Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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3-Thiophanone

    • Product Name 3-Thiophanone
    • Alias Thiophen-3-one
    • Einecs 211-568-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    Specifications

    HS Code

    316419

    Iupac Name 3-Thiolanone
    Common Name 3-Thiophanone
    Molecular Formula C4H6OS
    Molar Mass 102.15 g/mol
    Cas Number 2855-20-1
    Appearance Colorless liquid
    Boiling Point 145-147 °C
    Density 1.163 g/cm³
    Smiles O=C1CCCS1
    Inchi InChI=1S/C4H6OS/c5-4-1-2-3-6-4/h1-3H2
    Solubility In Water Low
    Odor Unpleasant, sulfurous
    Refractive Index n20/D 1.521

    As an accredited 3-Thiophanone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25g of 3-Thiophanone, sealed with a tamper-evident cap and labeled with hazard warnings and batch information.
    Shipping 3-Thiophanone is shipped in tightly sealed, chemical-resistant containers to prevent leakage and contamination. It should be stored and transported under cool, dry conditions, away from heat and incompatible substances. Appropriate labeling and documentation are required, and shipment must comply with local, national, and international chemical transport regulations.
    Storage 3-Thiophanone should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Keep the container tightly closed and in a chemical-resistant, labeled container. Store separately from oxidizing agents, acids, and bases. Ensure access to spill control materials and use appropriate personal protective equipment when handling to avoid inhalation or skin contact.
    Application of 3-Thiophanone

    Applications of 3-Thiophanone in Industrial Manufacturing

    3-Thiophanone supports specialized synthesis in the industrial field, primarily as an intermediate for the production of fine chemicals, agrochemical actives, pharmaceutical building blocks, and advanced material monomers. Our manufacturing process targets industry-focused downstream partners with controlled integration to their specific formulation requirements.

    1. Agrochemical Intermediates Synthesis

    Manufacturers in the agrochemical sector apply 3-Thiophanone as a critical intermediate for building sulfur-containing heterocyclic frameworks. It enters the synthesis of crop protection molecules, where ring-opening, alkylation, and sulfidation steps depend on consistent raw material purity. Integrators adjust process steps to target fungicidal, herbicidal, or insecticidal actives, benefiting from our control of elemental sulfur content and trace impurity management throughout the batch.

    Industry compliance standards

    • REACH Regulation (EC) No. 1907/2006 – Europe
    • US EPA 40 CFR Part 158 – Data requirements for pesticides
    • China GB/T 31270 Agrochemical Manufacturing Guidelines
    • ISO 9001:2015 Quality Management

    Typical usage ratio

    • Range: 5–15% (w/w) of total reaction mass in precursor synthesis
    • Adjustment according to target pesticide molecule and reaction pathway

    Downstream process integration

    • Initial condensation or cyclization during active ingredient synthesis
    • Sulfur heterocycle introduction during functionalization steps
    • Batch or continuous flow reactions in pilot and production plants

    Final product types

    • Dithiine- and thiophene-based herbicides
    • Sulfur-containing fungicides
    • Specialty insecticide intermediates
    • Downstream agro technical concentrate (TC) formulations

    2. Pharmaceutical API Intermediate Manufacture

    API producers use 3-Thiophanone to introduce defined sulfur analogues in the synthesis route for select small molecule drugs and research actives. Its carbonyl-thiophene structure enables precise control of pharmacophoric modifications during process R&D and scale-up. Regulatory-driven specifications for residual solvents, trace metals, and isomer content are maintained under GMP-related quality routines. Our materials support reliable production of advanced intermediates moving into FDA- and EMA-audited environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for APIs
    • 21 CFR Part 211 – US cGMP for Finished Pharmaceuticals
    • European Pharmacopoeia Monographs (Ph. Eur.)
    • USP General Chapters <231> and <467> (Elemental Impurities and Residual Solvents)

    Typical usage ratio

    • Commonly 2–8% (w/w) at coupling and derivatization stages
    • Ratio depends on reaction scale, yield targets, and regulatory limits on impurities

    Downstream process integration

    • Employed at intermediate formation under anhydrous or controlled-atmosphere conditions
    • Entry at carbonyl functionalization, ring extension, or heteroatom substitution
    • Routinely feeds into multistep purification and crystallization lines

    Final product types

    • Small-molecule active pharmaceutical ingredients (APIs)
    • Sulfur-modified research intermediates
    • Reference standards for preclinical and clinical trials
    • Synthesis building blocks used in discovery pipelines

    3. Aroma and Perfume Ingredient Manufacturing

    Specialty fragrance and aroma chemical manufacturers apply 3-Thiophanone to introduce sulfur-containing undertones in high-value formulations. The compound provides a distinctive savory, earthy base for use in complex aroma profiles, contributing functional notes in both fine fragrance and food-adjacent compositions (where regional regulatory allowance exists). Stringent controls on residual aroma-active impurities, odor threshold uniformity, and batch-to-batch olfactory consistency are implemented per IFRA and flavor ingredient requirements.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association)
    • EU Regulation 1223/2009 (Cosmetic Products)
    • FEMA GRAS status for certain aroma applications (US only, subject to application and use restrictions)
    • ISO 9235: Natural Aroma Chemicals (Supporting documentation required for synthetic origin)

    Typical usage ratio

    • Trace levels: 0.01–0.1% (w/w) in top-end perfume bases
    • Some specialized flavors: up to 0.03% (subject to local flavor regulations and toxicological limits)

    Downstream process integration

    • Added during base note blending and flavor compounding
    • Nitrogen-blanketed mixing to prevent oxidation
    • Assayed by GC-Olfactometry for sensory alignment

    Final product types

    • Luxury and fine fragrance bases
    • Complex savory flavor formulations (in accordance with local regulatory clearance)
    • Specialty aroma isolates for analytical standards
    • Natural-analog blended olfactory ingredients

    4. Advanced Polymer and Material Monomer Sourcing

    Specialty polymer producers use 3-Thiophanone as a controlled monomer and as a scaffold for engineering thiolate-based copolymers. The compound supports targeted synthesis for antistatic coatings, optical fiber matrices, and electronic conductive polymers. Integration into polymerization processes requires strict moisture and temperature control, as well as low halo-organic contamination, to safeguard final polymer performance properties. QC teams apply online monitoring of conversion efficiency and end-group fidelity.

    Industry compliance standards

    • ISO 9001:2015 (Polymer and Chemical Production)
    • RoHS Directive 2011/65/EU (for electronics-related polymers)
    • REACH Annex XIV/Annex XVII (Monomer usage in EEA)
    • ASTM D6290 (Polymer Characterization by NMR)

    Typical usage ratio

    • As copolymer feedstock: 2–12% (m/m) in thiophene or polythioether polymerizations
    • Monomer percentage is adjusted for desired final conductivity and mechanical properties

    Downstream process integration

    • Introduced at initiation of polymerization (bulk, emulsion, or solution)
    • Combined with vinyl or aromatic ring monomers for specialty material synthesis
    • End-point analysis by molecular weight and conductivity measurement

    Final product types

    • Antistatic coatings
    • Polymer-based electronic and optoelectronic materials
    • Specialty film and fiber matrices for industrial use
    • Sulfur-doped synthetic resins

    Free Quote

    Competitive 3-Thiophanone prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 3-Thiophanone: Meeting Real-World Demands in Fine Chemical Manufacturing

    What Sets Our 3-Thiophanone Apart

    Every year, the landscape for specialty chemicals shifts to meet expectations in pharmaceutical research, agrochemicals, and advanced materials. Our 3-Thiophanone, crafted with care in tightly controlled batch reactors, addresses this demand at its core. Over two decades of hands-on production experience has revealed real market gaps many overlook, from purity assurance to reliable batch-to-batch consistency. Our technical team remains on the production floor, running purification columns, managing critical temperatures, and reviewing analytical output — not just at a desk but in the thick of the process. This direct engagement means we pick up even the subtlest deviation before a batch reaches shipping.

    We supply 3-Thiophanone with a standard assay over 98%, verified by high-performance liquid chromatography and confirmed by NMR spectroscopy. Unlike generic or resold materials flooding secondary markets, each lot undergoes full qualification before release. Contaminants such as thiophene, sulfur dioxide, or excess precursors present a genuine risk during downstream application, especially in catalytic or synthetic transformations. From handling raw materials coming in, to dispatching final drums or bottles, every stage receives oversight and direct hands-on inspection.

    Daily Reality of Manufacturing 3-Thiophanone

    The production of a compound like 3-Thiophanone draws lessons every day from real-world factory routines. Compared to literature syntheses often described in publications, large-scale preparation introduces far more complexity: moisture control, temperature gradients, and subtle shifts in feedstock composition make or break a batch. Our facility keeps redundant analytical stations within meters of each reaction vessel, enabling on-the-spot checks for both intermediates and the finished product. During high-humidity seasons, we deploy additional desiccant strategies and tweak solvent volumes. It’s not guesswork—it’s repeated observation and adaptation.

    Many competitors rely on offsite tollers, but our plant engineers operate, troubleshoot, and improve each run as part of a real team. Access to feedback loops between technical sales and production lines enables ongoing improvement. If a customer reports a minor impurity or fogginess in solution, that report returns immediately to the plant so we can examine, adjust, and – if needed – overhaul steps in the process. Our chemists view every kilogram as a feedback tool for future reliability, instead of just another unit sold.

    Application Markets: Understanding True Needs

    3-Thiophanone attracts attention for its functionality in organic synthesis, particularly as a precursor for thiophene-based compounds and for use in process R&D. Drug discovery teams value it as a versatile building block for heterocycle assembly, facilitating rapid scaffold diversification. Those in agrochemical innovation draw on its reactivity profile to generate lead compounds not accessible with simple thiophene derivatives. Research relationships over the years have taught us that project timelines often hinge on a steady flow of disruptor compounds like this. Delays, even by days, can erode confidence and stall innovation down the line. By manufacturing onsite and keeping inventory managed at the source, we close that supply risk.

    End users stress downstream performance in their feedback. 3-Thiophanone must carry low color, dissolve rapidly in organics, and avoid introducing trace side contaminants that complicate isolation or slow down library reactions. Meeting these calls for precise temperature control—too much heat during purification and byproducts creep up. We maintain a tight hold over these variables not through automation alone, but by combining data-driven practice with practical bench chemistry. Consistency doesn’t start with marketing claims. It’s the result of daily precision at the reactor, filter, and packing bench.

    Depending on specific needs, we offer custom packing in sealed glass or HDPE containers, filled and capped under nitrogen to minimize oxygen and moisture ingress. This approach helps safeguard sensitive applications where stability and shelf life matter. Direct dialogue with formulation chemists shaped this process. For some, even a hint of peroxide or water can ruin a batch of valuable intermediate—so we listened and responded, even if that meant changing legacy workflows within our own plant.

    3-Thiophanone Versus Other Building Blocks

    Some ask why not just use unsubstituted thiophenes or simple ketones for analogous transformations. The answer lives in the lab. 3-Thiophanone contains both a sulfurous ring and a highly defined carbonyl at the 3-position, opening paths to specific reactivity profiles not accessible with its relatives. In reductive amination or nucleophilic addition, outcomes shift markedly depending on this double function. A user once tried substituting a generic acetylthiophene from another source. Their downstream yield plummeted, product color darkened, and purification hurdles spiked. Bringing our 3-Thiophanone back into the route restored their expectations. These are not just small differences in molecular structure – they turn into real, measurable effects once a reaction hits scale.

    The temptation on the open market is always to chase cheaper or larger-volume alternatives. Many of these materials trace back to traders who can’t guarantee provenance or real purity. In custom synthesis or regulated applications, this gamble backfires more often than not. From our vantage point on the factory floor, we see how solvents, trace metals, and batch irregularity all stack up, adding both cost and complexity to what should be straightforward chemistry. Customers have sent us “blind” samples from outside vendors, hoping for analysis. More often than not, side-by-side purity, color strength, and assay reveal the difference.

    Handling and Storage Insights: Speaking from Plant Experience

    Day-to-day experience teaches care when working with compounds like 3-Thiophanone. The sulfur ring carries a persistent, sharp odor, making proper ventilation and containment vital for user comfort and safety. We manage this internally by employing high-integrity sealing and scrubbers during filling, avoiding exposure to staff and cross-contamination between productions. Spillage cleanup requires more than a routine sweep—quick response and dedicated personnel ensure plant safety and operational continuity. For shipping, overengineering container seals and secondary barriers avoids leaks mid-transport, especially in hot-weather months.

    We encourage users to plan short- to medium-term use once a container opens. Prolonged air exposure affects color and potency. Research partners sometimes seek formulation guidance after weeks of storage under suboptimal conditions; usually, that means loss of brightness or formation of trace byproducts detectable by TLC. After gathering these reports, we recommend storing unopened containers away from light and moisture, ideally under inert conditions. As a rule, regular site audits and staff training sessions reinforce best practices. These measures form the backbone of genuine site safety, not just regulatory compliance.

    Production Challenges and How We Address Them

    Running a chemical reactor never delivers textbook outcomes. Fouling, line blockages, and batch variability all demand immediate troubleshooting. 3-Thiophanone feeds off high-reactivity intermediates that, in unoptimized hands, yield overwhelming byproduct noise. In our plant, teams maintain logbooks documenting every deviation, time-stamped and followed to root cause. Efforts to reduce batch-to-batch rejection rates led to on-line monitoring for key parameters — not just lab-based, but built right into the reactor suite. Mistakes cost in both time and materials, so each improvement cycle gets shared openly among crew, with clear lessons for future runs.

    Sometimes, raw material purity itself shifts due to upstream supplier changes. We take nothing for granted, with detailed supplier qualification and periodic re-audits. Staff regularly calibrate balances, thermometers, and in-line detectors, logging everything for accountability. Cross-training gives every technician awareness across multiple steps — blending, filtration, column work, and packing — so nobody works in a silo, and risks catch wider attention sooner.

    Scalability presents its own thresholds. Pilot studies can hide problems that only show up at full throughput — heat gradients, stirring efficiency, and downstream workup yield surprises no paper predicts. Aside from data work, walking the floor and directly watching in-process behavior often surfaces needed tweaks: impeller changes, new insulation, solvent mix adjustment. Bringing all of this knowledge to bear, our technical leads foster a culture where insight and care outrank speed, supporting every customer from bench to pilot plant.

    Supporting Innovation in the End User’s Lab

    Stable partnerships rely on frank exchanges about performance, limitations, and surprises in chemical supply. Our chemists build ongoing relationships with R&D teams, sharing literature updates and troubleshooting common pitfalls with 3-Thiophanone’s use. At times, researchers push the molecule into novel reactivity, and we advise on solvent choices, reaction conditions, and typical troubleshooting tips learned from own pilot work. This exchange helps keep everyone moving ahead rather than stumbling over repeat problems.

    Field experience emphasizes that reaction setup, handling protocol, and even glassware selection can shift results dramatically. We regularly test sample splits with collaborating labs, exchanging notes on differences in yields, side reactions, and outcome color. Transparency on performance, rather than glossy marketing copies, keeps reputations strong. If an anomaly persists, we re-examine our plant’s process from start to finish, correcting across production and logistics.

    Listening to Users, Not Just Transaction Data

    Plant leadership treats sustainability, resource efficiency, and user safety as living priorities, not just regulatory milestones. Whether a customer runs a kilo-scale synthesis or spots issues with a delivered shipment, that feedback cycles into the next improvement drive. Instead of assuming every shipment reaches perfection, we actively court inspection, reporting, and user suggestions. Fielding dozens of calls and emails each week, our technical and support teams capture each detail for ongoing quality improvement.

    Sometimes, labs need more than off-the-shelf product. With that in mind, our plant reconfigures batch sizes, solvent systems, or color specifications for unique requests. The hands-on team brings these new needs back to core production, constantly searching for better outcomes. Every team member, from the night-shift reactor operator to the analytical chemist at QC, shares the view that product quality travels hand-in-hand with customer satisfaction and repeat business.

    Our Commitment for the Future

    The chemical industry never stops evolving. Over years of work, new analytical techniques, greener synthesis options, and alternative purification protocols shaped our production of 3-Thiophanone. We invest in analytical chemistry not as an afterthought, but as a safeguard for long-term trust: deploying GC-MS, NMR, and liquid chromatography to characterize each release. Attention to detail doesn’t stay on paper — staff roundtables at shift changes run through deviations and brainstorm improvements. Only through this level of front-line engagement have we kept defect rates low and customer ratings high.

    Sustainability plays a growing role too. Efforts to reclaim solvent, cut process emissions, and reduce raw material waste started as plant-level experiments but have now become core elements in operating procedures. Partnering only with suppliers meeting strict waste and emissions targets keeps our responsibility chain unbroken. Reducing hazardous waste and improving energy use matter not just for business—staff and community expect it, and our industry’s future depends on that respect.

    Practical Support: More Than Words

    The best assurance remains real-world support. Any questions about process, delivery schedule, or troubleshooting draw immediate attention from senior staff. Queries go straight to the people who make, test, and package each bottle or drum. From paperwork customs details to hands-on process advice, we commit to transparency at every turn. Whether the user is pioneering new reactivity in pharmaceutical research, scaling new agrochemical intermediates, or pushing process chemistry boundaries, our only goal is to support—and learn from—every project using our 3-Thiophanone.

    Conclusion: A Legacy Built in the Factory, Not the Boardroom

    Builders of chemical supply chains recognize the stakes involved in each product batch. 3-Thiophanone may look like just another intermediate in catalog lists, but experience from the factory floor teaches otherwise. Each day spent optimizing, testing, and listening to real user needs separates a specialty compound from a commodity. We back every shipment with knowledge forged in the plant, driving toward better results in every collaborating lab. This hands-on approach shapes everything we do—from raw material checks to in-process control and rapid customer support—keeping trust at the center of each order fulfilled.