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Cis-Piperitone Oxide

    • Product Name Cis-Piperitone Oxide
    • Alias p-Mentha-1,8-dien-3-one, oxide
    • Einecs 673-366-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    634638

    CAS Number 491-07-6
    Molecular Formula C10H16O2
    Molecular Weight 168.23 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Herbal, mint-like
    Boiling Point 236-238°C
    Density 0.954 g/cm3
    Refractive Index 1.464 - 1.468
    Flash Point 93°C
    Solubility Insoluble in water, soluble in ethanol and oils
    Purity ≥95%
    Melting Point -1°C

    As an accredited Cis-Piperitone Oxide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cis-Piperitone Oxide is packaged in a sealed 25g amber glass bottle, labeled with hazard symbols and handling instructions for safe use.
    Shipping Cis-Piperitone Oxide is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. It is packaged according to applicable regulatory standards for hazardous chemicals, clearly labeled, and usually transported under ambient conditions. Proper documentation and safety data sheets (SDS) accompany each shipment to ensure safe handling and compliance during transit.
    Storage Cis-Piperitone Oxide should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidizers. It should be kept at room temperature and protected from moisture. Proper labeling and secondary containment are recommended to prevent accidental release or exposure.
    Application of Cis-Piperitone Oxide

    Applications of Cis-Piperitone Oxide in Industrial Manufacturing

    As a direct manufacturer of Cis-Piperitone Oxide, we supply this key intermediate into several well-defined downstream segments. Our consistent material quality, traceable batch records, and full platform integration ensure our customers meet regulatory, formulation, and process requirements in every application below.

    1. Fragrance Compounding for Fine Perfumes and Cosmetics

    Global fragrance houses and cosmetic manufacturers use Cis-Piperitone Oxide as a prized monoterpene for crafting green, minty accords in high-end perfume bases and hair care essences. Its distinct olfactory signature contributes to clean, refreshing top notes and balanced overall scent structures, especially in formulations seeking a natural herby character. Downstream processors require precise dosing into alcohol-based or solvent-free bulk blends, often using closed systems to prevent cross-contamination. Perfume and personal care companies rely on consistent organoleptic properties, assured by validated supply chains and analytical fingerprinting at arrival and during compounding.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards (latest amendment)
    • EU Regulation (EC) No 1223/2009 (Cosmetics Regulation)
    • Good Manufacturing Practices (GMP) for Cosmetics (ISO 22716)
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) compliance for use in EU markets

    Typical usage ratio

    • 0.05–0.5% of total fragrance formulation by weight, depending on intended odor intensity and blend type; higher levels may be adopted in herbal or functional products, subject to IFRA limits

    Downstream process integration

    • Direct addition to melters or mixing tanks during top note composition in fragrance blending
    • Inline or batch blending into alcohol/water bases for perfumery or anhydrous emulsions for creams and lotions
    • Homogenization and filtration before packaging to control volatiles loss

    Final product types

    • Fine perfumery bases and market-ready eau de toilette/eau de parfum
    • Premium hair styling products (gels, mists, serums)
    • Deodorant sticks and sprays
    • Lotion or liquid soap fragrance concentrates

    2. Synthesis of Menthone and Menthol Precursors

    Manufacturers in the aroma chemical sector utilize Cis-Piperitone Oxide as a high-purity intermediate for catalytic hydrogenation and isomerization steps leading to menthone and subsequently menthol. This transformation underpins the supply of cooling agents to oral hygiene, confectionery, and OTC pharmaceutical production. Feedstock quality and reaction conversion rates have direct impacts on downstream process efficiency and compliance with established pharmacopoeias. Solvent recovery and catalyst selection are critical for reliable batch-to-batch scale-up.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) specifications for menthol/menthone
    • US FDA 21 CFR 172.515 (Flavoring agents and related substances in food)
    • GMP (ICH Q7) guidelines for active ingredient intermediates
    • Food Chemicals Codex (FCC) for food grade downstream menthol

    Typical usage ratio

    • 100% conversion feed in target batch for menthone synthesis; adjusted according to reaction yield and desired throughput level

    Downstream process integration

    • Hydrogenation/isomerization reactors fed with piperitone oxide after pre-filtration
    • Fractional distillation units for post-reaction separation and purification
    • Crystallization and drying as final steps prior to formulation or compounding in menthol lines

    Final product types

    • Synthetic and natural-grade menthol crystals
    • L-menthone and d-menthone for flavor and fragrance use
    • Base ingredients for toothpaste, chewing gum, pharmaceutical topical gels

    3. Industrial Flavor Additive in Food Processing

    Food additive companies and industrial flavor manufacturers leverage Cis-Piperitone Oxide as a modulating ingredient in complex mint and herbal flavor profiles, particularly for hard candies, sugar-free confectionery, and functional beverages. Its powerful aroma and flavor intensity require precise metering and advanced flavor house protocols to ensure appropriate dispersion and stability under thermal or acidic conditions. All uses strictly align with approved flavor additive regulations in each target market and require validated traceability for food safety audits.

    Industry compliance standards

    • US FEMA GRAS status (FEMA No. 2956) for flavoring substances
    • EU Regulation (EC) No 1334/2008 (Flavorings and certain food ingredients with flavoring properties)
    • Codex Alimentarius General Standard for Food Additives (GSFA)
    • HACCP and ISO 22000 food safety management systems

    Typical usage ratio

    • 0.005–0.02% of finished product weight, depending on flavor intensity targets, product matrix, and local flavor house profiles

    Downstream process integration

    • Liquid or microencapsulated addition to flavor pre-mixes during syrup or dough preparation
    • Inline dosing during extrusion or coating for confectionery
    • Blend-in during beverage emulsification with post-mix adjustment

    Final product types

    • Mints, sugar-free chewing gum, breath fresheners
    • Herbal hard candies, lozenges
    • Functional and flavored waters

    4. Repellent Agent Formulation for Household and Institutional Use

    Home care and public health product manufacturers turn to Cis-Piperitone Oxide as a key active for designing botanical-based repellents against household pests and nuisance insects. Its efficacy in combining with other terpenoids facilitates the creation of non-synthetic, label-friendly alternatives. The additive enters water-miscible and oil-based emulsion systems with strict controls on concentration and compatibility, as most use cases must meet stringent safety and release standards prior to commercialization.

    Industry compliance standards

    • US EPA FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act) regulations for minimum risk pesticides
    • EU Biocidal Products Regulation (BPR, Regulation (EU) No 528/2012)
    • OECD Guideline 301 for ready biodegradability
    • Labeling under Globally Harmonized System (GHS)

    Typical usage ratio

    • 0.2–2% in water-based or oil-based spray and lotion formulations; exact level selected based on efficacy data and regulatory approval in each market

    Downstream process integration

    • Phase addition during final homogenization in bulk mixing tanks
    • Cold fill or aseptic filling to preserve active profile
    • QC release through GC-MS to confirm actives load and absence of restricted contaminants

    Final product types

    • Household aerosol or pump insect repellent sprays
    • Personal care repellent lotions and creams
    • Wipe and patch formats for public health programs

    5. Fine Chemical Intermediate for Piperitone Derivative Synthesis

    Agrochemical and active ingredient manufacturers process Cis-Piperitone Oxide as a strategic building block for advanced piperitone-derived molecules, including specialty synthons and chiral intermediates. Facilities require high assay material with robust impurity profiles, as downstream transformations such as Baeyer–Villiger oxidation and Grignard additions demand tight process controls for both yield and selectivity. Batch records, solvent recovery cycles, and in-process analytical checkpoints govern raw material intake, ensuring downstream customers receive non-routine, custom intermediates for further functionalization or formulation.

    Industry compliance standards

    • ISO 9001:2015 certified quality management
    • Responsible Care® chemical management system
    • Custom contract QC specifications agreed with downstream partners
    • Relevant environmental, health and safety regulations (OSHA, local EPA)

    Typical usage ratio

    • Stoichiometric feed from 50–100% of the limiting reagent load; process flow adjusted based on the derivative’s molecular structure and synthetic route

    Downstream process integration

    • Charge to jacketed reactors for multistep organic synthesis
    • Intermediate isolation and characterization after each synthetic stage prior to scale-up
    • Reactive distillation during process steps requiring product purity enhancement

    Final product types

    • Custom piperitone-based synthons supplied to pharma, agro, and specialty markets
    • Chiral building blocks for asymmetric synthesis platforms
    • Precursor agents for active crop-protection formulations
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    Certification & Compliance
    More Introduction

    Cis-Piperitone Oxide: Our Perspective as the Manufacturer

    Understanding Cis-Piperitone Oxide and Its Value

    Working day in and day out in the chemical manufacturing field, we see firsthand how specialty compounds shape industries and enable new possibilities. Cis-Piperitone Oxide stands out among those molecules that offer both complexity and practical value to our customers. Built from our ongoing commitment to consistency and direct quality control at every step, this compound shows impressive flexibility where both ingredient purity and performance matter most.

    As a producer that manages the entire process from raw botanical extraction to final filtration and packaging, every batch of Cis-Piperitone Oxide reflects the expertise gathered over years of real-world laboratory work. This is not a bulk commodity tossed into the market for general purpose. Instead, we engineer the compound specifically to serve demanding niches in fragrance, flavor, and advanced intermediates. Our laboratory teams track every variable from temperature sensitivity through to enantiomeric excess, meeting the expectations of formulators who refuse to settle.

    The Profile That Makes a Difference

    Cis-Piperitone Oxide comes with the kind of distinct scent profile that natural product chemists and perfume houses alike hunt for: its refreshing, green, mint-like aroma captures an elusive middle ground between herbal clarity and soft floral undertones. The purity level—achieved through careful fractionation and repeated distillation—often exceeds 97%, as monitored by GC-MS and supported by reference spectra. Our experience proves that this purity translates into cleaner, more reliable results for clients working at scale. That’s why formulators choose to source this compound directly from manufacturing sites like ours, instead of relying on secondhand suppliers.

    Through decades of hands-on production, we’ve established a repeatable model for turning raw plant material—carefully selected Mentha or related Lamiaceae species—into a single, crisply defined molecule. This reduces batch-to-batch drift, a concern often overlooked until an end product starts behaving unexpectedly. As the manufacturer, we know that stable performance comes not just from technical wizardry, but from designing plant harvest, extraction, and conversion protocols that never cut corners.

    The Real-World Role of Cis-Piperitone Oxide

    Our manufacturing experience reveals the wide reach of this compound. Cis-Piperitone Oxide has a recognized place as a highly impactful fragrance ingredient in fine perfumery, functional scents, detergents, and personal care products. Its natural, minty nuance can be found brightening soaps, creams, and cleaning agents, often providing a sense of freshness not easily obtained from more common terpene derivatives.

    Flavor chemists turn to this molecule for specific effects in food and beverage. Its ability to mimic or amplify minty and herbal notes helps create the nuanced taste that characterizes premium products. Crucially, the sensory profile differs from both menthol and citronellol, delivering a unique flavor signature that big-brand developers seek to protect as a market differentiator. As we have learned by working directly with formulation scientists, minor changes in oxide isomer ratios can shift flavor profiles dramatically. Having tight control over every isomeric detail makes the difference between an average and an award-winning formulation.

    Distinctions from Other Terpene Oxides and Synthetics

    From where we stand, side-by-side comparisons highlight where cis-piperitone oxide departs from other common fragrance and flavor molecules. Unlike synthetic menthol, cis-piperitone oxide introduces multifaceted, green, and subtly spicy notes. Unlike trans-piperitone oxide, the cis form—at equal purity—carries less warmth and greater brightness. Ingredient buyers who only specify “piperitone oxide” sometimes end up with unintended results; few suppliers offer an isolated, high-purity cis form, and the sensory distinction is obvious to trained noses.

    From the manufacturing floor, differences show up not only in aroma, but also in stability during storage and blending. The cis isomer resists oxidative breakdown better than its trans sibling, so products maintain their intended profiles longer on shelves. That’s a direct advantage for our brand partners seeking to guarantee a consistent experience for end users over time. Over the years, we have found that controlling exposure to heat, light, and contaminants solidifies these quality advantages; it’s not just about the molecular structure, but everything from plant sourcing to final encapsulation.

    Some buyers compare cis-piperitone oxide to other minty compounds like carvone or pulegone. They all offer coolness, but they behave distinctly during manufacturing and use. For example, where pulegone and carvone can introduce astringency at higher concentrations, cis-piperitone oxide lends itself to layering—providing character without overpowering a base. Our team regularly collaborates with development chemists to help them achieve this delicate balance, providing samples, spectral data, and formulation advice grounded in practical knowledge rather than guesswork.

    A Manufacturer’s Approach: Precision from Start to Finish

    We approach the production of cis-piperitone oxide with the kind of attention to detail that only comes from owning the process end-to-end. Everything starts with botanical selection. Not all Mentha plants yield equal results. We work with growers to harvest plants at peak oil content, monitoring both chemotype and field conditions. Once the raw material reaches our facility, we schedule immediate processing, keeping volatile precursors protected and minimizing time from harvest to conversion.

    Extraction involves precisely controlled steam distillation under vacuum—modifying parameters in response to seasonal variations and harvest differences. We have learned through long experience that subtle shifts in distillation temperature can lead to measurable changes in isomer content. Technicians monitor each batch using real-time chromatography, feeding back results that inform every next step of purification.

    Following extraction, we increase purity using fractional distillation columns designed and operated by our in-house engineering team. Standardized cleaning and calibration routines mean reduced cross-batch contamination—something third-party suppliers easily overlook. Once the oxide is isolated, we purify further using preparative chromatography when specifications demand even tighter control. Each lot receives full analytical documentation, including GC-MS fingerprinting and chiral analysis, so customers know exactly what to expect.

    Every product release reflects our ethos: no shortcuts. By managing all stages ourselves, we eliminate many of the unknowns common with resellers and bulk traders. Issues like inconsistent flavor, off-odor, or unwanted byproducts rarely surprise our downstream clients, because we watch every variable and fix problems before the materials ever leave our plant.

    Why Source Direct from the Manufacturer?

    Speaking as the manufacturer, direct sourcing often means lower risk for those creating fragrance or flavor blends. Over the decades, we’ve seen projects delayed and formulas compromised because intermediate traders substitute or dilute material to control costs, stripping out the trace elements that contribute to a truly complex scent or flavor. Our laboratory team communicates directly with clients, answering questions about isomer ratios, contaminants, or regulatory documentation that third parties can rarely address with accuracy.

    Transparency stands central to trust. Ingredient buyers walk through our production site, review our records, and inspect raw materials firsthand where regulations permit. We offer open-book traceability, tying every batch of cis-piperitone oxide back to source fields and processing logs. This level of disclosure benefits partners seeking strict compliance with standards like IFRA, FEMA, or local safety authorities. Knowing exactly how and where a molecule was produced builds confidence, especially for those managing brand risk on an international scale.

    Supporting Claims with Measurable Results

    Our production history with cis-piperitone oxide covers over a thousand batches shipped across global markets, from artisanal perfume houses in Grasse to multinational beverage developers in North America and Asia. We routinely submit our products to third-party labs for comparison and benchmark testing. Over the last three years, routine GC-MS analyses have confirmed our batches consistently contain below 0.2% trans-isomer impurity, and no detectable residues of common agricultural pesticides—a testament to both supplier screening and our own internal controls.

    In flavor applications, feedback from beverage companies points to more persistent, balanced mint notes compared to synthetics, with fewer reports of “burn” or off-notes even at higher concentrations. In fragrance, end-use testing in high-purity detergents confirmed that our cis-piperitone oxide maintained clarity and freshness after six months of accelerated shelf-life simulation—a real measure of stability that adds value in finished products staying on store shelves for extended periods.

    Problems Facing the Industry—and Our Solutions

    Working at the manufacturing level, we encounter recurring challenges unique to piperitone oxide production. Many competitors, seeking short-term profit, shortcut plant selection, mix isomer streams, or rely on imports of questionable botanical origin with variable oil content. These choices risk unpredictable chemistry—yielding muted flavors or fragrances, and exposing downstream users to recall risks if the profile shifts between batches.

    Our solution revolves around direct control. Multiyear contracts with dedicated farmers support consistent chemotypes, while in-house extraction and fractionation protect batch integrity. Rapid in-process monitoring pinpoints any drift in isomer ratio before a batch reaches the next step. Dedicated QA personnel intervene immediately if unusual readings appear, saving time and resources further down the line. Moreover, by avoiding large inventory stockpiles in uncontrolled environments, we cut down on the risk of light- or oxygen-driven degradation, which can undermine both the aroma and shelf life.

    We also recognize regulatory shifts on natural versus synthetic origins. Flavor and fragrance houses increasingly demand transparency about botanical origin, evidence of ethical sourcing, and proof of chemical equivalence to natural standards. Our facility tracks every input and validates every lot using internal assays and, where required, external labs. By investing in analytical chemistry—rather than outsourcing—our team answers detailed customer queries on identity, purity, and status for “natural” product labeling. Our records support labeling claims, easing the process of compliance documentation in global export markets.

    Continuous Learning and Feedback—From the Factory Floor to Our Clients

    Experience teaches us that producing a specialty ingredient like cis-piperitone oxide demands constant adaptation. We never stop refining our methods. Each production round, we capture feedback from lab technicians, operators, and—most importantly—clients who apply our product in commercial formulations. Sometimes, seemingly small changes, such as harvest timing or distillation pressure, yield measurable differences in downstream performance. Years ago, feedback from a long-time perfume maker prompted us to revisit filtration steps, leading to purer product with crisper sensory output.

    As manufacturing chemists, we also navigate sudden market shifts. Crop failures, new interpretations of regulatory code, and swings in demand all impact how and when we plan plantings and scale up extraction. By holding direct relationships throughout the supply chain and adapting quickly on the ground, we build resilience into our system. Customers trust us not to simply deliver a commodity, but to explain origin, timing, and technical details that might affect project outcomes.

    Our technical support goes well beyond specification sheets. Perfume chemists visit our labs to conduct joint trials, reviewing batch analytics in real time. Flavor customers run pilot batches alongside our own staff, making use of our analytical equipment and expertise developed through continual exposure to the real challenges of applied chemistry. This ongoing exchange brings new insight: sometimes the detail that makes the difference is as small as a secondary impurity, or a shift in the volatility profile picked up only after hundreds of field tests.

    Environmental and Social Responsibility

    The production of specialty ingredients carries responsibility not only to the customer, but also to the broader community. Many buyers ask where and how the plants for cis-piperitone oxide are grown, what methods the harvesters use, and how waste streams are treated. From the beginning, our operation committed to using field partners who practice responsible farm management—rotating crops, minimizing water use, and using biological pest control instead of harsh chemicals. Our extraction plants recycle process water and capture residual byproducts for use in biogas or animal feed, reducing waste and maximizing value from every kilogram of raw plant.

    Worker safety remains an everyday focus. Manufacturing teams operate with full access to PPE and modern ventilation. Hazardous steps are either automated or controlled through real-time gas monitoring, and we take pride in a safety record that stands apart from broader industry benchmarks. Training cycles ensure both new hires and experienced operators stay up to date with best practices, not only meeting but often exceeding legal requirements.

    Moving Forward—Innovation Rooted in Experience

    A commitment to innovation means not standing still. Over recent cycles, our team has piloted green chemistry methods for extraction—reducing energy input and further limiting solvent emissions. Early trials suggest we can push purity levels higher while reducing environmental footprint, offering customers both superior performance and a better story for eco-conscious branding. Ongoing collaborations with universities and research centers introduce novel catalysts and bio-based processing catalysts, promising new routes toward even more effective cis-piperitone oxide production.

    From the manufacturer’s perspective, the journey of cis-piperitone oxide is far from over. As customer applications become more sophisticated and regulatory standards more stringent, the need for reliable, high-purity, transparently sourced ingredients will only sharpen. Our role: keep leading with technical rigor, open communication, and boots-on-the-ground knowledge earned through years of practice. Direct manufacturing yields not just a product, but a partnership—offering certainty in a marketplace often clouded by variable material, vague assurances, or missing details.

    Summary of Our Approach and Commitment

    Producing and supplying cis-piperitone oxide is as much about stewardship as it is about technical skill. Our process integrates detailed botanical sourcing, accurate analytical control, and long-term customer support. By staying hands-on at every step, we anticipate and address problems before they escalate, sharing know-how with clients who value both high-quality chemicals and long-term relationships.

    Each decision we make shapes the properties and possibilities downstream. That’s why industry leaders come back to the original source: it’s the difference between acceptable results and standout performance in today’s demanding markets. Our practical experience, skilled workforce, and open-door policy drive ongoing improvement—ensuring that every barrel of cis-piperitone oxide fits the needs of tomorrow’s formulations while building on the foundations laid by years of careful industry practice.