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Ethyl Tartrate

    • Product Name Ethyl Tartrate
    • Alias (+/-)-Ethyl tartrate
    • Einecs 205-709-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    Specifications

    HS Code

    475510

    Chemical Name Ethyl Tartrate
    Molecular Formula C6H10O6
    Molecular Weight 178.14 g/mol
    Cas Number 13811-71-7
    Appearance Colorless to slightly yellow liquid
    Boiling Point 242-243 °C
    Density 1.32 g/cm³
    Solubility In Water Miscible
    Refractive Index 1.440 - 1.445
    Melting Point -
    Smell Characteristic mild odor
    Flash Point Approx. 121 °C
    Storage Temperature Store at room temperature
    Synonyms Tartaric acid diethyl ester

    As an accredited Ethyl Tartrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl Tartrate is supplied in a 500 mL amber glass bottle with a secure screw cap, featuring clear hazard labeling.
    Shipping Ethyl Tartrate should be shipped in tightly sealed containers, away from incompatible substances and moisture. It must be stored and transported in a cool, well-ventilated area, following all applicable local, national, and international regulations. Proper labeling and documentation are required to ensure safe handling during transit and delivery.
    Storage Ethyl tartrate should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from heat, ignition sources, and incompatible substances such as oxidizing agents. Protect the chemical from moisture and direct sunlight. Ensure proper labeling, and keep containers securely sealed to prevent contamination or evaporation. Follow all applicable safety and regulatory guidelines for safe storage.
    Application of Ethyl Tartrate

    Applications of Ethyl Tartrate in Industrial Manufacturing

    Ethyl tartrate demonstrates reliable performance across several well-established industrial applications due to its stereochemical properties and compatibility with downstream processing systems. As a direct manufacturer, we provide high-purity grades suitable for critical applications in pharmaceuticals, chiral intermediate production, food flavor formulation, and cosmetic ingredient manufacturing. The following sections detail specific industrial scenarios, process integration, regulatory considerations, precise formulation levels, and final downstream products.

    1. Chiral Building Block for Pharmaceutical Synthesis

    In active pharmaceutical ingredient (API) synthesis, ethyl tartrate acts as a highly selective chiral auxiliary or resolving agent, enabling stereoselective synthesis steps for a range of medications. Leading manufacturers utilize it during key resolutions or as an intermediate input in the production of single-enantiomer drugs, where stringent compliance and process reproducibility are critical. This application depends on assured optical purity, controlled process integration, and alignment with global pharmaceutical quality requirements for APIs.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP) (21 CFR Part 210/211, US FDA)
    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) and USP quality monographs
    • Qualified Person (QP) declaration requirements (EU Directives 2001/83/EC; 2003/94/EC)

    Typical usage ratio

    • Ranges from 5–20 mol% relative to target substrate, depending on enantiomeric resolution demand and chemical pathway. Precise loading designed through laboratory optimization to minimize waste and maintain yield.

    Downstream process integration

    • Added at enantioselective step following initial substrate activation (for example, after alkylation or amidation in small molecule synthesis); often removed or transformed downstream by hydrolysis or extraction before final API isolation.

    Final product types

    • Single-enantiomer active pharmaceutical ingredients (e.g., beta-blockers, certain antivirals, antihypertensives)
    • Intermediates for high-purity oncology and CNS drug substances

    2. Chiral Resolution Agent for Agrochemical Syntheses

    High-purity ethyl tartrate is widely employed by agrochemical manufacturers in the separation of racemic mixtures during synthesis and upscaling of chiral herbicides and fungicides. Use within these sectors requires detailed traceability, impurity control, and adherence to environmental regulatory frameworks, with the material directly influencing the safety and environmental compliance of the final pesticide formulation.

    Industry compliance standards

    • OECD Principles of Good Laboratory Practice (GLP)
    • Regulation (EC) No 1107/2009 for plant protection products
    • FAO/WHO specifications for pesticide active ingredients
    • ISO 17025-accredited analytical validation for impurities and stereochemistry

    Typical usage ratio

    • Dosage typically 3–15 mol% of total chiral substrate, fine-tuned based on separation efficiency and specific agrochemical molecular structure.

    Downstream process integration

    • Fed into chiral salt formation stage or as a resolving agent during post-synthetic purification; product mixture is filtered and washed post-crystallization, followed by further chemical transformations.

    Final product types

    • Enantiomerically pure herbicide active substances
    • Single-isomer fungicide ingredients supplied in bulk or formulated directly into plant protection products

    3. Flavor Ester Component for Food Fragrance Manufacturing

    Within the food and beverage sector, ethyl tartrate is used as a precursor or modifier for specialty fruit ester flavors, particularly in complex aroma creation for liqueurs, fruit preserves, and baked goods. Food-grade material must demonstrate purity, low metal content, and traceability as mandated by global food safety regulations. Its introduction in formulation impacts not only aroma quality but also food additive regulatory clearance in target markets.

    Industry compliance standards

    • FAO/WHO Joint Expert Committee on Food Additives (JECFA)
    • EU Regulation No. 1334/2008 on flavorings and certain food ingredients
    • Food Chemicals Codex (FCC) for purity and specifications
    • US FDA 21 CFR 172.515 (Flavoring Agents and Related Substances)

    Typical usage ratio

    • 0.02–0.2% by weight in finished flavor essence or base, adjusted for targeted sensory threshold and regulatory maximum category limits.

    Downstream process integration

    • Blended into esterification batch with alcohols and acids under controlled temperature before solvent stripping; homogeneous mixing ensures even aroma contribution in concentrated flavor compounds.

    Final product types

    • Natural fruit flavor concentrates for beverages and liqueurs
    • Flavoring preparations for bakery, confectionery, and dairy goods

    4. Cosmetic Ingredient for Skin Conditioning Formulations

    Cosmetic manufacturers incorporate ethyl tartrate as a mild skin-conditioning agent and complexing property modifier in select personal care emulsions. Usage aligns with cosmetic ingredient safety regulations, requiring thorough safety assessment and allergen control in final products. This scenario demands traceability to non-GMO and vegan-conform raw material sourcing where European and North American personal care regulations apply.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009
    • US FDA Voluntary Cosmetic Registration Program (VCRP)
    • IFRA Standards for fragrance allergens
    • Cruelty-Free and Vegan Certification frameworks (as required by market)

    Typical usage ratio

    • 0.1–0.5% in aqueous or emulsion base, calculated to optimize skin feel and reduce irritation; formulation testing required for leave-on vs. rinse-off categories.

    Downstream process integration

    • Added during the aqueous phase blending under cooled high-shear mixing before emulsifier introduction; stability assessed post-homogenization and during shelf-life testing.

    Final product types

    • Facial creams, emulsions, and moisturizing lotions
    • Serums and specialty personal care solutions targeting sensitive skin

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    Certification & Compliance
    More Introduction

    Ethyl Tartrate: Practical Insight from a Chemical Manufacturer

    Ethyl Tartrate in the Landscape of Organic Chemicals

    From the perspective of a hands-on chemical manufacturer, Ethyl Tartrate stands out for more than just its chemical formula. In our plant, every batch of this colorless to pale yellow liquid starts with natural tartaric acid derived from wine industry byproducts. Our process focuses on purity and consistent performance, targeting the needs of analysts, pharmaceutical developers, and specialty ingredient formulators. The direct production control means we tune the reaction conditions—not just for bulk output, but for batch-to-batch reliability.

    Ethyl Tartrate appears straightforward, with most demand coming from its ester forms. Few compounds offer the same clean stereochemistry and low impurity profile at scale. Our teams have addressed solvent selection, catalyst control, and distillation parameters to keep byproduct content below specified limits. In practice, this means reduced troubleshooting and more predictable performance on the customer side.

    Key Specifications and What They Really Mean

    As manufacturers, we measure more than just chemical purity by gas chromatography or HPLC. Moisture matters. Optical rotation values matter. Residual solvents matter, especially for pharmaceutical and food-related applications. Our Ethyl Tartrate typically carries an assay above 99%. Water content finishes under 0.2% w/w, and optical purity tracks closely to the input tartaric acid, supporting precise enantiomeric applications. Every production run, we review this data in-house before it leaves our facility.

    We do not ignore details such as elemental impurities and color. Many downstream uses require non-detectable heavy metals and clarity in solution. If a customer needs enhanced acetal stability, we communicate which grades pass stability screens. There is nothing theoretical about it: fine colorless liquid is less likely to trigger problems in pharma synthesis or analytical standards.

    Applications That Drive Specification Choices

    Our main customers come from three sectors: pharmaceuticals, fine chemicals, and chiral analytical labs. In the pharmaceutical world, Ethyl Tartrate acts as a chiral starting material or protecting group. Researchers have leveraged both enantiomers for intermediate synthesis and as resolving agents for active pharmaceutical ingredients. In-house, we have scaled up production of both (R,R)- and (S,S)-Ethyl Tartrate to ensure enantiopure batches, understanding how even minor cross-contamination can compromise a resolution process.

    In analytical chemistry, Ethyl Tartrate features in chiral calibration standards. Precision in optical rotation is not an afterthought—laboratory partners have shared stories where off-specification batches from other suppliers led to flawed calibrations. Through each production run, we record optical data for the batch file and send it with each shipment, so users know exactly what they are receiving.

    The flavor and fragrance industries tap Ethyl Tartrate for esterification reactions and as a trace chiral modifier. At this scale, functional group purity and odor neutrality matter more than theoretical shelf life. Our process avoids aromatic contamination by using dedicated reactors and exhaust controls, meeting the needs of experienced formulators who cannot risk product off-notes.

    The Difference That Manufacturing Control Brings

    Compared to sourcing from distributors or unknown intermediates, manufacturing ownership means we address issues at the source. Over the years, we’ve seen contracts lost to suppliers who cut corners on purification. The result: customers returned, citing unexpected yellowing, poor optical purity, or solvent residues above food-grade thresholds. More than once, we dedicated plant time to troubleshoot off-odors and ghost impurities. Those lessons led to regular equipment audits, operator training, and updated lab methods, not just compliance checklists.

    As raw material prices change, we review procurement and process efficiency monthly rather than waiting for market disruptions. For us, fluctuations in tartaric acid or ethanol mean updates to inventory controls, not sudden supply gaps. We maintain direct relationships with leading bioprocessors and ethanol distillers, giving us flexibility and transparency in procurement. Our teams know the value of a stable upstream chain—a lesson learned through decades in the sector.

    Quality Assurance—Beyond Certificates

    Our QA approach does not stop at standard release documents. Process engineers and QC chemists cross-train on both analytical and plant troubleshooting. When a specification falls out of line, we do not ship. That means regular spectroscopic analyses and impurity trending on all production runs. It also means investing in periodic third-party audits of our laboratories. The practical result is that customers see fewer out-of-specification complaints and less downtime in their own operations.

    Technical support flows directly from the shop floor and laboratory. When an unusual reaction intermediate or impurity turns up downstream, our chemists pick up the phone—not just a helpdesk responding with generic advice. Our production and R&D teams regularly compare notes on solvent evaporation profiles, batch scale-up constraints, and customer stability demands. The feedback loop brings new process improvements each quarter, not just paperwork.

    Ethyl Tartrate’s consistency over shelf life is a constant priority. Accelerated storage tests and real-world field samples are routine. If storage at elevated humidity reveals instability, we improve container choices or add desiccant packaging. This is not an abstract notion. With one pharmaceutical client, we changed bottle closure designs after discovering minor water ingress during international shipping seasons. Years of batch records and shipping histories make these incremental improvements visible.

    Comparing Ethyl Tartrate to Other Sweet Tasting Chiral Esters

    Ethyl Tartrate attracts interest thanks to its balance of low toxicity, clean taste profile, and high optical purity. Compared to other tartaric acid esters, it misses the plasticizing effect of the dimethyl and dibutyl derivatives, giving it an edge in food and flavor work. Our internal data compares sensory and reactivity profiles: Ethyl Tartrate’s bland odor and low volatility fit beverage and syrup applications—where benzyl or isopropyl esters might introduce unwanted notes or volatility concerns.

    Versus methyl tartrate, the ethyl version resists hydrolysis better during typical formulation or reaction processing. Ethyl esters offer improved solubility in nonpolar organic phases, so customers see less separation during mixing. In chiral synthesis, higher selectivity for certain resolutions gives Ethyl Tartrate an edge, and we've received requests from specialty labs precisely for that enantiomeric control.

    For users accustomed to mixed or racemates, switching to our enantiopure grades takes downstream stress off purification columns or crystallization units. Our plant operators see short runs for (R,R)- and (S,S)-enantiomers, tailored for the research and development sector but with bulk supply reliability. Direct production control here trims the cost and time associated with post-purification common in imported or anonymous supply stocks. We have tracked case studies with analytical labs who cut method development time after switching to our defined enantiomeric batches.

    Environmental Impact and Resource Traceability

    Manufacturers today bear more scrutiny for environmental responsibility. Having grown from small-batch synthesis to industrial-scale reactors, we put traceability into our procurement and effluent tracking. All tartrate raw material comes from wine lees—a byproduct otherwise discarded as waste. Ethanol and process solvents cycle through closed loop recovery units, slashing emissions and cutting landfill loads to a fraction of what was common a decade ago. Waste streams move through on-site neutralization and organic recycling. These measures are not marketing claims; they meet local regulations and serve long-term relationships with regulators and local communities.

    Solvent recovery stands at the center of our energy management strategy. On a site visit, you would see condensers, scrubbers, and continuous analytics tied to process controllers. Small losses get flagged and fixed, minimizing volatile yield loss and emissions. We believe in sharing full traceability data with downstream firms—regulators and private labs ask, and we deliver process batch sheets. Feedback from clean tech partners pushes us to try biological solvent degradation and greener cleaning routes over old-school caustic washes. No system is perfect, but our monthly metrics drive small improvements year after year.

    Supply, Packaging, and Partnering with Users

    Because we manufacture at source, clients expect a clear chain from first inquiry through delivery—no shipment vanishes into ambiguous distribution hubs. Every liter of Ethyl Tartrate ships from our plant after full documentation, dating, and batch records. We welcome pre-shipment inspection and can demonstrate real-time QC logs, as some partners request on every contract renewal.

    Packaging knows no shortcuts. Experience tells us drum gaskets, liner material, and sealants all affect product stability. Many lost hours in the past were due to packaging cost-cutting—usually after a container let in moisture or let out solvent before reaching its destination. Now we select closures for barrier properties, chemical resistance, and size flexibility. For small users, glass or HDPE bottles ship in tested cartons. Large customers rely on stainless IBCs or lined drums, with tamper-evident seals and labeled orientation markers. Staff check the fill level and headspace to guard against spillage or vapor pressure surprises.

    Shipping staff have learned to document transport hazard classifications—even for low-toxicity esters—and prepare contingency plans if customs or inspectors require extra details. Every delivery meets or beats required shelf life (usually at least two years from shipment date), as confirmed by periodic retained-sample analysis and documented stability.

    Responding to Market and Regulatory Shifts

    The regulatory environment for esters changes faster now than a decade ago. We routinely track European and US FDA guidelines around food and pharmaceutical ingredients. Ethyl Tartrate has no special exemption status: every impurity or process agent earns close scrutiny. As a manufacturing site, we invest in staying ahead of likely rule changes. Annual staff updates cover chemical registration, region-specific standards, and toxicology reports. We joined international working groups to share data and clarify what is necessary for robust product files and dossiers.

    Product stewardship goes past compliance. We encourage customers to request whatever analytical summaries, batch data, or application notes aid their own filings. Some partners even run shadow testing of onsite samples, comparing our results to theirs—a process that has solved more than one supply issue before it hit production scale. Regular dialogue with procurement and R&D teams makes sure we hear about changing application trends. It is this combination of regulatory readiness and customer integration that sets manufacturing apart from commodity resellers.

    Continuous Improvement: Listening to the End User Matters

    There is no substitute for real-world user feedback. Internal meetings devote time each month to customer voices from both local and export markets. The reality of a chemical manufacturer’s job is to chase down the details that drive or undermine real production lines. If a new customer method highlights a reactivity gap or detects an outside-the-norm impurity, our teams send samples to review the physical plant settings that could explain it. Lessons from these moments shaped investments in new distillation columns and revamped plant flows.

    No complicated theoretical frameworks guide this process—direct batch data and real user outcomes matter most. One chiral technologies partner triggered a review of our tartaric acid supplier pool after an unusual IR spectral match. Another international beverage flavor house helped us identify a degradation pathway triggered by slow, high-temperature sea freight. These are reminders that product stewardship is ongoing and practical. We spend as much time reviewing shipment and storage lessons as we do tweaking chemistry itself.

    Conclusion: From Manufacturer to User, Value Lies in Detail

    Ethyl Tartrate offers much more than its chemical structure. From sourcing practices and synthesis control to packaging and compliance, every link in the chain affects final product integrity. Our success as a manufacturer traces to detailed process management, flexible operations, and transparent dialogue with partners. Real manufacturing control means fewer surprises for end users, clear traceability, and support when applications or regulations shift. In a world where laboratory chemists, process engineers, and regulatory teams all expect reliability, we see quality Ethyl Tartrate not as a commodity, but as a continuing practical challenge. Every improvement and every setback from real production gets invested back into the next batch, closing the loop from manufacturing plant to benchtop and back again.