompatible substances, and ensure good ventilation during transit to minimize vapor buildup and risk of exposure.
    Storage 2,5-Xylenol should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of heat, sparks, or open flames. Keep it away from strong oxidizing agents and acids. Store at room temperature and protect from direct sunlight. Use appropriate secondary containment to prevent spills and ensure containers are clearly labeled.
    Application of 2,5-Xylenol

    Applications of 2,5-Xylenol in Industrial Manufacturing

    As an established primary producer, we supply high-purity 2,5-Xylenol for demanding sectors where reliability in formulation, process performance, and product quality are paramount. Our technical team ensures customers receive material engineered for precise industrial integration. Below, you will find detailed examples of how our product supports specialized downstream manufacturing worldwide.

    1. Synthesis of Agricultural Fungicide Intermediates

    Major agrochemical manufacturers use 2,5-Xylenol as a core intermediate for synthesizing essential active agents in fungicide production. The phenolic structure of the molecule allows targeted substitution reactions to generate specific methylated phenol derivatives, supporting scalable synthesis of modern pesticides with high field stability. Manufacturing sites incorporate the raw material directly into multi-step coupling and cyclization reactions under controlled temperature and pH conditions, ensuring purity profiles that meet demanding global agrochemical regulations.

    Industry compliance standards

    • EPA 40 CFR Part 180 - Tolerances and Exemptions for Pesticide Chemicals
    • OECD Good Laboratory Practice (GLP) guidelines
    • China GB2763 - Maximum Pesticide Residue Limits
    • REACH Annex XVII restrictions as relevant for formulation safety

    Typical usage ratio

    • 20–35% by weight in intermediate coupling reactions; adjusted based on the specificity of downstream substituents and yield optimization studies

    Downstream process integration

    • Added in the early reaction vessel as a key aromatic starting material for methylation, halogenation, or etherification
    • Introduced prior to ring closure and further derivatization for fungicidal efficacy
    • Included during in-process QC to verify conversion and minimize impurities
    • Processed under nitrogen blanket to avoid oxidative by-products

    Final product types

    • Systemic fungicides (e.g., derivatives for cereal, fruit, and vegetable crop protection)
    • Pyridine-type fungicidal actives
    • Control agents for leaf spot and blight
    • Custom agricultural pesticide intermediates for multinational portfolios

    2. Manufacture of High-Performance Antioxidants

    Antioxidant formulators in the polymer and rubber sectors use 2,5-Xylenol to build sterically-hindered phenolic stabilizers, which protect high-value materials from thermal and oxidative degradation. Our material enters proprietary condensation and alkylation routes, integrating at the monomer level to deliver consistent quality and performance. Accurate dosing ensures finished antioxidants meet tight melt-point and solubility specifications required by automotive, footwear, and electronics customers.

    Industry compliance standards

    • ISO 9001:2015 for chemical manufacturing quality management
    • FDA 21 CFR 177.2600 (elastomer and polymer additives, indirect food contact)
    • UL 94 flammability standards (polymer product fire safety)
    • RoHS Directive (2011/65/EU) for restricted substances

    Typical usage ratio

    • 15–25% in phenolic antioxidant synthesis; scaled according to batch yield and target molecular structure adjusted for polymer matrices

    Downstream process integration

    • Charged into alkylation or etherification vessels with controlled acid/base catalysis
    • Used as a primary phenolic block to ensure desired substitution patterns
    • Monitored via in-line HPLC and GC to optimize purity and minimize tars
    • Final antioxidants incorporated into extrusion or masterbatch lines

    Final product types

    • Heat-stabilizing antioxidants for polyolefins and engineering plastics
    • Rubber process stabilizers for tires and industrial hoses
    • Polyester resin antioxidants for textiles and automotive parts
    • Wire and cable compound additives

    3. Formulation of Phenolic Resins for Industrial Coatings

    Coatings and resin manufacturers employ 2,5-Xylenol to engineer phenolic resins with tailored cure profiles and adhesion properties. The material’s methyl substitution affords precise control over resin cross-linking and solvent resistance—particularly important for industrial baking enamels, can coatings, and fast-dry primers. Integrators leverage our stringent quality controls to achieve batch-to-batch consistency in high-shear mixers and reactor vessels, supporting stringent coatings performance claims.

    Industry compliance standards

    • ASTM D1653 – Standard Test Methods for Water Vapor Transmission of Organic Coating Films
    • EN 13523 series for coil coating performance
    • ISO 9001:2015 manufacturing traceability
    • EPA Method 24 (volatile content in coatings)

    Typical usage ratio

    • 12–22% by total phenolic content in resin synthesis; exact ratio refined according to required film hardness and cure speed

    Downstream process integration

    • Added in the resinification reactor prior to condensation and chain extension
    • Integrated with aldehydes (e.g. formaldehyde) for thermoset formation
    • Metered using in-line weighing systems to support traceability
    • Co-resin selection adjusted based on 2,5-Xylenol reactivity and target properties

    Final product types

    • Baking enamels for metal packaging
    • Protective primers for steel structures
    • Wire enamels for electrical winding
    • Chemically resistant industrial topcoats

    4. Production of Pharmaceutical Preservative Intermediates

    Our 2,5-Xylenol is engineered for pharmaceutical-grade synthesis, supplying active intermediate manufacturers with a purified phenolic precursor for parenteral and topical preservative systems. Pharmacopoeial QC ensures absence of critical impurities and consistent specific gravity. Production teams apply this material in targeted methylation and halogenation reactions—minimizing side-chain formation and optimizing yield, in compliance with GMP and pharmacopeia standards.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, FDA 21 CFR Parts 210/211)
    • European Pharmacopoeia (EP) monograph 01/2005:1637
    • USP <467> Residual Solvents
    • ICH Q3A (Impurities in new drug substances)

    Typical usage ratio

    • 10–18% in synthesis step of target pharmaceutical preservatives; adjusted for process yield and expected functional group transformations

    Downstream process integration

    • Fed into initial methylation reactors under validated conditions
    • Applied during halogenation for conversion to derivative preservatives (e.g., chloroxylenol)
    • Undergoes QA sampling at each step for pharmacopeial limit testing
    • Buffered to maintain pH for sensitive downstream reactions

    Final product types

    • Active intermediates for antimicrobial pharmaceutical additives
    • Preservative blends for injectable, ophthalmic, and topical formulations
    • Intermediate for chlorinated phenolic actives
    • Bulk pharmaceutical chemicals for global export

    5. Synthesis of Industrial Dye Intermediates

    Dye houses and pigment makers utilize 2,5-Xylenol as a key precursor in azo and anthraquinone dye synthesis. The positional methylation enables the construction of high-fastness chromophores for textile, leather, and plastic coloration. Our precise QC and lot traceability provide pigment manufacturers with confidence in hue control and consistency across large-scale batches, supporting integration with sulfonation or diazotization routes under high-shear conditions.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (textile chemical inputs)
    • EN 71-3:2019 (safety of toy colorants)
    • ISO 14001 for environmental management
    • REACH Annex XVII (aromatic amine restrictions for colorants)

    Typical usage ratio

    • 8–16% of reaction mass in initial dye coupling steps, with final ratio determined by required depth of shade and process yield

    Downstream process integration

    • Added to coupling tanks for diazotization with amines
    • Blended in sulfonation or alkylation stages prior to pigment filtration
    • Lot traceability through each coloration batch for regulatory reporting
    • Final filtration and pH adjustment to stabilize color strength

    Final product types

    • Azo and anthraquinone dyes for textiles and synthetic fibers
    • Colorants for food packaging (indirect contact grade)
    • High-performance pigments for plastic masterbatches
    • Inks for industrial printing and specialty applications

    6. Production of Specialty Lubricant Additives

    2,5-Xylenol functions as an essential building block in the synthesis of phenolic additives for high-performance lubricant formulations. Its structural reactivity enables oil-soluble antioxidants suitable for blending into industrial and automotive lubricants with elevated thermal and oxidative stability. Production lines implement our product in clean-room alkylation, ensuring controlled side-product levels and compatibility with base oil systems. Accurate dosing and in-process QC support formulating blenders in meeting demanding OEM and device manufacturer requirements worldwide.

    Industry compliance standards

    • ASTM D4951 (additive content of engine oils)
    • API Lubricant Standards (SN, CJ-4, etc.)
    • ISO 21469 (safety of lubricant additives in H1 applications)
    • REACH registration for specialty chemical additives

    Typical usage ratio

    • 5–12% for antioxidant additive synthesis, ratio aligned with base oil grade, additive package design, and finished product certification targets

    Downstream process integration

    • Introduced in initial phenolic alkylation reactors under inert gas
    • Subjected to in-situ monitoring for residual monomers
    • Purified and compounded as concentrated packages for lubes
    • Final blending with base oils on automated dosing lines

    Final product types

    • Automotive crankcase oil additives
    • Industrial gear and bearing lubricants
    • Compressor oil antioxidant packages
    • High-performance hydraulic oil stabilizers
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    Certification & Compliance
    More Introduction

    2,5-Xylenol: A Reliable Choice from Direct Chemical Manufacturing Experience

    Looking Closer at 2,5-Xylenol Production

    Producing 2,5-Xylenol starts with careful attention to both raw materials and process control. As a chemical manufacturer, we see every batch as an opportunity to reinforce our standards. Unlike traders who touch only finished goods, we shape the starting materials, chart every heating stage, measure each purification step, and stand behind the consistency of the end product. Our hands-on approach drives the reliability chemists expect once this intermediate reaches their hands.

    We manufacture 2,5-Xylenol with a focus on purity and payload, since unnecessary impurities disrupt downstream chemistry and put plant safety at risk. Laboratories and plants relying on 2,5-Xylenol for intermediates notice these differences, even if they can be hard to quantify on a simple data sheet. For us, the product leaves our site only after it crosses a certain threshold in GC analysis—not just at a single time, but every cycle, every batch. Trusted reputation in the chemical world depends on more than a single test; it takes years of repeat quality and transparency.

    Model, Specifications, and Production Reality

    The 2,5-Xylenol we supply carries our internal model code, but users care about core details: molecular formula C8H10O, CAS 95-87-4. Most of our output ranges above 99.0 percent purity by gas chromatography, as lower purities can introduce interference in applications. The melting point lands between 116 and 118°C, and those few degrees matter when downstream temperature control is strict. Density sits at around 1.05 g/cm³ at 25°C. We bottle in drum, steel container, or bulk tank depending on regular demand and project scale.

    Packing for 2,5-Xylenol is always evaluated with practical shipping risks in mind. Leakage costs too much—not only lost material but also time and possible environmental damage. We never leave secondary containment and transport stability as afterthoughts. Over decades, we’ve seen how inadequate drum materials, seal failure, or careless stacking can lead to costly spillage on arrival, which leaves lasting impressions that quality assurance can't mend with just an apology.

    End Uses: Why 2,5-Xylenol Remains Vital

    2,5-Xylenol stands as a key intermediate, with its placement of methyl groups and hydroxyl ring making it far more than a laboratory chemical curiosity. The shape and reactivity attract the agrochemical industry, where it finds utility in synthesizing specific crop protection agents. Anyone who works in chemical process design knows how finicky aryl intermediates can be—2,5-Xylenol resists side reactions better than many close analogs, giving more predictable results and easier downstream purifications.

    In the world of polymer developers, 2,5-Xylenol's ortho-para substitution pattern offers a stable building block, encouraging chain growth reactions or specific cross-linking without inviting excessive branching. Phenol resins derived from 2,5-Xylenol bring particular toughness and heat resistance—attributes easily traced back to the clean feedstock. We hear directly from plant technicians when variations affect curing profiles of their batches. This feedback keeps our team focused on reliable composition.

    Developers in pharmaceuticals pursue 2,5-Xylenol for advanced intermediates. Its precise pattern lets process chemists append other substituents, targeting molecules they cannot reach from the more common phenol or cresol feedstocks. Demand from this sector rises and falls with innovation cycles, but requests for extra impurity profiling or packaging in glass always signal experiments that matter. We take the responsibility to meet those needs seriously, and avoid substituting batches without thorough disclosure.

    The Subtle Differences: Comparing to Similar Phenolic Compounds

    Most users at scale know the practical distinction between 2,5-Xylenol and its isomers, such as 2,4-xylenol or 2,6-xylenol. The placement of methyl groups on the benzene ring—two units apart as in 2,5-x versus neighboring as in 2,4-x—translates to real-world effects on reactivity, solubility, and downstream product structure. Experienced chemists choose 2,5-Xylenol where thermal and chemical stability balance with the need for controlled substitution elsewhere on the ring. Shortcuts cost more than they save; using cheaper isomers as substitutes often results in lower yields or costly reprocessing.

    Differences surface in melting point profiles, color stability, and storage sensitivity. For example, 2,6-xylenol often brings a lower melting point and higher volatility, which influences process engineers during plant operation. Over the years, we’ve seen downstream users forced to redesign steps or adjust solvent mixes after shifting away from true 2,5-Xylenol. Such forced adaptations usually cost time that can’t be recovered. Mistaking one isomer for another based on paperwork rather than firsthand inspection leads to lab and plant frustration—something we work hard to avoid by tracking every batch back to its original synthesis lot.

    Packing methods, too, differ subtly for xylenol isomers. 2,5-Xylenol demands careful temperature control in all seasons, as caking or partial melting during humid storage can create measurement errors and loss of product. Our team learned the hard way how small lapses in warehouse AC maintenance cause issues—monomers that cake together hurt downstream measurement and make clean transfer a challenge. Prompted by this, we shifted storage approaches years ago, specifying appropriate temperature bands and clearly labelling all drums with required storage instructions.

    Quality Control: Challenges and Approach from the Production Floor

    Years in chemical production teach lessons that reach beyond reference manuals. Early on, we relied heavily on supplier purity certificates, which seemed complete until a few color complaints and sticky drums surfaced. Analytical routines expanded quickly—GC, HPLC, melting point, water content, and trace element analysis all became non-negotiable. Just a few batches with high impurities create headaches, so tightening controls is a daily commitment. Nobody wants customers tuning their reactors mid-plant run just to accommodate a slightly off-standard batch.

    Our production teams walk every lot through round-the-clock checks. Anything falling outside agreed limits triggers batch hold and root cause review—usually before the drums leave the packing area. Emphasis on real-time monitoring matters more for phenolic compounds because oxidation and slight byproduct formation happen surprisingly fast once exposed to air and light. Packaging follows controlled, inert conditions, so that every container opened at a partner’s site reflects what left our floor, down to the color and crystal structure.

    Raw material selection in 2,5-Xylenol production quietly shapes end-user experience. Low-quality feedstock bumps up minor byproducts—chlorides or traces of toluene derivatives—which eventually work their way into coatings, resins, or pharmaceutical intermediates. Over the years, we’ve worked to strengthen raw supplier screening, even if that means higher input costs. The gain in batch purity and reliability makes the initial investment worthwhile.

    Why Experience Matters in Handling and Logistics

    Shipping specialty chemicals can’t take shortcuts. A few years back, reports of loose caps and underfilled drums sparked an overhaul. Unstable containers in long-haul transit, especially at seasonal temperature extremes, led to costly on-site cleanup at customer storage. Today, our 2,5-Xylenol logistics include tamper-evident seals, secondary bundling, and regular audits at every handoff. Staff at transit points receive training on both routine inspection and emergency response.

    Customers working at plant scale want just-in-time delivery to minimize storage risk, so shipments go out on a strict schedule. Unpredictable climate adds challenges, so we build buffer time into all transit plans. Our logistics team coordinates so customers never face a production halt waiting on raw materials. Regular feedback from partners gives us headlines: a missed shipment can delay not just one stage but a whole cascade of operations. The back-and-forth communication and ability to triage real issues—no matter when they arise—makes a bigger difference than any stock list or brochure.

    We work with container suppliers to select gaskets that resist phenolic compounds specifically. Several years ago, we found subtle incompatibility between common rubber types and 2,5-Xylenol; slow leaching contaminated the contents. After testing and switching to PTFE-lined seals, complaints vanished. This kind of direct feedback cycle happens only when a manufacturer owns both the problem and the solution—an approach hard to find with indirect supply chains.

    Sustainability and Safety in Production Practices

    Handling phenolic intermediates creates risks, so priorities always include worker safety and waste minimization. Our plant setup includes continuous air scrubbing at production and packing points. This prevents low-level phenol fumes from escaping, a critical step as they pose health risks and unpleasant odors. Investing in better ventilation draws from direct experience; the subtle discomfort of spending hours near packing lines made this upgrade an obvious step years ago.

    Waste treatment practices play a central role. A decade ago, simple solvent flushes sufficed, but as regulations and stewardship standards toughened, we installed multi-stage scrubbing and incineration. The change came partly after neighbor feedback—offsite odors after rainfall signaled incomplete neutralization. Now, we recycle or incinerate byproducts before releasing any water or air effluent. Manufacturing accountability drives long-term relationships and protects the workers who rely on us.

    Packaging improvements contribute to sustainability as well. By moving away from single-use drums and introducing reusable tote options, we cut down on landfill waste and lower shipping costs over the project lifecycle. Direct requests from customers looking to shrink their environmental footprint push us to test new containers and collection programs, including rinsing stations and closed-loop returns.

    We focus equally on safe handling instructions and support materials, sharing incident histories with new users and updating our partners with any change in process. While chemical plants often compete fiercely on cost, we’ve found reputation grows from open conversation about safety routines and adjustments—sometimes inspired by mishaps, but more often from staying ahead of trouble before it hits.

    Customer Feedback and Ongoing Improvement

    The best adjustments come from end users. Over years in the field, patterns become clear—certain coatings firms prefer a slightly finer crystal, pharmaceutical partners request extra screening to reduce trace organics. Trends in requests help us predict where our customers’ industries are heading. Last year, repeated questions on melt blockages prompted a review of our drying process and tighter control on moisture content. Updates were rolled out in production not from market research, but from direct, honest ongoing conversations with users.

    We also host annual sessions at our facility where users walk the line, see the actual steps, and offer their perspective. This feedback—what matters on their side of the pipeline, what we could adjust—grows more nuanced each year, and shapes both short-term fixes and future investment. Several partners have pointed out how supply surges or shortages elsewhere highlight the value of having a manufacturer truly tuned to changing requirements. Large-volume projects often involve joint planning for inventory management and forecasting, which helps both sides avoid costly surprises.

    Continuous improvement runs deeper than published standards. Internal review after off-spec batches or delivery hiccups generates not just reports, but training adjustments and equipment upgrades. For instance, installing a second redundancy circuit on our chiller system came after a one-off blockage incident. The upfront cost saves time and trust—elements even more valuable than daily production throughput.

    Trends and Future Developments: What Direct Experience Shows

    The landscape for advanced phenolic intermediates like 2,5-Xylenol grows more dynamic every year. End-users are prioritizing traceability—knowing not just what’s in the barrel, but where each gram comes from, how it was made, and who certified it along the way. Automation in production and analytics, while valuable, can’t fully replace the role of a hands-on team. The repeated tweaking and human inspection give the reliability major plants depend on. Some shifts toward greener chemistry promise lower emissions and resource use down the line; already, we’re exploring new catalyst systems and waste heat recovery based on customer demand and evolving standards.

    Formulators ask more often for detailed impurity breakdowns, driven by tighter pharmaceutical and electronics specifications. This change means manufacturers must invest consistently in better analytics and documentation. Over the past year, we’ve upgraded our in-line monitoring, worked with partners to build shared audit trails, and rolled out more transparent tracking. While this raises costs, it also builds trust—the kind that shields partners from regulatory surprises or performance issues down the line.

    Smaller-batch and specialty users now look for custom packaging, longer shelf life, and assured change-management protocols. Our own facility now blocks out reserve production hours for these smaller but often high-value projects. By listening directly to production partners, batch engineers, and R&D labs, we keep pace with industry needs and respond faster than slower-moving distributors or resellers.

    Beyond current processes, we’re investigating bio-based routes to 2,5-Xylenol, aiming to cut dependence on petroleum feedstocks. While still at pilot stage, preliminary yields look promising and early stakeholder visits highlight how much value this shift could unlock for brand-conscious end users—especially in the specialty chemical and pharma space. Such transitions only succeed when built on solid foundations of quality, reliability, and transparent performance metrics, all anchored in the day-to-day understanding of production challenges and end-user needs.

    Direct Perspective: What Makes Manufacturer-Sourced 2,5-Xylenol Stand Out

    For users downstream, working directly with the source offers more than price advantages. Real-world chemical production doesn’t always follow textbook patterns. Variations—seasonal, procedural, or packing-related—leave their mark on final results. By engaging with a manufacturer, partners gain early warning of any run changes, access to backup batches on short notice, and the peace of mind that comes from knowing the same team answering inquiries makes and ships the material.

    Certifications and extensive documentation only tell part of the story. Site visits, discussions with the plant team, and joint troubleshooting build the kind of connections that outlive staff or contract changes. We’ve spent years exchanging troubleshooting notes, refining joint sampling protocols, and building downtime reporting—not out of obligation, but from seeing how productivity grows when both sides invest for the long view.

    Every kilogram of 2,5-Xylenol we produce reflects years of iteration, learning, and direct engagement with problems and their solutions. The process sits at the intersection of chemistry, engineering, and partnership. The trust built through open records, swift reaction to feedback, and investment in safer, more sustainable production sustains both the integrity of our plant and the performance of our partners’ products.

    For those seeking reliability, responsiveness, and in-depth technical support, a manufacturer-led approach to chemical sourcing offers clear advantages. The foundation rests not just on technical sheets, but on lived commitment to quality, safety, and ongoing improvement—made visible in every drum, every shipment, and every open line of communication.