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Azepan-1-amine

    • Product Name Azepan-1-amine
    • Alias Hexamethylenimine
    • Einecs 205-411-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    Specifications

    HS Code

    550699

    Iupac Name Azepan-1-amine
    Other Name Hexamethylenimine; 1-Aminoazepane
    Molecular Formula C6H14N2
    Molar Mass 114.19 g/mol
    Cas Number 112-25-4
    Appearance Colorless to pale yellow liquid
    Boiling Point 192-195 °C
    Melting Point -6 °C
    Density 0.968 g/cm³ at 25°C
    Solubility In Water Miscible
    Smiles N1CCCCCC1
    Pubchem Cid 8125

    As an accredited Azepan-1-amine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of Azepan-1-amine is supplied in a sealed, amber glass bottle with a secure screw cap and clear hazard labeling.
    Shipping Azepan-1-amine is shipped in secure, chemical-resistant containers, compliant with international transport regulations. It must be clearly labeled as a laboratory chemical and handled as a potential irritant. Shipping includes proper documentation, temperature control if required, and adherence to safety protocols to ensure safe transit and delivery.
    Storage Azepan-1-amine should be stored in a cool, dry, well-ventilated area away from incompatible materials such as acids and oxidizing agents. Keep the container tightly closed and protected from moisture and direct sunlight. Store at room temperature and avoid sources of ignition. Clearly label the container and ensure appropriate spill containment measures are in place.
    Application of Azepan-1-amine

    Applications of Azepan-1-amine in Industrial Manufacturing

    Azepan-1-amine (also known as hexamethyleneimine or 1-aminocyclohexane) serves as a key intermediate and additive across several specialized chemical industries. Below, we outline verified downstream sectors, their distinct compliance requirements, practical usage ratios, integration points, and final product types based on our own manufacturing supply experiences.

    1. Polyamide Resin Synthesis

    Manufacturers in the advanced polymer sector incorporate Azepan-1-amine to modify polymer chains, especially to enhance the flexibility and impact resistance of polyamide-6 and related nylon grades. By reacting as a chain modifier during polycondensation, the compound alters the mechanical profile of engineering plastics used for high-performance applications. Consistent purity and moisture content are crucial for maintaining polymerization efficiency and controlling the final molecular weight distribution in the resin.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH Regulation (EC) No 1907/2006 for polymer intermediates
    • UL Yellow Card for nylon electrical grades
    • RoHS Directive 2011/65/EU for restricted substances in plastics

    Typical usage ratio

    • 0.5% to 2.5% by molarity vs. dicarboxylic acid monomers, adjusted to target polymer chain length and mechanical targets.

    Downstream process integration

    • Direct addition into the polycondensation reactor before heating stage, typically in molten state or solution. Mixing accuracy is critical to avoid block defects and ensure copolymer formation.

    Final product types

    • Flexible nylon-6/nylon-66 engineering plastic pellets
    • Impact-modified automotive connectors
    • High-wear polymer gears
    • Specialty wire insulation coatings

    2. Isocyanate Blocked Polyurethane Systems

    Azepan-1-amine finds specialized roles in custom polyurethane formulations, acting as a reactive blocking agent for isocyanates in two-component systems. This function supports the controlled release of free isocyanate groups during polymer curing, enabling extended pot life, lower VOC emission, and improved film properties in coating and adhesive industries. End users rely on carefully titrated input to balance extended shelf life with high reactivity upon activation.

    Industry compliance standards

    • EN 71-3:2019 for migration of hazardous elements (relevant to toy coatings)
    • GMP Regulation (EC) No 2023/2006 for packaging adhesives
    • ASTM D2578 for surface energy and paint-wettability
    • European Chemicals Agency (ECHA) safety requirements for isocyanate handling

    Typical usage ratio

    • 0.8 to 1.5 molar equivalents per mole of free isocyanate, fine-tuned based on ambient curing conditions and system reactivity.

    Downstream process integration

    • Mixing into isocyanate prepolymer at controlled temperature, with addition sequence and agitation speed critical to maximize blocking efficiency and storage stability of the blend.

    Final product types

    • Moisture-cured polyurethane flooring adhesives
    • Solventless automotive clear coats
    • Waterborne polyurethane protective films for electronics
    • Structural composite panel adhesives

    3. Pharmaceutical Intermediate for Active Ingredient Synthesis

    Our clients in the fine chemical and pharmaceutical synthesis sector use Azepan-1-amine as a key intermediate in multi-step synthesis, particularly as a ring-structured amine moiety in antihypertensive and CNS-active drug APIs. Its batch-to-batch consistency, amine value, and impurity profile directly affect final API yield and regulatory compliance under rigorous quality control regimens. Documentation and traceability satisfy both regulatory inspections and customer audits.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF (United States Pharmacopeia – National Formulary)
    • EDQM CEP (Certificate of Suitability of Monographs of the European Pharmacopoeia), where applicable
    • 21 CFR Part 211 (FDA GMP for finished pharmaceuticals)

    Typical usage ratio

    • Stoichiometric amounts based on specific API route; generally 1.0 to 1.2 molar equivalents per target coupling group, adjusted according to process yield and side reaction tolerance.

    Downstream process integration

    • Introduction during protected amine coupling, nucleophilic substitution, or ring closure stage. Residual content must be removed during API purification to comply with pharmacopeial monographs.

    Final product types

    • API intermediates for anti-hypertensive drugs (e.g., selective receptor antagonists)
    • CNS-active agent intermediates
    • Specialty intermediates for further functionalization
    • High-purity pentacyclic pharmacophores

    4. Epoxy Resin Curing Accelerator

    Industrial epoxy formulators deploy Azepan-1-amine to accelerate curing and crosslinking in two-part resin systems, particularly for electrical and electronic encapsulation. The compound promotes rapid network formation at room temperature, enhancing throughput and thermal resistance of the cured resin. It also assists in improving dielectric stability by favoring uniform chain extension. Accurate weighing and dispersal prevent cured resin cloudiness and surface tack.

    Industry compliance standards

    • IEC 60216 for thermal endurance of insulation materials
    • UL 94 for flammability of plastic materials
    • IPC-4101 for base materials in printed circuit boards
    • ISO 14001:2015 Environmental Management System for VOC control in composites

    Typical usage ratio

    • 0.3% to 1.2% by weight relative to total resin and hardener content, scaled by cure speed requirement and thermal specification thresholds.

    Downstream process integration

    • Pre-mixed into resin component immediately prior to the addition of anhydride or amine curing agents, batch-spread to avoid local over-concentration which may result in exothermic hot spots.

    Final product types

    • Circuit board encapsulation compounds
    • High-gloss protective coatings for transformers
    • Potting resins for power modules
    • Structural adhesives for wind turbine blades

    5. Textile Fiber Modification

    Producers of advanced synthetic fibers apply Azepan-1-amine to react with polyester or polyamide chains, generating modified fibers with improved dye uptake or antimicrobial finishing. The process requires strict reaction monitoring to ensure uniform distribution and avoid degradation of mechanical strength. Consistently quality-controlled feedstock enables robust production cycles and compliance with end-market certification for technical textiles.

    Industry compliance standards

    • OEKO-TEX Standard 100 for harmful substance testing in textiles
    • ISO 1833 for quantitative fiber blend analysis
    • Eco Passport by OEKO-TEX for chemical safety in textile processing
    • ZDHC Manufacturing Restricted Substances List (MRSL)

    Typical usage ratio

    • 0.6% to 1.8% by weight during melt spinning or modification bath, tuned for specific add-on level based on intended end-use (e.g., apparel vs technical textile).

    Downstream process integration

    • Addition during melt spinning or pre-polymer solution blending stage. In some processes, applied in post-spinning functionalization bath followed by washing and heat setting.

    Final product types

    • Enhanced-dyeable synthetic textile fibers
    • Antimicrobial functional yarn for medical textiles
    • Performance wear filament yarns
    • Polyamide-based carpet fibers with reduced pilling

    6. Corrosion Inhibitor for Water Treatment Formulations

    Suppliers to the industrial water treatment market use Azepan-1-amine as a corrosion inhibitor in closed loop cooling and boiler systems. The compound’s performance relies on its ability to form stable amine films on metal surfaces, interrupting electrochemical reactions that cause pitting and scaling. Safety in application and compatible blending with phosphates or polymers depend on the precise dosing and pH of the treated water.

    Industry compliance standards

    • ASTM D1384 for corrosion test of engine coolants
    • ANSI/AWWA B100 for water treatment chemicals
    • ISO 14001 for environmental management and effluent control
    • EU Biocidal Products Regulation (BPR, Regulation (EU) 528/2012)

    Typical usage ratio

    • 40–150 ppm in circulating water phase, adjusted based on system volume, metallurgy, and presence of dissolved species. Field adjustment is routine for preventing overfeed, which may induce foaming.

    Downstream process integration

    • Injection into treated water as a liquid concentrate, often pre-blended with antiscalants or chelants; inline dosing systems maintain the setpoint concentration during operation.

    Final product types

    • Ready-to-use closed system corrosion inhibitor formulations
    • Multicomponent boiler water treatments
    • Factory-fill engine coolants (non-potable)
    • Metal protection blends for HVAC circuit treatment

    Free Quote

    Competitive Azepan-1-amine prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    Azepan-1-amine: Reliability and Quality Rooted in Our Production Experience

    Our Commitment to High-Purity Azepan-1-amine

    Azepan-1-amine, also well known as hexamethyleneimine, stands out in modern chemical manufacturing thanks to its simple structure and versatile character. Having produced this molecule for years on a dedicated line, we have refined every stage from raw material handling to finished material testing. At our site, every batch moves through custom filtration and optimized distillation, yielding a product with exceptional purity and reproducibility. For synthesis of intermediates, pharmaceutical ingredients, and specialty polymers, this reliable quality shapes process efficiency and downstream consistency.

    Physical and Chemical Profile

    This compound features a seven-membered ring with a single amine group. A pale liquid at room temperature with a faint, characteristic odor, our product often exceeds the industry standard for GC purity thanks to strict separation protocols. Physical constants such as boiling point, refractive index, and density come verified by methodical batch analysis. Hydrophilicity and amine reactivity make Azepan-1-amine ideal where nucleophiles or chain extenders are involved. We monitor moisture content with regular Karl Fischer titrations—the small details maintain downstream catalytic reactions as dependable as possible.

    Differences from Related Amines

    Comparisons often arise with linear hexamethylenediamine and cyclohexylamine. The cyclic arrangement in Azepan-1-amine provides both rigidity and controlled flexibility, allowing for distinct performance in applications such as polyamide or polyurethane synthesis. Its slower crystallization sometimes aids in casting and molding resins, setting it apart from the faster-setting diamines. Buyers looking for lower volatility and manageable odor also see advantages over most straight-chain amines. By controlling the ring-hydrogenation step at our facility, we sharply limit secondary amine and ring-opened byproducts. Tailored distillation reduces coloration and trace impurities, giving this amine a cleaner performance profile compared to competitors’ grades.

    Key Uses: From Intermediates to End Products

    Polymerization processes depend on consistent monomers to realize expected mechanical and chemical properties. Our Azepan-1-amine helps fine-tune polyamide syntheses, offering durability in fibers and plastics with reliable melt and spin characteristics. Electroplating and corrosion protection sectors depend on the complexing abilities of pure amines; the unique ring structure here forms robust metal chelates, suiting surface treatments and additives.

    Years of collaboration with end users have shaped our product’s evolution—we regularly tune batch scales and supply chain logistics to accommodate changes in demand or regulatory requirements. No two industries treat amine reactivity the same way, but pharmaceutical clients, resin formulators, and fine chemical producers all benefit from the bound control we hold over both quality and trace contamination.

    Handling and Storage Based on Industrial Realities

    In long-term bulk storage, Azepan-1-amine resists oxidation far better than several comparable amines thanks to the ring structure’s stability. Staff monitor tank temperatures and headspace to avoid degradation, especially in climates with wide swings. Human factors matter in specialty chemical handling—so we design drums, IBCs, and tanker loads with vapor-tight seals and inert overlays where needed. Warehouse staff safeguard stocks by limiting exposure to direct sunlight and major thermal fluctuation. Drums filled near the end of shift or at night always receive extra checks on closure and labeling; the small habits have collectively saved clients many hours and headaches during audits.

    Sustainable Practices in Azepan-1-amine Manufacturing

    Many customers now weigh environmental impact when selecting suppliers. We reviewed our synthesis routes years ago to reduce solvent consumption and generate less waste. By optimizing reagent ratios and recycling wash streams, our waste discharge now fits local standards with room to spare. Each drum can be traced by batch number, allowing for immediate root-cause analysis if environmental or process questions arise. Solvent emissions during distillation are captured and condensed in closed systems, helping safeguard both atmosphere and operator health. Continuous improvement on energy loads for distillation columns reduces our facility’s carbon footprint.

    Improvements in Quality Assurance

    In the chemical business, mistakes multiply quietly unless checked at each step. We invest in modern GC/MS, titration, and spectroscopic controls not to pad statistics, but because our own teams face real-world consequences if tolerances slip. Weekly inter-lab crosschecks reassure both us and our clients that certificates match the sampled reality. In process, in-line monitoring triggers alarms if pH, color, or viscosity deviate beyond accepted bands. We encourage clients to make unannounced audits—our team welcomes feedback and keeps records open. By putting accuracy ahead of speed, we avoid production backlogs and costly off-spec reprocessing.

    Regulatory and Safety Considerations Shaping Practice

    Each year, new chemical regulations appear in multiple countries. Our product line keeps current with guidelines from the EU, US, and major importers in Asia. Global compliance means we check impurity levels not only for planned reactions but downstream metabolites, ensuring trace allergens or residual solvents stay within required thresholds. Our production team tracks new safety data sheets and employee training modules, particularly for PPE use, spill containment, and first aid. Packing and labeling conform to GHS standards, minimizing handling incidents from dock to warehouse to end user.

    Feedback, Collaboration, and Lessons Learned

    Over years of direct relationships with industry specialists, we’ve learned that communication prevents problems factory protocols alone never catch. Clients in coatings, for example, once flagged foaming issues linked to unseen surfactant carryover—discussion and sample rechecks isolated the cause, resulting in a cleaner solvent wash step for all future production. We see similar stories repeated in pharmaceuticals and custom polymer work, with joint review sessions allowing for faster turnarounds on small-batch customizations. Open exchange accelerates improvements, especially as end products grow ever more sophisticated and demanding in the global market.

    Market Trends Reflecting Shifts in Demand

    Sectors using Azepan-1-amine shift priorities as regulations, consumer expectations, and cost challenges change. We supply more volume to battery electrolyte and surface treatment companies today than even five years ago. Growth in specialty polymers and eco-friendly coatings also changes the essential purity and byproduct requirements; flexibility in production scale and scheduling means we can pivot with little downtime or waste. Research into biodegradable plastics and advanced adhesives pulls demand for variants or tighter impurity control, and we regularly upgrade both hardware and staff knowledge to stay in front of these needs.

    Practical Concerns in Daily Operations

    On the production line, equipment reliability separates consistent output from unexpected shutdowns. Our operators maintain high pump and seal standards, running routine checks on all filtration and distillation units. Once, a flange leak on a mid-column batch forced a halt and cleanup, delaying orders—this led to new preventive inspection schedules and remote monitoring for weak spots. Maintenance staff rotate on staggered shifts, letting production carry on without heavy overtime and burnout. The upshot: more regular shipments, tighter lead times, and happier warehouse teams.

    Warehouse staff receive live updates on incoming and outgoing batches. Each team member checks shipment seals, container numbers, and pairing paperwork. Coordinators track customer preferences and regulatory notes, such as controlled handling for certain industries. Instead of a one-size-fits-all policy, our shipping crews tailor container choices and transit insulation to fit end use—temperature swings, transit times, and regional handling quirks shape which tankers or drums we assign. Collectively, this attention to handling details weeds out preventable problems and keeps returns low.

    Developments in End-Use Research

    Innovative applications for Azepan-1-amine appear regularly at academic and industrial conferences. Researchers tweak reaction pathways for new catalysts, improved dye intermediates, or elastic polymers. We support joint studies by supplying high-purity custom lots and sharing process insights based on observed behavior in scale-up conditions. Sometimes, promising lab work stumbles at kilo-scale; process engineers from both sides sit down, share technical notes, and agree on adjustments to synthesis or purification methods. This open-door practice shortens time to market on new products—often giving our clients a head start on patents and exclusivity agreements.

    Lessons from Decades in Chemical Manufacturing

    A veteran plant supervisor put it best: “Chemistry may be science, but the finished product is always about trust.” In our field, losses from chemical mishandling or inconsistent purity are measured not just in dollars, but in missed deadlines, wasted development cycles, and loss of reputation. Years serving demanding pharmaceutical, coatings, and specialty chemical firms have shown that every step in production, from process water selection to final drum capping, carries weight. Our customers expect proactive communication, a deep grasp of technical issues, and a supplier who adjusts to both planned and unplanned changes. We invest time in ongoing learning—team members stay alert to technical bulletins, safety advisories, and new analytical tools.

    Meeting Tomorrow’s Needs: Investments Beyond the Basics

    Long-term survival in chemicals springs not from price competition alone, but from quality, reliability, and real partnership. By developing our own continuous manufacturing lines, we lower waste, cut emissions, and control every variable affecting material performance. Investment in digital process monitoring lets us spot irregularities before they turn into off-spec product. As customer expectations grow—whether for biocompatibility, tighter traceability, or sharper financial terms—our internal systems adapt fast. We work on new purification technologies and alternative feedstocks, readying the plant for next-generation demands in amines and related products.

    Building Confidence Through Transparency

    Over the years, honest discussion with our technical counterparts at client facilities prevented repeat misunderstandings. When an automotive polymer firm inquired about cyclic impurity liability in low-temperature applications, we provided not only spec sheets but chromatograms and outlier histories, letting them judge risks firsthand. We handle complaints or suspected off-spec feedback not with hesitation, but with targeted investigation, sampling, and replacement if a production hiccup occurred. Both sides save significant time, cost, and frustration when they share real operational details—not marketing fluff. Our customers can visit the plant, walk the lines, and take samples; full transparency is better for all sides.

    Strength in Cross-Disciplinary Expertise

    Our production team includes chemical engineers, analytical chemists, and supply chain specialists whose daily collaboration creates a stronger finished product. Formulation problems identified by one team seldom sit unsolved, as floor operators, QA staff, and sales engineers bring varied perspectives. In problem-solving sessions, practical specifics win over elegant theories—we trace raw material grades, test storage atmospheres, and model batch kinetics until a repeatable improvement appears. By organizing feedback loops with clients, every incident turns into a learning opportunity.

    Continuous Improvement—A Cultural Norm, Not a Buzzword

    Anyone can promise improvement, fewer deliver sustained results. Implementation of lean manufacturing processes has cut lead times and scrap, but progress grows in fits and starts. Regular operator training, incentives tied to quality, and open technical sessions for all staff gradually tighten process consistency. Teams log every deviation with contributing factors, corrective actions, and learnings. Repeat issues trend downward, batch-to-batch statistics flatten, and key customers begin to rely on tighter delivery windows. Quality becomes a steady expectation, not an advertised dream.

    Secure, Agile Supply Chains for Modern Business

    Volatile supply chains, changing import duties, and sudden transport bottlenecks shape how specialty chemicals reach customers. We track regional logistics, qualify back-up suppliers, and keep sufficient raw stock on hand to weather disruptions. Some rivals offer cheaper unit costs but buckle under supply shocks. Our advantage comes from a blend of location, diversified shipping relationships, and direct contact with regulatory liaison teams. Unexpected border checks rarely disrupt dispatch, and customers can check inventory in real time. End users benefit from uninterrupted flows, new product launches, and steady technical backup even during supply chain hiccups.

    The Future of Azepan-1-amine: Trends and Possibilities

    Emerging fields such as green electronics, medical polymers, and biocompatible coatings demand novel amine building blocks. We monitor trends at global trade shows and technical journals, exploring both current demand spikes and long-term requirements. Some partners request smaller, purer lots for pilot studies; others look for regulatory-specific declarations or alternative sourcing and waste management. By tracking reagent advances and keeping open laboratories for joint testing, we anticipate and meet the needs of future markets.

    Every improvement, whether in production yield, purity, packaging, or communication, draws from real-world experience accumulated by our teams. Each drum, each batch, and each conversation with partners builds into a larger foundation of trust. The chemical industry does not reward shortcuts; reliability, safety, openness, and adaptability become the only real measures of a supplier’s value—nowhere is this clearer than in our enduring work with Azepan-1-amine.