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Butanimide

    • Product Name Butanimide
    • Alias Barbital
    • Einecs 204-674-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    558430

    name Butanimide
    IUPAC_name Butanamide
    CAS_number 541-35-5
    molecular_formula C4H9NO
    molar_mass 87.12 g/mol
    appearance White crystalline solid
    melting_point 115-117°C
    boiling_point 215-217°C
    density 0.978 g/cm³
    solubility_in_water Moderately soluble
    pubchem_CID 12066
    synonyms N-Butyramide, n-Butylamide
    SMILES CCCC(=O)N
    InChI InChI=1S/C4H9NO/c1-2-3-4(5)6/h2-3H2,1H3,(H2,5,6)
    storage_conditions Store in a cool, dry place

    As an accredited Butanimide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Butanimide is packaged in a tightly sealed 500g amber glass bottle with hazard labeling, safety data, and batch identification clearly displayed.
    Shipping Butanimide is shipped in tightly sealed, clearly labeled containers made of compatible materials to prevent leaks. It should be transported in accordance with applicable regulations, avoiding exposure to moisture and extreme temperatures. Proper documentation and handling procedures are essential to ensure safety and compliance during shipping and storage.
    Storage Butanimide should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Keep the chemical out of direct sunlight and store at room temperature. Ensure containers are properly labeled and access is limited to trained personnel to prevent accidental exposure or release.
    Application of Butanimide

    Applications of Butanimide in Industrial Manufacturing

    As a direct manufacturer of Butanimide, we supply this raw material to key industrial sectors where precise performance, regulatory compliance, and controlled integration define downstream application value. The following sections outline the main industrial uses of Butanimide, showcasing process specifics and sector requirements.

    1. Pharmaceutical Intermediate Synthesis

    Butanimide serves as a vital intermediate in the synthesis of multiple pharmaceutical actives, utilized primarily in heterocycle formation and amidation reactions. Leading pharmaceutical companies demand controlled impurity profiles and batch traceability, as the intermediate enters core building block steps in small-molecule API manufacture. Downstream integration occurs during multi-step organic synthesis, especially where selective nitrogen incorporation is required. Optimization of input ratios ensures yield maximization and purity compliance for registered products.

    Industry compliance standards

    • Current Good Manufacturing Practices (cGMP, ICH Q7)
    • USP, EP, JP monograph benchmarks (where applicable)
    • FDA & EMA regulatory guidance for intermediates
    • REACH registration for synthesis in Europe

    Typical usage ratio

    • 0.5–1.5 molar equivalents per synthesis step, adjusted based on target molecule and reaction pathway

    Downstream process integration

    • Introduced during amidation or cyclization stages in organic synthetic routes
    • Dosed with precision to limit byproduct formation and maintain batch reproducibility
    • Monitored by HPLC and NMR for conversion and residuals

    Final product types

    • Anticonvulsant APIs
    • Analogues for central nervous system drugs
    • Intermediates for custom synthesis projects

    2. Agrochemical Synthesis

    In proprietary agrochemical R&D and large-scale production, Butanimide forms essential scaffold components in selective herbicide and fungicide active ingredients. The compound integrates during functionalization steps in active molecule assembly, requiring tight process control for downstream crop-protection safety reviews. Formulation chemists vary input loading to balance yield and downstream purification needs, particularly in multi-tonne production.

    Industry compliance standards

    • FAO/WHO pesticide specification programs
    • ISO 9001 for quality process controls
    • REACH registration for European distribution
    • EPA tolerance limits for residuals in US markets

    Typical usage ratio

    • Up to 2 moles per mole of target intermediate, determined by target molecule structure and manufacturability

    Downstream process integration

    • Charged at cyclization or amidation stages in actives synthesis
    • Requires purity monitoring via LC-MS during batch progress
    • Feeds directly into crystallization or isolation of technical material

    Final product types

    • Selective triazole and imide herbicides
    • Nitrogenated fungicide actives
    • Custom high-value agrochemical intermediates

    3. Polymer Modifier Synthesis

    Manufacturers in specialty materials incorporate Butanimide as a reactive intermediate to introduce imide linkages into advanced polymers. The addition typically occurs at polycondensation stages to improve thermal, chemical, or dielectric properties of engineered plastics. Processing parameters depend on the end-use environment's mechanical and performance requirements, requiring consistent lot purity and repeatability within narrow tolerance bands.

    Industry compliance standards

    • ISO 9001:2015 certified QC systems
    • RoHS and REACH regulatory benchmarks
    • ASTM D638 mechanical property testing
    • UL compliance for electrical insulation polymers

    Typical usage ratio

    • 1–10% w/w in total polymer feed, modulated for polymer chain extension and specific property targets

    Downstream process integration

    • Added directly to melt or solution-polymerization reactors
    • Participates in condensation or chain-extension steps for advanced materials
    • Post-integration quality checks via FTIR and DSC

    Final product types

    • Polyimide engineering resins
    • Imide-modified epoxy formulations
    • High-performance electrical insulation compounds

    4. Dye and Pigment Intermediate Processing

    Colorant and pigment manufacturers select Butanimide as a key intermediate in synthesizing specialized organic dyes, where it enables the construction of stable chromophores and extended conjugation systems. The material integrates during final condensation and coupling reactions to give high purity, lightfast, and chemically resistant pigments. Control of residual solvent and unreacted material is critical to meet end-market safety and quality claims.

    Industry compliance standards

    • EN 71-3 for coloring materials in toys
    • OEKO-TEX Standard 100 for textile applications
    • AP(89)1 Council of Europe for food contact colorants
    • ISO 9001 colorant manufacturing controls

    Typical usage ratio

    • 0.8–1.3 molar equivalents relative to final dye molecule, dependent on required shade and fastness properties

    Downstream process integration

    • Reacted with aromatic amines in coupling or condensation stages
    • Monitored for complete incorporation by HPLC and GC-MS
    • Processed post-reaction for solvent removal and particle size refinement

    Final product types

    • Azo and anthraquinone dye intermediates
    • High performance color pigments for plastics and coatings
    • Disperse dye bases for fibers
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    Certification & Compliance
    More Introduction

    Butanimide: Reliable Performance Built on Experience

    Introduction to Butanimide as Manufactured at Scale

    As a chemical producer, we approach the manufacture of Butanimide with a focus on consistency, traceability, and robust supply. For years, our facility has produced this specialty compound using reliable synthesis routes, honed for industrial-scale yields and dependable purity. Butanimide is not a common commodity—it sits among the more technically demanding intermediates, but the process can be mastered by those willing to invest in careful process control and analytical rigor.

    Our standard model for Butanimide falls under the designation BA-234, which reflects the current refinement of our process. Purity exceeds 99% by GC assay, with trace side-products removed by multi-stage distillation. Moisture analysis—critical for downstream reactions—currently averages below 0.05%, measured using Karl Fischer titration, and periodically validated with independent labs to verify repeatability.

    How Butanimide Fits into Chemical Manufacturing

    Butanimide’s chemical backbone supports a host of industrial transformations. Its imide group provides high reactivity in nucleophilic substitution, making it favored for the synthesis of advanced intermediates, especially those used for pharmaceutical precursors or specialty polymers. Fine chemical producers rely on clean, predictable imide sources because impurities compound through each reaction step—affecting final yields and, more importantly, process safety.

    One unique aspect of Butanimide, as we’ve learned, is its dual role as both a synthetic building block and a functional additive. In recent years, some of our customers—especially those developing custom catalysts—have leveraged Butanimide’s structure for ligand design, and share feedback about its ability to enhance process specificity. The practical implication: Butanimide’s value extends beyond its molecular weight—it functions as both a reaction partner and a functional scaffold.

    Process Safety, Storage, and Handling Considerations

    It’s one thing to produce a ton of chemistry in lab-scale glassware; it’s another to fill drums destined for international shipment. Butanimide’s stability under routine storage allows us to ship the material by standard packaging, and we use mild steel drums lined with inert barriers to prevent moisture ingress or oxidation. Our logistics team monitors shipment temperatures, especially in summer, since Butanimide’s melting point sits close to ambient room temperature. Packing lines run batch samples several times daily for peroxide checks, since any decomposition event would compromise not just the batch, but downstream instrumentation for our customers.

    We’ve worked with industrial users who require bulk tanks, and our field technical team always recommends using inert nitrogen blanketing during long-term holding. In one instance—six years ago—a customer in the Midwest stored unsealed drums during a humid summer. Moisture led to visible caking and color drift, requiring full batch reclamation. Since then, we’ve equipped all exports with integrated hygrometers in multi-container shipments.

    Comparison to Other Chemical Building Blocks

    Compared with standard imides or amides—like phthalimide or succinimide—Butanimide provides a longer carbon chain, which influences both its solubility and steric profile. This change is not trivial. Small imides sometimes struggle to dissolve in organic solvents, or form microphases that clog transfer lines at scale. Butanimide’s extended backbone keeps it soluble in most polar aprotic solvents, including acetonitrile and dimethylformamide. That means less downtime, easier filtration, and lower probability of feedstock crystallizing in cold environments.

    Phthalimide, which many pharmaceutical chemists use, occasionally interacts unfavorable with some catalysts due to ring-strain issues and aromatic substitution side reactions. With Butanimide, we’ve seen higher selectivity in Alkylation reactions, and customers provide feedback that unwanted byproducts are reduced—sometimes by as much as 40%, based on their own QA data. In practice, that translates to both cleaner main-product profile, and less effort for downstream purification.

    Some suppliers promote high-volume maleimides or succinimides as general solutions. From what our technicians observe, those more common imides bring issues: higher melting points, lower process yields, and less flexibility for end-product designers. Butanimide’s flexible carbon chain supports more diverse chemistry. Epoxy resin producers who use Butanimide notice fewer gelation issues in final blends, and one specialty electronics manufacturer credited the consistent electrical breakdown voltages in their insulating films to the use of our BA-234 Butanimide, traceable through several production years.

    Applications: Customer Experiences and Process Results

    Our customers share detailed production logs, which we use to refine both product and service. Over the past decade, pharmaceutical companies have adopted Butanimide for several API projects, seeking improved control over reaction enantioselectivity. Not every process lands on the same synthetic route, but key users found that Butanimide acts as a more forgiving partner for reductive amination steps, with lower risk of over-reduction.

    Epoxy formulators prize Butanimide for its ability to improve toughness without sacrificing clarity or electrical integrity. Resin batches incorporating BA-234 show increased shelf stability. Employee training sessions for our own packagers now use cross-sections of these resins to illustrate the clarity attainable with technical-grade Butanimide, versus alternatives that may introduce haze or color. Paint and coating companies typically prefer lower melt imides for better incorporation into their mixing processes, so we’ve heard positive feedback on Butanimide for supporting faster blending and color consistency.

    In polymer chemistry, Butanimide’s role as a chain extender or modifier has started gaining traction. A specialty manufacturer of optical fibers conducted a year-long pilot, evaluating Butanimide against succinimide and maleimide. The conclusion was clear: blends using Butanimide produced finer fiber diameters, higher tensile strength, and higher resistance to ambient UV degradation. For fiber manufacturers, those characteristics bring improved quality and lower rejection rates, affecting their operating costs directly. Feedback from technical managers in automotive industries shows a similar pattern, with reports of higher thermal aging resistance in engine gasket materials that use our imide as a binder.

    Production Insight: What Matters Most During Synthesis

    From direct plant experience, one major challenge in Butanimide production comes during the cyclization step. Batch exotherm must be closely regulated. Years ago, we recognized that poorly controlled temperature ramps introduce colored impurities, which no downstream step can remove. By adding automated calorimetry monitors, we caught thermal spikes early. A former oversight—letting charge temperatures drift just a few degrees—cost a full shift of reprocessing.

    We avoid raw materials with variable chain length or off-gas content. Our procurement team sources only those starting materials certified for low side-reactions—otherwise, output consistency slips and downstream customers detect the difference quickly. Analytical chemists in our QA lab verify each drum, with retention samples archived for every batch. As a result, in four years, we’ve faced just two customer reports relating to composition drift, both traceable to out-of-specification input batches.

    No chemical plant can promise zero issues, but with Butanimide, we find the strongest results come by integrating real-time analytics through all synthesis, purification, and packaging steps. For us, the most effective controls have been a blend of open communication with large regular buyers, and investments in lab instrumentation—even where costs rise. Several of our partners credit this continuous feedback loop as the driver behind consistently strong performance in their product lines.

    Why Purity and Supply Chain Transparency Count

    Offering high-purity Butanimide isn’t just a sales pitch. Downstream applications, especially in regulated fields like pharmaceuticals or medical device polymers, depend on detailed, validated traceability. Every drum we ship carries documentation tied to fully auditable lot records, including supply source, synthesis batch, final assay, and transport conditions. Occasionally, a customer will request destructively sampled batch inspection before unloading—a sign that end users take traceability as seriously as we do.

    Butanimide, unlike some lower-value intermediates, cannot be reworked easily if the batch falls out of specification. In the past, users accustomed to generic imides have pressed us about sourcing shortcuts—using cheaper feedstocks or blended grades. Our position remains clear: even small deviations in purity or moisture alter the process conditions, set off unexpected product behaviors, and lower end-product value. For sectors dependent on certifications or long qualification cycles, a supply-chain hiccup in raw materials can halt production for weeks. Regular third-party audits and complete openness about supply chain sources minimize disruption risk.

    To date, the majority of our industrial clients require annual site audits, down to level of worker training and packing inspections. We receive their feedback in quarterly reviews, and incorporate both strength and improvement points directly into production planning. This transparency not only maintains regulatory confidence; it builds trust, which translates into multi-year relationships with top-tier customers.

    Environmental Practices and Corporate Responsibility

    Manufacturing imides brings a real set of environmental questions: how to handle byproducts, minimize energy input, and reduce waste. Our plant has made steady progress here, both from customer pressure—particularly from EU-based partners under tighter environmental oversight—and from internal targets. Waste streams rich in N-organics can no longer go to standard landfill, so we installed solvent recovery units that recycle much of the process solvent. Overhead cuts both raw material costs and compliance risk.

    Several years ago, routine discharge tests showed unanticipated side-product traces. This discovery prompted a plant-wide audit, and led to the installation of multi-stage bio-treatment on process water. External agencies now conduct biannual sampling. These efforts bring us not only into compliance, but also in line with the expectations of responsible buyers, who increasingly ask to inspect environmental metrics.

    Energy management counts for both cost control and decarbonization efforts. By shifting to closed-loop heating for cyclization reactors, and substituting a fraction of grid energy for onsite solar, we have reduced process emissions over 12% since the program’s launch. Staff at our main facility receive regular education on chemical storage best practices, spill containment, and waste segregation, each step guided by learnings from both internal incidents and customer inspections.

    Ongoing Research and Development in Butanimide Chemistry

    While the fundamentals of Butanimide synthesis are established, we continuously investigate alternatives that promise better yields, lower impact, or improved product performance. Collaboration with university groups has brought incremental improvements in reaction time and selectivity. In one ongoing project, we are evaluating novel catalysts that could lower required temperatures and cut energy input. Although pilot results are promising, scaling to production batch sizes takes time—a reality accepted by both our leadership and partners waiting for cost and environmental gains.

    On the analytical front, newer techniques in gas and liquid chromatography, along with mass spectrometry, have enhanced our ability to spot trace-level contaminants. These advances let us catch drift early, reducing risk and lowering the threshold for preventive maintenance. Our approach to R&D balances incremental progress with clear return on investment. Direct feedback from end users shapes these priorities. When formulators hint at pain points—such as unwanted color pickup or variable viscosity in downstream blends—these observations go straight to our development chemists for action.

    From time to time, regulatory changes or user demand prompt new product versions. For specific customers, we have manufactured custom grade Butanimide with targeted impurity profiles. If a customer’s process requires an ultra-dry version, or if trace elements must stay below certain thresholds, small-batch production and parallel QA lets us respond directly to those requests.

    Building Partnerships Through Technical Support

    Shipments leave our plant with more than just a Bill of Lading. Technical support forms the backbone of every serious supply partnership. Most users—particularly in specialist sectors like battery materials or advanced coatings—encounter unfamiliar issues at some point. Our technical team regularly travels to customer sites to troubleshoot process problems, identify contamination sources, or help optimize their equipment. This boots-on-the-ground experience informs both how we produce Butanimide, and how we advise its use in novel manufacturing environments.

    A few years back, one electronics manufacturer ran into an unexpected impurity showing up after a process change. Joint troubleshooting uncovered a non-obvious batch-handling error, and led to a switch in their storage practices, eliminating the issue. By working alongside both process engineers and QA analysts, solutions arrive faster and usually stick. Based on cumulative experience, technical handover meetings before initial deliveries have cut start-up time and reduced consumables waste in customer facilities.

    Training sessions for customer operators—focused on safe drum handling, batch verification, and transfer protocols—limit avoidable mistakes. Our team shares both the reasoning behind each best practice and anecdotes about incidents from the field, making training memorable and context-specific.

    Addressing Supply Chain Disruptions and Fluctuating Demand

    Chemicals like Butanimide often flow through global supply chains, sensitive to raw material swings, labor constraints, and transit disruptions. We manage these pressures by maintaining strategic safety stocks at multiple sites, and by contracting forward supply for key inputs. During pandemic-related slowdowns, we prioritized supply continuity for long-standing customers, sometimes pulling material from reserve tanks built for exactly these scenarios.

    Some buyers attempt to hedge against market swings by sourcing from multiple traders or spot-buyers, only to encounter out-of-specification product or delayed shipments. Direct sourcing from a consistent manufacturer like us generally avoids these pitfalls. By mapping supply chain exposures, engaging with primary suppliers on rolling forecasts, and flagging transit risks early, we’re able to adjust batch size, change shipping routes, or accelerate production when customer projects require faster turnarounds.

    We invite customers to share demand projections as far forward as practical. This visibility helps us allocate capacity and avoid unnecessary shortages or surpluses, streamlining both inventory management and delivery timelines.

    Conclusion: The Value of Direct Manufacturer Experience

    Every drum of Butanimide reflects lessons learned—through incident reports, customer feedback, and operational audits. End-use industries depend on chemical manufacturers willing to go beyond the spec sheet, providing assurance not just of quality, but also of predictable supply, transparency, and responsive technical partnership. Over decades, our plant team has converted hard-won experience into day-to-day decisions that benefit every customer relying on BA-234 Butanimide for high-value applications.

    In our business, chemistry means more than molecules. It means careful stewardship of detail, ongoing dialogue with users, commitment to quality, and readiness to adapt as both market and scientific frontiers evolve. Those making a switch to Butanimide for the first time—their formulations, their operators, their customers—all benefit from a direct working relationship with people who know the chemistry from the inside. Our doors remain open to new questions, new challenges, and new possibilities for hands-on progress in specialty manufacturing.