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1,4-Dichlorobutane

    • Product Name 1,4-Dichlorobutane
    • Alias 1,4-Dichlorobutan
    • Einecs 203-708-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    320143

    CAS Number 110-56-5
    Molecular Formula C4H8Cl2
    Molar Mass 127.02 g/mol
    Appearance Colorless liquid
    Boiling Point 161-163 °C
    Melting Point -35 °C
    Density 1.17 g/cm3 at 20 °C
    Refractive Index 1.450
    Flash Point 57 °C (closed cup)
    Solubility in Water Insoluble
    Vapor Pressure 2.1 mmHg at 25 °C
    Odor Characteristic, chloroform-like
    Purity Typically ≥98%
    Synonyms Tetramethylene dichloride
    UN Number 2529

    As an accredited 1,4-Dichlorobutane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 1,4-Dichlorobutane is packaged in a 500 mL amber glass bottle with a screw cap and labeled with hazard warnings.
    Shipping 1,4-Dichlorobutane should be shipped in tightly sealed containers, away from heat, sparks, and open flames. It must be labeled as a hazardous material (flammable liquid, UN 2514) and stored in a cool, well-ventilated area, following all applicable regulations. Protective measures must be taken to prevent leaks and environmental contamination.
    Storage 1,4-Dichlorobutane should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers. It should be kept in tightly closed containers, clearly labeled, and protected from moisture. Proper safety measures, such as using chemical-resistant shelving and spill containment, are essential to prevent leaks or accidental exposure.
    Application of 1,4-Dichlorobutane

    Applications of 1,4-Dichlorobutane in Industrial Manufacturing

    We supply 1,4-dichlorobutane with a focus on value-added industrial chains. Our experience supports downstream manufacturers across fine chemicals, polymer additives, specialty monomers, pharmaceutical intermediates, and organic synthesis applications. Each application scenario below details relevant compliance, usage concentration, feed route, and resulting end products.

    1. Polyamide and Nylon Intermediate

    Producers of polyamide resins use 1,4-dichlorobutane as a reactive dihalide for synthesizing long-chain nylon intermediates, including adiponitrile-based polyamides. The compound reacts with sodium cyanide or other nucleophiles to build linear chains with targeted molecular weight distributions. This pathway requires monitoring for residual chlorine and byproduct control. Our quality consistency supports both polymer and monomer process engineers in maximizing throughput and reducing side reactions. Downstream blending and extrusion lines integrate the material to generate engineered plastics for demanding mechanical environments.

    Industry compliance standards

    • REACH (EU Regulation 1907/2006) registration and SVHC screening
    • ISO 9001:2015 quality control throughout polymer supply chain
    • EU food contact compliance (for specific grades, e.g., Commission Regulation (EU) No 10/2011)
    • RoHS Directive (2011/65/EU) for electronics-grade polyamides

    Typical usage ratio

    • Monomer feedstock: 15–40% by mol in adiponitrile or dinitrile synthesis lines.
    • Adjustment based on chain length target and conversion efficiency in batch vs. continuous reactors.

    Downstream process integration

    • Nucleophilic substitution reactor inlet following initial charge of sodium cyanide or related nucleophile
    • Monomer purification, direct coupling with diamines for polymer condensation
    • Extruder or polymerizer feed for subsequent fiber or pellet formation

    Final product types

    • High-performance nylon-6,6 engineering plastics
    • Polyamide flexible films and fibers
    • Automotive-grade molded parts
    • Food contact-safe containers (with migration testing)

    2. Pharmaceutical Intermediate for Vasodilators

    API manufacturers deploy 1,4-dichlorobutane as a core building block for the synthesis of tetrahydrofuran rings and related heterocyclic structures. Especially in the production of vasodilator drugs such as pentoxifylline derivatives, it reacts in intramolecular cyclization and alkylation routes. Laundry-grade control on solvent residues and impurity profiles is required, with rigorous traceability from upstream to final fermentation and crystallization.

    Industry compliance standards

    • GMP (Guidelines for Active Pharmaceutical Ingredients, ICH Q7)
    • Ph. Eur., USP, and JP monographs for intermediates
    • DMF (Drug Master File) preparation for FDA and NMPA filings
    • REACH registration for export to the EU

    Typical usage ratio

    • Intermediate synthesis: 8–20% by mol, tuned according to stoichiometric pathway of specific cyclization reactions.
    • Variability based on excess to drive completion and minimize byproducts.

    Downstream process integration

    • Charged as key alkylating agent in closed-system reactors
    • Direct addition prior to bromination, hydrogenation, or PTC (phase-transfer catalysis) steps
    • Followed by distillation and multi-step purification for API-grade intermediates

    Final product types

    • Pentoxifylline and derivatives
    • Pyrrolidine and piperidine-based pharmaceuticals
    • Advanced intermediates for cardiovascular APIs
    • Clinical trial-grade specialty synthons

    3. Synthesis of Tetrahydrofuran (THF)

    Downstream specialty chemical plants convert 1,4-dichlorobutane to tetrahydrofuran using catalytic or dehalogenative cyclization processes. This route supports industrial THF flowlines where feedstock security and process yield matter. Our in-process monitoring and batch certification help manage chloride residue and minimize halogenated byproducts, which is critical for solvent packing and quality assurance in polymer and resin production.

    Industry compliance standards

    • ISO 14001:2015 for emission and effluent control in THF plants
    • REACH (Annex II) SVHC risk management in European production
    • OSHA Process Safety Management standards (US CFR 1910.119) for hazardous feedstock handling
    • China EHS (GB/T 24001-2016/ISO 14001:2015) for environmental acceptance

    Typical usage ratio

    • Feedstock charge: 30–60% by mass of reactor fill, depending on conversion technology and cycle time.
    • Ratio controlled according to catalyst type and targeted batch size.

    Downstream process integration

    • Initial feedstock in dehalogenation or catalytic cyclization reactors
    • Gas scrubbing and fractional distillation to purify THF from byproducts
    • Solvent-grade testing before downstream supply to polymerization or adhesive lines

    Final product types

    • Industrial and electronic-grade THF solvent
    • Polymerization initiators in PTMEG and spandex manufacturing
    • Adhesive and coating solvent systems
    • Laboratory analytical-grade solvents

    4. Agrochemical Intermediate Manufacturing

    Crop protection chemical producers introduce 1,4-dichlorobutane into their synthetic schemes to assemble specific aliphatic and cyclic agrochemical building blocks. Insecticide and herbicide formulations often require precise control of halogen content and chain-length homogeneity, which our tight specification enables. The material participates in nucleophilic substitution and ring closure reactions under strict batch record-keeping for regulatory traceability.

    Industry compliance standards

    • FAO/WHO specifications for pesticide technical materials
    • ISO 9001:2015 for agrochemical manufacturing quality systems
    • REACH registration for Europe-market agro-intermediates
    • Local environmental permitting (e.g., US EPA TSCA, China MEE regulations)

    Typical usage ratio

    • Process charge: 10–25% by mol in nucleophilic substitution for chain-extended intermediates.
    • Ratio adjusted according to downstream crop protection molecule’s specific structure and conversion efficiency.

    Downstream process integration

    • Feedline introduction after pre-heating or blending with base catalyst
    • Direct usage in closed alkylation or cycloaddition steps
    • Integrated with in-line chromatographic monitoring for reaction completion

    Final product types

    • Selective herbicide and insecticide active intermediates
    • Alkylated agrochemical precursors
    • Ring-closed crop protection agents
    • Custom contract synthesis agro-inputs

    5. Electrolyte Additive Precursors in Lithium Battery Manufacturing

    Advanced battery material firms utilize 1,4-dichlorobutane to synthesize specialty additives for lithium-ion battery electrolyte formulations. Its precise structure and reactivity open up synthesis of cyclic ether-based film-forming agents and chloride-free chain extenders. Consistent impurity control and batch-to-batch validation are critical to prevent battery cell performance degradation. The material’s utility supports both mass-market power cell lines and specialty high-performance battery research.

    Industry compliance standards

    • UL 2580 and IEC 62660 for battery system safety
    • ISO 9001:2015 and ISO 14001:2015 for process quality and environmental impact
    • REACH registration and lithium battery-specific additive MSDS requirements
    • China GB/T 36276-2018 for new energy vehicle battery system safety

    Typical usage ratio

    • Additive synthesis: 2–10% by mass in cyclic ether or carbonate intermediate synthesis streams.
    • Usage optimized by electrochemical testing and purity benchmarking.

    Downstream process integration

    • Controlled feed into additive synthesis reactors following solvent dewatering
    • Conversion to film-forming agents prior to blending with bulk electrolyte
    • Purification and impurity filtration before distribution to battery pack assembly plants

    Final product types

    • Battery-grade cyclic ether additives
    • Electrolyte stabilizers for power and energy-dense cells
    • Chain extenders and performance enhancers for pouch and cylindrical cells
    • Research-grade lithium battery electrolyte formulations
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    Certification & Compliance
    More Introduction

    Understanding 1,4-Dichlorobutane: A Manufacturer’s Perspective

    The Role of 1,4-Dichlorobutane in Modern Industry

    Every day inside our facility, our chemists and engineers watch countless drums of 1,4-dichlorobutane move down the production lines. For more than a decade, this chlorinated hydrocarbon has played a reliable part in manufacturing processes ranging from high-performance polymers to pharmaceuticals and specialty chemicals. Our experience with 1,4-dichlorobutane tells us that it brings efficiency, consistency, and straightforward utility to protocols where specific molecular frameworks are required.

    Before we started producing 1,4-dichlorobutane in volume, our teams relied primarily on linear dichlorobutanes with different halogen positions and often ran into issues with selectivity and reactivity. The symmetrical structure of 1,4-dichlorobutane, with its two chlorine atoms sitting at the terminal positions on the butane chain, opened new possibilities. This structural detail influences everything from reaction yields to end-product purity, and it continues to shape downstream chemistry in unexpected but meaningful ways.

    Model and Specifications: What Sets Our Process Apart

    We have refined the model of our 1,4-dichlorobutane process over years of incremental improvements, both in hardware and quality control. Each batch leaves our site with well-defined specifications—high purity, minimal moisture content, and precise control over byproducts. Our quality assurance teams measure purity using gas chromatography, aiming for a typical assay above 99.5%. The distillation process is carefully tuned to strip out unwanted isomers, ensuring very low levels of 1,3-dichlorobutane and 2,3-dichlorobutane. Some competitors accept a mix of isomers; from hands-on experience, we have seen that downstream synthesis works far better with high isomeric purity.

    Physical properties matter to every operator who lifts a drum or runs a reaction. 1,4-dichlorobutane appears as a clear, colorless liquid, stable under ambient warehouse conditions. Volatility is moderate; we advise consistent containment to minimize product loss and exposure risk. The faint, sweet odor signals the presence of organochlorides, never overpowering but always a reminder for safety-conscious personnel.

    Practical Uses: Building Blocks and Performance

    In the field, we watch our 1,4-dichlorobutane transform into polyamides, specialty nylon-4,6, or prized intermediates for fine chemicals. One of the most common routes involves reacting 1,4-dichlorobutane with sodium cyanide to yield adiponitrile, a vital precursor in nylon-6,6 production. We’ve seen firsthand that the clean conversion minimizes waste and keeps the process economically sound.

    Different users prioritize different applications. For agriculture, downstream partners install our compound in the synthesis of plant protection agents, seeking molecular frameworks that withstand environmental stress. Pharmaceutical customers depend on highly pure 1,4-dichlorobutane as a critical intermediate in active pharmaceutical ingredient manufacture. Their feedback, gathered through years of technical meetings, has shown that small differences in quality influence reproducibility and ultimately patient outcomes. We respect those links in the supply chain, knowing that our choices impact lives far beyond the factory gates.

    Notably, 1,4-dichlorobutane also serves niche roles in specialty polymer chemistry, enabling producers to build block copolymers or custom elastomers for high-value markets. Every specification matters to these innovators, and their demands have driven us to refine our purification steps. Working closely with their technical teams, we’ve introduced extra stripping columns and more frequent composition checks to ensure no unexpected byproducts slip through. With those changes in place, our partners report improved polymer properties and reduced troubleshooting in their plants.

    Comparisons: 1,4-Dichlorobutane vs. Alternative Products

    Many in our industry use other halogenated butanes or even look to brominated cousins for certain applications. 1,2-dichlorobutane and 1,3-dichlorobutane have different chlorine arrangements, which directly affects how and where reactions occur. We have tested these isomers in similar synthesis pipelines only to see lower reactivity or the generation of unwanted side byproducts. A chemist who runs nickel-catalyzed coupling reactions notices the difference right away—a less predictable product profile, cloudier solutions, and extra steps required for purification. Engineers in our pilot plant traced these issues back to subtle differences in intermolecular reactivity and decided to keep focusing on 1,4-dichlorobutane to avoid these pitfalls.

    Raw material selection remains pivotal for safety, handling, and waste disposal. Since the 1,4-isomer has predictable behavior under standard reaction conditions, operators report fewer runaway reactions and better control during exothermic steps. We have measured lower environmental emissions during incineration and waste handling compared with more reactive halogenated alternatives. By learning from mishaps in the earlier days of plant operation, we refined our handling protocols. Fume extraction and drum labeling practices have been modified accordingly, always informed by on-the-ground experience.

    In pharmaceuticals, regulatory expectations require traceability and consistent impurity profiles. Compared to alternatives, our 1,4-dichlorobutane holds up to the scrutiny of modern analytical labs. Third-party auditors and internal teams run parallel tests, confirming that the impurity spectra match the stringent requirements for pharma-grade starting materials. Years ago, suppliers cut corners by offering mixed isomer drums labeled as “dichlorobutane.” Quality failures surfaced downstream, halting production and leading to extra costs. We learned then that nothing replaces single-isomer supply for high-value pharmaceutical and specialty chemical work.

    Operational Lessons and Challenges

    Producing chlorinated hydrocarbons often tests our ingenuity and patience. The reaction steps to chlorinate butane are exothermic and require close monitoring. We run all critical parts of the process on closed systems, with pressure and temperature sensors linked to automated shutdowns. Over time, our operators have encountered unplanned deviations—fluctuations in raw materials or shifts in catalytic efficiency—that required fast thinking and deep process understanding. By logging every operational challenge and reviewing them with our team, we have built a better process year after year.

    Our storage, transfer, and packaging protocols have also grown more robust. Chlorinated products can corrode common steel, so we switched to lined drums and valves, reducing maintenance downtime and contamination risk. If anyone thinks integrity of storage systems is a trivial matter, they probably have not faced a shipment rejection due to metal contamination. We respect the reality that the physical logistics of simple, reliable containment is essential for any chlorinated product, especially when it travels halfway across the world in a shipping container.

    Health, Safety, and Environmental Realities

    Anyone working in chemical manufacturing knows the importance of health and safety. 1,4-Dichlorobutane, like many chlorinated solvents, requires protective equipment and well-ventilated spaces. Over the years, we have tightened our personal protective equipment standards and improved air monitoring in line with regulatory demands. Internal accident investigations reinforce the importance of eye protection and gloves, as even minor splashes can cause irritation. Safe handling practices start with the team on the floor and stay current thanks to continuous training, reinforced by feedback loops between the lab and front-line operators.

    Plant emissions control also matters. Regulations around chlorinated organics grow stricter every year, and rightfully so. We have added vapor recovery units and condensers to cut fugitive emissions. By investing in scrubber upgrades and improved leak-detection systems, we’ve lowered chloro-organic traces in plant emissions, keeping air quality within local limits. Wastewater from the synthesis steps is routed through on-site treatment, including activated carbon and chemical neutralization. These measures represent years of iteration, with lessons gained from audits, community interactions, and our own monitoring programs.

    Disposal of chlorinated wastes can weigh heavily on budgets and schedules. Early in our production, we underestimated the logistical challenges of bulk waste removal. Experience taught us to separate and pre-treat streams as much as possible to simplify downstream disposal or incineration. Our engineering staff implemented batching schedules that reduce peak output of waste, easing the strain on treatment facilities and limiting environmental impact.

    Quality Assurance: Learning from the Line

    Quality is not just paperwork in our world. It grows from every sample pulled, every drum filled, and every report written at the end of the shift. Feedback flows in from across the process—operators catch small inconsistencies in color or odor; the lab runs fast turnaround tests, flagging any impurity spikes. Production supervisors investigate upstream steps to catch root causes. This cycle of detection, correction, and prevention has shaped our plant’s culture. It preserves order even during high-pressure runs and allows us to meet the standards expected by aerospace, pharma, and agrochemical customers alike.

    In global supply chains, consistency wins trust over time. Our records show that buyers who once tried cheaper or mixed-isomer sources often switched back after facing unexpected discrepancies. Improved logistics tracking, clear documentation, and responsive support form the backbone of our supply relationships. Every order shipped from our facility travels with detailed batch records, ensuring that any issue—no matter how small—can be traced and rectified. We welcome plant audits and provide open access to our production and testing documentation, knowing transparency cements long-term partnerships.

    Responsiveness and Product Support

    A manufacturer’s job does not end when a drum leaves the facility. Many of our partners call with technical questions about compatibility, solvent choice, or reaction troubleshooting. Our technical team, shaped by direct manufacturing experience, answers with practical solutions. If a polymer chemist calls asking about thermal decomposition under high load, our engineers reference real-world thermal stability data from our own reactors. When a pharmaceutical customer encounters an analytical question, our lab brings up archived impurity spectra so they can cross-check results. This hands-on problem-solving stands as part of our commitment—real expertise, not sales platitudes.

    Sharing these practical insights, we also collect knowledge that circles back into our own operation. What works in a customer’s high-shear reactor can illuminate a process improvement at home. A new downstream complaint might point to subtle aging effects in packaged material. This loop keeps our standards fresh and drives more responsive technical support. As the world expects tighter supply chains and less process waste, we’ve learned that open communication with users is not just good business—it drives innovation and improves safety.

    Looking Ahead: Sustainability and Innovation

    Sustainability shapes every new investment we consider for our 1,4-dichlorobutane facility. Our research and development teams experiment with process intensification—bringing in new catalysts to cut down energy use or experimenting with membrane technologies to recover solvents from waste streams. The goal is practical: lower the environmental impact without sacrificing quality or throughput.

    We also look for renewable feedstock alternatives, knowing that one day demand will grow for chlorinated intermediates derived from bio-based butane. While current economics still favor traditional routes, our teams are running pilot studies and watching global trends. Chemistry often moves in cycles, and pressure for greener routes will continue to mount.

    For now, we work to anticipate emerging regulations and incorporate them into our equipment upgrades and operational practices. Team members visit trade shows, attend regulatory seminars, and share findings with shop-floor staff. Knowledge flows in every direction. Production staff highlight equipment bottlenecks; environmental officers suggest sampling improvements. This culture of collaboration and shared purpose stands as our most effective tool for adapting to challenge and uncertainty.

    Lessons from a Decade of 1,4-Dichlorobutane Production

    As a team that has seen the full lifecycle of 1,4-dichlorobutane—from raw materials to finished application—we view every improvement as a chain reaction. Each adjustment in synthesis, storage, or logistics ripples down the line, affecting customers’ yields and final product quality. Sometimes problems reveal themselves in subtle ways: a surprising off-odor, a missed shipment window, a polymer with just slightly lower tensile strength. Tackling these requires patience, skilled observation, and honest communication between all parts of our operation.

    We don’t see the business of chemistry as a race to the bottom. Our advantage comes from doing the basics right: tracking every tank, running every test, backing up every invoice with confidence in what we ship. Where others try shortcuts with mixed isomers or less refined purification, our experience leads us to maintain focus on product consistency. It pays off each time a partner reports improved yields, fewer rework cycles, or a safer plant environment.

    Building a Strong Team and Continuous Training

    Our plant’s performance reflects the people who run it. Training does not happen once; it unfolds in regular sessions, hands-on workshops, and everyday problem-solving. New operators learn by shadowing seasoned staff, picking up practical knowledge that no manual can capture. Maintenance crews rotate through every critical system so that minor annoyances—heater surges, valve leaks, pressure drops—never become sources of downtime.

    We rely on direct feedback from the team. Disruptions, unexpected shutdowns, or near-misses drive corrective actions and sometimes, larger upgrades. The process of sharing lessons builds not just skill, but trust—a foundation on which safe, reliable 1,4-dichlorobutane production stands.

    Partnering for the Long Haul

    Our vision for 1,4-dichlorobutane manufacturing focuses on shared successes with customers, suppliers, and communities. Whether supporting a shift to more sustainable chemistry or helping a client troubleshoot a stubborn reaction problem, real collaboration shapes our daily work. As market expectations evolve and regulations tighten, we stay focused: durable quality, safe operations, and open communication.

    1,4-Dichlorobutane production balances chemistry, engineering, logistics, and human insight. Every batch reflects the accumulated lessons of years on the line—mistakes learned from, successes built upon, and partnerships strengthened. As a chemical manufacturer, we bring not just a product but real experience, responsible stewardship, and a commitment to future improvement.