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1-Aminoethanol

    • Product Name 1-Aminoethanol
    • Alias Ethylethanolamine
    • Einecs 200-535-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    638978

    name 1-Aminoethanol
    IUPAC_name 1-aminoethanol
    molecular_formula C2H7NO
    molar_mass 61.08 g/mol
    CAS_number 616-39-7
    appearance Colorless liquid
    density 0.93 g/cm3
    boiling_point 120 °C
    melting_point -44 °C
    solubility_in_water Miscible
    structure CH3CHOHNH2
    pubchem_CID 12223

    As an accredited 1-Aminoethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 1-Aminoethanol is packaged in a 250 mL amber glass bottle with a secure screw cap and hazard labeling.
    Shipping 1-Aminoethanol should be shipped in tightly sealed, clearly labeled containers suitable for chemicals. It must be transported according to local, national, and international regulations for hazardous materials, keeping it away from incompatible substances and sources of ignition. Proper documentation, including safety data sheets, must accompany all shipments to ensure safe handling and compliance.
    Storage 1-Aminoethanol should be stored in a tightly sealed container, protected from light and moisture. It should be kept in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Proper labeling and secure shelving are recommended to prevent accidental release. Personal protective equipment should be used when handling the chemical.
    Application of 1-Aminoethanol

    Applications of 1-Aminoethanol in Industrial Manufacturing

    1-Aminoethanol serves as a key intermediate in several industrial sectors. The following sections outline its core applications, with practical details for each downstream field based on process, compliance, and product-specific requirements.

    1. Pharmaceutical Intermediate for Active Pharmaceutical Ingredients (APIs)

    Synthesis of chiral alcohol-based APIs often requires 1-Aminoethanol as a precursor or building block. Manufacturers apply this intermediate to assemble β-amino alcohol frameworks present in antihistamines, antiarrhythmics, and select CNS agents. The stereochemical properties of 1-Aminoethanol assist in consistent batch-to-batch chiral purity, pivotal for regulated drug synthesis.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • Ph. Eur. monograph 2.2.24 (for related substances, if applicable)
    • US FDA 21 CFR Part 211
    • Chinese Pharmacopoeia (for API production compliance)

    Typical usage ratio

    • 5–20% as a molar reactant in multi-step organic synthesis, adjusted for yield and stoichiometry

    Downstream process integration

    • Aldol condensation, reduction, or amidation step as part of core molecule assembly
    • Direct input in chiral auxiliary or resolution processes
    • Batch-wise addition in reactor charging
    • Precursor for further amination or functional group interconversions during API construction

    Final product types

    • Antihistamines (e.g., Chlorphenamine)
    • Cardiac antiarrhythmic drugs
    • CNS pharmaceuticals with β-amino alcohol structures
    • Drug substance intermediates for further synthesis

    2. Fine Chemical Synthesis (Chiral Auxiliaries and Resolving Agents)

    Producers of fine chemicals rely on 1-Aminoethanol as a chiral building block or resolving agent, particularly in the resolution of racemic mixtures and to induce specific optical isomerism in target compounds. Its stereochemistry underpins control over asymmetric synthesis routes, frequently seen in high-purity specialty chemical manufacturing for both pharma and performance chemicals.

    Industry compliance standards

    • ISO 9001 Quality Management for specialty chemicals
    • REACH (EC 1907/2006) registration for handling in the EU
    • Responsible Care® chemical safety systems

    Typical usage ratio

    • 1.5–8% relative to main substrate, optimized based on enantiomeric excess target and conversion rate

    Downstream process integration

    • Preparation of chiral salts for racemate separation (e.g., salt formation with carboxylic acids)
    • Starting point for chiral ligand or catalyst synthesis
    • Integration into crystallization or extraction units
    • Addition prior to chromatographic or azeotropic resolution steps

    Final product types

    • Enantiopure fine chemicals
    • Chiral auxiliaries for synthetic R&D
    • Resolving agents for laboratory and industrial separations
    • Specialty intermediates used in fragrance or flavor synthesis

    3. Organic Synthesis of Agrochemical Intermediates

    Manufacturers in the agrochemical sector incorporate 1-Aminoethanol for synthesizing herbicide and pesticide intermediates where β-amino alcohol moieties are functional. The controlled use of this raw material supports key condensation and substitution reactions designed for scalable active ingredient outputs. Precision in its addition can influence reaction selectivity and final product purity, critical for meeting agricultural regulatory standards.

    Industry compliance standards

    • FAO/WHO specifications for pesticide technical materials
    • ISO 17025 for laboratory process validation
    • EPA regulations for synthesis of pesticide active ingredients (USA)
    • REACH compliance for raw material sourcing and registration

    Typical usage ratio

    • 3–10% as reaction feedstock in intermediate formation, adapted for desired active moiety yield

    Downstream process integration

    • Nucleophilic substitution during formation of β-amino alcohol intermediates
    • Input in condensation or cyclization reactions upstream of active ingredient production
    • Inline feeding within multistep batch or continuous agrochemical synthesis pipelines
    • Precursor modification during chlorination, alkylation, or esterification

    Final product types

    • Pesticide technical intermediates
    • Bespoke herbicide building blocks
    • Fungicide development intermediates
    • Custom agrochemical synthesis for field use formulations

    4. Additive in Cement and Concrete Admixture Formulations

    In construction chemistry, producers use 1-Aminoethanol as a minor additive in select cement admixtures. The amino alcohol structure offers specific chelating and setting control functions, affecting hydration reaction rates and improving early-stage workability. This application demands stringent quality monitoring, as admixture-level fine tuning influences mechanical performance and compliance with industry standards.

    Industry compliance standards

    • ASTM C494/C494M for chemical admixtures in concrete
    • EN 934-2 (European specification for admixtures)
    • ISO 14001 for production site environmental management
    • National Ready Mixed Concrete Association (NRMCA) admixture guidelines

    Typical usage ratio

    • 0.05–0.5% of cement mass, with dosing based on target slump, set time, and compatibility with main admixture package

    Downstream process integration

    • Metered addition to liquid admixture blends during batch formulation
    • Incorporation within premix or dry-mix chemical packages
    • Integration in pilot plant trials for performance verification
    • Onsite final blending for customized concrete mixes

    Final product types

    • Workability modifiers for high-performance concrete
    • Hydration control admixtures
    • Special grout formulations with quick-set function
    • Ready-mix concrete solutions for infrastructure projects

    5. Analytical Chemistry Reagent for Enantioselective Analysis

    1-Aminoethanol enables formation of diastereomeric derivatives in analytical labs for chiral GC and HPLC separation. Laboratories and analytical reagent manufacturers prepare derivatization kits using this compound, especially for the enantioselective analysis of α-hydroxy acids and related chiral substrates. The precision in reagent quantity and purity directly impacts chromatographic resolution and quantitation accuracy.

    Industry compliance standards

    • ISO 17034 for production of reference materials
    • GLP (Good Laboratory Practice) for chemical analysis
    • EN ISO/IEC 17025 testing laboratory accreditation
    • USP General Chapter <621> for chromatography

    Typical usage ratio

    • 1:1 molar ratio with target analyte, optimized as required for derivatization efficiency and instrument detection

    Downstream process integration

    • Direct addition as a derivatization reagent in sample preparation workflow
    • Blending with chiral carboxylic acid substrates for pre-injection treatment
    • Integration with solid-phase or liquid chromatography sample preparation kits
    • Calibration batch production for standardization kits

    Final product types

    • Enantioselective analysis kits
    • Reference standards for chromatographic QC
    • Certified derivatization agents
    • Lab consumables for pharmaceutical and food quality analysis
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    Certification & Compliance
    More Introduction

    1-Aminoethanol: A Versatile Chemical for Industrial Solutions

    Introduction to 1-Aminoethanol

    In our plant, 1-Aminoethanol plays a key role across a wide range of industrial activities. We synthesize it under tightly controlled conditions because stability and purity count for our downstream partners. Over the past years, we've seen demand for this compound grow, especially as industries explore more refined or sustainable production methods in pharmaceuticals and specialty chemicals. Our experience with 1-Aminoethanol reflects the way fine details in manufacturing can ripple through entire supply chains, affecting not just quality but also cost management and operational safety.

    Our Experience in Production

    Producing 1-Aminoethanol requires careful handling from the very start. Even slight changes in raw material grade or process temperature alter both the yield and the impurity profile. Our facility uses a method that we've refined through repeated optimization, skipping unnecessary solvents and keeping reaction times as short as possible. By precise control of reaction temperature and pressure, we can increase product consistency. Over many production runs, patterns emerge—lowering the degree of moisture intrusion cuts down on side product formation, save on post-production purification, and avoids the disappointment of a batch falling out of specification.

    Quality and Model Choices

    We produce 1-Aminoethanol using a standard model that targets a purity of around 99 percent, which suits lab-scale and commercial-scale syntheses alike. Our experience shows that the highest demand comes from customers running pharmaceutical intermediates and fine chemical synthesis, both of which have no tolerance for contamination. Lower grades, with purity around 95 percent, see use in less critical applications, such as certain coatings or industrial reagents. Consistently, pharmaceutical partners stress the importance of trace impurity data. From routine gas chromatography to NMR, every batch receives thorough analysis, because even parts-per-million contamination triggers costly rework or stalled production lines downstream.

    Physical and Chemical Properties

    1-Aminoethanol is a colorless solid under typical storage conditions at our facility, though it can appear as a viscous liquid in some process environments, making transfer and storage straightforward. Its melting and boiling points provide an advantage compared to closely related chemicals, making it simpler to recover and purify. Through years of handling, we have learned that even at ambient conditions, this material absorbs moisture quickly. Humidity control isn’t a luxury in production buildings—it’s a necessity. Every batch spends as little time as possible exposed to open air before we seal it in moisture-proof containers, because slight hydration upsets crystallization and impairs its usefulness for downstream synthesis.

    Usage Across Industries

    The most common inquiries we field relate to 1-Aminoethanol’s role as a synthesis intermediate. In our experience, customers in pharmaceutical manufacturing and research turn to this compound for constructing heterocyclic frameworks. It serves as a key building block because its reactivity with both electrophiles and nucleophiles opens up a broad menu of downstream modifications. Manufacturers in agrochemicals and dye intermediates value similar features. Unlike other amine-alcohols, our 1-Aminoethanol exhibits a desirable reaction selectivity—customers have shown us that they routinely achieve higher conversion rates and lower by-product formation in their custom reactions when they start with a well-purified sample from our facility, instead of a multi-purpose grade from bulk chemical sources.

    Handling Considerations and Operator Safety

    Nothing beats direct experience when it comes to safe handling. 1-Aminoethanol’s low volatility seems like a blessing at first glance, since inhalation hazards sit lower than with lighter amines. Still, small spills dissolve into water on skin or equipment, and that basicity causes irritation or corrosion. Over the years, we’ve customized our pack-out stations with splash-shielded containers and double-walled pails, because careless transfer of open drums cost us wasted product and unnecessary cleanups. Operators wear gloves and goggles, without exception. Training never stops at the rulebook—we hold regular refreshers and walk through incident reports from our own site and industry peers. Focusing on details saves not only product but also long-term trust with both staff and customers.

    Differences From Other Products

    In our day-to-day work, questions about substitutions for 1-Aminoethanol come up. Some customers consider swapping it for 2-Aminoethanol or even simple ethanolamine. Experience tells us these compounds have fundamental differences. 2-Aminoethanol, for instance, has its amino group on a secondary carbon, making its downstream reactivity, stability in storage, and by-product profiles distinct from the primary alpha-amino alcohol we make. Our trials in synthetic pathways highlight that the difference isn’t just theoretical: changing the position of the amino group alters yields and selectivity when synthesizing active pharmaceutical ingredients. It’s more than academic; it affects costs, waste, and compliance margins.

    Alternative building-blocks like methylamine or isopropanolamine deliver different basicity or steric demands. Those who aim for the tightest possible process control recognize the knock-on effects: new impurities, altered solvent requirements, and regulatory documentation headaches. We walk each customer through the reasons, using data from our process labs and decades of case studies, so that the right choice happens for each synthetic route. Our confidence in 1-Aminoethanol comes from both its performance in our own in-house reactions and the feedback loops with long-standing partners who share yields, impurity profiles, and application outcomes back to us.

    Regulatory and Quality Commitment

    Meeting legal and regulatory expectations leaves no room for shortcuts. Pharmaceutical applications demand not only high purity but also extensive documentation. Our manufacturing records track batch histories, raw material certificates, and deviation logs, which streamline everything from customer audits to governmental inspections. We work under frameworks such as Good Manufacturing Practice (GMP) and ISO quality standards—not just for the sake of compliance, but to save our clients from the pain of rejected shipments or unnecessary requalification processes. Our audit team participates in external benchmarking, because in many markets, rules change faster than the products themselves, and yesterday’s documentation is rarely enough for tomorrow’s shipments.

    Packaging, Storage, and Transport

    After years shipping 1-Aminoethanol, we've learned where weak points turn into product loss. Our standard is to package it in sealed, moisture-barrier plastic drums or steel containers, depending on end-user preferences or volume requirements. Bulk shipments use lined intermediate containers with integrated desiccant packs. We stress-test all packaging with temperature and vibration cycling, to avoid the time and expense of shipment claims. Transport sits at the intersection of efficient logistics and regulatory boundaries. Our shipping team coordinates with logistics partners to avoid unnecessary transit delays, because time in warehouses raises the risk of cross-contamination or product degradation.

    Customers with dedicated storage facilities often ask about shelf life and inventory rotation. Based on our stability data, tightly sealed containers kept in low humidity environments can retain specification compliance for up to 12 months without physical or chemical change. Opened product should be consumed quickly, as atmospheric exposure hastens hydrolysis and oxidation. In instances where partial lots remain unused, inert gas backfilling extends usable life, a practice based on both manufacturer experience and feedback from high-volume buyers in the pharmaceutical sector.

    Environmental and Waste Management

    Our plant experience underscores the importance of responsible waste handling. 1-Aminoethanol cannot simply be rinsed away or poured into general effluent streams. Breakdown products, especially under acidic wastewater treatment, create issues downstream—both as regulated contaminants and as contributors to chemical oxygen demand. Over the years, we have installed closed-loop recovery systems and on-site neutralization tanks, turning process waste into recoverable feedstock. These changes reduce our environmental footprint and save both money and regulatory headaches. Our in-house environmental team continuously monitors emissions and explores new ways to minimize both hazardous and non-hazardous waste. They work closely with regulatory bodies, anticipating changes in discharge limits so we don't fall behind compliance curves.

    Continuous Improvement and Technical Collaboration

    One thing stands out in specialty chemical manufacturing: nothing stands still. Each year, collaborations with academic labs and technical partners reveal new potential for 1-Aminoethanol. Our pilot units have trialed it in new catalytic systems for green chemistry, yielding higher conversion rates for certain intermediates with less toxic by-product load. We keep pilot-scale units active not just to support sales, but to help customers develop and test novel applications. Sometimes, a seemingly minor tweak in reaction temperature or a new catalyst system allows us to offer custom grades matching unique customer requirements.

    Feedback loops matter. Many process improvements start as direct requests from the customers’ research and development teams who push our product outside standard boundaries. They bring us data from bench-top reactions, and we respond by trialing alternative purification, packaging, or even filler choices. Only active engagement between manufacturer and end-user creates reliable solutions—it’s never just about shipping product out the door. This knowledge transfer sharpens our skills and cements the long-term relationships that benefit all parties.

    Market Trends and Future Outlook

    Recently, growing interest in green chemistry and bio-based processes shaped the discussion about synthesis routes for compounds like 1-Aminoethanol. Our research team keeps a close watch on emerging technologies. We already see customers asking for renewable sourcing or smaller carbon footprints, not just as a marketing feature but as a hard requirement for regulatory submission in international markets. For these projects, we develop alternative feedstock assessments, work through pilot trials, and provide life-cycle data to customers preparing environmental impact filings. It’s a learning process—and we share results openly, even when outcomes challenge traditional operating assumptions.

    Competitive pressure continues to rise, as lower-cost and lower-purity imports cut into market share for certain segments. Our focus stays on high-value, high-purity applications where every part per million counts. Our expanded technical support team guides customers on process upgrades, helping them stretch each kilogram further and proving that value comes not just from raw tonnage, but through overall operational savings, fewer process upsets, and easier compliance.

    Summary: The Manufacturer’s Perspective

    Years of producing 1-Aminoethanol reveal how every detail, from humidity in the reactor hall to minor tweaks in purification, sets apart high-quality material from commodity grades. The journey from basic raw materials to a finished, specification-compliant batch draws on experience not just with machines, but with people: operators, lab analysts, safety teams, and customers who challenge us with new applications. Our commitment runs beyond sales into support, technical troubleshooting, and a willingness to adjust operating models as industry requirements and science itself move forward. The real value of 1-Aminoethanol shows in the manufacturing partnerships it forms—a bond that grows stronger, batch after batch, as both sides work together to deliver results.