Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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Vitamin B13

    • Product Name Vitamin B13
    • Alias Orotic acid
    • Einecs 205-124-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    205739

    name Vitamin B13
    alternative_name Orotic Acid
    chemical_formula C5H4N2O4
    molecular_weight 156.10 g/mol
    appearance White crystalline powder
    solubility Slightly soluble in water
    source Milk, root vegetables, whey
    function Intermediate in pyrimidine metabolism
    discovery_year 1904
    stability Stable under normal conditions
    common_uses Previously studied for liver and heart health
    toxicity Low at typical dietary levels

    As an accredited Vitamin B13 factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, opaque plastic bottle labeled "Vitamin B13, 100g." Secure screw cap, chemical safety symbols, batch number, and storage instructions included.
    Shipping Vitamin B13 (or orotic acid) should be shipped in tightly sealed containers, protected from light and moisture. Handle with care, using gloves and eye protection. During transit, maintain at room temperature and comply with local, state, and international regulations for chemical substances. Proper labeling and documentation are essential for safe shipping.
    Storage Vitamin B13 (or orotic acid) should be stored in a cool, dry place away from direct sunlight and moisture. Keep the container tightly closed and store at room temperature, preferably between 15–25°C (59–77°F). Ensure it is kept away from incompatible substances, such as strong oxidizers, and out of reach of children and unauthorized personnel.
    Application of Vitamin B13

    Applications of Vitamin B13 in Industrial Manufacturing

    Vitamin B13 (orotic acid) is applied in specialized industrial production sectors, where its unique biochemical and functional properties support advanced formulation and process requirements. Our manufacturing-grade Vitamin B13 meets strict sourcing and quality standards, enabling integration within defined downstream industries under real-world compliance frameworks.

    1. Nutritional Supplement Formulation for Infant Formula

    Manufacturers producing infant formula blends apply Vitamin B13 for its contributive role in enhancing nucleic acid metabolism, supporting cellular energy use, and improving nutritional profiles. Strict formulation controls and process integration steps are required to meet infant nutrition safety, traceability, and international regulatory standards. Microencapsulation and uniform dry blending ensure distribution throughout milk powder matrices without degradation.

    Industry compliance standards

    • Codex Alimentarius Standard for Infant Formula (CXS 72-1981)
    • EU Regulation (EU) No 609/2013 for infant formula
    • China GB 10765 National Food Safety Standard for Infant Formula
    • ISO 22000 Food Safety Management Systems

    Typical usage ratio

    • 0.01% – 0.03% (w/w) of total product, adjusted according to formula stage and regional regulations

    Downstream process integration

    • Added post-UHT to base blend before spray drying, or incorporated during microencapsulation step for stability; monitored by batch QC for uniform distribution

    Final product types

    • Starter infant formula powder (0–6 months)
    • Follow-on formula powder (6–12 months)
    • Specialized medical infant formulas

    2. Animal Nutrition Premix Manufacturing

    Vitamin B13 contributes to poultry and swine premixes, promoting improved feed conversion, animal growth, and resilience in intensive breeding environments. Its addition requires precise pre-mix blending and stable integration, subject to livestock feed additive regulations, and traceability protocols from procurement to finished premix delivery. Measures are taken to prevent homogeneity loss during large-scale batch formulation.

    Industry compliance standards

    • Directive 2002/32/EC on undesirable substances in animal feed (EU)
    • AAFCO Feed Ingredient Definitions (US)
    • FAMI-QS European Feed Additives and PreMixtures System
    • China GB/T 13078 Feed Hygiene Standard

    Typical usage ratio

    • 0.02% – 0.1% (g/kg feed), varied per species, growth stage, and total vitamin blend

    Downstream process integration

    • Incorporated into vitamin premix via ribbon blending or fluidized bed mixer prior to pelleting or extrusion; verified for dusting loss and homogeneity post-blend

    Final product types

    • Compound livestock and poultry premixes
    • Bespoke feed additives for farming operations
    • Commercial animal growth supplements

    3. Pharmaceutical API in Liver Health Formulations

    In the pharmaceutical sector, Vitamin B13 functions as an active ingredient supporting hepatic cell recovery and metabolic health. API-grade material complies with pharmacopoeial purity and GMP standards, requiring cleanroom handling and validated documentation through each stage of tablet, capsule, or injectable formulation. Release and stability testing are critical prior to final dosage form production and regulatory submission.

    Industry compliance standards

    • European Pharmacopoeia (EP)
    • United States Pharmacopeia (USP)
    • China Pharmacopoeia (ChP)
    • ICH Q7 Good Manufacturing Practice for APIs

    Typical usage ratio

    • 50–300 mg per tablet/capsule, with dosage determined by indication and regulatory approval

    Downstream process integration

    • Dispensed directly into granulation—either wet mix or direct compression—under GMP suite conditions; monitored via in-process controls prior to primary packing

    Final product types

    • Hepatoprotective tablets and capsules
    • Prescription liver health blends
    • Adjunctive metabolic support pharmaceuticals

    4. Fermentation Media Component in Biotech Production

    Research and industrial biotechnology facilities use Vitamin B13 as a critical growth factor in microbial and yeast fermentation processes, where it enhances nucleic acid synthesis and supports cell viability. Media formulations require accurate metering, sterile addition, and endotoxin control, ensuring consistency in product yields and meeting biotech production quality standards. Any variance can directly impact batch performance and final product characteristics.

    Industry compliance standards

    • ISO 13485 Medical Device Quality Management (if producing biopharma proteins)
    • US FDA 21 CFR Part 211 cGMP for finished pharmaceuticals (where applicable)
    • EU EudraLex Vol. 4 GMP for Biotechnology-derived Medicinal Products
    • Internal bioprocess QC protocols for cell culture media

    Typical usage ratio

    • 0.001% – 0.005% (w/v) depending on microbe species and batch scale, optimized for target biomass/output

    Downstream process integration

    • Added to sterilized fermentation medium as a pre-inoculation supplement or continuously dosed to bioreactors according to real-time nutrient demand models

    Final product types

    • Biopharmaceutical proteins
    • Probiotic cultures
    • Industrial enzymes
    • Advanced fermentation-based specialty metabolites

    5. Nutraceutical Powder Blends for Sports Nutrition

    Sports nutrition manufacturers include Vitamin B13 in high-performance powder blends supporting endurance and recovery, leveraging its metabolic function in muscle cell energy pathways. Ingredient addition follows strict food-grade quality controls, with standardized sampling and allergen separation for fitness and health market requirements. Homogeneous dry mixing safeguards dosage consistency for consumer safety and labeling transparency.

    Industry compliance standards

    • FDA 21 CFR Part 111 Dietary Supplement GMPs (US)
    • EFSA Food Supplements Directive 2002/46/EC (EU)
    • China GB 16740 Health Food Raw Material Standard
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 100–250 mg per serving (powder blend); varies by product category and synergy with co-nutrients

    Downstream process integration

    • Incorporated during high-shear dry blending before sachet or jar filling; monitored for cross-contamination with other active ingredients

    Final product types

    • Sports supplement powders
    • Pre-workout and recovery blends
    • Endurance drink powder mixes

    6. Medical Food for Metabolic Disorder Diets

    Medical nutrition producers utilize Vitamin B13 in formulated medical foods designed for inborn metabolic disorders, where its biochemical support addresses defined deficiencies. This application demands pharmaceutical-grade sourcing, batch-to-batch traceability, and precise measurement to comply with therapeutic food regulations. Addition takes place in validated environments, with stability testing on finished blends before market release.

    Industry compliance standards

    • US FDA 21 CFR 101.9 Medical Food Labeling
    • European Food for Special Medical Purposes (FSMP) Regulation (EU) 2016/128
    • China GB 29922 for FSMP Compliance
    • WHO/FAO Codex Standards for Disease-Specific Foods

    Typical usage ratio

    • 10–50 mg per daily portion, tailored to patient prescription and diagnosis

    Downstream process integration

    • Dosed into nutrient blend during liquid homogenization or powder blending, followed by aseptic packaging and batch-record verification

    Final product types

    • Oral nutritional supplements for metabolic disease
    • Tube feeding medical nutrition formulas
    • Dietetic foods for clinical use
    Free Quote

    Competitive Vitamin B13 prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing Our Vitamin B13: A Manufacturing Perspective

    Producing Vitamin B13: Experience from the Factory Floor

    In the chemical industry, people often focus on the headline vitamins — the big names that draw all the attention. Vitamin B13, otherwise known as orotic acid, often doesn’t enter mainstream discussion. Our work as a direct manufacturer of Vitamin B13 connects us with real-world users in food, feed, and specialty health applications. We witness day-to-day the unique demands this uncommon vitamin faces, from making particle size consistent under strict process controls, to protecting its stability under challenging storage or process environments.

    Through investment in specialized production lines and rigorous batch monitoring, we oversee every step of its synthesis. By managing temperatures and pH balance throughout the reaction, we prevent by-products and guarantee a consistent form. We don’t outsource any of the key steps. Our experience for decades tells us the smallest fluctuations during crystallization will influence solubility and shelf-stability. This is not just theory: we’ve retooled lines mid-production in response to shifts in raw material quality, especially when the source of intermediate reagents varies from year to year.

    Understanding the Product: Model, Specifications, Consistency

    Our Vitamin B13 follows an ultra-pure standard, suitable for integrations in pharmaceutical, nutraceutical, and feed additive settings. We’ve built the process to achieve an orotic acid content of no less than 99.6%, always based on assay values from each batch leaving the plant. Particle size is not merely a technical parameter but makes a difference in dispersibility and long-term stability—so we calibrate mills and sieves after every major maintenance cycle. Most users prefer our main type, a dense white crystalline powder, because it dissolves efficiently in neutral solutions and shows reliable handling properties under humidity-controlled storage.

    We have always avoided fillers or anti-caking agents unless required by a customer’s documented process. This means fewer surprises once end-users blend our Vitamin B13 in their own environments. For animal nutrition customers, we offer a slightly granulated form to ensure easier mixing into compound feed. For supplement manufacturers, we create a superfine powder version, which allows direct tableting and encapsulation without further milling.

    The Specifics That Matter: Usage in Real Applications

    Several industries still overlook the practical value of orotic acid. Our partners in the field have educated us about its specific role as a nutritional factor. In animal nutrition, especially for young livestock, Vitamin B13 has earned respect for helping with growth and developmental processes such as nucleic acid synthesis. The chemistry behind this function isn’t guesswork — we have worked with feed mills who tracked improved conversion ratios when animals received diets containing this substance.

    Dietary supplement makers constantly ask about its difference from other B group vitamins. We demonstrate that orotic acid works at a cellular level to encourage healthy metabolic pathways, but unlike most other B-vitamins, its absorption and effect depend on how finely the product is prepared and what excipients are used. Our formulation stays stable in multi-component mixes, as shown by extended retention rates in finished supplements after months of storage at fluctuating warehouse temperatures.

    Pharmaceutical companies have developed specialized formulations using Vitamin B13 for specific metabolic disorders. We keep close contact with R&D managers who request smaller, highly controlled batches for clinical nutrition studies. Our production teams must shift to ultra-cleanroom segments, apply even stricter filtration, and pack the lots under nitrogen to ensure no cross-contamination. Hands-on feedback from these users has led us to refine our isolation steps several times, so we can meet the increased stringency without loss of throughput.

    Why Vitamin B13 Differs from Other Vitamin Choices

    Often, people who source Vitamin B complex products treat them as interchangeable. Each B-vitamin has unique chemical structures and biological roles. With Vitamin B13, the story is different. It does not act in classic coenzyme pathways like niacin, thiamin, or cobalamin. Instead, orotic acid directly contributes to pyrimidine nucleotide synthesis, impacting genetic material replication and repair mechanisms. Commercially, this means our product goes far beyond a standard “B vitamin premix” — it offers benefits that can’t be replaced by other group members.

    The difference also shows up at the production level. Many B vitamins are synthesized using fermentative methods, often with genetically modified organisms fermenting basic sugars or substrates. Vitamin B13 is manufactured through a series of strictly chemical steps followed by purification and crystallization. Unlike some more commercialized vitamins, where secondary by-products can remain without affecting function, every trace of surplus reactant in orotic acid production affects purity and downstream application. Our team keeps specs tight — we will not approve release if metals, organic residuals, or unidentified peaks show up in profile analysis.

    Feed manufacturers sometimes question why our Vitamin B13 costs more than other vitamin offerings. The reason is found in raw materials and batch complexity: fewer sources exist for precursor chemicals, and more process steps are required. Also, the risk of trace levels of undesirable by-products is higher, so we dedicate more resources to purification and batch testing at every shift. No batch leaves our warehouse without documentation and traceable analysis right down to the original chemical inputs. Feedback from users always focuses on the predictable results they see in feed conversion or supplement stability, and we believe this is directly connected to our production controls.

    Quality in Every Lot: From Raw Material to Finished Product

    We source our starting acids and reagents from longstanding partners, never spot-buying just for price. Several years back, we experienced a brief quality drop after a temporary raw material supplier failed to meet our specifications. Instead of shipping subpar batches, our team halted all output and traced the variance. This episode led us to develop more advanced analytics in our onsite labs, with compound fingerprinting across all incoming chemicals — verifying identity and purity before the first production step begins. This might seem excessive to outsiders, but many downstream users rely on this diligence to maintain the quality and reproducibility of their own products.

    Cooperation with universities and independent labs gave us access to new methods of impurity mapping. Some may call this overengineering. We see it as necessary insurance, especially with regulatory scrutiny rising worldwide over feed and supplement ingredients. This mindset filters down to our batch-to-batch release controls, where full-out analysis screens for known and unknown contaminants. Our technical team runs extra controls if any major environmental factor in our supply chain changes, such as a new transport route or altered warehouse climate, so product identity stays consistent through every step.

    Supporting Responsible Use and Innovation in Applications

    Regulatory demands around Vitamin B13 vary widely. Some regions do not treat it as an essential vitamin but as a specialty additive, while others allow more widespread inclusion in premixes and finished products. We monitor both legal and practical developments, working closely with consultants and customer compliance teams. For instance, veterinary-feed clients sometimes request low-dust product for safer handling, and supplement producers look for specific granulation choices to optimize their tableting. We respond by customizing particle size and packaging, instead of a one-size-fits-all approach.

    True innovation in this field only works with collaboration. A supplement blender proposed a new encapsulation method, requiring even tighter limits on moisture uptake. We shifted product storage and batching cycles so Vitamin B13 would meet these specs without stabilizing agents. As a team, we value these hands-on challenges, keeping us connected to the formulation science that shapes the next generation of nutritional products.

    From a practical viewpoint, our product helps bridge the gap between science and implementation. We don’t rely solely on textbook process parameters. We take real-life feedback from users — what clogs their feeders, what causes sticking at high-speed presses, what increases shelf-life — and adapt our process accordingly. Our long-term contracts often include onsite visits to larger customers, where our technical managers observe usage and recommend troubleshooting. This loop between production and application protects users against costly downtime and product failure at the point of use.

    Tackling Storage, Transport, and Longevity

    Vitamin B13 is more sensitive than many expect. We have learned through mishaps that temperature and moisture swings create clumping or degrade appearance. Our packaging team sources multilayer bags with high-barrier properties. For warm or humid regions, we adjust shipment schedules to avoid delays at ports or border crossings, and we work with logistics providers experienced in handling temperature-sensitive powders.

    Customers often run long-term stability tests on our lots. We take part in these studies, running parallel samples under heat and humidity to identify potential issues before they occur in the market. In several case studies, adjusting our final drying step by a margin improved shelf life by months, especially in challenging environments. We favor clear labeling about storage conditions, but recognize that not every warehouse delivers perfect conditions, so our process includes an extra buffer for handling stress factors.

    Certain customers with high-throughput lines have reported increased static and dusting issues under low humidity. We don’t just accept standard solutions; instead, our plant operators test adjustments to particle charge during the final sieving. These process innovations came from listening directly to client feedback, not from a textbook. Effective communication between operator, QC lab, and customer sits at the core of our business approach.

    Looking Ahead: The Future of Vitamin B13 Manufacturing

    Decades in the chemical manufacturing business have shown that even modest products can have significant technical potential when treated with respect for detail. With the global push for healthier animal protein and cleaner food supplements, attention to less-known nutrients like Vitamin B13 will only rise. No regulatory roadmap exists that covers all possible uses for this substance, so we keep our approach flexible. As researchers uncover more about orotic acid’s metabolic roles and feed companies test new blending techniques, our team stands ready to support with targeted product adjustments and fast-turnaround analysis.

    Global supply chain fluctuations impact pricing and raw material availability for chemicals like Vitamin B13. We mitigate risks through diversified sourcing but avoid compromising on quality just to cut costs. If shortage or disruption strikes, we communicate early with customers and, when possible, suggest process tweaks or substitute forms suitable for their application. Reliability matters above everything, and we prefer to temporarily limit sales than push subpar product into the market.

    To stay ahead, we invest in team knowledge as much as in hardware. Regular training, outside lab partnerships, and site safety reviews keep our process aligned with the highest industry standards. We regularly share knowledge with industry peers, including presentations at technical conferences, not to sell, but to raise awareness about correct and safe use. This openness has helped us stay at the forefront of information surrounding Vitamin B13’s roles and limitations.

    Scientific research around orotic acid is growing, but not every finding translates directly into application. Our technical support team works with R&D groups worldwide to validate performance in intended scenarios. Some product launches failed elsewhere due to lack of real-world testing. By offering pilot-lot supply and site-level introduction support, we help minimize launch failures. Our history shows that the best results occur when theory meets manufacturing expertise and field-tested application feedback.

    Final Thoughts from the Production Line

    From the first raw chemical input to the last packed drum, our Vitamin B13 tells a story of control, innovation, and commitment to customer success. We don’t approach orotic acid as just another commodity — every day, our operators and technicians apply firsthand knowledge to keep quality high, from particle size through purity to batch consistency. The true value of our Vitamin B13 lies not only in purity analysis or compliance statements, but also in the consistent, predictable performance that our users expect and depend on year after year.

    Continuous user dialogue, careful adaptation, and respected process discipline drive our process. We see the vitamin world growing more complex as consumer expectations shift. Through all these changes, our experience as a manufacturer guides us. Vitamin B13 may not be the most publicized member of the vitamin family, but those who work with it understand the detail and dedication required to deliver a product that works — in the factory, in the field, on the shelf, and in the lab.