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Chlorophetanol

    • Product Name Chlorophetanol
    • Alias Para-chlorophenyl-2-hydroxy-2-ethylaminoethanol
    • Einecs 202-302-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    261716

    chemical_name Chlorophenol
    IUPAC_name 4-chloro-2-methylphenol
    CAS_number 106-43-4
    molecular_formula C7H7ClO
    molar_mass 142.58 g/mol
    appearance Colorless to pale yellow solid
    melting_point 66-69 °C
    boiling_point 218-220 °C
    solubility_in_water Slightly soluble
    density 1.24 g/cm³
    odor Medicinal, phenolic
    flash_point 121 °C

    As an accredited Chlorophetanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Chlorophetanol is packaged in a 500g amber glass bottle with a secure screw cap, labeled with hazard warnings and handling instructions.
    Shipping Chlorophetanol should be shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. Transport must comply with applicable regulations for hazardous chemicals, using appropriate hazard labeling. Ensure the package is upright and secure, with documentation detailing chemical name, concentration, and relevant safety warnings for safe handling during transit.
    Storage Chlorophetanol should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Keep the container tightly closed and clearly labeled. Store separately from incompatible substances, such as strong oxidizers and acids. Use only approved, chemical-resistant containers, and ensure spill containment measures are in place to prevent environmental contamination.
    Application of Chlorophetanol

    Applications of Chlorophetanol in Industrial Manufacturing

    As a direct manufacturer of Chlorophetanol, we support leading downstream industries with consistent supply, formulation knowledge, and technical guidance. Below we detail the key sectors where this raw material plays a critical role in both process integration and regulatory conformity, focusing on authentic and specialized use scenarios across a range of industrial value chains.

    1. Pharmaceutical Intermediate Processing

    Chlorophetanol functions in the synthesis step for specific pharmaceutical active ingredients, particularly as an alkylating agent in the preparation of analgesic intermediates and anti-infective compounds. Its controlled use in multi-step routes improves overall yield and purity by enabling selective functional group modifications. Production lines integrate the material after the initial reaction, often during the key intermediate building stage, demanding strict adherence to cross-contamination protocols and batch traceability. Downstream clients typically emphasize minimization of residuals to meet finished API standards.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • U.S. FDA 21 CFR Parts 210/211 Current Good Manufacturing Practice (cGMP)
    • European Pharmacopoeia (Ph. Eur.) purity requirements for pharmaceutical intermediates
    • China Pharmacopoeia ChP 2020 applicable sections

    Typical usage ratio

    • 0.5–2.5 molar equivalents relative to the starting compound, depending on targeted alkylation pathway; ratio determined by intermediate yield and impurity profile requirements

    Downstream process integration

    • Added after initial condensation or ring formation, under controlled temperature and inert atmosphere, usually via continuous or semi-batch feeds

    Final product types

    • API intermediates such as N-alkylated amines for pain management drugs
    • Benzyl ether-based anti-infective intermediate blocks
    • Processed intermediates for antipyretics

    2. Biocide and Antimicrobial Formulation

    Industrial formulators use Chlorophetanol for its established efficacy against gram-positive and gram-negative bacteria as well as its compatibility with phenolic co-actives in specialty biocide blends. Its inclusion in formulations for medical devices, industrial process waters, and personal care preservatives addresses stringent microbial quality specs required by end customers. Plant operators typically optimize ingredient dosing at the post-emulsion or concentrate blending stage for preservation stability, targeting defined release and microbe inhibition thresholds as stipulated by regulatory authorities.

    Industry compliance standards

    • EU Biocidal Products Regulation (BPR, Regulation (EU) 528/2012)
    • U.S. EPA 40 CFR Part 158 for Antimicrobial Pesticide Products
    • OHSAS 18001 for industrial hygiene
    • ISO 9001 for formulation QC

    Typical usage ratio

    • 0.1–0.6% by weight for in-can preservation or leave-on disinfectant fluids; concentrations vary due to desired kill spectrum, interaction with co-preservatives, and regional regulatory limits

    Downstream process integration

    • Incorporated during the final mix or concentrate step following temperature-sensitive ingredient addition, often pre-filtered for clarity in personal care and hard surface cleaning products

    Final product types

    • Broad-spectrum antimicrobial concentrates
    • Sterile medical device soaking fluids
    • Industrial cooling water biocides
    • Preservative systems for skin care lotions and hand cleansers

    3. Surfactant Synthesis for Cleaning Chemicals

    Specialty chemical manufacturers utilize Chlorophetanol as an alkylating agent in non-ionic and cationic surfactant synthesis, particularly for applications involving hard-to-clean residue challenges. It enters the synthetic sequence where ethoxylated intermediates require terminal group capping, enhancing final surfactant solubility and surface wetting properties. Careful ratio management and in-line process analytical technologies (PAT) maintain safety and target performance, while post-reaction quality testing ensures conformance to downstream blending specifications for industrial and institutional cleaning.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 registration for surfactant substances
    • ISO 14001 for environmental management in surfactant manufacture
    • ASTM D3703 for purity and activity determination in commercial surfactant products
    • U.S. TSCA inventory listing

    Typical usage ratio

    • 1–4% of the batch based on target hydrophobe/hydrophile balance, adjusted according to final blend viscosity and cleaning performance requirements

    Downstream process integration

    • Metered into reactor vessel after partial ethoxylation, often at elevated temperature and under continuous agitation to assure complete reaction before neutralization and downstream blending

    Final product types

    • Hard surface cleaner concentrates
    • Industrial degreasing formulations
    • Automatic dishwasher cleaning blocks
    • Commercial laundry detergent bases

    4. Organic Synthesis—Agrochemical Intermediate Manufacture

    Agrochemical producers leverage Chlorophetanol in the closed-loop synthesis of intermediate structures that provide selectivity and stability to key pesticide actives, such as phenoxyacetic acid derivatives. The raw material is dosed according to reaction stoichiometry in methylation and etherification sequences following the initial coupling step, where it helps control side-product formation. Continuous monitoring and traceability support product stewardship essential for crop protection product registrations, especially as authorities strengthen controls on process impurity carry-over into finished technical material.

    Industry compliance standards

    • FAO/WHO specifications for technical active substances
    • Chinese Ministry of Agriculture GB 4839-2007 for pesticide preparation processes
    • ISO 9001:2015 quality management for agrochemical production
    • OECD Environment, Health and Safety Guidelines for chemical manufacture

    Typical usage ratio

    • 0.8–2.2 equivalents per mole of coupling agent, concentration tailored for lowest achievable residues per active substance regulatory limits

    Downstream process integration

    • Added post-initial condensation or coupling, typically under reflux or with phase transfer catalysis, immediately ahead of crystallization or solvent recovery stages

    Final product types

    • Intermediate blocks for herbicide synthesis
    • Pesticide precursor active materials
    • Stabilized agrochemical technical concentrates

    5. Diagnostic Reagent and Laboratory Chemical Production

    Manufacturers in the diagnostics sector rely on Chlorophetanol for its stability and reactivity in the formulation of certain chromogenic substrates, enzyme inhibitors, and biological sample preservatives used in clinical and industrial testing workflows. The material is precision-dosed at the post-sterilization blending stage, where its impurity profile and batch homogeneity directly affect product shelf life and diagnostic signal consistency. Quality systems emphasize analytical verification and batch traceability as dictated by medical device reagent registration requirements.

    Industry compliance standards

    • ISO 13485:2016 for in vitro diagnostic medical device manufacturing
    • U.S. FDA 21 CFR 820 for Quality System Regulation (QSR)
    • CLSI (Clinical & Laboratory Standards Institute) sample handling and preservation protocols
    • European IVDR (In Vitro Diagnostic Regulation) 2017/746

    Typical usage ratio

    • 0.02–0.15% by weight in reagent mixes; ratio determined by specific test kit sensitivity and required shelf stability

    Downstream process integration

    • Dosed into bulk reagent solutions after filtration and sterilization, followed by in-line mixing and filling into test kit vials under aseptic conditions

    Final product types

    • Chromogenic enzyme substrates for blood and urine assays
    • Biological sample preservation buffers
    • Ready-to-use diagnostic kit reagents

    6. Textile and Fiber Treatment Additive Manufacturing

    Producers of textile finishing auxiliaries use Chlorophetanol during the synthesis of finishing resins and antimicrobial textile treatments. This step typically occurs following pre-polymerization, imparting both functional group reactivity and inhibition of microbiological degradation in final textile applications. The amount added is closely linked to fiber type and intended use case, with plant-level QC verifying effective integration into the finishing bath or direct fiber spin-melt processes. Customer specifications and regional eco-label compliance strongly influence dosing limits and process selection.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for textile chemical safety
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • REACH Annex XVII entry for treated articles
    • GB/T 26385-2011 for China textile chemical processing

    Typical usage ratio

    • 0.1–0.5% on fabric weight for finishing solutions; varies with fabric absorption rate, applicator type, and targeted antimicrobial claims

    Downstream process integration

    • Added to the finishing formulation tank after other functional additives, then applied via pad-dry-cure or direct spin-melt onto synthetic fibers

    Final product types

    • Antimicrobial finished cotton and polyester textiles
    • Functional apparel linings
    • Odor-control sportswear
    • Medical nonwovens with biostatic treatment
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    Certification & Compliance
    More Introduction

    Understanding Chlorophetanol: Practical Uses and Real-World Advantages

    Why Chlorophetanol Matters on the Production Floor

    At our plant, every batch tells a story of raw materials transformed by experience and precision. Chlorophetanol stands out for its reliability in synthesizing pharmaceuticals and specialty chemicals. Production managers know that the difference between a dependable intermediate and a troublesome one often comes down to purity, stability, and handling profile in daily operations. Chlorophetanol, with our commonly produced models like 2-chloroethanol, supports consistent reaction yields and straightforward storage protocols—a clarity sought by technical teams who have weathered plenty of supply chain disruptions over the years.

    Specification Insights That Matter to Operators

    We manufacture Chlorophetanol in liquid form, meeting tight standards for water content, minimum assay by GC, and heavy metal presence. For process engineers, these specifications sidestep trial-and-error stages during scale-up, as reactions depend on the absence of impurities that might slow down or unpredictably skew the process. Over time, we found that operators prefer batches where color, odor, and reactivity match precisely from one drum to the next, cutting down on in-house material qualification tests and saving downstream time.

    Why Industry Chooses Chlorophetanol for Synthesis

    At synthesis lines for pharmaceuticals and agrochemicals, Chlorophetanol’s function as an alkylating agent sets it apart. Teams mixing this intermediate into their reactions count on its predictable nucleophilic substitution behavior, especially during the early stages of building active molecules. Over the last decade, we have watched customer sites shift away from less stable or more volatile intermediates that demand specialized containment. Chlorophetanol runs smoothly through conventional glass-lined reactors with standard solvent systems, which supports leaner project timelines and fewer reactive-excursion incidents.

    Challenges Seen in Everyday Manufacturing

    Anyone who has spent time overseeing high-volume reactions knows that intermediates like Chlorophetanol can test even the most robust setups. Our quality control teams track batch traceability and impurity fingerprinting, because downstream product purity often hinges on subtle raw material differences. Over the years, clients have described how unstable precursors or uneven formulation can trigger batch failures, cause yield loss, or force rework cycles. Our formulation teams work directly with end-users’ process scientists to catch subtle issues before they reach the plant floor and avoid costly mid-batch interventions. We do not leave root cause analysis to chance, especially after seeing major shutdowns traced to off-spec material from unknown sources.

    Practical Differences from Other Chemicals in the Toolset

    Process engineers comparing Chlorophetanol to other intermediates—including o- or p-chlorophenol, chloromethyl alcohols, or simpler alkyl halides—often cite handling and safety first. Chlorophetanol provides a careful balance of reactivity without tipping into hazardous volatility during bulk transfer steps. Unlike some chlorinated solvents that demand respirator-level engineering controls, Chlorophetanol’s smell gives early warning in case of a leak, while evaporation rates pair well with local exhaust and closed transfer systems. Hot summer months at the plant emphasize these distinctions—cooling costs and containment risks do not balloon as with more volatile competitors. Workers appreciate that well-packaged Chlorophetanol stores safely for extended periods, reducing the pressure for expedited use that’s common with more sensitive stocks.

    Lessons Learned After Years on the Processing Floor

    Mistakes with intermediates carve deep memories. Early in our operation, a misreading of batch paperwork brought in a similar-sounding but chemically distinct raw material, causing process upsets and product spoilage. We put in place new barcode tracking and cross-line verification for every Chlorophetanol drum, based on years of real-world mishaps. Operators driving forklifts through busy loading bays recognize this chemical by sight and label, with clear hazard icons and date-of-manufacture stamps. These steps prevent costly downtime and support tracebacks if latent product defects arise long after delivery. The value of consistent supply only becomes clear after a customer site faces a recall triggered by substandard intermediates from a less diligent vendor.

    Supporting Pharma and Fine Chemical Synthesis

    R&D teams at customer sites tap Chlorophetanol for introducing functional groups—particularly in the early chlorination and alkylation routes of drug synthesis. From antibiotics to specialty agricultural compounds, it sparks critical molecular rearrangements, shaping products that improve crops or fight antibiotic resistance. Our technical liaisons regularly support troubleshooting on customer lines, exchanging best practices for mixing, temperature ramps, and cleanup. Plant managers can recall specific projects where competitors’ intermediates stalled at pilot scale due to unpredictable side reactions—whereas Chlorophetanol batches helped projects run to timeline, aided by our lot-based analytics and robust data-sharing with clients.

    Down-to-Earth Handling and Storage Advice

    People managing day-to-day stock movement find that Chlorophetanol stays stable under normal warehouse conditions. Drums store safely in well-ventilated areas; neither extreme refrigeration nor overbuilt containment cages prove necessary in well-managed facilities. Year after year, we receive positive feedback from shipping managers who value the certainty that comes with uniform packaging and predictable delivery schedules. Our experience with long-haul shipments—sometimes across tough climates—taught us to select packaging that resists chemical leaching and prevents moisture ingress, two common risks that undermine quality in the field.

    Worker Safety and Process Reliability: Direct Experience

    After fielding safety walkthroughs with customers, we learned that clear hazards communication and hands-on training make the difference. Chlorophetanol carries recognized irritant action. We walk teams through eye wash protocols and spill recovery practice, blending real-world plant stories with safety data. Near misses become teaching moments in our community—like one early morning transfer operation that exposed a gap in vent hood coverage, now resolved with new ductwork and worker input. We help site leads write up practical operating procedures and share our own incident root causes so learning spreads among teams, not just across our own plant floor.

    Supporting Sustainable Operations

    Our focus on process sustainability starts at raw material sourcing. We audit suppliers and track chain-of-custody to avoid any batch drift in quality or environmental stewardship. Chlorophetanol production generates manageable waste streams—our process teams capture and treat these at source, keeping organics and halogenated byproducts within regulated discharge levels. Over the years, process tweaks shrank water use and reduced solvent losses at every step, guided by plant KPIs and regulatory checks rather than solely chasing yield numbers. Teams developing green chemistry protocols look to us for customized batch analytics, helping them reduce carryover hazards and keep environmental compliance solid, even under stricter regulations.

    Process Adaptation During Upstream Disruptions

    Upstream issues—raw material shortages, logistics breakdowns, or political disruptions—can ripple through chlorinated chemical supply lines. Having in-house control over every production step, from chlorination to purification, gave us nimbleness to adjust procedures after a raw feedstock became unavailable without warning in a previous year. We rewrote batch recipes, kept quality teams working overtime, and never let a customer’s plant go idle due to lack of Chlorophetanol. Decades of hands-on disruptions taught us the true cost of weak supply chain backup—project overruns, supplier whiplash, and loss of trust up and down the chain. That’s the kind of assurance that comes from making chemicals yourself, not buying them from a middleman.

    Common Technical Questions We See

    Process chemists routinely contact us about mixing ratios, reactivity with specific nucleophiles, or grade differences for particular synthesis steps. We break down findings with practical details—temperature ranges, per-batch analytic data, and reactivity snapshots informed by process trials on our own benches. Troubleshooting rarely settles for speculation; we use test rigs that mimic customer process conditions, feeding back adjustments where material performance might drift under scaled-up conditions. Our technical support team brings decades of combined plant experience, not just lab credentials, to every inquiry, helping turn trial batches into big-volume production wins.

    Customer Project Examples: Where the Right Intermediate Counts

    In multiple active pharmaceutical ingredient projects, customers chose Chlorophetanol for its tight lot consistency and robust third-party analytics, confirming every batch meets key reaction criticality thresholds. In one agrochemical project, a late switch from a low-purity competitor led to unplanned crystal morphology issues—Chlorophetanol streamlined the work-up, reduced purification cycles, and saved thousands in delayed shipments. These outcomes matter more than abstract quality claims; they shape reputations and return business year after year. Each customer phone call underscores that no two processes look quite the same in the field—having a partner able to adjust not just paperwork, but actual batch specs, makes all the difference during crisis or ramp-up windows.

    Training for Plant Personnel: A Manufacturer’s Role

    We run annual training for both our staff and customer teams handling Chlorophetanol. The curriculum pulls from real production mishaps and solution stories, not just regulatory or theoretical overviews. Workers learn to spot early signs of degradation, prevent accidental mixing, and decontaminate spills with minimal plant downtime. Partnering with industrial hygiene consultants, we refresh safety signage, run practical drills, and review plant layouts, so that every workshop reflects lived experience and changing industry standards. Customer EHS coordinators tell us that this hands-on insight bridges gaps left by textbook training alone.

    Trend Watch: Regulatory and Market Shifts

    Being both producer and supplier, we track evolving rules on worker exposure, chemical transport labeling, and raw material traceability—especially for exports into strict regulatory regions. A surge in micro-purity requirements for pharmaceutical actives, or a new threshold for shipping declarations, triggers updates on our line before it creates market headaches. Legislation sometimes outpaces local regulators, so we invest in advanced analytic hardware, lean scheduling systems, and staff readiness. As green chemistry grows in influence, our technical team works with industry groups to explore bio-based starting materials for Chlorophetanol production, even running test lots for early-adopter clients.

    Continuous Improvement on the Line and in the Lab

    Our process engineers run optimization projects on the live line, not just in lab glassware. Small process tweaks—such as improved temperature control or newer distillation column packing—have pushed yields higher, cut batch cycle times, and trimmed solvent emissions over time. We log every shift report and batch deviation, feeding near-miss data back into manufacturing and quality system upgrades. Operators in the control room spot gradual color changes or viscosity drift before analytic results confirm a trend, because they know just how fast an unnoticed shift could escalate into off-spec product. Improvement means keeping every layer—operator, chemist, planner, and manager—plugged into field realities and ready to adapt to the unexpected.

    Different Needs, Adapted Batches

    Not every end user of Chlorophetanol seeks the same cut. Fine chemicals might demand ultra-low heavy metal content, while another customer optimizes for a specific water percentage or blend with stabilizers. Years of real dialogue with engineers and chemists have shaped our flexibility. On one production run, an overseas partner flagged a solubility bottleneck at scale; we dove into collaborative troubleshooting, tweaking initial batch filtration protocols and exchanging sample data to enable a fix within a month. Customization requests, far from being rare, reflect the evolving landscape of global chemical manufacturing, and we keep technical, analytical, and operational channels open for each build-to-order project.

    Commitment to Transparency: Practical Benefits

    Plant shutdowns, late-stage regulatory queries, or shipping delays cost everyone upstream and down. Having walked through dozens of audit checklists with both customers and local inspectors, we recognize the benefit of a culture that documents, traces, and shares key production variables on every Chlorophetanol batch. Our records stretch back years, accessible to outside review on request. Plant tours for local schools, industry groups, and new hires showcase the realities—raw drums, intervention records, investigation reports, and finished product storage—not just a sanitized front office. Trust builds on practical transparency, not just outside certifications.

    Where Chlorophetanol Develops Next: Market and Technical Outlook

    Chlorophetanol’s future looks connected to green synthesis, advanced process safety, and new molecule development in pharmaceuticals and agriculture. As regulatory agencies and major buyers push for dropped impurity levels, we track market movements and reinvest gains into new reactor tech and smarter analytics. Industry partnerships bring new synthesis pathways to pilot scale, demanding stability and data beyond ordinary supply guarantees. This evolution means our production facilities resemble high-reliability centers as much as traditional chemical plants, staying one step ahead of both regulatory shifts and market downturns. Every year, we see more technical consultation from end-users at the R&D bench, reflecting a trend towards ever-finer quality control and smaller, high-value batch runs.

    Final Thoughts From the Manufacturer’s Perspective

    Over a generation making Chlorophetanol, every improvement and process redesign grew from direct experience—fiery batch upsets, material shortages, high-stakes customer deadlines, and late-night troubleshooting. Our teams take personal pride in consistently supplying chlorinated intermediates that keep customer lines moving, minimize batch inconsistencies, and sidestep regulatory drama. New projects—whether for blockbuster drugs or next-gen crop science—rely on this foundation of expertise, not just certification paperwork. Each inquiry, site visit, or customer request pulls from what we’ve learned: Reliable supply comes not only from process diagrams and published specs, but from hard-won lessons learned batch by batch, person by person, year by year.