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1-Bromo-2,4-Dinitrobenzene

    • Product Name 1-Bromo-2,4-Dinitrobenzene
    • Alias 2,4-Dinitrobromobenzene
    • Einecs 204-325-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    635018

    Name 1-Bromo-2,4-Dinitrobenzene
    Cas Number 585-71-7
    Molecular Formula C6H3BrN2O4
    Molecular Weight 247.00
    Appearance Yellow crystalline solid
    Melting Point 74-76°C
    Solubility Slightly soluble in water; soluble in organic solvents
    Density 1.97 g/cm3
    Pubchem Cid 12036
    Smiles C1=CC(=C(C=C1N(=O)=O)Br)[N+](=O)[O-]
    Inchi InChI=1S/C6H3BrN2O4/c7-4-1-2-6(9(12)13)5(3-4)8(10)11/h1-3H

    As an accredited 1-Bromo-2,4-Dinitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle labeled "1-Bromo-2,4-Dinitrobenzene, 25g". Includes hazard symbols, CAS number, supplier logo, and tightly sealed screw cap.
    Shipping **Shipping Description for 1-Bromo-2,4-Dinitrobenzene:** Ships as a hazardous material (UN 1325), packed in tightly sealed containers, compliant with local and international chemical transport regulations. Requires labeling as an oxidizing solid and potentially harmful substance. Store away from heat, flames, and incompatible materials. Proper documentation and handling by trained personnel are mandatory.
    Storage Store 1-Bromo-2,4-dinitrobenzene in a cool, dry, and well-ventilated area away from sources of ignition and incompatible materials such as strong reducing agents. Keep the container tightly closed and protected from moisture and direct sunlight. Use approved containers and label them clearly. Ensure proper handling with personal protective equipment to avoid inhalation, ingestion, or skin contact.
    Application of 1-Bromo-2,4-Dinitrobenzene

    Applications of 1-Bromo-2,4-Dinitrobenzene in Industrial Manufacturing

    We leverage proprietary synthesis expertise to supply 1-Bromo-2,4-Dinitrobenzene for specialized applications across agrochemical, pharmaceutical intermediate, dyestuff, and polymer additive markets. Each sector applies unique quality, compliance, and performance demands that we address at scale to ensure consistency in downstream customer processes.

    1. Synthesis of Agrochemical Intermediates

    1-Bromo-2,4-Dinitrobenzene acts as a critical electrophilic agent for constructing selective herbicide and insecticide intermediates, particularly for nitroaniline and nitrophenyl urea derivatives. Major players in crop protection leverage this raw material in nucleophilic aromatic substitution reactions to introduce key functional groups, supporting bioactivity and persistence in final agrochemical products. Strict regulatory standards mandate documentation of raw material traceability, contaminant control, and process residual management throughout downstream conversion steps.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • ISO 9001:2015 (production quality systems)
    • REACH Annex XVII (Europe, limitation of nitro compounds)
    • US EPA 40 CFR 180 (pesticide residue tolerances)

    Typical usage ratio

    • 3 – 15% by weight as core building block, depending on the target molecule complexity and batch scale; process chemists adjust input based on required conversion yield and side-reaction minimization.

    Downstream process integration

    • Introduced during initial nucleophilic substitution or amination step of multi-stage synthesis, usually in polar aprotic solvents under controlled temperature, followed by downstream derivatization and neutralization steps.

    Final product types

    • Active herbicidal intermediates (e.g., 2,4-dinitroaniline derivatives)
    • Pre-cursor compounds for systemic insecticides
    • Key intermediates for soil sterilants and fungicides

    2. API Intermediate in Pharmaceutical Synthesis

    Pharmaceutical manufacturers employ this compound as a selective arylating and derivatizing agent in the synthesis of advanced intermediates for APIs such as anticancer, anti-tuberculosis, and certain CNS drugs. Where high purity and predictable reactivity are mandatory, our material enables reproducible batch syntheses conforming to rigorous pharmacopoeia and cGMP requirements, while stringent impurity profiling safeguards against carryover in finished drug substances.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) <941> identification for nitroaromatic intermediates
    • EDQM CEP for pharmaceutical intermediates
    • 21 CFR Parts 210–211 (cGMP for finished pharmaceuticals)

    Typical usage ratio

    • 1 – 7% by molar equivalent, calculated against the coupling partner; precise stoichiometry tailored to eliminate unreacted starting material, guided by IPC and LC-MS monitoring.

    Downstream process integration

    • Deployed in core arylation or denitration step within multi-pot synthesis, often under inert atmosphere, with real-time pH and residual monitoring to enable rapid work-up and isolation of purified intermediates.

    Final product types

    • Pharmaceutical intermediates for oral and injectable APIs
    • Precursor structures for oncology therapies
    • Processed raw material for central nervous system drug synthesis

    3. Diazo Dye Manufacturing

    Our material is widely integrated within the diazotization workflow at aromatics and colorant manufacturers to produce high-performance yellow and orange azo dyes. Its electron-withdrawing nitro groups enhance chromophore conjugation and coupling reactivity, driving consistent batch-to-batch shade reproducibility for textile, paper, and plastics coloration. Downstream customers prioritize purity and metal trace certification to meet industry labeling and end-use regulatory requirements.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (for textiles)
    • ZDHC Gateway Conformance Guidance for Dyestuff
    • EN 71-3 (toys safety for azo colorants)
    • REACH Annex XVII (prohibited arylamines and nitroaromatics)

    Typical usage ratio

    • 5 – 18% by total batch mass; adjusted for dye shade intensity and dispersion requirements during the diazotization/coupling stage.

    Downstream process integration

    • Charged post-diazotization to initiate aromatic coupling with amines or phenols, following pH-adjusted isolation, filtration, and spray-drying to yield pigment granules or powders.

    Final product types

    • Textile dye formulations (powder, liquid, paste)
    • High tint strength pigments for plastics and inks
    • Paper coloring agents (cellulose-compatible dyes)

    4. Polymer Crosslinking Additive

    Producers of specialty polymers or engineering plastics incorporate this compound as a crosslinking and chain-modification agent, especially in applications demanding enhanced solvent resistance or thermal stability. The nitro and bromo functional groups provide dual points for controlled nucleophilic substitution, enabling tailored property modification during resin formulation and compounding, requiring careful raw material quality documentation as dictated by polymer segment end-use.

    Industry compliance standards

    • ISO 10993-5 (for biocompatibility in select applications, e.g., medical plastics)
    • ASTM D638 (plastic physical property testing)
    • REACH Regulation (EC) No 1907/2006 for monomers and additives
    • RoHS 2 Directive 2011/65/EU (for E&E polymers)

    Typical usage ratio

    • 0.1 – 1.5% by resin mass, optimized for target crosslink density; modified according to polymer backbone reactivity and processing parameters such as melt temperature and shear rate.

    Downstream process integration

    • Masterbatch blending or in-situ polymerization addition, followed by extrusion, pelletizing, or molding; post-addition curing protocols specified by R&D teams based on performance metrics.

    Final product types

    • Advanced engineering thermoplastics (e.g., modified polyamides)
    • High durability coatings
    • Crosslinked resin beads for filtration media
    Free Quote

    Competitive 1-Bromo-2,4-Dinitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 1-Bromo-2,4-Dinitrobenzene: An Insight from the Manufacturer

    Understanding the Substance: Foundation and Identity

    Working with chemicals over decades brings a certain respect for molecules that regularly reward careful hands and steady processes. 1-Bromo-2,4-dinitrobenzene, with its unique structure—a benzene ring substituted with bromine at the first carbon and nitro groups at the second and fourth positions—offers more than just numeric intrigue. It goes beyond laboratory curiosity and plays a practical role across many chemical sectors. The product code many labs reference reflects the simple precision built into every batch here. At our manufacturing units, quality means purity above 99% and consistent particle size, both critical for researchers aiming at reliable results.

    Manufacturing isn’t just about replication. It’s about understanding from raw ingredients to finished goods. Making 1-bromo-2,4-dinitrobenzene involves selecting high-purity starting materials, maintaining exacting control over reaction temperatures, and using non-reactive vessels so nothing interferes with the bromine or nitro groups. We’ve refined this synthesis to minimize side reactions, especially significant with substances so reactive. Many who purchase from us notice immediately that there’s less byproduct contamination and a sharper melting range—which proves our approach works.

    Workers in our facility see up close what makes 1-bromo-2,4-dinitrobenzene stand apart from seemingly similar compounds. The interplay between the electron-withdrawing nitro groups and the halogen core impacts how chemists downstream can use it, whether as an electrophilic aromatic substitution partner or as an intermediate. In environmental monitoring, pharmaceutical research, and dye precursor synthesis, the properties of this compound—both its reactivity and stability—set the pace for productive discovery.

    Specifications Built for Precision

    We control product quality not by shortcutting, but by heeding the lessons of past batches and market feedback. The crystalline powder that leaves our hands shows off a bright yellow color, a visual cue tied to real chemical characteristics. Moisture levels matter here; even half a percent shift can alter how this compound behaves in further processing. Each batch is sealed with low permeability films to avoid any atmospheric exposure, a detail born from years learning how subtle contamination undermines customer results.

    Our technical staff reports that most customers require 1-bromo-2,4-dinitrobenzene in volumes ranging from a few hundred grams to multi-kilo lots. Handling the larger scale involves not only safety checks but keeping the same purity. Some suppliers cut corners to maximize yield at the expense of repeatable performance. We never compromise. For those needing fully traceable documentation and wider certificates, our internal lab issues assay reports, confirmation of the spectral fingerprint, and even residual solvent analyses. Every shipment gets the same attention, whether destined for academic synthesis or industrial pilot lines.

    Longevity matters. We don’t box up this material and move on. Customers often ask months later if their product still meets the spec, especially after storage. Our experience shows the compound, when dry and sealed, holds up for more than two years under recommended conditions. Warehouse managers in both tropical and temperate zones confirm our packaging keeps hydrolysis and decomposition at bay, something not all competitors achieve. Regular shelf-life studies support these claims.

    Uses That Go Beyond Paper

    Purchasing managers and synthetic chemists often overlook the hidden roles played by simple molecules. 1-bromo-2,4-dinitrobenzene pops up in teaching laboratories as a model substrate for nucleophilic aromatic substitution—an exercise that teaches aspiring chemists how electron-withdrawing groups activate certain aromatic positions. Each year, batches head to universities, where students see firsthand how reaction rates shift with structural changes. The sharp melting point and color make it easy to spot in student experiments, allowing instructors to focus on teaching the fundamentals, not troubleshooting impure samples.

    On the industrial side, this molecule’s reactivity lends itself as a building block for surfactants and specialty dyes. Brominated nitrobenzenes rarely get stuck in the process pipeline since they offer well-understood reactivity patterns. By substituting various amine nucleophiles in place of bromine, customers turn our product into more complex aromatic amines that serve as bright colorants, pharmaceutical precursors, or agrochemical intermediates. Our in-house chemists sometimes assist partner firms with unusual substitutions or scale-up advice, since real-world conditions deviate from textbook idealizations.

    Analytical chemists have shared feedback that 1-bromo-2,4-dinitrobenzene works well as a derivatization agent for thiol quantification. This application in protein chemistry or environmental analysis shows the breadth of ways customers deploy our material outside traditional organic synthesis. The nitro groups help form intensely colored adducts with sulfur-containing analytes, giving reliable, quantifiable results by UV-Vis spectroscopy. We supply reference samples, complete with structural confirmation, so new users feel confident in their calibrations.

    What Sets 1-Bromo-2,4-Dinitrobenzene Apart?

    There’s no shortage of substituted nitrobenzenes or bromobenzenes in catalogues. What makes this compound notable is the precise arrangement and balance between bromine and nitro groups. Compared to 1-chloro-2,4-dinitrobenzene, for instance, the bromo variant boasts higher selectivity in certain substitution reactions due to the greater leaving group capability of bromine. Laboratories working with nucleophilic aromatic substitutions report higher yields and fewer side-products—which translates directly to less time spent on purification.

    Similar products, such as mono-nitro or meta-dinitrobenzene derivatives, do not match the same reactivity pattern. Some fail to act as effective leaving groups or yield less predictable reaction products. Multi-substituted benzenes with different group arrangements very often react differently or pose tougher safety hazards. Several regulatory agencies impose stricter rules on certain positional isomers due to their toxicological profiles, so working with this specific compound allows some flexibility and lower compliance costs for professional users.

    Through the years, some customers have tried blending alternatives or recovering spent material. The chemistry rarely justifies the savings. An inferior product or one with off-spec purity often triggers process failures, regulatory questions, or extended downtime. We’ve solved more than a handful of headaches when returning clients rediscover the value in ordering directly from a source who understands the subtle differences between apparently similar molecules. Repurposed supply chains usually miss those details; here, we see them in every batch and every crystallizer run.

    Production: Lessons from Experience

    No two production cycles look exactly alike. Fluctuations in raw material markets, seasonal shifts in temperature, or even batch-to-batch idiosyncrasies present challenges. To overcome these, we standardized not by rigid automation but by training teams to recognize a correct outcome. As raw bromobenzene and dinitro precursors flow into the process, every valve setting and temperature gauge gets monitored in real time. Subtle differences in color usually alert experienced operators if side reactions try sneaking in. A faint green tinge or excessive dust points to the need for further filtration or adjusting storage parameters.

    As we scale manufacturing, equipment cleaning schedules—often overlooked—become critical. Repeated syntheses without thorough vessel cleaning lead to cross-contamination, a lesson any long-term producer remembers. Process documentation for every batch is filed, not because auditors might look, but because small details today prevent storms down the line. We’ve seen more than one competitor falter after ignoring these fundamentals.

    Strict quality control stations offer only part of the story. Our teams cooperate with long-time suppliers for consistent ingredient sourcing, vetting shipments beyond certificates of analysis. Reagents that ride in half-empty drums or with unverified lots risk introducing variables, a mistake history proves costly. It’s not enough to buy cheap and scrub the evidence; quality built in from the ground up survives transportation, storage, and eventual use better than something simply rebranded or repackaged.

    Packaging and Logistics: Protecting the Value

    Transporting hazardous substances requires more than following regulations. You know something as sensitive as 1-bromo-2,4-dinitrobenzene needs moisture control and light shielding. We use heat-sealed, double-laminated bags and robust drums precisely because even trace leaks degrade the product or cause safety incidents. Before shipment, samples spend days in accelerated stability chambers to predict worst-case exposure effects—real-world conditions often exceed laboratory optimism. What ships from our doors withstands unpredictable climates and journeys without succumbing to caking or color change.

    Heavy packaging doesn’t exist just to impress. Labs taking delivery in coastal or high-humidity environments benefit directly, since the powder doesn’t clump or degrade after arrival. One misstep in packaging quickly erases careful manufacturing. Over the years, this detailed approach has earned trust from clients who expect their shipments to perform the same each time, regardless of weather, warehouse, or customs delays. Even in the hands of new buyers, the robust packaging design reduces breakage, spillage, or accidental exposure.

    Onsite storage at customer facilities is easier due to clear guidance based on our ongoing product studies. Recommendations for cool, dry, shaded environments come from direct measurements, not generic safety booklets. Where storage rooms prove less than ideal, our team often suggests practical workarounds—secondary desiccants, insulated drums, or rotating older stock—that prevent loss. This advice comes only from lived experience, not copied from standards.

    Supporting Safe, Informed Use

    Some specialty chemicals attract casual buyers or newcomers. Our stance is clear: only professionals with suitable training should handle 1-bromo-2,4-dinitrobenzene. Its volatility, potential for skin and respiratory irritation, and sensitivity to reducing agents make safe handling crucial. Our documentation includes not just the required labels and warnings, but tailored pointers learned from our team observing accidents and mishandling across different industries.

    Over time, direct phone calls and support emails have taught us that even experienced chemists sometimes need reminders. Proper glove selection—nitrile preferred over latex—avoids unwanted permeation. Controlled fume hood airflow, careful weighing protocols to minimize airborne dust, and dedicated waste containers prevent cross-contamination with incompatible materials. These recommendations don’t stem from abstract theory but the practical reality faced by real teams, often in less-than-ideal lab or plant settings.

    Beyond physical hazards, we’ve tracked regulatory shifts in handling aromatic nitro compounds. Shipping rules, workplace exposure standards, and documentation requirements shift each year. Our team joins industry forums and working groups not just to stay compliant but to share everyday findings and improve guidelines. This vigilance brings peace of mind to buyers who must satisfy local inspectors or corporate safety audits without losing workflow efficiency.

    Collaborative Research and Process Support

    From time to time, researchers reach out for application support, process troubleshooting, or scale-up advice. Supplying more than a chemical—offering process insight—creates value both for us and for our partners. Laboratories switching from benchtop synthesis to pilot reactors run into non-obvious challenges with stirring, heat transfer, or product isolation. We draw on both academic references and our on-site process engineering notes, helping partners avoid the common pitfalls that derail scale growth.

    Industrial teams designing new amine derivatives or colorants occasionally seek advice about optimizing substitutions or managing effluent streams. Our process chemists share strategies for minimizing unwanted byproducts, ensuring easier downstream purification. This cooperative approach benefits both the customer and our production facility, since we hear firsthand how our product performs outside strict lab controls.

    Sometimes, batch consistency concerns arise if customers blend our product with off-brand or legacy stocks. Whenever questions about analytical results land in our inbox, we offer parallel testing—comparing side-by-side samples with our high-purity material. More than one client has discovered that cost-saving substitutions end up more expensive after factoring in downtime and quality failures. Real answers, grounded in experimentation, win out over speculation or internet lore.

    Environmental Responsibility and Future Prospects

    Handling halogenated and nitro aromatic chemicals commands respect for environmental stewardship. Waste minimization isn’t just regulatory compliance—it’s an operational priority. In our plant, spent solvent recovery and catalytic decomposition of minor byproducts keep emissions within tight bounds. Recent investments in improved filtration and condensate reuse reduce both environmental impact and operational costs.

    We’ve participated in regional working groups to share improved destruction technologies and best practices for aromatic nitro waste. Recycling containers after neutralization, energy-efficient drying, and on-site effluent treatment loops into our ongoing improvement mandates. Customer feedback sometimes drives innovation: companies reporting problematic emissions after using older synthetic routes inspired our team to test new exhaust scrubbing treatments—successes that ultimately get shared across supply chains.

    Sustainability poses tougher questions in chemical manufacturing than in many industries. The distinct electronic structure that makes 1-bromo-2,4-dinitrobenzene so useful also means stricter regulation and higher scrutiny. Testing newer, green oxidants and process intensification techniques shows some promise, though large-scale adoption remains just over the horizon. Broadening collaboration between manufacturers, academic researchers, and downstream users paves the way for safer and more responsible production over time.

    Conclusion: Manufacturing with Experience and Insight

    Every kilogram of 1-bromo-2,4-dinitrobenzene that leaves our plant represents more than a chemical transaction. Years of hands-on experience, process control, and support for customers across the world shape each batch. The distinctions between our product and similar compounds reflect not just their molecular structure, but our efforts to guarantee purity, safety, and consistency at every phase. Chemists, researchers, and industrial users can trust in a line of communication and guidance rooted in genuine practice, not anonymous distribution. Our continued commitment puts quality chemistry in the hands of experts—right where it matters most.