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HS Code |
100532 |
| name | Ac-DL-Met-OH |
| synonyms | N-Acetyl-DL-methionine |
| molecular_formula | C7H13NO3S |
| CAS_number | 1115-47-5 |
| appearance | White to off-white powder |
| purity | Typically ≥98% |
| solubility | Soluble in water |
| storage_temperature | 2-8°C |
| SMILES | CC(=O)N[C@@H](CCSC)C(=O)O |
As an accredited Ac-DL-Met-OH factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Ac-DL-Met-OH is supplied in a sealed amber glass bottle containing 25 grams, labeled with product details and handling instructions. |
| Shipping | Ac-DL-Met-OH is typically shipped at ambient temperature and packaged in tightly sealed containers to prevent moisture exposure. It is classified as a non-hazardous, stable compound under normal shipping conditions. Ensure compliance with all relevant local and international shipping regulations when transporting this chemical. |
| Storage | Ac-DL-Met-OH (N-Acetyl-DL-methionine) should be stored in a tightly sealed container at 2-8°C, protected from light, moisture, and incompatible substances. Store in a cool, dry, and well-ventilated area. Avoid exposure to excessive heat and humidity. Ensure proper labeling and segregation from strong oxidizing agents to maintain stability and prevent degradation. |
Applications of Ac-DL-Met-OH in Industrial ManufacturingAc-DL-Met-OH, known as N-Acetyl-DL-Methionine, serves as a specialty amino acid derivative for industrial production. Downstream manufacturers utilize this intermediate in niche biochemical and life science applications that demand precise input control, traceable sourcing, and consistent technical support. Our fully integrated production enables tailored solutions by direct engagement with technical teams at the application development phase. 1. Parenteral Nutrition Solutions in Pharmaceutical ManufacturingPharmaceutical producers use N-Acetyl-DL-Methionine as a sulfur-donor and biologically active ingredient for amino acid mixtures in parenteral nutrition, particularly in formulations necessitating stable methionine analogs for patient safety and regulatory demands. Compounding facilities introduce it into amino acid blends where direct methionine is unsuitable due to stability or compatibility challenges with other ingredients. This input supports precise SO4 content and ensures batch-to-batch nutritional consistency, aligning with stringent hospital and outpatient therapy requirements. Our in-process analytical data supports QC release and facilitates pharmacopoeial submissions across global markets. Industry compliance standards
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2. Cell Culture Media Production for Biotech and Vaccine ManufacturingBiotechnology and vaccine manufacturers incorporate this acetylated methionine into custom and off-the-shelf cell culture media, where it functions as a sulfur-amino acid supply and enhances oxidative stress control in high-density cell cultivation systems. Media formulators choose this derivative for improved solution clarity and reduced byproduct formation compared to DL-methionine. Technical documentation from our site supports regulatory submissions for upstream bioprocesses that require transparency in raw material traceability and performance in living cell environments. Industry compliance standards
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3. Food Additives for Sports and Clinical Nutrition ManufacturingFunctional food and clinical nutrition manufacturers select our N-Acetyl-DL-Methionine as a specialty ingredient for fortified protein blends where direct use of methionine raises flavor or stability concerns. The neutral taste and improved shelf-life enable precise sulfur amino acid fortification in powder and ready-to-drink products targeted to specialized dietary regimes. Regulatory documentation and processing support are available to ease local approval in global food-grade applications. Industry compliance standards
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4. Diagnostic Reagents and Analytical StandardsDiagnostic reagent and in-vitro diagnostics producers use acetylated methionine as a calibration and substrate compound for specialty enzymatic reaction kits and reference standards. This derivative supports enzymatic activity reference, stability controls, and known concentration assays in automated laboratory systems. Our material supports both research-use-only and select in-vitro diagnostic device applications. Industry compliance standards
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At our manufacturing site, we have watched the feed industry evolve over decades. The search for effective methionine sources keeps intensifying as nutritionists and integrators face mounting pressure for both cost control and improved animal performance. Ac-DL-Met-OH, also known as DL-methionine hydroxy analogue, belongs to the family of methionine products but stands apart due to its structure and behavior in feed applications. In practice, the product offers an alternative to traditional DL-Methionine by dropping the ammonium group and replacing it with a hydroxy group, resulting in 2-hydroxy-4-methylthiobutyric acid. The industry also often refers to it as MHA or HMB.
The most common grade of Ac-DL-Met-OH reaches the market as a colorless to light yellow, somewhat viscous liquid, though solid forms are also available. For the liquid version, the active component generally falls above 88%. Purity levels and consistency are crucial because minor deviations can influence how feed mixes store and deliver nutrition downstream, so we commit to strict analytical batch testing. The pH tends towards the acidic side, and the characteristic sulfurous odor signals its stability and freshness. Producers in hot, humid zones often lean on its stability over storage, reporting less caking in bins and smoother conveying than classic methionine powders.
Ac-DL-Met-OH enters premixes easily due to its liquid nature, easing the workload for feed mills that have invested in liquid dosing lines. Many broiler and swine applications take advantage of this, especially where high volumes demand quick, consistent dosing. Mills dealing with frequent dust issues find Ac-DL-Met-OH far more manageable than standard DL-methionine, which tends to raise airborne particulates during handling. To anyone in charge of mill maintenance or working on the line, this reduced dust translates to easier cleaning and fewer stoppages during operation.
From a chemist’s perspective, Ac-DL-Met-OH lacks the amino group, classing it as an analogue, not a true amino acid. The animal gut converts it into active methionine via transamination. This step may sound complex, but decades of research confirm that most commercial poultry and swine species convert the hydroxy analogue efficiently. The difference comes to light with young chicks or high-stress flocks—conversion rates trend slightly lower, so nutritionists sometimes adjust application rates by 6–10% compared to pure DL-methionine. Users gain the upside of slow, steady methionine release, which reduces spikes in plasma methionine levels. Over several production cycles, some integrators have tracked improved protein retention and lower ammonia emissions in litter, especially under high-density growing.
Direct field experience shows Ac-DL-Met-OH diverges from DL-methionine in several key categories. Solubility in water improves logistics for mills operating liquid dosing tanks, as DL-methionine must first dissolve then blend, which may not go smoothly at low temperatures. Ac-DL-Met-OH maintains flow even in cooler conditions, which reduces downtime and protects vital micronutrient blends from uneven mixing. The product comes with a slightly lower methionine equivalence on a per-weight basis—a point confirmed through digestibility trials and metabolic feeding studies across Asia, Europe and the Americas. Those swapping from DL-methionine learn to adjust their dosing based on total sulfur amino acid balance rather than simple gram-for-gram replacement.
Taste and palatability matter in finishing rations, especially for swine and aquaculture. Ac-DL-Met-OH’s lower bitterness compared to the crystalline form of DL-methionine leads to steadier feed intake. This real effect occurs most clearly with sensitive species like weanling pigs or aquatic animals prone to feed refusal under stress. Customers who struggled with intake drops when switching to alternatives find Ac-DL-Met-OH brings relief, especially when intake must remain high and stressors cannot be avoided.
Mills with existing liquid lines generally transition easily into Ac-DL-Met-OH supplementation; we’ve helped on-the-ground teams commission new tanks and dosing pumps. For mills accustomed to scooping DL-methionine powder, introducing a liquid system does require capital—bulk storage, corrosion-resistant pumps, and inline flow meters calibrated for viscous liquids. On the upside, batch uniformity and speed of incorporation improve. We’ve witnessed single-shift teams complete five or more feed runs without stopping for auger jamming or dust control—key points when tight delivery windows and biosecurity limit downtime. For smaller mills, we sometimes recommend tote-based or barrel dosing systems as a middle step, which can be managed even in regions with low automation.
Bulk transportation and storage capacity favor the liquid form of Ac-DL-Met-OH. Tankers move higher product volumes with less packaging waste than palletized bags of crystalline DL-methionine. In our operation, we’ve documented reductions in empty drum disposal and less plastic use as partners opt for reusable tanks and on-site tank farms. On-farm, operators report less packaging debris around feed bins, which streamlines daily operations and reduces labor assigned to rubbish collection—a hidden but real cost for integrators. Product spills or leaks, if managed promptly, tend to be less hazardous than powdered amino acids, as the acid-based liquid breaks down in handling areas, limiting the mess and time needed for containment.
Modern animal agriculture faces high protein demands, coupled with a push to cut excess nitrogen. Ac-DL-Met-OH enables more precise amino acid balancing in rations, allowing diets to reduce crude protein levels while sustaining growth rates and feed efficiency. We’ve seen integrators shift to lower-protein corn-soy formulas yet keep growth targets steady thanks to reliable methionine supply from Ac-DL-Met-OH. This fine tuning extends beyond sheets of nutrient specs—real operators notice less wasted feed protein and report reductions in nitrogen ammonia volatilization from broiler and hog litter. In operations where waste management is under scrutiny, this change brings wider benefits.
From the chemical plant floor to your facility gate, each batch faces tight scrutiny. Methionine content, water balance, acidity, and contamination all receive regular checks, at both process and finished product stages. We run regular audits of raw material supply and chain of custody, minimizing off-spec shipments before they load for tankers or totes. Our labs track both known and trace contaminants—residual solvents and heavy metals—that could accumulate after months of storage or cause problems for sensitive species. Partners who raise organic, antibiotic-free, or premium protein lines lean on our testing to avoid costly recalls or performance slumps due to feed ingredient drift.
Feed makers pursuing antibiotic reduction, specialty protein sources, or niche species appreciate the flexibility built into Ac-DL-Met-OH. Its non-amino acid structure sidesteps some regulatory red tape in certain feed jurisdictions. This opens the door to next-generation formulations, including insect meals, plant concentrates, and fermentation byproducts where the balance of limiting amino acids shifts with each raw batch. Some value-added poultry and swine producers report better consistency when layering Ac-DL-Met-OH on top of complex diets built around alternative grains or non-conventional protein sources.
Not everyone runs a mega-integration or automated mill. Family-run farms and batching sites in humid or tropical regions face their own set of struggles. Ac-DL-Met-OH withstands storage in less-than-perfect barns without turning lumpy or hard, a complaint we field often about DL-methionine in edge-of-field bins. For those handling 50-liter drums in open-air sheds, simple decanting and dilution with water remain straightforward tasks, even with minimum training. Power cuts, temperature swings, and time delays challenge any product, but Ac-DL-Met-OH’s shelf life and physical consistency hold up reliably. All of these points do more than address a spec sheet—they answer the needs voiced daily by people running local feed systems on tight budgets and unpredictable supply chains.
Methionine supplementation forms a vital link in the effort to improve animal health, meat quality, and end-consumer satisfaction. Flocks or herds fed balanced diets with Ac-DL-Met-OH achieve stronger growth, better feathering or hair coat, and fewer bouts of metabolic disease. Some broiler growers highlight the improvement in litter conditions and reduced mortality thanks to steadier amino acid ratios in the ration. Integrators supplying higher-welfare markets or those aiming for global export use Ac-DL-Met-OH to fine-tune their nutrient program, avoiding wide swings tied to ingredient cost spikes. Over time, consistent animal performance lays the groundwork for confidence and traceability down the value chain, sparing both retailers and regulators the headaches that surface when ingredient quality fluctuates.
Ac-DL-Met-OH will continue to play an important part in the movement toward responsible animal protein production. Population growth, climate volatility, and a global emphasis on reducing emissions bring feed formulation into focus in a way not seen before. That spotlight creates challenges—constant pressure to cut cost, enhance animal health, stay compliant, and reduce environmental footprint all at once. In our daily operations, we work closely with nutritionists, mill managers, and integrators to tweak application methods, handle logistics, trace ingredients and manage cost volatility. Adaptations in crop usage, weather-driven volatility and changes in animal genetics keep us on our toes. Success goes to those who can adjust rapidly, and Ac-DL-Met-OH proves its flexibility and reliability across many different systems and conditions.
New product development never stops. Feedback from people actually running feed lines or animal production systems pushes us to keep improving. Whether it is adapting flow properties for local climates, changing packaging to fit upgraded mill layouts, reformulating for stricter residue limits or rolling out more detailed trace analysis, the focus stays fixed on what solves field-level problems. Ac-DL-Met-OH has advanced step by step because operators, integrators, and field nutritionists turned real challenges over to the factory floor and asked for workable answers—not theory, but products that make a difference under actual use conditions.
Having worked with hundreds of feed makers and thousands of end users, we recognize that the selection of a methionine source is rarely a matter of chemistry alone. Every operation presents a mix of labor limitations, cost pressures, logistical twists, and nutrition targets. Ac-DL-Met-OH may not be a fit for every single case, but its strengths—liquid dosing, reduced dust, high shelf life, performance under mixed climate and ingredient regimes—solve day-to-day problems most factories face. Consistent composition, quality control, and trace backing matter not as marketing talk, but as day-to-day operational insurance for the people spending on feed additives.
To stay responsive, we listen to plant managers installing new tanks, integrators shifting to low-protein diets, and nutritionists interpreting growth data. Issues like dosage accuracy, storage stability, and feed palatability yield detailed solutions only by working with the teams who encounter them first. This collaborative feedback loop has shaped how we produce, handle, and deliver Ac-DL-Met-OH. It pushes us to maintain strict process controls, keep our analytical systems updated, and measure batch uniformity as a rule, not a luxury. End results travel far from the factory—whether feeding birds under strict welfare systems or producing pork in nutrient-sensitive watersheds.
Operators sometimes ask about cost-to-benefit ratios, shelf life under real-world storage, or interactions with micro-ingredient blends. Through years of batch data and site visits, we’ve observed that Ac-DL-Met-OH performs steadily through wide swings in ambient temperature and humidity. Real-life pallet storage and dosing logistics confirm reduced waste from caking, faster clean-out, and more straightforward spill management than DL-methionine powder. In mixed-ration plants, the compatibility with trace mineral carriers and enzymes means teams spend less time troubleshooting lost activity or overdosing due to powder separation.
Feed production does not reward complexity for its own sake. Simple, robust procedures win. Ac-DL-Met-OH fits this pattern—easier to dose, less mess, reliable under unpredictable supply or storage conditions, with measurable benefits for animal growth and waste reduction. The product’s journey from synthesis to finished ration rests on years of industrial experience, field testing, and risk management. As a result, the industry sees Ac-DL-Met-OH not for abstract claims but for daily value where it counts—lower operating cost, reduced equipment downtime, and a smoother flow from plant to farm.
Each batch of Ac-DL-Met-OH carries the work and insight of teams dedicated to improving animal nutrition and operational performance. From careful raw material sourcing through final QA, the focus remains practical: deliver a methionine source that supports performance, shelf life, and processing efficiency, standing up to the field-level challenges reported by our customers worldwide. Feed operations choosing Ac-DL-Met-OH gain a practical, flexible, and proven ally in meeting global nutrition challenges both now and into the future.