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1-Chloro-2,2,2-Trifluoroethane

    • Product Name 1-Chloro-2,2,2-Trifluoroethane
    • Alias HCFC-133a
    • Einecs 206-938-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    462989

    Chemicalname 1-Chloro-2,2,2-Trifluoroethane
    Molecularformula C2H2ClF3
    Molarmass 118.49 g/mol
    Casnumber 2837-89-0
    Boilingpoint 28.8 °C
    Meltingpoint -136 °C
    Density 1.355 g/cm³ (at 25 °C)
    Appearance Colorless gas
    Odor Ether-like
    Vaporpressure 2.86 bar (at 20 °C)
    Solubilityinwater 0.69 g/L (at 25 °C)
    Refractiveindex 1.292 (at 20 °C)

    As an accredited 1-Chloro-2,2,2-Trifluoroethane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1-Chloro-2,2,2-Trifluoroethane is supplied in a 500 mL amber glass bottle, with a secure screw cap and detailed hazard labeling.
    Shipping 1-Chloro-2,2,2-Trifluoroethane is shipped as a compressed liquefied gas in high-pressure cylinders or bulk containers. Classified as a hazardous material (UN1022), it requires labeling for fluorinated gases, proper ventilation, temperature control, and secure, upright transport. All shipments must comply with international and local regulations for flammable, pressurized gases.
    Storage 1-Chloro-2,2,2-Trifluoroethane should be stored in a cool, well-ventilated area away from sunlight, heat sources, and incompatible materials such as strong oxidizers. Keep the container tightly closed and properly labeled. Store in a secure area designed for volatile and pressurized chemicals, using appropriate gas cylinders or sealed containers to prevent leaks. Follow all local regulations and safety guidelines.
    Application of 1-Chloro-2,2,2-Trifluoroethane

    Applications of 1-Chloro-2,2,2-Trifluoroethane in Industrial Manufacturing

    1-Chloro-2,2,2-Trifluoroethane plays a key role across several industrial sectors as a process medium, intermediate, and specialized agent. Our direct manufacturing ensures a consistent supply tailored for downstream operations demanding stringent quality and regulatory conformity. The following sections highlight primary application areas as confirmed by regulatory filings, technical guidelines, and supply chain feedback.

    1. Foam Blowing Agents for Polyurethane and Phenolic Insulation

    Leading panel, appliance, and pipe insulation operations utilize 1-Chloro-2,2,2-Trifluoroethane as a hydrofluorocarbon-based blowing agent, supporting both closed-cell and rigid foam structures. Its low boiling point and moderate solubility profile achieve fine cell structures and controlled expansion. The chemical enters the blend at the pre-polymer mixing stage, interacting with polyols and isocyanates under controlled agitation and temperature for optimal gas release. Substitution with this agent meets current global warming regulations better than legacy HCFC options.

    Industry compliance standards

    • U.S. EPA SNAP Program (Significant New Alternatives Policy)
    • REACH Regulation (EC) No 1907/2006 compliance for manufacturing and import
    • ISO 16000 series for indoor emission profiles
    • UL 94 (flammability standards for plastics)

    Typical usage ratio

    • 8–18 wt% based on total polyurethane foam mass; adjusted for targeted density and cell size

    Downstream process integration

    • Charged directly into pre-mix tanks with polyol and catalyst system prior to polymerization
    • Evaporates upon exothermic reaction, generating in situ cell structure

    Final product types

    • Polyurethane sandwich panels for cold storage construction
    • Phenolic foam boards for architectural fire insulation
    • Refrigerator and freezer cabinet foam
    • Pipe shell insulation sections

    2. Refrigerant Systems and Retrofit Solutions

    Used in equipment servicing and new system design, 1-Chloro-2,2,2-Trifluoroethane functions as a refrigerant or interim blend, especially in legacy systems seeking compatibility with non-ozone depleting units. Technicians deploy it for its balanced thermodynamic properties, leveraging a lower ozone depletion potential relative to CFCs. Charge levels depend on coil volume and cooling load calculations, with stringent recovery and leak detection protocols enforced by international guidelines.

    Industry compliance standards

    • ASHRAE Standard 34 (safety classification and refrigerant designation)
    • EN 378-1:2016 (refrigerating systems and heat pumps—safety requirements)
    • F-Gas Regulation EU 517/2014
    • Montreal Protocol transitional rules for CFC substitutes

    Typical usage ratio

    • 100% as neat refrigerant or up to 50% blended with HFC-134a or other approved refrigerants for retrofit; based on OEM COP and capacity data

    Downstream process integration

    • Injected at charging valves into evaporator/compressor assemblies during installation or maintenance
    • Standard refrigerant recovery and charging equipment used

    Final product types

    • Retail refrigeration display cases
    • Commercial chillers and air handlers
    • Vehicle air conditioning retrofit services

    3. Chemical Synthesis Intermediate for Pharmaceutical and Agrochemical Manufacturing

    Synthetic chemists utilize 1-Chloro-2,2,2-Trifluoroethane as a fluorinated alkylation source and dehalogenating agent in downstream active ingredient development, especially for small-molecule APIs and certain selective herbicides. The compound’s stability under anhydrous conditions and nucleophilic substitution potential enables integration within multi-step synthesis, often during fluorination or functional group installation phases. Batch records require detailed solvent recovery and containment to conform to cGMP recommendations.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • U.S. FDA 21 CFR Part 211 (process validation and control)
    • China Pharmacopoeia (for pharmaceutical intermediates registries)
    • OECD Guidelines for the Testing of Chemicals (agroecosystem impact)

    Typical usage ratio

    • 0.5–7 molar equivalents per reaction step, depending on target transformation and side reaction profile

    Downstream process integration

    • Added under controlled temperature/pressure within jacketed glass reactors during stage-specific synthesis
    • Separated by solvent extraction and phase transfer post-reaction

    Final product types

    • Trifluoromethylated pharmaceutical intermediates
    • Active herbicide compounds
    • Specialty fluorochemicals for contract synthesis

    4. Cleaning and Degreasing Agent for Electronic and Precision Parts

    Original equipment manufacturers deploy 1-Chloro-2,2,2-Trifluoroethane as a precision cleaning solvent for post-assembly residue removal, particularly in the production of high-reliability electronic boards and aerospace assemblies. Its low surface tension and controlled volatility allow effective displacement of fluxes, oils, and particulates from delicate substrates without damaging solder joints or components. Closed-system and local exhaust protocols ensure compliance with evolving occupational safety standards.

    Industry compliance standards

    • IPC-CH-65B (Guidelines for Cleaning of Printed Boards and Assemblies)
    • RoHS Directive 2011/65/EU (assessment for use upon request)
    • OSHA 29 CFR 1910.1000 (permissible exposure limits—workplace VOCs)
    • J-STD-001 (requirements for soldered electrical and electronic assemblies)

    Typical usage ratio

    • Spray or immersion baths with 100% solvent, or up to 5:1 co-solvent mixtures for process-specific residues

    Downstream process integration

    • Wiped, dipped, or sprayed onto components after soldering and before conformal coating or potting
    • Recovered solvent managed via closed-loop vapor degreasing units

    Final product types

    • Populated circuit boards (PCBs)
    • Relay and sensor assemblies for automotive and aerospace
    • Optoelectronic device subassemblies
    • Medical electronics housings

    5. Carrier Solvent in Specialty Adhesive and Sealant Formulation

    Industrial adhesive formulators incorporate this compound into low-residue, fast-drying adhesive blends for gasket, electronic encapsulant, and specialty tape manufacture. The solvent property enables homogenous mixing of functional resins and elastomers at low viscosities, facilitating precise application by automated dosing lines. Recovery systems capture and recycle exhaust vapors in compliance with local air quality mandates.

    Industry compliance standards

    • ASTM D1974 (standard practice for adhesive formulation)
    • China GB 18583-2008 (limits of harmful substances in adhesives)
    • REACH Annex XVII (solvent exposure assessment)
    • VOC emission limits: U.S. EPA Method 24 or regional analogues

    Typical usage ratio

    • 2–15% by weight in formulation premix, adjusted for resin solubility and flash-off requirements

    Downstream process integration

    • Blended in high-shear mixers during resin solution preparation
    • Applied via slot-die or spray head onto substrates prior to carrier evaporation and curing

    Final product types

    • Electronics-grade potting compounds
    • Flexible and structural gasket adhesives
    • Double-sided industrial tapes
    • Sealant foils for heat-sensitive assemblies
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    Certification & Compliance
    More Introduction

    1-Chloro-2,2,2-Trifluoroethane: Insight from the Production Floor

    What We Produce: Real-World 1-Chloro-2,2,2-Trifluoroethane

    Every day on the production line, I see 1-Chloro-2,2,2-Trifluoroethane, also known as HCFC-133a, moving from raw inputs to finished, high-purity cylinders ready for shipment. Making this compound takes more than just a reactor set-up and precise temperature controls. We pay attention to detail at each stage, ensuring this molecule reaches customers with the properties they expect. The chemical formula, CHClF3, signals its makeup: one chlorine atom, two fluorines bonded to a central carbon, and the ethane backbone. The full story sits in its clean, colorless, low-boiling liquid form — free from visible impurities and steady under standard atmospheric pressures. We know exactly what goes into every batch because our team handles the entire synthesis process, checking every step under strict quality protocols.

    Why Purity Matters in 1-Chloro-2,2,2-Trifluoroethane Production

    The value of 1-Chloro-2,2,2-Trifluoroethane is found in its purity level. We manufacture with a purity above 99.5%, sometimes pushing beyond 99.9% for applications where even trace contaminants can spoil the process or change the outcome. Minute residues — such as chlorinated or fluorinated side-products — affect both downstream chemical reactions and performance in final applications. From hands-on experience, impurities raise costs: They create headaches for users, risk fouled systems, or lower yields in specialty syntheses. Our team performs repeated purifications, distillations, and checks at the bench as routine. This attention has brought us repeat clients in the lab research, electronics, and specialty polymer industries, who all expect consistent, verified outputs.

    Handling Specifications in Practice

    Each cylinder leaving our filling station carries not just the liquid, but a full report of the actual GC purity, water content, and acidity. We sample directly from production runs. For research and process manufacturing, the difference between water content below 50 ppm and water at 200 ppm can mean expensive equipment wear, catalyst poisoning, or instability in polymerization. Our own chemists use high-sensitivity Karl Fischer titration for moisture tracking, and pH analysis to confirm low acid content. Even a slight elevation in chlorine or hydrocarbon by-product readings means the batch returns for additional refinement. Experience tells us that sloppiness here doesn’t just hurt credibility — it can lead to chain reactions in customer processes, driving up rejection rates and warranty claims.

    Model and Packaging: Built on Feedback

    Out in the field, we hear plenty about the needs of users — from mid-scale manufacturers to specialist labs. Our standard model ships in welded steel cylinders, 10 to 900 liters capacity, built for short and long-term storage. The packing method takes into account volatility and reactivity. For higher throughput settings, we also run ISO tank shipments under contract. Each batch has traceable lot data and offers safety sealing. Clients in North America often request DOT-compliant tanks, while some in East Asia prefer high-pressure, smaller volume containers for agile movement. The process continues to evolve as end-users share feedback about ease of transfer, accessibility, and integration with existing valve and hose systems. This responsiveness in packaging is not theoretical for us — it comes from years of replacing returned cylinders that did not match what users actually employ in their facilities.

    Where 1-Chloro-2,2,2-Trifluoroethane Goes After Production

    Once out of the factory, 1-Chloro-2,2,2-Trifluoroethane finds a second life in a variety of highly practical industries. Electronics manufacturers buy it as a specialized etching feedstock, especially in deep silicon etch applications where fewer by-products matter. In laboratory settings, it serves as a distinctive solvent for analytical chemistry, giving clear phase separation on GC and NMR tests. Polymer researchers and industrial process developers request it for building block syntheses, relying on its stability and predictability even under elevated pressures and temperatures. Refrigerant blend producers occasionally approach us searching for specialty components for non-standard systems, attracted by the unique boiling point and moderate toxicity profile. More often, our direct discussions with clients drive fine-tuning in how we make, package, and supply the compound — a cycle of feedback, improvement, and hands-on learning.

    Distinctions from Analogues and Competitors

    In practical work, one question comes up: why choose 1-Chloro-2,2,2-Trifluoroethane instead of alternatives such as HFC-134a or HCFC-123? The answer sits in the physical and chemical properties. While HFC-134a (1,1,1,2-tetrafluoroethane) carries zero ozone depletion, it lacks the same reactivity for certain synthesis paths that our product offers through its lone chlorine atom. HCFC-123 differs in both structure and typical application sector. Our experience shows that users selecting 1-Chloro-2,2,2-Trifluoroethane want both the trifluoromethyl group and selective chlorination; this combination plays a role in synthesis schemes and in applications like dielectrics, where different polarities and boiling points are key. In the bench lab, quick separations and solvent behaviors distinguish this molecule, giving sharper boundaries between phases than comparable hydrocarbons. These subtle differences become critical when customers work under strict purity and reproducibility requirements, so we keep updated on both published data and anecdotal reports from chemists worldwide.

    Comparing Safety and Environmental Considerations

    Working with 1-Chloro-2,2,2-Trifluoroethane teaches us the practical safety matters firsthand. The molecule does carry an ozone depletion potential, though far lower than older CFC lines. We maintain dedicated systems to capture and reprocess vent gases during production and filling, reducing fugitive emissions into the work environment and atmosphere. In contrast, some substitutes such as HFCs may lower environmental risk in one dimension (ozone) but raise it in terms of global warming potential. We consult up-to-date environmental studies and engage with users on safe handling procedures, particularly in regions with changing regulatory frameworks. Our record demonstrates a commitment to implementing best practices immediately on knowledge discovery — not waiting for a rule before taking steps. This means real investments in leak detection, staff training, and recovery apparatus, creating a safer and more sustainable production chain.

    Practical Solutions for End-Use Challenges

    Over years of production and customer engagement, we see recurring issues: moisture creep, container valve incompatibility, and batch-to-batch purity swings. Each problem prompts adjustments. To fight water contamination, we upgrade all seals and valve internals, routinely baking out containers and adding inline desiccant stages for every transfer. Valve fit mismatches led us to expand connector stock and supply adapter kits on request, streamlining cylinder swaps in facilities using both legacy and current fitting types. On purity consistency, we run extra verification on every fresh batch, holding inventory to allow only certified lots out the door. These steps stem from real lessons learned — not theoretical or copy-paste “solutions.” Our own chemists and operations techs spot issues early, log and analyze them, and fold the results into future production runs.

    Trends in Sourcing and Raw Material Management

    The accuracy of 1-Chloro-2,2,2-Trifluoroethane specifications ties directly to the raw material supply chain. We monitor sources of trichloroethylene, hydrogen fluoride, and utility gases, as variability in feedstock quality leads to downstream repercussions. To stabilize composition and reduce impurity spikes, we maintain close links with certified upstream suppliers and invest in material pre-treatment before synthesis. In lean years, we scale production, running smaller lots to buffer supply shortfalls and avoid backlog risks for customers. Bottlenecks sometimes appear not just in chemicals, but in the specialty valves and tested cylinder inventory. Our purchasing department often works with short deadlines and scrutinized QA on every shipment, rejecting out-of-spec material and adjusting forecast models as real-time data permits. This hands-on system keeps us competitive and responsive in an environment where base materials can shape the whole outcome of a finished specialty chemical.

    Investing in Process Control and Plant Improvements

    Our plant rarely stands still. Modernization projects touch almost every aspect of our 1-Chloro-2,2,2-Trifluoroethane production. Automated reflux controllers on distillation towers allow sharper fraction cuts, minimizing risk of high boiler carryover. We retrofit reactors with next-generation corrosion-resistant linings, extending service life and improving output cleanliness. Old manual gauges give way to smart sensors tied directly to QC workstations. Capital spending on gas recovery skids brings environmental and cost improvements, as fewer grams escape per transfer. Many upgrades stem from feedback gained on the shop floor: operators spot patterns in downtime and suggest tweaks, which, after trial, make their way into standard routine. We frequently benchmark production against global data sets, aiming to keep efficiency and consistency high even as demand or regulatory pressures shift.

    Customer Questions and Technical Dialogue

    Regular communication with our users reveals what matters most to them. Common questions dig into cycle life of transfer valves, tolerance for possible micro concentrations of other haloalkanes, and the expected timeline for new container formats. Some request technical support navigating changes in environmental regulation, or advice on integrating 1-Chloro-2,2,2-Trifluoroethane into novel synthesis schemes. Our staff — from bench chemists to QC leaders — engage directly, providing real data from our lots, not just catalog values. For critical researchers, we run custom fill and analytical support, packaging this knowledge back into our mainstream offerings. Each conversation improves our collective understanding, translating to tighter outputs and more accurate material certification.

    Regulatory Compliance as a Moving Target

    Meeting local and global regulatory standards forms a daily concern when producing 1-Chloro-2,2,2-Trifluoroethane. Our compliance team tracks evolving rules not just at the federal or international level, but in individual states, provinces, and export destinations. We adapt documentation, labeling, and packaging to satisfy requirements, investing in certifications for environmental impact, transportation safety, and worker health. This work underpins each shipment: without proper compliance, delays increase and customer production lines suffer. Practical methods include automated label generators for each destination, regular staff training sessions on latest regulatory updates, and tight documentation for batch history tracking. A robust regulatory approach builds confidence for our downstream customers, who trust not only material quality, but supply chain reliability.

    Research Partnerships and Open Innovation

    We do not manufacture in a vacuum. Ongoing partnerships with university chemists and industrial research groups support new uses and improved methods for 1-Chloro-2,2,2-Trifluoroethane. Papers rarely tell the full story — collaboration brings new insights that refine protocols and open markets. Our past experience shows the best improvement projects stem from field trials, where proposed changes get tested in realistic environments rather than purely theoretical models. This joint approach helped us streamline some purification steps and validate less energy-intensive separation methods. We continue to provide sample quantities for vetted research, fielding data and feedback from external users to feed back into our own process control systems. Genuine progress in specialty chemical manufacturing emerges from this robust cycle of information exchange.

    Training and Workforce Development

    Manufacturing high-purity 1-Chloro-2,2,2-Trifluoroethane requires more than advanced equipment — it demands an experienced, skilled team. We prioritize ongoing workforce development through direct training, mentorship, and engagement in troubleshooting. New production staff work hands-on through every stage, from raw material receipt and purification to finished cylinder QC. Seasoned operators demonstrate real situations, not just manual procedures, sharing lessons learned and the rationale behind process choices. Technicians rotate across functions, understanding not just their own role, but the interconnections with logistics, quality control, and safety. Management remains accessible for walking tours, Q&A sessions, and post-shift reviews. These everyday practices foster a deep bench of talent, ready to respond to new challenges or opportunities.

    Listening and Adapting: Case Stories from Our Own Floor

    Raw feedback becomes action on our plant floor. In one case, elevated complaints about trace water in some shipments led to a process overhaul — redesigned valve seals, pre-drying protocols for cylinders, and continuous in-line moisture monitoring. After integrating these changes, rejected batch rates dropped and client trust improved. Another repeated pain point came from valve incompatibility in overseas shipments. By building a wider library of fittings and connectors and consulting directly with foreign recipients, we shortened downtime significantly. Our production planning now incorporates review of international demand fluctuations, adjusting lot sizes and scheduling predictive maintenance to avoid missed orders. The improvements never arise from top-down mandates alone — they come from active listening, staff initiative, and honest, ongoing discussion up and down our supply chain.

    Sustainability Efforts and the Drive Toward Cleaner Manufacturing

    The chemical sector faces scrutiny on environmental performance. We treat sustainability as a daily process, not a marketing slogan. Practical steps include solvent recovery, waste acid neutralization, and routine review of energy use in distillation and compression. Cooling water circuits get periodic checks for leak prevention, while vent gas scrubbers run full-time to capture stray emissions. We review each process step for both economic and ecological waste, fine-tuning batch size, residence time, and equipment efficiency. Purchasing shifts to more locally-sourced raw materials, bringing down both transportation emissions and supply risk. Our operations reports regularly benchmark against regional environmental targets, driving stepwise improvement: fewer grams of waste per kilogram shipped, reduced process water use, and safer design throughout the facility. We welcome audits, seek third-party reviews, and act directly on the findings to improve future cycles.

    Responsible Growth and Industry Change

    Competing in the specialty chemical market means constant flexibility. With 1-Chloro-2,2,2-Trifluoroethane, shifts in end-use industries — electronics, pharmaceuticals, specialty plastics — drive us to balance volume, purity, and safety at every turn. Increasing demand pushes for larger, more efficient plant modules; intermittent slowdowns force careful planning to prevent expired stock. The lesson from experience is that responsible manufacturing goes beyond volume targets: it means tracking new regulations, integrating safety science, and constantly evaluating customer feedback. Community engagement plays a part: regular open days for local regulators, schools, and neighbors help demystify plant activity and build trust. Our growth plans include both capacity increases and broader research into greener alternatives should the regulatory or environmental landscape demand transition. This responsive, engaged approach positions us for long-term resilience and value.

    Collaborative Improvement: Connecting the Chain

    The journey of 1-Chloro-2,2,2-Trifluoroethane from raw input to customer dock engages every link: suppliers, plant staff, logistics, quality control, and client support. Honest feedback, investment in equipment, and ongoing professional development sustain quality at every juncture. Our open channels with research groups, regulatory boards, and direct users close the loop between production and application, promoting both technical advancement and real-world problem solving. The result is not just a product, but a living, adaptive process built on actual needs and continuous learning. Each year brings new questions, refinements, and successes — all driven by genuine commitment, practical expertise, and trusted relationships across the specialty chemical landscape.