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1-Chloro-1-Nitropropane

    • Product Name 1-Chloro-1-Nitropropane
    • Alias 1-chloro-1-nitropropane
    • Einecs 210-757-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    787043

    Cas Number 600-25-9
    Molecular Formula C3H6ClNO2
    Molecular Weight 123.54
    Appearance Colorless to pale yellow liquid
    Boiling Point 162-164°C
    Melting Point -52°C
    Density 1.303 g/cm3 (20°C)
    Refractive Index 1.433 (20°C)
    Flash Point 64°C (closed cup)
    Solubility In Water Slightly soluble
    Synonyms 1-Nitro-1-chloropropane
    Pubchem Id 11705

    As an accredited 1-Chloro-1-Nitropropane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1-Chloro-1-Nitropropane is supplied in a 250 mL amber glass bottle with a leak-proof screw cap and hazard labeling.
    Shipping 1-Chloro-1-Nitropropane is shipped as a hazardous chemical under UN number 1760 (Corrosive liquids, n.o.s.). It must be packaged in approved containers, clearly labeled, and accompanied by appropriate safety and hazard documentation. Transport regulations require secure handling to prevent leaks or exposure, following all local and international shipping guidelines.
    Storage **1-Chloro-1-nitropropane** should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and heat. Keep it in tightly closed containers made of compatible materials. Store separately from strong oxidizers, acids, and bases. Clearly label the storage area, and ensure access is restricted to trained personnel. Avoid direct sunlight and moisture.
    Application of 1-Chloro-1-Nitropropane

    Applications of 1-Chloro-1-Nitropropane in Industrial Manufacturing

    As a dedicated chemical raw material manufacturer, we supply 1-chloro-1-nitropropane to specialized industrial sectors with a focus on precise process integration and regulatory alignment. Below we outline its direct downstream industrial use in defined, compliant fields.

    1. Pharmaceutical Intermediate for Active Pharmaceutical Ingredients

    Pharmaceutical companies use 1-chloro-1-nitropropane as a building block in synthesizing complex intermediates during the production of specific APIs, especially nitroalkane derivatives or as a precursor in the formation of custom heterocyclic compounds. The raw material is introduced after halogenation but before secondary amination and reduction steps, ensuring controlled substitution chemistry to meet stringent impurity thresholds. Downstream processors must document residual solvents and by-product minimization throughout the validated method, following global pharmaceutical standards. Companies handle material dosing based on targeted output of the intermediate, with stepwise increments fine-tuned through process validation.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF and EP monograph residual solvent guidelines
    • 21 CFR Part 211 (USA FDA cGMPs)
    • EU GMP Volume 4 Part II (APIs)

    Typical usage ratio

    • 5–15% by mass relative to batch scale, adjusted for yield by process phase and specific molecular transformation requirements

    Downstream process integration

    • Added post-primary halogenation in batch reactors
    • Incorporated prior to nitro group reduction or amine substitution
    • Monitored for in-process control of residual by GC-MS
    • Removed or transformed during downstream isolation and purification

    Final product types

    • Specialty anti-infective drug intermediates
    • Oncology and CNS small-molecule intermediates
    • Contract-manufactured custom pharma building blocks
    • API synthons for export markets

    2. Agrochemical Synthesis — Herbicide and Fungicide Intermediates

    Leading agrochemical manufacturers employ 1-chloro-1-nitropropane as a functionalized alkyl source when constructing active intermediates found in selected herbicide and fungicide actives. The compound participates in nucleophilic substitution and coupling reactions within multi-step syntheses, particularly where controlled chloride introduction affects compound bioactivity. Quality assurance teams implement batch tracking and impurity profiling to comply with international agricultural chemical regulations, especially for export-bound formulations.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • US EPA 40 CFR Part 180 (Pesticide Tolerances)
    • REACH Annex VII–X (EC No. 1907/2006)
    • China GB 2763 Food Safety National Standard for Pesticide Residues

    Typical usage ratio

    • 2–10% by weight in target intermediate production, modified depending on conversion efficiency and process scale

    Downstream process integration

    • Charged to reaction vessel after initial formation of active aromatic/nitro group
    • Participates in step-growth or condensation step prior to formulation
    • Reaction progress tracked by HPLC and NMR methods
    • Residual levels confirmed against plant protection requirements before downstream formulation

    Final product types

    • Precursor intermediates for phenoxyalkyl-based herbicides
    • Nitroalkane-derived fungicide intermediates
    • Synthetic crop protection active ingredients
    • Bulk intermediate blocks for multinational agrochemical brands

    3. Fine Chemical Manufacture — Custom Nitroalkane Synthesis

    Producers specializing in fine chemicals rely on 1-chloro-1-nitropropane for constructing custom nitroalkanes, used as core blocks or specialties like chain-elongated esters and alcohols. The material integrates into multi-step alkylation or reduction sequences driven by tightly verified analytical controls. Downstream customers demand detailed certificates confirming trace contaminants and alignment with ISO-certified QC routines for finished organics, especially when targeting auxiliary substances for cross-industry use in electronics and flavors.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • Customer-specific technical agreements for traceability
    • Responsible Care® global chemical industry initiative
    • RoHS 2.0 for electronics-adjacent applications

    Typical usage ratio

    • 3–8% integrated in staged addition for yield optimization; exact dosing depends on downstream chain length and final purity specs

    Downstream process integration

    • Introduced post-initial condensation reactions in glass-lined reactors
    • Reacted under controlled temperature and pH, monitored by HPLC
    • Intermediate analyte isolation with low-temperature distillation
    • Quality control at every transfer and final product crystallization

    Final product types

    • Nitroalkane intermediates (C3-C6)
    • Chain-elongated nitroalcohols
    • Specialty building blocks for electronics industry
    • Component aldehydes and esters for fine chemical markets

    4. Dye and Pigment Precursor in Organic Colorant Synthesis

    Colorant and pigment specialists use 1-chloro-1-nitropropane during the synthesis of complex organic dyes, especially in chromophore extension and modification stages where the nitro and chloro functionality permits subsequent coupling or reduction. Material traceability, feedstock purity, and batch reproducibility ensure compliance with strict textile and plastics industry standards, especially in regulated colorant sectors such as automotive coatings and engineered polymers.

    Industry compliance standards

    • EN 71-3 Safety of Toys (migration of certain elements in pigments)
    • OEKO-TEX® Standard 100 (textile colorants)
    • ISO 9001:2015 for quality management in pigment manufacturing
    • REACH SVHC assessment for chromophoric precursors

    Typical usage ratio

    • 1–7% by mol functionality; adjusted based on dye monomer structure and target chromaticity

    Downstream process integration

    • Fed into batch synthesis after primary aromatic backbone formation
    • Nitro group serves as a handle for subsequent reduction or diazotization
    • Reaction endpoint confirmed by TLC and spectrophotometry
    • Purification follows, with compliance verification via LC-MS

    Final product types

    • Direct and disperse textile dyes
    • Synthetic pigments for plastics and coatings
    • Automotive and high-performance organic pigments
    • Colorant intermediates for specialty ink manufacturers
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    Certification & Compliance
    More Introduction

    1-Chloro-1-Nitropropane: A Closer Look from the Manufacturer’s Perspective

    Understanding Our Craft: Bringing 1-Chloro-1-Nitropropane to Life

    Over the years, we have dedicated ourselves to the production of specialty nitroalkanes, among which 1-Chloro-1-Nitropropane stands out. Producing this chemical means working with precision and a strict adherence to safety and regulatory guidelines. Every batch comes from a controlled process, underpinned by decades of experience and fine-tuned operating parameters. With roots in industrial nitroalkane manufacturing, our processes honor both science and the hands-on know-how hard won on the factory floor.

    Product Overview and Key Specifications

    1-Chloro-1-Nitropropane, identified with the molecular formula C3H6ClNO2, finds itself in a category of nitroalkanes with versatile reactivity. Its typical appearance—clear to pale yellow liquid—tells part of the story, yet the real value emerges in its functional groups. The presence of both chloro and nitro groups in a three-carbon backbone creates a profile adept at serving as an intermediate. Each batch undergoes gas chromatographic analysis, so we guarantee high assay purities, often exceeding 98% when the process is dialed in. Impurity controls focus on keeping di-nitro and poly-chloro contaminants below trace levels, which ensures predictable performance down the reaction line.

    Boiling point, specific gravity, and refractive index are all routinely measured to verify not just that the material matches our technical literature, but that it behaves as expected during transfer, storage, and downstream use. Some customers come to us specifically for the consistency batch-to-batch, without worrying about subtle shifts that could throw off their syntheses. Physical consistency, in our production runs, isn’t a byproduct—it’s the result of direct process control, careful feedstock selection, and calibrated reaction conditions. Years of monitoring and fine-tuning each step have allowed us to minimize byproducts and maintain a degree of purity that gives our clients confidence, whether they work in laboratory-scale research or full-scale manufacturing.

    Real-World Application and Performance: Why Industries Rely on this Molecule

    In our years of producing and distributing 1-Chloro-1-Nitropropane, we have learned much from our end users. This molecule doesn’t often make headlines, yet it occupies a key position in the syntheses of pharmaceuticals, agricultural intermediates, and specialty chemicals. The electron-withdrawing nitro group, alongside the reactive chlorine, means this compound can open up reaction pathways that other nitropropanes cannot. Not all nitroalkanes function as efficient alkylating or acylating agents. Here, the additional chloro substituent extends the chemistry, giving organic chemists a sharp tool when building more elaborate molecules. For instance, the pharmaceutical sector often requires intermediates capable of precise substitution or further transformation—a need ably met by controlled batches of 1-Chloro-1-Nitropropane.

    One repeat customer, engaged in producing a specific fungicide, explained that only 1-Chloro-1-Nitropropane, at the right purity and isomeric profile, enabled the desired ring closure in their synthetic route. Off-spec material simply led to decreased yields or downstream purifications that weren't economically feasible. This direct feedback has informed adjustments on our end. Sometimes it involves tweaking distillation parameters to draw off a particularly stubborn impurity, while other times, the work is in adjusting reagent grades or reaction contact times. Direct feedback loops between chemical manufacturers and clients matter—without them, intermediate producers risk swinging in the dark.

    Key Differences: What Distinguishes 1-Chloro-1-Nitropropane from Other Nitroalkanes?

    A closer look at the market offers a sea of nitroalkanes, but not all of them function alike. Comparing 1-Chloro-1-Nitropropane to more conventional nitroalkanes such as nitromethane or 1-nitropropane illustrates this clearly. Chloro-substitution matters. It expands reaction capabilities—creating access to synthetic routes not available through basic nitroalkanes. Our technical team spends considerable time talking shop with clients, helping them recognize whether 1-chloro functionalization is necessary for their applications or if a simpler nitroalkane suffices.

    Take nitroethane or 2-nitropropane, for example. They find frequent use as solvents or basic alkylating agents in laboratory syntheses but lack the reactivity provided by a halogen. If a chemist aims to introduce a nitroalkyl group and a leaving group in a single step, the chloro-nitro pairing becomes invaluable. That subtlety makes all the difference in multistep processes where yield, reactivity, and selectivity determine production efficiency and final costs.

    Switching between these compounds is not a matter of convenience—choosing the correct one relies on understanding electronic and steric effects within the reaction mechanisms. Our manufacturing floor never loses sight of those details. Each variation in feedstock, catalyst, and reaction time influences the final product. Customers pick up on this, notably those who have migrated from generic nitropropane to our 1-Chloro-1-Nitropropane in search of improved conversion efficiency.

    Handling, Safety, and Trust: The Human Element in Production

    Industrial chemistry never truly leaves behind the human touch. Every new operator on our production floor learns by shadowing veterans who emphasize safe handling at each step. Even though our automated systems track temperature, pressure, and flow, it only takes one missed connection for an off-batch to form. We run regular training, audit every safety practice, and listen closely to seasoned workers’ practical advice for maintenance and cleaning. Our investment in reliable, corrosion-resistant piping and storage vessels comes straight from first-hand experience—early batches faced more frequent issues before we changed pump seals and introduced sealed transfer lines, which eliminated undesired exposure to ambient moisture and air.

    Handling chlorinated nitro compounds carries certain risks, particularly from both inhalation and skin contact. We implemented on-the-floor sensors and air exchangers years ago after an incident with a batch that vented prematurely, which led to one of our engineers encouraging weekly drills and chemical awareness sessions. We tightened shipping restrictions and reinforced drum seals after customers reported cap loosening in transit—a feedback loop that has since reduced leaks and boosted customer satisfaction. Constant communication between operators, shipping staff, and our technical departments keeps us accountable, transparent, and responsive.

    Environmental and Regulatory Realities

    Not a week goes by without a new set of guidelines introduced somewhere on the globe covering chemical traceability or emissions. Our compliance team wakes up to the daily challenge of aligning production and documentation with all relevant regulations. Every vessel fill, drum transfer, and load-out includes an auditable digital paper trail. Customers in markets such as the European Union or North America expect a supporting document package—including both Certificates of Analysis and third-party residue analysis. Our laboratory teams keep digital logs, which not only boost confidence in product consistency, but provide quick answers to auditors or clients with concerns about heavy metals or halogenated byproducts.

    Solvent use, energy efficiency, and emissions controls have evolved since our early days. Even the process water leaving our reactors gets treated and monitored before discharge. Recycling byproducts and controlling venting of halogenated gases goes beyond legal requirement—it became ingrained after several years collecting on-site data and collaborating with regulators. Our ongoing review of process parameters allows continual reduction of waste, saving money long-term and building goodwill with the communities near our plants.

    Collaborative Problem-Solving: Listening to Users, Improving Production

    Having worked with a wide range of downstream users, we know open dialogue is the only way a manufacturer can keep pace. Once, a customer running a multi-step pharmaceutical synthesis flagged minor but persistent color impurities in our 1-Chloro-1-Nitropropane. Rather than dismissing it as minor, we traced it back to a feedstock supplier who had slightly altered their distillation practice, changing the byproduct profile. Couldn’t have caught it just by reviewing in-house paperwork. We resolved the issue by switching lots and tightening our check of supplier data. Production did not halt—neither did trust. That kind of transparency, paired with technical rigor, makes the difference in a field where every skipped step risks a failed batch or lost contract.

    We have worked jointly with clients to trial reaction conditions, sometimes even sending technical staff to help optimize usage. Reports from the field feed directly into how we design our internal quality controls. Our support doesn’t end at delivery. Routine follow-ups let us gather detailed feedback not just on product purity but also on packaging issues, labeling, and logistical hiccups. We believe every concern is a chance to do better, not just for the next client but for every batch moving forward.

    Looking Forward: Innovation, Adaptability, and Reliability

    Even as the fundamentals of organic chemistry stay the same, demanded specifications continue to evolve. Researchers constantly push reaction boundaries, and manufacturers need to keep pace or get left behind. Over time, clients who once accepted a broader impurity profile now request ultra-high purities, sometimes specific to a single isomer. In response, we invested in upgraded distillation columns and in-line monitoring, allowing split-second adjustments. Automated feedback loops between analytics and process control now assist our engineers, though hands-on oversight remains indispensable.

    From our perspective, reliability in production does not stem only from robust hardware or sophisticated analytics. Experience in troubleshooting—carried by every technician, engineer, and quality manager on the floor—keeps the plant running and customers happy. Our best operators know how to interpret instrument trends and catch discrepancies that a spreadsheet might miss. Over time, this culture of diligence has elevated product quality, built trust, and cultivated long-term relationships with chemical users who value continuity and direct accountability.

    Conclusion: Putting Experience and Integrity at the Forefront of Supply

    The world does not pause for chemical supply interruptions. Our work to produce 1-Chloro-1-Nitropropane goes beyond just hitting purity marks or passing regulatory checks. Every drum represents countless hours of design, troubleshooting, learning, and adapting to evolving customer needs. The technical demands placed upon intermediates in pharmaceutical and agrochemical synthesis highlight just how critical reliable manufacturers have become. In many ways, this product serves not just as a chemical input, but as a testament to decades of manufacturing knowledge, attention to detail, and the ability to pivot as industries move forward. Our customers depend on quality and reliability—not just from our product, but from the people who produce it, stand behind it, and never stop striving to do better.