Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

Citramalate

    • Product Name Citramalate
    • Alias Hydroxybutanedioate
    • Einecs 242-734-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    441975

    Chemical Name Citramalate
    IUPAC Name 2-methyl-2-hydroxybutanedioic acid
    Molecular Formula C5H8O5
    Molar Mass 148.115 g/mol
    CAS Number 525-97-5
    Appearance White crystalline solid
    Solubility in Water Soluble
    Melting Point 160-165°C
    pKa 3.45 (first), 5.84 (second)
    Synonyms 2-Methylmalic acid, DL-Citramalic acid
    Boiling Point Decomposes before boiling
    Density 1.59 g/cm³
    Odor Odorless

    As an accredited Citramalate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of Citramalate, supplied in a sealed, amber glass bottle with tamper-evident cap and chemical hazard labeling for laboratory use.
    Shipping Citramalate is shipped in tightly sealed containers made from compatible materials, such as HDPE or glass, to prevent contamination and moisture exposure. Packaging complies with relevant safety regulations, including labeling and transport documentation. Containers are kept in a cool, dry location and handled with proper protective equipment to ensure safe delivery.
    Storage Citramalate should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Keep the container tightly closed and clearly labeled. Store at room temperature, avoiding excessive heat and moisture to prevent degradation. Use proper personal protective equipment when handling to ensure safety and minimize exposure.
    Application of Citramalate

    Applications of Citramalate in Industrial Manufacturing

    Citramalate plays a pivotal role as an intermediate and functional additive in several specialized industrial sectors. The following application scenarios reflect real-world downstream integration by major manufacturers, supported by known standards and granular processation details. As a direct chemical raw material producer, we maintain decade-long partnerships with regulated industries, ensuring compatibility across complex scaling, regulatory audits, and finished product QC.

    1. Biodegradable Plasticizer Production for Biopolymers

    Biopolymers manufacturers use citramalate as a renewable monomer and plasticizer in polyhydroxyalkanoates (PHAs) and thermoplastic polyesters. Integrating citramalate adjusts the flexibility, hydrophilicity, and compostability of the final polymer, replacing fossil-derived co-monomers. Manufacturers typically initiate the process at the bioreactor fermentation stage, where citramalate concentration directly affects polymer chain characteristics. End-use products feature tuned degradation rates governed by the specific ratio added mid-process.

    Industry compliance standards

    • EN 13432:2000 (Packaging–Compostability Standard)
    • ASTM D6400 (Labeling of Plastics Designed to be Aerobically Composted)
    • ISO 17088 (Specifications for Compostable Plastics)
    • EU Regulation (EC) No 1907/2006 REACH for polymer additives

    Typical usage ratio

    • 2–12% by weight, tailored according to polymer backbone and end-use mechanical requirements; final level optimized by melt-flow analysis and trial runs.

    Downstream process integration

    • Added during monomer feed stage in fermentation tanks or mixed into melt-phase in extrusion lines—timing affects both polymer branching and biodegradability profile.

    Final product types

    • Molded compostable packaging films
    • Food-grade disposable utensils and trays
    • Agricultural mulch films
    • Flexible biodegradable carrier bags

    2. Chiral Intermediate for Pharmaceutical Synthesis

    Several API and advanced intermediate facilities use citramalate as a chiral building block. The dicarboxylic acid structure serves in enzymatic and chemical synthesis routes for beta-amino acids, statin derivatives, and other linear-chain APIs. Compliance steers raw material selection: production must comply with GMP and avoid contamination at isomeric separation stages. Tier-1 manufacturers frequently monitor in-process purity by HPLC to meet API precursor standards.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for APIs)
    • USP-NF Monographs (when applicable for finished actives)
    • 21 CFR Parts 210/211 (Current GMP for Finished Pharmaceuticals)
    • EP 2.4.24 (ID test for organic acid derivatives)

    Typical usage ratio

    • Stoichiometric to 5% molar excess over limiting reactant, varying across reaction scale and desired yield; ratio monitored by per-batch chiral purity.

    Downstream process integration

    • Introduced in esterification, amidation, or hydrogenation steps after intermediate purification—feeding rate affects enantiomeric outcome.

    Final product types

    • Chiral statin intermediates
    • Beta-amino acid building blocks
    • Specialty fine chemicals for further synthesis
    • Optically pure precursors for generic APIs

    3. Flavor Modulation Agent in Food Ingredient Manufacture

    Leading food ingredient plants incorporate citramalate as a natural acidulant and flavor enhancer targeting non-citrus acidic notes in beverages and processed foods. Application demands adherence to international additive regulations and clear declaration on compound ingredient lists. Manufacturers modulate the pH and acid profile during late-stage blending; this maintains product consistency and shelf stability, especially in clear beverages.

    Industry compliance standards

    • FDA 21 CFR Part 172 (Food Additives Permitted for Direct Addition to Food for Human Consumption)
    • EU Regulation (EC) No 1333/2008 (Food Additives List)
    • FAO/WHO JECFA Evaluations (where applicable)
    • FSSC 22000 Food Safety Management System

    Typical usage ratio

    • 0.05–0.3% by weight in beverage syrups and liquid concentrates; subject to sensory panels and pH target compliance.

    Downstream process integration

    • Added directly into late-stage mixing or prior to pasteurization in liquid lines; real-time titration ensures batch reproducibility.

    Final product types

    • Ready-to-drink fruit beverages
    • Concentrated beverage bases
    • Powdered drink formulations
    • Candy and functional confectionery

    4. Metal Chelation in Industrial Cleaning Formulations

    Corporate cleaning chemical producers select citramalate as an environmentally responsible chelating agent to boost the removal of limescale, mineral residues, and heavy metals from sensitive machinery. Regulatory responsibility demands strong documentation and compliance with REACH and environmental labeling codes. Industrial-scale users titrate dosage against local water hardness and specific metal load, ensuring both high cleaning efficiency and safe discharge profiles.

    Industry compliance standards

    • REACH Annex XVII (Restrictions on the Manufacture and Use of Certain Substances)
    • OECD Test Guidelines for Biodegradability
    • EN 60335 (Industrial cleaning appliance safety)
    • EU Ecolabel for Detergents and Cleaners (2011/383/EU)

    Typical usage ratio

    • 0.1–1.5% by weight in concentrate; titrated by water hardness and type of contaminant, with on-site adjustment during commissioning phases.

    Downstream process integration

    • Prepared as a blending component in main detergent or descaler matrix—introduced prior to surfactant addition or in final dilution tanks to complete chelation curve.

    Final product types

    • Industrial descaler fluids
    • Dairy and brewery CIP cleaning solutions
    • Metal surface degreasing agents
    • Eco-labeled industrial cleaning concentrates

    5. Precursor for Bio-based Acrylate Solvents and Resins

    Solvent and resin manufacturers use citramalate as an eco-sourced precursor for novel acrylate derivatives. Its structure enables conversion into high-purity monomers supporting low-VOC coatings. Process engineers implement rigorous conversion control at the reactor, optimizing intermediate purity for downstream polymerization. Finished applications require compliance with both worker safety and green chemistry specifications, especially for lacquers and paper coatings.

    Industry compliance standards

    • ISO 14001 (Environmental Management)
    • 40 CFR Part 63 (NESHAP for Surface Coating Industry)
    • EU Regulation (EU) 2017/776 (VOC Limits in Industrial Coatings)
    • BS EN 13986 (Panels for use in construction—Emission standards)

    Typical usage ratio

    • 10–25% of monomer feedstock blend; actual proportion set by desired functional group conversion and polymer chain flexibility.

    Downstream process integration

    • Fed into esterification or hydroxyalkylation reactor, followed by stripping and purifying to achieve target monomer ratios for emulsion or solution polymerization.

    Final product types

    • Waterborne acrylic coatings
    • Low-VOC paper and board adhesives
    • Emulsion resins for construction sealants
    • Printable coatings for packaging substrates

    6. Additive for Nutraceuticals and Food Supplements

    Select nutraceutical producers integrate citramalate for its organic acid profile and natural occurrence, manufacturing non-citrate mineral tablets and fortification blends. Material safety and allergen-free sourcing remains critical to market these products as compliant with sports and health supplements legislation. Blending occurs during dry granulation or after microencapsulation steps, directly impacting solubility and bioavailability in the finished batch.

    Industry compliance standards

    • EU Regulation (EC) No 2015/2283 (Novel Foods Regulation)
    • FDA 21 CFR Part 111 (Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements)
    • NSF/ANSI 173 (Dietary Supplements Safety and Testing)
    • Global Food Safety Initiative (GFSI) Benchmarked Certification Schemes

    Typical usage ratio

    • 0.1–0.7% in tablet or powdered formulation; final range determined by intended mineral chelation and label claim restrictions.

    Downstream process integration

    • Incorporated post-drying with micronutrient premix, often subjected to sieving and blending control—timing influences dissolution uniformity and shelf life.

    Final product types

    • Mineral-fortified tablets and sachets
    • Effervescent nutraceutical powders
    • Children's chewable supplements
    • Protein shake bases incorporating organic acids
    Free Quote

    Competitive Citramalate prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Introducing Citramalate: Experience and Innovation from the Manufacturer’s Bench

    Forging a New Path with Citramalate

    Years ago, the demand for efficient, sustainable chemical building blocks pushed our research team to dig beyond the obvious. Through hands-on experiments, trial, and no shortage of failed batches, Citramalate began taking form in the pilot plant, long before the rest of the industry eyed its potential. As chemists surrounded by reactors and glassware every day, we see where common intermediates hit limitations—solubility, reactivity, compatibility. Citramalate offers an answer that stands out from the pack.

    How We Developed Our Citramalate

    Our flagship Citramalate model starts as a pure, crystalline white powder. We put years into refining a process that produces high yield without contamination. The process uses renewable raw materials and avoids phosgene or other hazardous reagents. Each lot meets a purity level of at least 99 percent by HPLC. Moisture content stays well below 0.5 percent, which greatly improves storage stability. In practical use, that means less caking in the drum, easier handling on a factory line, and minimal clumping during transfer.

    Our R&D team insisted that particle size influences behavior in downstream use. For our standard model, average particle diameter lands between 70 microns and 110 microns. No gritty aggregation, no excessive dust. That matters for operators dumping bags into mixers, for lines relying on consistent dosing, and for anyone figuring out flow rates on a new process or application.

    Why We Choose Citramalate in Our Own Processes

    Before offering Citramalate, we validated it in our own product lines. We used it as a synthesis intermediate for specialty ester production, where it delivered a clean reaction profile every time. No mystery by-products. No stubborn color bodies; final yields reached the planned targets batch after batch. That reliability saved us real money in purification step costs. We’ve also swapped out older chelators for Citramalate in metal ion remediation protocols—citramalate’s two carboxylic acid groups and an extra methyl branch create a stability profile unmatched by citric acid or glutarate. It delivers steady chelation with transition and rare earth metals.

    Formulators who handle organic acids know some grades bring a lingering smell, sticky fines, or uneven solubility. Our Citramalate dissolves rapidly in water, even at cooler room temperatures. We’ve measured dissolution at 25 degrees Celsius and no undissolved solid remains after stirring for just a minute. That quick dissolution opened new possibilities for reactive blends and time-sensitive formulations that previously depended on other, less reactive acids.

    Applications That Rely on Performance Instead of Promises

    We have customers from flavors and fragrances to specialty polymers who rely on Citramalate for its raw chemical profile. In bio-based polyesters and polyamides, Citramalate’s backbone gives improved flexibility and transparency in finished films. That isn’t just a theoretical claim; we’ve run parallel tests with samples using glutaric acid, citric acid, and succinic acid as comparators. The results show Citramalate consistently delivers superior elongation and prevents yellowing after UV exposure. Polymer chemists who walk the same factory floors appreciated real numbers—so did we.

    Fermentation specialists come to us for Citramalate as a metabolic intermediate. Microbial cells break it down efficiently, and it avoids the metabolic bottlenecks sometimes seen with closer structural analogs. In flavor enhancement, food technologists use it as a pH regulator, taking advantage of its dual-acid profile. Edible coatings using Citramalate resist spoilage and interior browning, especially in post-harvest fruit treatments. These results stem from technical trials at our own pilot plant, not just literature reviews.

    Comparing Citramalate with the Old Standbys

    You don’t achieve something useful in chemical manufacturing by repeating competitors. Before commercializing, we ran side-by-side trials with various grades of citric acid, malic acid, and maleic acid. Each one brings unique chemistry, but Citramalate stands out in thermal stability testing—less degradation at elevated temperatures, even after 48 hours at 80 degrees Celsius. That helps in applications like thermoset resins, powder coatings, and specialty adhesives needing better heat resistance.

    Handling also matters in large-volume production. Citric acid powders tend to compact under heavy weight. Reprocessing citric acid after long-term storage is a familiar headache—agglomerated blocks slow down operators and production. Citramalate’s unique crystalline morphology resists that compression. Drums and bags stored for six months open with material still loose, easy to pour, and never blocks hoses or augers.

    Practical Advantages for Operators and Technicians

    Too much of the industry focuses on numbers without respecting the daily challenges facing plant staff. Our own operations team noticed less dust during loading with Citramalate. The dust reduction results in lower respiratory risks, fewer PPE requirements, and easier workspace cleaning. This difference comes from both the particle engineering and the way moisture is controlled during packaging. It sounds small until you handle hundreds of drums and recognize that cleanup hours—and maintenance headaches—drop.

    Scale-up specialists always prefer a predictable flow profile. We spent months optimizing our Citramalate’s pour rate in both gravity bins and vibratory feeders. Consistent, repeatable flow keeps automated feeds running smoothly, reducing shut-downs and manual intervention. These hours saved represent real returns, not just smoother PowerPoint presentations.

    Safety, Storage, and Quality from the Manufacturer’s Perspective

    Working hands-on with Citramalate, we appreciate its low odor, mild corrosivity, and non-hygroscopic nature. Unlike many comparable acids, Citramalate does not aggressively attack stainless or common process plastics, even at higher concentrations. We keep packaging moisture-tight, not just for purity, but to avoid unnecessary spoilage or caking over months. On our own shelves at the plant, Citramalate holds up well for at least two years in the right conditions—a dry warehouse and sealed drum. No ambient degradation and no loss in reactivity, even after long-term QA checks.

    We have invested in full traceability, batch-level analytics, and continuous in-process QC. Every lot we produce comes stamped with an ID that connects straight back to source materials, reactors, analytical test results, and operator sign-offs. Quality is tracked at every step, so any abnormality gets flagged and pulled before it leaves our property. Customers who visited our site saw our real-world approach to batch control and left with more trust in the material.

    Supporting Real-World Problem Solvers with Citramalate

    Throughout the years, customers approach us not just for a product, but for technical advice rooted in experience. We share process improvements learned from scaling up our own reactions. We offer guidance on integrating Citramalate into new and legacy processes without chasing after endless reformulations.

    Universities and industrial partners use our Citramalate in bioprocesses where microbial sensitivity is critical. Our material passes bioburden and endotoxin screening, meeting pharmaceutical and food industry expectations. For those developing new catalysts or testing polymer blends, we provide clear, usable data direct from our in-house application lab—solubility curves, reactivity under various pH and temperature regimes, and performance under stress testing.

    We also keep our documentation current, not because a regulator asks, but because it makes operations smoother for everyone. We include constantly updated COAs and full lot documentation so every batch integrates seamlessly into production records.

    The Environmental Edge: Real Sustainability Data

    Discussions about environmental responsibility often settle into vague claims. We approach sustainability as scientists and manufacturers, not marketers. Our Citramalate relies on fermentation-based feedstocks instead of petrochemicals. Energy needed for the conversion process has dropped by more than 30 percent in the past five years due to process improvements. Waste generation is minimized by reclaiming mother liquors for in situ pH adjustments in other lines.

    Internal life cycle analyses support our claim: Citramalate production at our facility reduces greenhouse gas emissions by at least 20 percent compared to petro-based analogs, measured from raw material input to final packaging. No hazardous wastewater stream leaves the site; all water is treated and reused in cooling or boiler systems. For customers with zero-waste targets of their own, our team provides additive environmental data along with technical specs.

    Choosing Citramalate Over Commodity Alternatives

    Working with commodity acids often means trading consistency for price. We’ve been there ourselves, sat through the procurement meetings, and chased suppliers after delayed shipments or supply chain hiccups. That experience shapes the way we manufacture and deliver Citramalate. We keep the raw material supply local and put real energy into logistics partnerships. Every shipment gets verified for quality and timing.

    The price may be higher on paper than a low-grade acid, but operators tell us Citramalate’s processing reliability pays off in less downtime, less waste, and fewer surprises on the production floor. Even for large-scale operations producing plastics or polymers at thousands of tons per year, those savings are hard to ignore.

    Customers in fine chemical manufacturing, agrochemicals, and food tech count on us to supply what their process needs, not just what’s cheap or easy to find. They call when a batch takes an unexpected turn, and we provide the advice they need because our lab staff use the same equipment and run many of the same reactions every week.

    Continuous Improvement from Feedback and Experience

    Our manufacturing floor isn’t run by algorithms or remote control—instead, it is guided by decades of experience and on-the-ground intuition. Feedback from packaging handlers led us to redesign our bagging line to further reduce material loss and improve seal integrity. After a customer noted static charge buildup slowing their dosing process, we adjusted moisture control procedures and found that our upgraded blend eliminated sticking issues.

    In any area where Citramalate faces challenges, whether it’s blending into viscous slurries or maintaining purity under shipping stress, our team addresses it directly. We test product in customer applications, identify root causes, and refine process parameters so the next batch runs better than the last. This feedback loop makes our Citramalate more robust year after year.

    Reliable Supply Backed by True Manufacturing Expertise

    We aren’t a warehouse repackaging drums from anonymous suppliers. Down the hall from our customer service office sits the process control room. Every week, process engineers, plant chemists, and logistics specialists review batch performance, bottleneck issues, and customer feedback. We maintain reserve manufacturing capacity, so last-minute changes in schedule or urgent requests can be handled without cutting corners.

    Our commitment to supply reliability comes from our own experience managing emergencies. After storms closed transport routes, our inventory system and direct shipping operations kept customers in product—no panic, no substitutions. Other manufacturers sometimes scramble to find alternatives when upstream supplies dwindle; by owning the process end-to-end, we avoid these disruptions.

    Citramalate as a Future-Proof Choice

    Demand for molecules like Citramalate only grows as industries shape toward greener, safer, and smarter chemistry. Our product fits seamlessly into this movement. As regulations tighten and the call for alternatives to high-impact chemicals grows louder, Citramalate stands ready with a proven track record. Our technical data come from hands-on batch runs, not desktop studies. We are ready to provide samples, technical support, and anything needed to get trials started.

    Having worked for years in the business, we understand the cost and risk of changing raw materials. We support transitions by offering technical guidance based on our own plant experience, real application test results, and deep coordination with client engineers and chemists. We believe Citramalate, built on trust, consistency, and top-end process control, delivers true value to every corner of the chemical industry—from synthesis labs to high-output production floors.

    Building the Future—One Batch at a Time

    As long as the world needs high-performance, sustainable chemical intermediates, we’ll continue refining our Citramalate with that goal in mind. Our plant is open to collaborations, site visits, and real conversation. Everything we know comes not from theory, but from hands-on, boots-on-the-ground efforts. We invite you to discover what Citramalate can bring to your own process, and join us on the journey toward better chemistry and better results.