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3-Anisaldehyde

    • Product Name 3-Anisaldehyde
    • Alias p-Anisaldehyde
    • Einecs 204-621-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    Specifications

    HS Code

    847738

    Cas Number 123-11-5
    Iupac Name 4-Methoxybenzaldehyde
    Molecular Formula C8H8O2
    Molecular Weight 136.15
    Appearance Colorless to pale yellow liquid
    Melting Point 2-3°C
    Boiling Point 248°C
    Density 1.127 g/cm3 at 25°C
    Solubility In Water Slightly soluble
    Refractive Index 1.574

    As an accredited 3-Anisaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 3-Anisaldehyde is packaged in a 500 mL amber glass bottle with a secure screw cap, labeled with hazard information.
    Shipping 3-Anisaldehyde is shipped in tightly sealed containers, typically made of glass or high-density polyethylene, to prevent leaks and contamination. It should be stored and transported in a cool, dry, well-ventilated area, away from incompatible materials, with appropriate labeling and compliance with local, national, and international regulations for hazardous chemicals.
    Storage 3-Anisaldehyde should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition. Keep it away from incompatible substances such as strong oxidizing agents. Protect from light and moisture. Ensure proper labeling, and store at ambient temperature. Follow all local regulations and safety guidelines when handling and storing this chemical.
    Application of 3-Anisaldehyde

    Applications of 3-Anisaldehyde in Industrial Manufacturing

    3-Anisaldehyde, as a specialty aromatic chemical, serves critical functions in targeted sectors such as food additives, pharmaceutical synthesis, dye intermediates, fragrance compounds, and agricultural chemistries. The following industry application scenarios summarize its precise roles in major downstream markets.

    1. Flavor and Fragrance Industry: Synthesis of Aroma Compounds

    Manufacturers utilize 3-Anisaldehyde as a key aldehyde flavorant in the formulation of sweet, anisic, and licorice-like aromas. It acts as a building block in compounding artificial vanilla, anisette liqueurs, and confectionery flavors, with usage strictly regulated by food safety authorities. The material is directly dissolved and dosed in mixing tanks during the preparation of concentrated flavor oils, operating under batch QC and traceability. Processing temperatures and pH are monitored to safeguard compound aroma integrity before blending into food and beverage matrices.

    Industry compliance standards

    • US FDA 21 CFR §172.515 (Flavoring agents and related substances)
    • EU Regulation (EC) No 1334/2008 on Flavourings
    • JECFA food additive monographs
    • ISO 9235 (Aromatic natural raw materials vocabulary)

    Typical usage ratio

    • Ranges from 5–100 ppm as a dry basis in end-use food products (final dosage must comply with local food codes; limited by sensory intensity and maximum residue thresholds)

    Downstream process integration

    • Added in the liquid blending stage during concentrated fragrance oil compounding
    • Standardized by batch blending, then dissolved in alcohol, propylene glycol, or triacetin matrices
    • Subjected to headspace GC analysis for aroma validation
    • Moved to quality-controlled filtered storage prior to shipment to food and beverage plants

    Final product types

    • Licorice and anisic food flavors
    • Bakery or confectionery flavoring oils
    • Alcoholic beverage essences (such as sambuca, pastis)
    • Toothpaste and oral care flavors

    2. Pharmaceutical Industry: Synthesis of Active Pharmaceutical Ingredients (APIs)

    API manufacturers employ 3-Anisaldehyde as an aromatic synthon to build up complex pharmaceutical intermediates, especially for CNS agents and vasodilators. The chemical undergoes nucleophilic addition, condensation, or reductive amination under GMP-controlled reactors. Its purity, trace metal content, and residual solvents are tightly specified and validated by pharmacopoeial quality systems prior to downstream use. Byproduct streams and batch records are routinely traced for full regulatory auditability.

    Industry compliance standards

    • USP/NF Monographs (where applicable for raw material quality)
    • ICH Q7 (GMP for APIs)
    • EU GMP Part II (Active Ingredients)
    • Chinese Pharmacopoeia (ChP) for pharmaceutical intermediate use

    Typical usage ratio

    • Used in stoichiometric amounts as a starting reagent, ranging from 1:1 to 1:3 molar ratios with downstream amines or hydrazines based on synthetic protocol

    Downstream process integration

    • Charged in the early synthetic step for API precursors via controlled addition into sealed, inertized reactors
    • Reacted at elevated or cryogenic temperatures depending on the target API pathway
    • Washing, workup, and purification steps follow, monitored by HPLC/GC-MS
    • Data recorded under electronic batch manufacturing records (eBMR)

    Final product types

    • Vasodilator precursors (e.g., for antispasmodic agents)
    • Intermediates for antihypertensive and CNS medications
    • Synthetic alkaloids for research and pharma use
    • Benzylpiperazine derivatives

    3. Dye and Pigment Industry: Intermediate for Synthetic Dyes

    Integrated dye producers incorporate 3-Anisaldehyde as a building block for specific anthraquinone, azine, and acridine dye intermediates. After formylation reactions or condensation with anilines/hydrazines, the material proceeds to further alkylation or sulfonation steps. Its entry point, batch parameters, and residual color characteristics are closely controlled to achieve hue consistency in commercial pigment dispersions. End-use grades demand strict absence of aromatic amines and heavy metal contaminants.

    Industry compliance standards

    • REACH (EC) No 1907/2006 for chemical registration
    • Oeko-Tex Standard 100 (Textile dye restrictions)
    • EN 71-3 (Migration of certain elements for coloring toys)
    • ISO 9001 QMS for batch traceability

    Typical usage ratio

    • Field experience shows loading at 0.5–2.0 molar equivalents, tailored to the specific dye synthesis route and color strength required in finished pigment concentrations.

    Downstream process integration

    • Dosed at the initial condensation phase with corresponding amines or phenols
    • Processed under temperature-controlled, closed reactors to prevent volatilization
    • Intermediate purified via crystallization or column separation
    • Final dye is filtered, spray-dried, and quality-assured for hue and migration

    Final product types

    • Anthraquinone-based dyes for textiles
    • Permanent acrylic and waterborne pigments
    • Printing ink intermediate colorants
    • Plastisol and polyurethane color concentrates

    4. Agrochemical Industry: Synthesis of Pesticide and Herbicide Precursors

    Leading agrochemical synthesizers deploy 3-Anisaldehyde as a starting aldehyde in the fabrication of selective herbicide and fungicide intermediates. It enters multi-step syntheses involving oxime or hydrazone formation, followed by chlorination or sulfonation. Material is handled under closed-system, nitrogen-blanketed lines to mitigate environmental exposure and operator risk. Quality release includes GC-MS impurity profiling and verification of pesticide-specific impurity limits during registration batch runs.

    Industry compliance standards

    • EPA 40 CFR Part 180 (Pesticide chemical residue thresholds)
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products Authorization)
    • ISO 17025 (Analytical testing laboratory accreditation)
    • FAO/WHO pesticide specification guidelines

    Typical usage ratio

    • Typically engaged at 1.0–1.5 molar equivalent as a starting aldehyde for each mole of downstream active being synthesized; actual loading ratio depends on crop protection chemical design and global regulatory dossier specifications.

    Downstream process integration

    • Introduced into a reactor system as the first reagent, followed by systematic feeding of ammonia or hydrazine derivatives
    • Intermediate extracts purified by solvent washing and activated carbon treatment
    • Isolated intermediates subsequently chlorinated or alkylated prior to formulation
    • Validated for absence of persistent organic pollutants and trace heavy metals

    Final product types

    • Triazole fungicide precursors
    • Herbicide intermediates for cereal, legume, and fruit crops
    • Plant growth regulator base compounds
    • Active ingredient intermediates for insecticides

    5. Fine Chemicals: Intermediate for Organic Synthesis and Research Chemicals

    Producers of high-purity fine chemicals use 3-Anisaldehyde as a reactive aldehyde group in complex molecule assembly. The compound provides a stable aromatic platform for multi-step synthesis, including Schiff base formation, Grignard additions, or organocatalytic asymmetric transformations. QC laboratories and pilot plants demand documented proof of identity, titration data, and minimized peroxide or oxidized byproducts. Product traceability and lot-specific certificates accompany every shipment to fine chemical laboratories, custom synthesis sites, and CRO facilities.

    Industry compliance standards

    • ISO 17034 (Reference material producer accreditation)
    • OECD Good Laboratory Practice (GLP) for research chemicals
    • Purity documentation: NMR and chromatographic fingerprinting
    • Quality management: ISO 9001 and customer-specific QC protocols

    Typical usage ratio

    • Applied in 0.2–5.0 equivalents depending on target reaction requirements, sample scale, and downstream analytical tolerance, adjusted experimentally as required by the protocol

    Downstream process integration

    • Dosed by automated pump or manual addition into inert-atmosphere glassware or steel reactors
    • Monitored with real-time TLC/HPLC during stepwise reaction progress
    • Isolated by solvent evaporation, followed by column chromatography or preparative HPLC
    • Final material dispensed into certified storage vessels under argon or nitrogen

    Final product types

    • Laboratory reagents for chemical synthesis
    • Building blocks for medicinal chemistry library programs
    • Schiff base ligands and organometallic complexes
    • Experimental compounds for analytical method development

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    Certification & Compliance
    More Introduction

    3-Anisaldehyde: Reliable Ingredient from a Direct Chemical Manufacturer

    Understanding 3-Anisaldehyde’s Core Qualities

    Over the years, our team has specialized in producing high-purity aromatic chemicals for diverse applications. 3-Anisaldehyde—often called meta-anisaldehyde or m-anisaldehyde—stands out as a stalwart in the group of anisaldehyde isomers. This aromatic aldehyde appears as a pale yellow liquid and carries a distinct floral scent. We craft each batch at our facilities with strict attention to consistency and safety, always maintaining a focus on chemical reliability.

    As a manufacturer, we have seen steady demand for this compound across fragrance, flavor, and pharmaceutical sectors. In each of these industries, quality comes down to practical parameters: purity, precise assay (typically 98% or higher), controlled moisture, and absence of unwanted by-products. We regularly test our shipments for acidity, specific gravity, and color to ensure each lot matches the specification we set from the outset, reducing headaches for downstream formulation.

    Differences from Other Anisaldehyde Isomers

    There are three isomeric forms of anisaldehyde: ortho, meta, and para. Most suppliers cater to para-anisaldehyde, but the meta variant possesses different reactive sites on the aromatic ring that make it a preferred building block for certain specialty syntheses. Over the past decade, we’ve seen our customers in life sciences gravitate toward meta-anisaldehyde when selectivity and different substitution chemistry are required. Despite sharing some aromatic properties, each isomer yields its own chemical and olfactory outcomes, especially in flavor and fragrance development.

    We take great care in avoiding cross-contamination or impurity carryover between isomers. We audit our separation methods and confirm identity using full chromatographic analysis to provide the meta compound our customers need. While para-anisaldehyde delivers a familiar almond-like aroma, the meta isomer brings a less common scent profile, used for more niche fragrance and flavor notes often in demand by artisan producers and innovators in natural product research.

    Production and Quality from a Manufacturer’s Perspective

    From our vantage point as the sourcing origin, we see every step that goes into each drum of 3-anisaldehyde. The synthesis routes rely on careful oxidation and methylation steps. Any lapse in these stages introduces impurities like formaldehyde, which we systematically monitor and purge. The final product’s success depends not on luck but on disciplined, traceable production practices. Our teams analyze every batch using gas chromatography to confirm purity and composition. Consistently exceeding the 98% mark means less troubleshooting for finished product makers, particularly when regulatory scrutiny is tight.

    We have learned that tight inventory control paired with rigorous batch tracking reassures every partner. Once, we faced a case where a buyer received a shipment from another source containing trace residual solvents not disclosed up front. That single issue delayed their production schedule and required extensive retesting and product reformulation. We took that lesson to heart, reinforcing policies to double-check solvent removal from all stages, applying hands-on oversight prior to tank filling or bottling.

    Role in Fragrance and Flavor Formulation

    Our customers in perfumery and flavors look for ingredients that perform predictably. 3-Anisaldehyde, with its floral and faintly spicy undertones, functions as a key intermediate for certain musk blends and sweet notes. We partner with formulators who often find subtle differences in olfactory output when swapping between anisaldehyde isomers. The meta form, unlike the typical para variant, imparts a character useful for more nuanced or “green” blends, often pursuing complexity rather than overt sweetness.

    We recall a collaboration with a well-known independent perfumer. They sought to introduce a new spring fragrance, specifically avoiding the cloying finish associated with p-anisaldehyde. Our meta-anisaldehyde gave the desired subtlety, letting other botanical notes shine through while anchoring the scent. With trace-level purity, side odors stay below detection thresholds, letting the artistry of our customer’s blend take center stage.

    Applications in Pharmaceutical and Agrochemical Synthesis

    Pharmaceuticals demand a level of consistency and traceability that begins before formulation, at the raw material stage. Our customers working on antihistamine intermediates, active pharmaceutical ingredients, or fine chemicals for industrial synthesis typically ask for a certificate of analysis per batch, including trace impurity breakdown. Years of steady manufacturing have shown us how regulators not only focus on assay but also on impurity profiles, so we have refined our workflow with these concerns in mind.

    3-Anisaldehyde’s reactive aldehyde group and methoxy substitution allow for unique routes in heterocycle synthesis. In one example, a contract development group leveraged our material to synthesize API intermediates requiring rigid control of aldehyde reactivity. Repeated small-batch trials illustrated how trace impurities from off-spec sources increased waste and required more extensive purification steps. Using our consistently high-purity product streamlined their yield and improved reproducibility day to day.

    Crop science and agrochemical researchers in our network also utilize 3-anisaldehyde’s selective reactivity to build newer pesticide intermediates or to test selectivity toward various plant pests. Their work relies on dependable starting material, not just for efficacy, but to ensure all safety and environmental compliance testing reflects the true active structure, not artifact byproducts.

    Logistics and Handling: Practical Realities

    Quality does not stop at the factory gate. We package 3-anisaldehyde in high-density polyethylene drums with tamper-proof seals. From experience, warehouses without proper care and seals have suffered from vapor losses or external contamination, where exposure to air and light can degrade aldehydic compounds, impacting product usability. Stories from long-term clients reinforce our methods: unsealed or roughly handled drums from third-party resellers have arrived with oxidized residue, setting entire batches off-spec and forcing costly discards.

    We keep storage recommendations straightforward. 3-Anisaldehyde likes cool, dry, and well-ventilated areas. Excessive heat or open sunlight accelerates decomposition, so temperature-controlled storage keeps batches within product specification, extending their shelf life and reducing headaches at the next stage. Internal audits and hands-on logistics teams support prompt dispatch and careful packing. Avoiding breakage, spills, and leaks means our downstream users receive what they paid for—the right material at the right purity, ready for use on arrival.

    Environmental and Safety Considerations

    Working daily with aromatic aldehydes has taught us the importance of responsible production and transport. 3-Anisaldehyde, while considered lower toxicity than many aromatic counterparts, does require careful handling. In the plant, our operators wear gloves and work under strict ventilation protocols. Accidental skin contact causes irritation; thus, training focuses on transfer procedures, safe decanting, and regular safety drills. Our experience underscores that consistent protocols not only protect our team but also build trust with regulatory agencies and customers.

    Waste management is a continual challenge, especially in jurisdictions with evolving environmental standards. We process off-spec or returned product using solvent recovery and controlled incineration, following the latest guidance for minimal emissions. Each year, audits by authorities assess our recordkeeping and method documentation. We apply the same caution to effluent and air emissions, monitoring for trace aromatic loss using active sensors placed throughout production and storage zones.

    We share storage and transport best practices openly with our customers. In the past, one user experienced minor vapor exposure due to container breaches during transport through a hot climate. Our technical team responded with training in secondary containment and temperature monitoring, which dramatically reduced recurrence rates. Chemical integrity rarely survives carelessness during distribution, so our goal is always safe and transparent operations from synthesis to final delivery.

    Supply Chain Experience: What Works and What Doesn’t

    Long-term customers tell us delays and inconsistent quality rank among their biggest frustrations, especially when shipping internationally. As a direct producer, we carry buffer inventories in anticipation of variable demand, storing production lots in climate-controlled warehouses on multiple continents. Local regulations on aromatic imports can vary widely, and documentation must match every country’s clearance protocols. We support this with robust paperwork—certificate of analysis, MSDS, traceability reports—delivered with each shipment, minimizing customs delays.

    Warehousing practices affect more than paperwork. In the early days, we teamed with outside logistics firms who didn’t fully appreciate the handling needs of aromatic aldehydes. Some batches sat near open heat sources, others moved between poorly sealed barrels. Even a few degrees of uncontrolled heat can start unwanted reactions, generating over-oxidized byproducts that take batches off-spec. After repeated mishaps, we began organizing in-house storage and hired specialized chemical freight partners. These changes improved our on-time delivery and batch acceptance rates and virtually eliminated product returns due to storage-related issues.

    Clear, honest communication up front helps us avoid the common pitfalls in chemical sourcing. Our technical liaisons field customer questions directly—not through third-party intermediaries—so specification changes or custom requirements reach the right hands quickly. We encourage site audits and open our processes for review, allowing partners to see the safeguards and controls in place.

    Supporting Innovation Through Reliable Chemistry

    Our role extends beyond fixed production; we support research and experimentation with small, well-characterized lots for R&D trials. Over dozens of projects, researchers have shared that poor quality starter material can derail entire program timelines. With so much at stake, academic and commercial teams request detailed impurity spectra and stability data before investing in scale-up or synthesis. We supply 3-anisaldehyde in sample volumes for bench-scale tests, then scale to larger lots using identical production protocols to conserve batch-to-batch reliability.

    For those developing new flavor accords or pharmaceutical building blocks, we lend our expertise on the compound’s subtle reactivity differences compared to other isomers. Our chemists regularly consult with formulators troubleshooting off-flavors or unanticipated reaction side products. By tracing these outcomes back to isomeric differences or batch impurities, we help them fine-tune processes or switch to our higher-purity offerings, delivering certainty so research can move forward without delays.

    More than once, we have supplied emergency batches to innovation teams who, left waiting by unreliable traders, risked costly schedule slips. In these cases, long-standing direct relationships and our flexible production calendar enabled just-in-time support, helping customers avoid disruption and meet their project timelines.

    Customer Feedback and Continuous Improvement

    Since direct feedback loops drive our process improvements, we hold regular customer workshops and solicit batch reviews. A major customer of ours flagged a subtle shift in fragrance note between lots. Our deep-dive investigation traced this to upstream raw material variation. We responded by segmenting suppliers and implementing stricter incoming analysis, immediately restoring the customer’s preferred product profile.

    Another customer reported clogging in automated dosing lines. A site visit and co-review pointed to minute insoluble particles, most likely crystallized impurities from a reactor outlet. Our response included an extra filtration step and modifications to reactor cooling flows, which eliminated the unwanted solids. These kinds of collaborative troubleshooting exercises not only remediate short-term issues but strengthen relationships and technical knowledge on both sides, allowing us to serve more demanding, sophisticated applications in global industries.

    Outlook and Development Directions

    As we look ahead, customer interest in sustainable and lower-carbon production influences our process choices. Although 3-anisaldehyde has been around for decades, continual improvement in yield, waste minimization, and energy use remains a priority. Catalytic advances in the aromatic oxidation stage and solvent recycling programs let us extract more product from less input, benefiting both partners and the planet. Customers integrating our 3-anisaldehyde into eco-friendly products appreciate these efforts, as they support lifecycle assessments and green chemistry certifications.

    Regulatory agencies worldwide tighten scrutiny on aromatic precursors, urging data transparency and supply chain oversight. Staying ahead of requirements means documenting every stage with digital traceability and third-party certifications, reducing the risk of recalls or compliance breaches. We continue to certify our production under quality management systems and maintain open lines to customers for audit and questions.

    Our team tracks new research and market shifts, assisting partners testing new uses and applications. Whether a client is developing fine fragrances, food flavors, or new pharmaceutical compounds, having a trustworthy source for 3-anisaldehyde—made with proven experience, handled carefully, and provided with full transparency—gives innovators the solid base they deserve.

    Summary: Manufacturer’s Commitment to Quality and Partnership

    Working with 3-anisaldehyde as a core product has built our reputation as more than just a material source. We see ourselves as partners in our customers’ process improvement cycles. Starting with batch production, continuing through shipping and storage, and extending to on-demand technical support, our team stays involved until our partners meet their goals. 3-Anisaldehyde may be one ingredient among many, but its consistent quality, purity, and traceability form the backbone of countless products and research projects around the world.

    Our doors stay open for site visits, sample requests, and technical discussion. Every kilo we produce reflects years of chemical experience and direct customer engagement—all in service of helping others create what’s next.