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Ethyl Carbamate

    • Product Name Ethyl Carbamate
    • Alias Urethane
    • Einecs 202-006-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    Specifications

    HS Code

    951007

    Chemical Name Ethyl Carbamate
    Synonyms Urethane
    Chemical Formula C3H7NO2
    Molecular Weight 89.09 g/mol
    Appearance Colorless, odorless crystalline solid
    Melting Point 48-50°C
    Boiling Point 182°C
    Solubility In Water Very soluble
    Cas Number 51-79-6
    Density 1.10 g/cm³ (at 20°C)

    As an accredited Ethyl Carbamate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl Carbamate is supplied in a 500 mL amber glass bottle, featuring a tamper-evident cap and proper hazard labeling.
    Shipping Ethyl Carbamate should be shipped in tightly sealed containers, kept in a cool, dry, and well-ventilated area away from heat, sparks, and incompatible materials. It must be handled as a hazardous material, clearly labeled, and comply with local and international transport regulations, ensuring protection against physical damage and moisture during transit.
    Storage Ethyl carbamate should be stored in a tightly closed container in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and acids. It should be kept away from sources of ignition and direct sunlight. Proper labeling and secondary containment are recommended to prevent accidental spills. Always store ethyl carbamate according to regulatory guidelines and safety protocols.
    Application of Ethyl Carbamate

    Applications of Ethyl Carbamate in Industrial Manufacturing

    Ethyl carbamate serves several practical roles in regulated industrial manufacturing sectors, integrated at defined process stages and always managed under strict compliance supervision. As an established chemical intermediate, it contributes value in select downstream applications within the agrochemical, pharmaceutical, and laboratory synthesis fields. The following application scenarios outline the material’s industrial use cases with detail on compliance, precise formulation, downstream integration, and the actual types of finished products manufactured by industry clients.

    1. Synthesis Intermediate for Crop Protection Agents

    Major agrochemical producers incorporate ethyl carbamate as a key building block during the multi-step synthesis of certain urethane-based herbicide and fungicide actives. Regulatory frameworks require careful dosing and process validation owing to strict environmental and worker safety controls associated with plant protection chemicals. Manufacturers optimize addition rates based on reaction kinetics and purity requirements particular to urethane derivatives, especially where structure-activity relationships drive the effectiveness of the final crop protection compound.

    Industry compliance standards

    • Regulation (EC) No 1107/2009 (EU Plant Protection Product Regulation)
    • US EPA 40 CFR Part 180 (Pesticide Tolerances)
    • ISO 9001:2015 (Quality Management for Agrochemical Manufacturing)
    • REACH Registration – Article 10 Dossier (EU)

    Typical usage ratio

    • 2–8% by weight of the active ingredient precursor blend; adjusted according to molecular yield targets and impurity control measures.

    Downstream process integration

    • Directly charged into esterification or carbamoylation reactors after initial feedstock purification; included within closed systems to capture fugitive emissions.

    Final product types

    • Urethane-based fungicide technical concentrate
    • Herbicide technical grade intermediates
    • Finished crop treatment formulations (e.g., SC, EC types)

    2. Pharmaceutical Intermediate for Barbiturate Synthesis

    In pharmaceutical manufacturing, ethyl carbamate plays a recognized role as a precursor in the synthesis of certain barbiturate molecules under GMP-regulated procedures. Its chemical reactivity supports defined modifications on the barbituric acid ring, ensuring batch-to-batch reproducibility and the purity required by international pharmacopeias. API producers closely monitor input weights during controlled reactions, as downstream quality depends on maintaining a consistent molar ratio and validated removal of residual intermediates.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) monographs
    • US Pharmacopeia (USP)
    • ICH Q7 Good Manufacturing Practice for APIs
    • WHO GMP Guidelines

    Typical usage ratio

    • 3–10 mol% relative to barbituric acid equivalents; varies by target synthesis route and purification needs.

    Downstream process integration

    • Added at the cyclization or alkylation synthesis step in dedicated GMP reaction suites, followed by validated removal through crystallization and extraction.

    Final product types

    • Barbiturate API intermediates
    • Bulk pharmaceutical ingredients (BPIs) for sedative drug formulations

    3. Laboratory Reagent for Carbamoylation Reactions

    Chemical research and QC laboratories within industrial and academic institutions select ethyl carbamate as a standard reagent for controlled carbamoylation reactions, particularly when screening for novel urethane linkages or stabilizing agents. Custom synthesis groups weigh the reagent precisely depending on the molar proportion needed for substrate conversion and routinely document process conditions for reproducibility and auditing purposes. Its inclusion forms part of established protocols aligned with globally recognized laboratory practice standards.

    Industry compliance standards

    • OECD Good Laboratory Practice (GLP) Principles
    • ISO/IEC 17025 Laboratory Accreditation
    • National Institute of Standards and Technology (NIST) guidelines

    Typical usage ratio

    • 1–5 mmol per reaction batch; scaled according to substrate load and experimental design.

    Downstream process integration

    • Reagent addition during monitored carbamoylation reactions in fume hoods or contained glassware; followed by product isolation and chromatographic analysis.

    Final product types

    • Reference standards for analytical validation
    • Research-scale urethane compounds for structural analysis
    • Calibration solutions prepared for instrument QC

    4. Veterinary Sedative Formulation Intermediary

    Veterinary pharmaceutical producers employ ethyl carbamate as a synthesis intermediate in the multistep production of sedative agents for animal surgery and research applications. Process chemists adhere to veterinary pharmacopeia standards while precisely controlling the dosing and reaction parameters. The material enters during early-stage condensation and must undergo downstream purification to remove any trace impurities, supporting the stringent safety and efficacy standards required for veterinary drug approvals.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.)—Veterinary Section
    • US FDA Center for Veterinary Medicine (CVM) Guidance
    • VICH GL Guideline Series (Veterinary International Cooperation on Harmonisation)

    Typical usage ratio

    • 3–12% by weight of total reactants in sedative precursor streams; adjusted by finished product strength and animal species calibration studies.

    Downstream process integration

    • Charged into primary condensation reactors before backbone ring closure; followed by multilayer extraction, solvent change, and QC verification for veterinary-grade intermediates.

    Final product types

    • Bulk veterinary sedative active ingredients
    • Animal injectable sedative formulations

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    Certification & Compliance
    More Introduction

    Ethyl Carbamate: Experience from the Production Floor

    Our Journey with Ethyl Carbamate

    Manufacturing Ethyl Carbamate is no small task. Over decades of hands-on work, the fine details in making this compound become obvious—both in the factory and in the ways it shows up in downstream use. We have shaped our process to deliver a product that matches the high standards research, pharmaceuticals, and industrial applications demand.

    Ethyl Carbamate, with its chemical formula C2H5OCONH2, often goes by another name in laboratory circles: urethane. In our line, it’s produced in clear, crystalline form, and each batch must hit purity levels above 99%. Our team maintains strict batch consistency—it's the difference between reliable results in your application and a string of troubleshooting calls. We use continuous feedback from both our process instruments and our customers' method validation work to refine each lot.

    The Daily Facts in Manufacturing

    Every batch at our plant begins with close control over raw materials. High-purity ethanol and urea react at controlled temperatures and pressures. It sounds straightforward in textbooks, but the in-person reality is a careful dance: temperature spikes can create side reactions, off-odors, or fine dust that clogs downstream filters. We stick with stainless steel reactors and glass-lined vessels—no shortcuts, because we’ve learned how fast contaminated surfaces can change the output, even in trace amounts.

    Once we reach crystallization, we pour extra effort into filtration and drying. We’ve swapped out filter papers over the years, clocking how minor changes affect crystal size, flow, and purity. Our drying step avoids hot spots—too much local heat bakes unwanted byproducts into the material. Each time, we check with on-site gas chromatography and HPLC. Numbers have to line up with what our customer labs get later, or the phone rings and we’re troubleshooting every step.

    Factual Differences: Ethyl Carbamate versus Other Carbamates

    Not all carbamates play the same role in industry and lab work. Ethyl Carbamate stands out for its solubility in water, alcohols, and some non-polar solvents. It doesn’t just ‘dissolve adequately’—in our experience, it offers the mixability you need in formulations for synthetic intermediates and research. When compared to methyl carbamate or isopropyl carbamate, the ethyl group changes both physical and chemical behavior.

    Take methyl carbamate. It may look similar on paper, but in practice, we see more volatility and a sharper odor. It also brings a lower boiling point, which may not work for thermal or process stability where the reaction requires a certain robustness. Isopropyl carbamate drifts further still—our trials show it reacts more slowly and demands different solvent conditions that don’t always mesh with standard plant equipment. Ethyl Carbamate holds its form in a broader temperature range and doesn’t introduce as many variable impurities during storage or application.

    Model and Specification Details from Real-World Batching

    From the warehouse to the quality control lab, our Ethyl Carbamate batches come off the line with a purity specification above 99%. Typical moisture stays below 0.2%. We remove fine particulates and confirm particle size for downstream mixing. Each model number tracks the reactor and process conditions, so issues can be traced to specific days, shifts, and even operator teams. Samples go daily to in-house spectrometry and chemical analysis. These steps aren’t just bureaucracy; they let us respond right away to small faults in the batch before it reaches any customer order.

    Our main grade is tailored for research and industrial synthesis, not as a pharmaceutical or food additive. We work within clear regulatory limits, respecting both international conventions and our own rigorous ethics code. Some applications call for extra purification milestones. In those cases, we draw on custom orders and batch isolation, using column chromatography right by the main reactor hall.

    Why Customers Choose Our Ethyl Carbamate

    Trust with our clients comes from hands-on expertise, not marketing gloss. Research teams return to us year after year, describing how our consistency saves them weeks of repeated reactions. In industrial synthesis, especially as an intermediate for fine chemical and agrochemical sectors, users need a solid, reliable input. Problems with batch-to-batch variability or undetected contaminants lead to stalling at pilot scale or, worse, expensive recalls. We’ve solved these headaches by shipping every consignment with documented traceability and batch data.

    We also noticed early on that packaging can affect long-term stability. Some of our competitors used lighter plastic drums, which seemed fine in the short term but didn’t provide the barrier to moisture and light the compound needs. We moved to tightly sealed, opaque containers that meet transit regulations and withstand rough handling. Reports from logistics showed us that shrink-wrapped pallets and vacuum-sealed liners preserve product quality right up to the time it lands on a customer’s dock. Our warehouse team performs real stress tests in summer and winter, and that feedback shaped our choice of packaging—real results, not just supplier claims.

    Downstream Applications and Daily Practice

    We see Ethyl Carbamate moving into synthesis routes for barbiturates, pesticides, and certain cancer research compounds. Each of these fields puts its own unique pressures on material quality. In barbiturate chemistry, inconsistent Ethyl Carbamate leads to variable yields, costly purification, and reproducibility worries. Agrochemical companies talk to us about scale-up issues where even minor byproduct traces impact field trial outcomes.

    Our own process design tackles these problems at the root. While some outfits rely only on final purity checks, we built in-process controls into our reactors: inline probes catch temperature jumps, off-gas monitors flag side reactions, and every operator is trained to spot odd colors, textures, or foam. We log every deviation, using it for both internal review and future process adjustment. Over the past decade, this cut down our out-of-spec waste by more than 75%.

    Health, Safety, and Responsible Production

    Ethyl Carbamate’s history includes scrutiny for its carcinogenic potential, especially in food and beverage contexts. Our responsibility as a manufacturer means we keep this front and center, both in our operations and in our communications. We monitor process emissions, air quality in the plant, and safe disposal of all residues. Operators wear personal protective equipment not as a formality, but because trace exposure over weeks and months adds up.

    We share complete analytical results with our clients, offering full transparency in both trace contaminant reporting and compliance documentation. This builds trust with industrial hygienists and regulatory auditors who face tight requirements and growing scrutiny worldwide. We never ship food-grade Ethyl Carbamate or license our material into beverage uses. For research and synthesis, we build in all required handling training and hazard communication into every shipment.

    Challenges and Solutions from the Manufacturer’s Perspective

    Manufacturing Ethyl Carbamate at scale throws up practical problems: raw material price swings, supply chain bottlenecks, regulatory changes, and unplanned downtime. Each challenge brings its own lessons.

    For raw material supply, we don’t just hunt for the lowest price. Ethanol and urea come with purity grades that sometimes fluctuate with global supply. We pre-qualify multiple sources, audit supplier plants, and stock enough buffer to weather shipping delays. More than once, a new shipment showed off-spec analysis results—better to catch this before it ever touches the process line.

    We upgrade equipment in line with real bottlenecks. An early sticking point was filtration: crystal build-up cut flow and pushed plant engineers to redesign filter housings and drying ovens. Maintenance routines build from direct experience—greasing seals, inspecting gaskets, or recalibrating thermocouples. It’s not glamorous, but one overlooked detail in filtration or reactor temperature control can burn an entire day’s run, costing tens of thousands.

    On regulatory fronts, we have watched closely as different markets tighten their standards for process safety, labeling, and shipping. Our team attends conferences and workshops to keep up with shifts in legislation and best practice. It pays off in smoother audits and fewer delays at customs.

    Handling downtime demands clear protocols. We schedule regular shutdowns for cleaning and preventative repairs, avoiding costly breakdowns at busy production periods. Over the years, we’ve built a culture that values reporting even the smallest irregularity—catching a tiny leak, a strange smell, or an out-of-spec reading early sets a higher standard for the final compound.

    Continuous Improvement: Taking Feedback Seriously

    Customers’ real-world uses give us the most direct and practical feedback there is. We invite every industrial or research partner to share their results, issues, and suggestions—for example, reporting minor color changes or new application needs. One spring, a research lab using Ethyl Carbamate for an agrochemical intermediate pointed out that crystal morphology affected their dissolving rates. Our technical staff ran small-batch trials, adjusted crystallization rates, and ultimately delivered a new variant tailored to those dissolving needs. This wasn’t just customer service—these adjustments fed back into our main production, raising the standard for everyone.

    We also adapt batch scale for development and pilot needs. Some R&D teams don’t need tons—they value sub-kilo lots matched to their process scale, with the same quality checks as our standard runs. We designed filling and packaging stations for precise small-batch fulfillment, cutting both cost and lead time. This flexibility has built long-term partnerships across the sector.

    Environmental Responsibility and Community Involvement

    Our production site runs a closed-loop water system, recycling wash streams and cooling water. We treat all effluents on site, keeping discharge levels well below local regulations. Dim light and air emission controls aren’t just compliance—they keep our neighbors and our own people safe from any off-gassing during large runs. Noise dampening improvements in engine rooms came from employee suggestions; as a medium-sized chemical maker, we listen to both internal staff and the community nearby.

    We run seasonal safety drills and review every incident—even near-misses. Our approach says: a safe plant runs better, and defects stay lower when people feel respected and looked after. We sponsor local education workshops about chemical safety and career opportunities in industry. Feedback from employees and the local community helps us align our standards with their expectations, building lasting trust.

    Looking Forward: Challenges and Growth

    Ethyl Carbamate production never stands still. New research demands tighter purity and better tracking. Market pressure means holding costs in check, even as energy and raw inputs fluctuate. We see growth potential in partnerships with specialty chemical and pharma, offering custom synthesis and joint R&D. Demands will only get tougher as end-use regulation raises the bar.

    Digital monitoring has become essential. Years ago, paper logs and clipboards left too much room for error. Today, our plant integrates process control, sample tracking, and real-time performance data. This workflow does not replace a skilled staff. Instead, it arms us with more reliable data to diagnose and adjust. Many of our improvements started with a question from a plant operator or a client call. These prompts point us towards upgrades that last.

    We challenge ourselves each year to review process yield, waste output, and energy use. The industry standard keeps moving as expectations rise, both in the regulatory world and from clients who rely on tight process data. Our investments in training and real-time analytics pay off most during troubleshooting or innovation—every hour spent streamlining operations means more stable batches, better feedback, and a product that supports the new science and manufacturing out in the field.

    Conclusion: Moving Forward with Confidence

    Making Ethyl Carbamate brings daily reminders of the importance of discipline, learning from experience, and honest communication. Decades in chemical manufacturing have proven that every shortcut or overlooked detail comes back to bite later, whether in customer complaints, regulatory fines, or plant safety incidents. Our facility uses proven methods, but it’s the willingness to improve that sets us apart. Each year sees new investments in people, equipment, and quality systems.

    Our client relationships center on transparency—full traceability, shared data, and honest conversations when challenges arise. For those seeking a reliable source of Ethyl Carbamate, produced by an experienced manufacturer and backed by practical know-how, our team delivers consistency, safety, and informed support, every step of the way.