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acridin-2-amine

    • Product Name acridin-2-amine
    • Alias 2-aminoacridine
    • Einecs 218-760-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    Specifications

    HS Code

    157158

    Iupac Name acridin-2-amine
    Molecular Formula C13H10N2
    Molar Mass 194.23 g/mol
    Cas Number 613-22-7
    Pubchem Cid 83734
    Appearance Yellow solid
    Boiling Point 430.3°C at 760 mmHg
    Melting Point 149-152°C
    Density 1.26 g/cm³
    Solubility In Water Slightly soluble
    Smiles C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2N
    Inchi InChI=1S/C13H10N2/c14-13-8-7-11-10-5-2-1-4-9(10)6-3-12(11)15-13/h1-8H,(H2,14,15)
    Synonyms 2-Aminoacridine

    As an accredited acridin-2-amine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 10 grams of acridin-2-amine; labeled with hazard warnings, purity, lot number, and storage instructions.
    Shipping Acridin-2-amine should be shipped in tightly sealed containers, protected from light and moisture. It should be packaged according to standard regulations for chemicals, ensuring it is clearly labeled and accompanied by the appropriate safety data documentation. Transportation should adhere to all relevant local and international hazardous material shipping guidelines.
    Storage **Acridin-2-amine** should be stored in a tightly sealed container, away from light and incompatible substances such as strong oxidizers. Store it in a cool, dry, well-ventilated area, ideally at room temperature. Ensure proper labeling and keep away from sources of ignition. Use chemical-resistant storage cabinets designated for hazardous organic compounds if available.
    Application of acridin-2-amine

    Applications of Acridin-2-amine in Industrial Manufacturing

    Acridin-2-amine, produced in-house under stringent quality management systems, serves as a specialty intermediate for several high-value industrial and scientific downstream sectors. Our expertise supports clients in regulated markets by providing material with consistent quality and documented traceability. Below, we detail the established industrial use cases, highlighting technical integration details for each application scenario.

    1. Active Pharmaceutical Ingredient (API) Synthesis — Antimalarial and Anticancer Drug Manufacturing

    Pharmaceutical firms incorporate acridin-2-amine as a key starting material or synthetic intermediate in the targeted synthesis of certain acridine-based APIs, particularly for antimalarial and anticancer drug classes. Production facilities require reliable source traceability, batch-to-batch consistency, and conformance with international pharmaceutical standards. The amine group supports selective amination and condensation reactions, facilitating scaffold construction for final drug molecules.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Part II
    • United States Pharmacopeia (USP) general chapters applicable to starting materials
    • European Pharmacopoeia (Ph. Eur.) for relevant API final monographs

    Typical usage ratio

    • 0.9–1.2 molar equivalents relative to main condensation partners; adjustment based on reaction scale and molecular design

    Downstream process integration

    • Charged into the initial or intermediate synthetic steps (nucleophilic substitution or cyclization), purified as an isolated intermediate before final API assembly

    Final product types

    • Antimalarial APIs (e.g., derivatives structurally related to amodiaquine)
    • Acridine-based anticancer drug precursors

    2. Fluorescent Dye Synthesis for DNA/RNA Analysis

    Genomics laboratories and specialty chemistry manufacturers employ acridin-2-amine as a precursor in the large-scale synthesis of fluorescent intercalating dyes used in nucleic acid detection assays. Processors require analytical-grade purity and low background impurity levels to ensure dye signal specificity and safety in downstream diagnostic use. The material enables the controlled synthesis of mono- and di-substituted acridine fluorophores through selective amine functionalization.

    Industry compliance standards

    • ISO 13485:2016 (Medical device quality management for diagnostic reagents)
    • OECD Good Laboratory Practice (for reagents used in clinical research)
    • REACH Regulation (EC 1907/2006) registration as a chemical intermediate

    Typical usage ratio

    • 1.0–1.5 equivalents per target dye; depends on fluorophore synthesis route and efficiency of side-chain modification

    Downstream process integration

    • Integrated at the amide coupling or direct aromatic substitution stage in dye molecule assembly, followed by chromatographic purification and formulation with buffer systems

    Final product types

    • DNA intercalating stains for electrophoresis gels (e.g., acridine orange derivatives)
    • Fluorometric assay kits for laboratory RNA/DNA visualization

    3. Anti-Corrosion Additive Manufacture for Industrial Lubricants

    In the specialty lubricants and hydraulic fluid sector, chemical formulators utilize acridin-2-amine as a precursor in the synthesis of certain anti-corrosion additives designed for severe industrial environments. The compound, after functionalization, introduces nitrogen-based coordination centers that bind metal ions, helping to prevent oxidative wear and surface corrosion in heavy equipment.

    Industry compliance standards

    • ASTM D665 - Standard Test Method for Rust-Preventing Characteristics of Inhibited Mineral Oil in the Presence of Water
    • ISO 15380 (lubricants, industrial oils, and related products — Determination of anti-corrosion properties)
    • REACH compliance for lubricant additives

    Typical usage ratio

    • 0.05–0.15% by weight in final lubricant blend; varies according to fluid system composition and required corrosion resistance performance

    Downstream process integration

    • Introduced during additive package synthesis, then formulated with base oils and secondary inhibitors in blending vessels; subjected to QC for solubility and long-term stability in finished lubricants

    Final product types

    • Anti-corrosion hydraulic fluids for metalworking machinery
    • Metal-preserving lubricants for industrial transmission systems

    4. Specialty Polymer Synthesis for OLED Materials and High-Performance Coatings

    Advanced materials manufacturers integrate acridin-2-amine in the synthesis of specialty monomers required for optoelectronic polymer production, such as organic light-emitting diode (OLED) emitter layers. The aromatic amine functionality allows for precision control during polymer backbone construction, imparting charge-transport and electron affinity characteristics essential for device performance. Downstream operators require reliable supply for batch and continuous-flow synthesis, alongside electronic-grade purity documentation.

    Industry compliance standards

    • IEC 62341-5-1 for OLED devices (component materials requirements)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances in electrical and electronic equipment)
    • ISO 9001:2015 for quality consistency in specialty polymer synthesis

    Typical usage ratio

    • 5–20 mol% relative to monomer feed for co-polymerization; proportion adjusted based on emission wavelength and charge-transfer targets

    Downstream process integration

    • Fed into automated polymerization reactors for solution or solid-phase synthesis, followed by isolation and purification prior to film casting or ink formulation

    Final product types

    • Emitter layers in OLED display panels and lighting modules
    • Conductive polymer coatings for flexible electronics

    5. Analytical Reagent Production for Environmental and Clinical Testing

    Analytical laboratories and diagnostic kit manufacturers rely on acridin-2-amine to prepare specialized reagents used in colorimetric and fluorometric detection of environmental pollutants or clinical markers. Its aromatic structure and amine functionality enable derivatization for selective analyte detection in aqueous and organic matrices. Customers demand lot-to-lot reproducibility and strict documentation for analytical method validation.

    Industry compliance standards

    • ISO 17034:2016 (General requirements for competence of reference material producers)
    • ISO/IEC 17025 (Testing and calibration laboratories accreditation)
    • EPA Method 8310 for Polycyclic Aromatic Hydrocarbons (when used as a standard or labeling agent)

    Typical usage ratio

    • Concentrations vary from 1–100 μg/mL in analytical preparations; determined by detection sensitivity and matrix complexity

    Downstream process integration

    • Employed at the reagent synthesis step for derivatization or as a part of labeling solutions; formulated and aliquoted under controlled conditions to ensure shelf stability and performance

    Final product types

    • Analytical reagent kits for environmental contaminant detection
    • Clinical markers and test strips for laboratory assays

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    Certification & Compliance
    More Introduction

    Acridin-2-amine: Built for Technological Progress

    Genuine Chemical Expertise Behind Acridin-2-amine

    From the start of our journey in fine chemical manufacturing, we’ve taken pride in building real products that serve practical scientific needs. Acridin-2-amine exemplifies this philosophy. Our teams control the full process in our own facilities—from initial synthesis up through purification and final packaging. By handling every stage, we keep quality squarely in our hands, learn from each production run, and fine-tune methods that deliver a consistent crystalline material.

    On the site floor, our chemists push for both efficiency and purity through methods earned from decades of hands-on tweaking. We don’t just follow an abstract standard. Instead, we dive into the actual conditions, running repeated pilot productions, learning how small variations—like time, reagent source, pH, or temperature—can impact the formation of acridin-2-amine’s key aromatic structure. With careful distillation and recrystallization driven by real data, we’ve shaped a robust method for achieving reliable product grade.

    Acridin-2-amine’s unique structure—a fused tricyclic ring system, amino group at position two—means the compound draws interest from many fields. Our batches meet specifications regular researchers trust, achieving low levels of related impurities. High-purity, bright yellow needles form the hallmark of our most recent lot, matching published melting points without deviation and tested for trace metal content. Spectroscopy and chromatography results tell the story of how tight our controls are. That confidence comes from years of lab work, factory troubleshooting, and direct customer feedback.

    Real-World Use: What Acridin-2-amine Solves

    The research landscape keeps shifting, and new ideas call for reliable building blocks. Acridin-2-amine supports both classic and emerging inquiries in photophysics, organic electronics, and medicinal chemistry. The fused acridine scaffold forms a base for developing DNA intercalators, potential anticancer agents, and photoluminescent dyes. Academic groups and industrial innovators pick up acridin-2-amine when they need a nitrogen-rich, conjugated core for fine-tuning molecular properties.

    From our experience, graduate researchers value our product’s consistency most during reproducibility challenges. A bottle of acridin-2-amine from our line allows side-by-side results in DNA-binding studies and spectrofluorimetric analyses, with batch-to-batch spectral data provided up front. Chemical engineers appreciate the strong amine functionality at the 2-position, which opens further modification routes—whether through acylation, alkylation, or cross-coupling. We’ve seen pharmaceutical partners use our acridin-2-amine in early synthetic paths toward functionalized derivatives, sometimes leveraging its planarity for structure–activity relationship studies. Our product’s physical form handles moisture and moderate storage challenges in the average lab setting without caking, bridging basic lab work and production-scale efforts.

    Users have shared stories of how the crystalline form and particle size distribution cut down extra purification steps. An organic electronics startup pointed out that our acridin-2-amine solved long-standing reproducibility issues in thin-film fabrication for OLED devices. Direct syntheses involving our compound streamline imine and amide coupling, providing authentic, structurally defined intermediates that catalysis researchers crave.

    What Sets Our Acridin-2-amine Apart

    Acridin-2-amine sits among a family of amine-functionalized heterocycles, with small differences in substitution points making a big impact on chemical reactivity. Many traders blend batches or shuffle inventory from unknown facilities, leading to wide purity swings and shifting impurity profiles. By contrast, our plant supervisors oversee every mixing tank, distillation column, and filter—so we can stand behind every lot with real data and history. Customers often tell us they notice fewer unidentified traces in their NMR and HPLC runs compared to material taken off the open market.

    We skip unnecessary handling and repackaging. Direct production, on-site quality checks, and prompt shipping mean fewer unknowns and less degradation along the way. Acridin-2-amine leaves our facility in air-tight, appropriate chemistry-grade containers after a validated series of steps, always accompanied by a real certificate showing the actual batch tests. Our shipping team logs who loaded each dispatch and what day it left the facility, tracing every bottle from synthesis line to user lab.

    In the early years, we fielded many confused calls when outside suppliers mislabeled close analogs—acridin-4-amine or acridin-9-amine—since those isomers look similar under some analytical eyes but act very differently in actual experimentation. We don’t substitute or mask structural differences just to make a sale. Each shipment comes with full spectral confirmation: proton NMR, carbon NMR, FTIR, mass spec, chromatograms, and, when required, full elemental analysis. If there’s a supply challenge—like an irregular growth in industrial or academic demand—our teams run additional quality holding checks to ensure stock integrity, so priority research stays on track across disciplines.

    Acridin-2-amine’s batch color, melting point, and spectral data get checked, saved, and shared with our science-focused customer base. Decades working in heterocycle synthesis taught us how cut corners, like improper washing or inadequate recrystallization, can haunt final products with retention of mother liquors or persistent off-products. Our focus always remains on direct purity and traceability, not just on passing minimum assay labels. Chemists notice subtle differences—odor, texture, solubility shifts, and one-off impurity spikes. We take every feedback loop seriously and fold it back into production for even better results next time.

    Specification Honesty: Why Precision Matters

    In chemical manufacturing, glossing over details on specifications only creates confusion in the lab. Acridin-2-amine’s purity isn’t measured on just one mode; we use a blend of techniques, including HPLC area percentage, trace iron and copper screening, and actual melting range measurement, not just an estimate. Purchasers and researchers receive exact recent batch records, updated each season as we refine our procedure and as new tools join the lab arsenal. Some markets cut corners with “technical grade” materials or blended intermediates. We have seen the knock-on effects: scattered research results, wasted solvents, and hard-to-repeat projects.

    Beyond the strict numbers, we pay attention to how the material handles. Lab workers care if a product flows well, disperses in solvents evenly, or forms clumps after time in storage. Our teams package acridin-2-amine in ways proven through shipping trials and partner labs abroad. Moisture guards, light-protective outer layers, and inert-gas fills keep the material close to its native, just-synthesized state long after it leaves our plant.

    If users find any issue, they don’t run into endless calls to call centers. Customers reach the actual process chemists and QA leads running their own lines, who can explain why a batch varied or how a particular specification links back to a change in upstream supply. These open lines, built on shared problem-solving, matter more than sterile certificates. We base our future improvements on these shared experiences. This deep loop of communication has made acridin-2-amine one of the more trusted options in its molecular family.

    Supporting Future Chemistry: Innovation Roots

    Acridin-2-amine once belonged mostly in libraries of specialized academic chemists hunting for new photophysical effects. That changed as more disciplines recognized how ring-fused amines feed into broad technologies—OLED research, targeted medical agents, and even environmental sensor development. Our own R&D teams run collaborative pilot projects, offering early-access material with expanded characterization, like electrochemical behavior or photoluminescence quantum yields, so customers get data that pushes fields beyond static analytical tabs. Larger industrial partners sometimes ask for tailored batch sizes, or uncommon forms—milled powders, matched-exact particle size, or exotic salt derivatives. We’ve responded by investing in scalable, lower-waste synthesis and nimble drying and sieving lines.

    Many of our improvements come straight from user requests. As researchers began working on acridin-2-amine-labeled biomolecules, we refined our purification steps to eliminate residual mineral acids, making downstream work-up easier. During a push into wearable sensor films, thin-layer deposition teams told us about stray iron traces muddying their photoluminescence. We upgraded feedstock analysis and tweaked our metal-scavenging washes to deliver a near-zero metallic signature. These on-the-ground collaborations move technology forward, and our legacy reflects their success. Each improvement builds collective trust and proves that active, responsive manufacturing can shape a chemical’s real-world story.

    Access to process details—actual chromatographic traces, not just summaries—and rapid turnarounds on questions lets both research startups and established labs compare and challenge our claims. Labs pushing frontier science require more than just a bottle offering a single purity value. They want proof that every batch meets rigorous empirical benchmarks. A recent project in photodynamic therapy called for ultra-low moisture content. We retrofitted vacuum ovens, tracked down atmospheric leak sources, and posted the full test report publically for peer review. Our production is transparent enough for independent audit, and we welcome external review of any given lot.

    Over time, we have seen competitors view batch-to-batch transparency as risk, keeping methods behind closed doors or mixing synthetics from multiple plants. Our culture formed the opposite way, opening the books so users could challenge results and suggest the next improvements. As a result, acridin-2-amine produced here marks a different standard than the generic, repackaged fare that circulates through intermediary markets.

    Differences from Related Products

    The acridine family branches out into dozens of analogs—acridin-4-amine, 9-aminoacridine, N-substituted acridines—and the subtle differences in atomic position drive major functional changes downstream. Acridin-2-amine, with its amine at the 2-position, brings a different electronic effect and ring conjugation, affecting both binding interactions and photophysical properties.

    In real practice, swapping acridin-2-amine for something like 9-aminoacridine can change intercalator-DNA affinity, cytotoxicity, even observed colorimetric response under UV. Lab projects chasing structure–activity relationships need clean, uncontaminated analogs. Some suppliers blend or substitute, causing confusion when batches display unexpected melting points, altered spectral patterns, or new toxicological signatures. We maintain separate, dedicated production lines and keep storage containers segregated by isomer—preventing any cross-contamination from shared equipment or uncleaned glassware. This strict system just makes sense after years watching labs lose weeks of work to subtle chemical switches or poorly labeled supply.

    From a synthetic standpoint, acridin-2-amine’s reactive amine group grants flexibility for follow-up chemistry, like forming Schiff bases or N-acylation partners, while the unique ring location tunes both reactivity and selectivity. Other amines, placed elsewhere on the acridine skeleton, often require different activation strategies or protective group patterns. We share full production logs to distinguish our material clearly from neighboring isomers.

    Our plant history includes direct analog syntheses for major academic partners, and our chemists readily discuss the chemical logic driving reaction condition choices. Users appreciate the fact that our product isn’t just another member of a confusing catalog but stands out for traceability, compound integrity, and empirical, peer-verifiable results. Switching to our acridin-2-amine has led to improved reaction reproducibility, cleaner product formation, and greater downstream successes in diverse research and production lines.

    Challenges Ahead and Opportunities

    While acridin-2-amine supplies have grown thanks to improved technology and scalable synthetic planning, the field keeps evolving. Emerging photonic and biological applications push for even lower impurity levels, and some researchers demand product forms suited for automated handling—fine powders, specific solubilized states, or pre-weighed aliquots. Meeting these needs calls for faster response between lab discoveries and production line upgrades.

    We listen. Each story of a failed PCR due to unintended trace contaminants or a misbehaving fluorescence experiment resulting from a marginal side-product moves us to dive deeper into root-cause analysis. This cycle doesn’t end at QA handoff. Production teams routinely test new cleaning regimes, and R&D shares findings immediately with end users, not just as a courtesy but because better chemistry grows from open collaboration. We invest in new instrumentation (LC-MS, micro-elemental analyzers, environmental chambers) guided by collective user feedback, not just market forecasts.

    In practical terms, this means more flexibility in our logistics and batch production. When industrial clients ask for kilo quantities and academic labs take smaller, micro-batch aliquots, we channel learnings back to formulation and storage so each format fits its real-world use. Unique project requirements affect timelines and shipping—our teams thrive on these creative challenges, tailoring not by cutting corners but by finding truly scalable improvements.

    Responsibility, Safety, and Trust

    Respect for chemical safety stands at the core of our daily routine. We control access, train every handler, and record all batch movement from raw input to finished goods. Real safety grows from discipline, not regulatory paperwork alone. Years of working with sensitive, aromatic amines—the kind prone to light, air, and residual moisture sensitivity—have shaped practices that protect both our people and our partners.

    We refuse shortcuts that put safety second, whether shoving nonstandard packaging into shipment or skipping checks to hit a tight deadline. The plant’s long record of environmental compliance and community trust grew from investing in efficient waste capture, solvent recycling, and direct dialogue with users about chemical management at every stage. If an end user needs application-specific advice, technical leaders offer direct consultation, based on seasoned practice, not just reading from documents.

    By centering the production of acridin-2-amine in a culture that values accountability, from the ground up, we offer more than a bottle. We craft a transparent, traceable route to a compound that supports chemical innovation, industry partnership, and safer science. Feedback received from users—novice researchers, advanced development teams, or industry partners—builds our standards continually higher. Every batch improvement reflects this shared momentum.