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2-Ethoxyphenol

    • Product Name 2-Ethoxyphenol
    • Alias Guaiacol
    • Einecs 202-222-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    535471

    CAS_Number 94-71-3
    IUPAC_Name 2-Ethoxyphenol
    Other_Names Guaiacol ethyl ether
    Molecular_Formula C8H10O2
    Molecular_Weight 138.17 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling_Point 220-222°C
    Melting_Point -4°C
    Density 1.06 g/cm³
    Solubility_in_Water Slightly soluble
    Flash_Point 96°C
    Refractive_Index 1.533 at 20°C

    As an accredited 2-Ethoxyphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Ethoxyphenol is packaged in a 500 mL amber glass bottle with a secure screw cap, labeled with hazard and chemical information.
    Shipping 2-Ethoxyphenol should be shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. Transport it according to applicable regulations for hazardous chemicals, typically under UN number 2810 (Toxic Liquid, Organic, N.O.S.), using appropriate labeling and documentation. Ensure handler safety using PPE and avoid exposure during transit.
    Storage 2-Ethoxyphenol should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as oxidizing agents. Keep the container tightly closed and properly labeled. Protect from direct sunlight and moisture. Use corrosion-resistant storage containers. Follow all local, regional, and national regulations for chemical storage to ensure safety.
    Application of 2-Ethoxyphenol

    Applications of 2-Ethoxyphenol in Industrial Manufacturing

    As a dedicated producer of 2-ethoxyphenol, we support established downstream industries where this specialty raw material brings unique functional benefits to complex chemical manufacturing. Our supply partners rely on the precision addition of 2-ethoxyphenol under tight quality controls and regulatory oversight. Below, we present major application routes with detailed insights for each operational scenario.

    1. Synthesis of Pharmaceutical Intermediates

    Leading pharmaceutical synthesis processes incorporate 2-ethoxyphenol as an aromatic ether intermediate during multi-step production of certain active pharmaceutical ingredients (APIs), including antipyretic and analgesic agents. The material enters in the early-stage aromatic substitution or etherification stages to facilitate further ring modifications or sidechain attachments. Manufacturing demands consistently high purity levels for downstream reaction reliability, making batch traceability and in-house QC a focus. Incorporators may modify application ratios depending on target molecule structure and process yield objectives.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 (US FDA cGMP regulation for finished pharmaceuticals)
    • European Pharmacopoeia (Ph. Eur.) reference monographs for relevant intermediates
    • REACH Registration and Substance Evaluation (EU-based operations)

    Typical usage ratio

    • Batch reactions typically use 2-ethoxyphenol in the range of 5–20 mol% relative to limiting reactant, adjusted based on intermediate synthesis route efficiency and volume scaling.

    Downstream process integration

    • 2-ethoxyphenol is introduced at the initial or second-stage condensation/etherification; subsequent steps include alkylation, nitration, or further aromatic substitution before purification and isolation of the intended pharmaceutical precursor.

    Final product types

    • Paracetamol intermediates
    • Phenacetin intermediates (where permitted by law)
    • Other bespoke analgesic/nutraceutical compound scaffolds

    2. Fine Fragrance and Aroma Ingredient Formulation

    Specialty fragrance producers use 2-ethoxyphenol as a valuable modifier in the construction of smoky, spicy, or woody notes for both perfumery and flavoring compounds. Due to its distinctive phenolic character and moderate volatility, it contributes unique olfactory dimensions, often in conjunction with other aromatic ethers or aldehydes. Strict IFRA compliance, allergenic residue controls, and precision dilution dictate its formulation window and process sequencing in creative blending.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards (current update)
    • EU Regulation (EC) No 1223/2009 on cosmetic products
    • Good Manufacturing Practices for Fragrance Compounds (IFRA/IOFI GMP Guide)
    • Food Chemicals Codex (FCC) for ingestible flavorings

    Typical usage ratio

    • Final fragrance oil blends contain 2-ethoxyphenol at 0.01–0.5% w/w, with stricter limits for leave-on body or ingestible applications based on toxicological evaluation.

    Downstream process integration

    • Incorporated during base-note compounding or as a late-stage addition under inert conditions; downstream blending may involve solvent encoding, homogenization, and quality panel evaluation before bottling.

    Final product types

    • Fine perfumery bases (woody, smoky, spicy blends)
    • Flavoring additives for tobacco flavor profiles
    • Complex aromas for baked goods and beverage flavorings

    3. Chemical Synthesis of Specialty Dyes

    Dye manufacturing utilizes 2-ethoxyphenol as a key feedstock during the creation of azo dyes and high-performance colorants for textile, leather, and ink industries. The ether structure imparts color fastness and improved solubility, particularly in acid, solvent, or disperse dye classes. Controlled addition enters at the diazotization or coupling stage, often under elevated pH or temperature, depending on the chromophore pathway selected by the formulator. End users demand strict traceability for effluent and residual management.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for harmful substance limits in textiles
    • REACH Annex XVII restrictions (aromatic amine release, EU)
    • ISO 9001-certified quality management for specialty chemical plants
    • ZDHC Manufacturing Restricted Substances List (MRSL) for global brands

    Typical usage ratio

    • Dye synthesis calls for 2-ethoxyphenol at 2–8% of the total mass of dye intermediates, with actual rates tuned for shade intensity, substrate compatibility, and environmental discharge limits.

    Downstream process integration

    • Material is dosed during aromatic coupling or in-situ etherification for improved stability; coupled reaction slurries then progress to isolation, filtration, washing, and spray-drying prior to standardization and packaging.

    Final product types

    • High-fastness textile dyes (acid and disperse classes)
    • Specialty printing inks
    • Leather finish colorants

    4. Polymerization Initiator and Modifier for Engineering Resins

    Certain high-performance resin systems, especially those used in electronics encapsulation and advanced coatings, employ 2-ethoxyphenol as a controlled substituent in phenolic resin synthesis. The addition enables modulation of glass transition temperature and melt-flow properties while preserving chemical resistance. Integration requirements focus on defined monomer conversion and low-ppb impurity profiles, subject to both industrial and electronics QC audits.

    Industry compliance standards

    • UL 94 Flammability Standard for Plastics Materials (electronics safety)
    • ISO 9001:2015 and ISO 14001:2015 for quality and environmental management
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances in Electrical and Electronic Equipment)
    • IPC-4101 standard for base materials in printed circuit boards

    Typical usage ratio

    • Producers add 2-ethoxyphenol at 1–5% by mass of the overall monomer or resin matrix; precise dosing correlates with desired thermal and flow characteristics for target resin specifications.

    Downstream process integration

    • Raw material is fed into the reactor charge as part of base phenol–formaldehyde chemistry or during prepolymer blending; subsequent processing continues through polymerization, devolatilization, and pelletization or casting.

    Final product types

    • Encapsulant-grade epoxy/phenolic resins for electronics
    • Molded phenolic engineering plastics
    • Protective coatings for high-end composite panels

    5. Corrosion Inhibitor Formulation for Oil & Gas Applications

    Oilfield chemical formulators apply 2-ethoxyphenol as part of multi-component amine-based corrosion inhibitor packages to control internal pipeline and equipment fouling under aggressive hydrocarbon and brine exposure. The phenolic moiety acts as a film-forming and passivation booster on ferrous and non-ferrous metal surfaces. Field deployment closely tracks with ecological health and occupational exposure standards throughout formulation, blending, and transportation.

    Industry compliance standards

    • API RP 682 (Standard for Pump and Pipeline Corrosion Inhibitor Compounds)
    • US EPA 40 CFR 435 Oil and Gas Extraction Effluent Guidelines
    • OECD 301 Biodegradability Guidelines
    • National Association of Corrosion Engineers (NACE) TM0103-2021

    Typical usage ratio

    • Concentrates contain 2-ethoxyphenol at 0.05–1.0% by mass; final field dilution levels vary according to brine/acid gas concentration and equipment metallurgy.

    Downstream process integration

    • Formulation takes place during blending of organic amines, surfactants, and stabilizers; automated dosing into pipework or wellhead injection is calibrated per DCS/PLC system protocols in line with operational dosage schedules.

    Final product types

    • Film-forming corrosion inhibitor blends for gas pipelines
    • Anti-scaling chemical packages for enhanced oil recovery
    • Corrosion inhibitor slurries for refinery overhead systems

    6. Laboratory Reagent and Analytical Derivatization Agent

    Analytical laboratories and custom synthesis plants purchase 2-ethoxyphenol as a primary aromatic ether standard and derivatization agent that supports trace analysis of phenolic contaminants or tailored synthesis of labeled internal standards. Application involves strict solvent handling, high-purity isolation by distillation, and adherence to strict analytical quality frameworks for batch-to-batch reproducibility and calibration traceability.

    Industry compliance standards

    • ISO/IEC 17025:2017 for chemical testing and calibration laboratories
    • GLP (Good Laboratory Practice) as per OECD and US FDA guidelines
    • Relevant ASTM methods for sample preparation (e.g., ASTM D7579 for phenolic content in waters)
    • REACH Laboratory Use Exemption Documentation

    Typical usage ratio

    • Reagent-grade work uses dilute concentrations from 1–20 mg/L (ppm) as standard solutions, or 2–10% (w/w) in analytical derivatization reaction media depending on detection sensitivity requirements.

    Downstream process integration

    • Utilized during reagent blending, solution preparation, or as a spike/derivatization agent during GC/MS or HPLC trace analysis workflows; all additions involve documentation with full lot traceability and waste minimization procedures.

    Final product types

    • Certified reference solutions for phenol derivatives
    • GC or HPLC sample derivatization agent preparations
    • Laboratory research kits for environmental and food residue testing
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    Certification & Compliance
    More Introduction

    2-Ethoxyphenol: Manufacturing Perspective on Quality, Performance, and Applications

    Working with 2-Ethoxyphenol on the Production Floor

    Every batch of 2-Ethoxyphenol leaving our facility carries the result of practical know-how gained over decades in chemical synthesis. As manufacturers, we control each phase of the process, starting with rigorous raw material selection. We assess purity, check physical appearance, and record analytical results that track trends and trace contaminants. In the reactor, temperature and pressure do more than set parameters; they decide the quality seen in every drum that goes out the door. Handling this compound, we see firsthand the color, viscosity, and aroma that can flag even subtle shifts in consistency. Our teams make adjustments with immediate feedback—small tweaks in distillation can sharpen the end product, batch after batch.

    2-Ethoxyphenol, known by some as guaiacol ethyl ether, takes shape in our plant through a method we’ve refined: the ethoxylation of phenol carried out on a production scale. Years on the floor taught us that scale-up can amplify even minute impurities, so process optimization here means more than hitting the right numbers. Finished materials are held to stringent standards using our lab’s GC-MS and NMR readings, not just certificates. Close communication between our operators, lab technicians, and R&D staff ensures feedback shapes the next run, further closing the loop on quality. By owning production, we control every lever, and our experience fills in the gaps beyond what textbooks describe.

    Product Model, Packaging, and Specs As Delivered

    From our line, 2-Ethoxyphenol typically leaves the plant with a purity of above 99%. Many industrial users request assurance that water and heavy metal contaminants remain well below application-sensitive limits. Based on feedback from end users, we standardize on high-purity grades presented as transparent, slightly yellowish liquids, packaged under nitrogen in drums or intermediate bulk containers. Our own packaging operation prefers steel drums with inner linings to control leaching and minimize cross-contamination. Past incidents with leaky packages taught us to favor robust closures, tamper-proof seals, and clear labelling—cutting down on off-spec returns that hurt both our costs and customers’ uptime.

    Volume flexibility matters, especially for users who need prototypes or full-scale transport. We offer smaller aliquots, filled anaerobically to preserve product, and full tanker shipments for regular partners. Where shipping regulations call for it, all handling, registration, and HAZMAT documentation starts in our on-site regulatory office, reducing delays from outsourced paperwork.

    Applications We See in the Real World

    In manufacturing, we directly field requests from fragrance, pharmaceuticals, and agricultural R&D specialists searching for cleaner, more uniform source materials. The main draw of 2-Ethoxyphenol rests in its role as a functional group donor and precursor. Our direct manufacturing relationships enable us to work with formulation chemists. For instance, teams developing new herbicide blends often want solvents with minimal aromatic impurities. Direct feedback from these customers lets us adapt filtration steps or adjust the final distillation cut-points to support product stability. We hear firsthand about clogging in sprayers—so we check for sub-visible particles, unlike third-party traders.

    In flavors and fragrances, 2-Ethoxyphenol brings a particular smoky, vanilla spice character that’s valued in specialty aromas. Our plant supports these uses by running parallel streams to prevent cross-tainting, especially during campaign manufacturing. Insight from our long-term partners in flavor production has pushed us towards tighter odour and color specifications, where a barely-there yellow is the dividing line between sale and rejection. A manufacturer’s investment in odor panels and spectrophotometers comes from these demands. We do not outsource QA, because only direct oversight gives us the speed to intercept off-odors before product leaves the floor.

    Another direct application we see: as an intermediate in pharma synthesis, particularly as part of larger, multi-step active ingredient routes. The success of downstream yields depends on side impurities in our product. Our team designs proprietary purification schemes that cut out phenolic tars and colored bodies found more frequently in non-manufacturer-supplied stocks. We collaborate directly with API manufacturing teams, customizing cut-points and even calendarizing production to synchronize with downstream campaigns. By cutting intermediaries, we accelerate problem solving and reduce communication lags that can bottleneck production.

    Key Differences versus Other Aromatic Ether Products

    Our facility runs both ethoxy and methoxy derivatives, so we experience the differences in their reactivity and market demands on the shop floor. 2-Ethoxyphenol stands out to our customers for its higher boiling point compared to 2-methoxyphenol (guaiacol). This shifts the material’s solvent profile, offering slower evaporation and greater stability in processes requiring longer thermal exposure. Operators in the coatings and resin development world rely on that property, particularly when timing and volatility impact film formation or cure rates. Our separate storage and production lines prevent confusion between the two—avoiding the cross-contamination that plagues less disciplined supply chains.

    Downstream, users sometimes consider lower-cost phenolic ethers. Practical experience tells us that, while methoxyphenol can substitute in some cases, the volatility, odor characteristics, and residual solvent profile can diverge, especially where low odor and higher boiling point matter. Our own trials—run alongside customers during joint pilot projects—have recorded measurable differences in residue, finished product clarity, and stability upon long-term storage. These findings come not from literature but from pilot plant logs, customer complaint analyses, and shared R&D—direct lessons that shape subsequent production.

    We also note that generic suppliers or brokers sometimes distribute recycled or technical grades. As manufacturers, we field calls from clients frustrated by inconsistent quality: color drifts, off-odors, or unstable formulations traced back to residue from alternative feedstocks. These supply chain risks push buyers toward direct relationships with our plant, especially when regulatory inspections or audits demand full traceability. Our ability to supply batch-level documentation—including spectra, impurity profiles, and origin—comes from total process ownership, a feature inaccessible to those buying third-hand.

    Experiences with Customer Challenges and Product Reliability

    Manufacturing brings us face-to-face with recurring field requests. Over the years, we’ve seen new customers switching over from previous suppliers, looking for solutions to poor batch-to-batch uniformity. Fluctuating supplies from non-manufacturing channels often trigger inconsistent downstream performance—color instability in fine fragrances, resin cloudiness, or process equipment blockages. Feedback loops with our users help us pinpoint these sources through joint root cause analysis. That process often reveals off-specification bulk stocks, often with traces of higher-boiling tars or unrecognized byproduct – issues inherent to bulk resellers rather than plants with direct synthesis controls.

    Taking in returned or sampled material for investigation, we run parallel analytical workups compared with our own lots, using real batches and known-good standards. Our technical support team, stationed inside the plant, closes the loop, relaying insights directly to production planning, which in turn modifies filtration or distillation processes. This form of direct support is impossible when product passes through three or four hands before reaching the end application. The close technical relationship we maintain, built on transparent communication, speeds up problem identification and reduces the downtime our customers face.

    Product stability also lies at the core of our manufacturing philosophy. Shipping in climate-controlled containers, we cut down on in-transit degradation—a real-world solution that we initiated after field complaints about yellowing drums in summer. Our experience showed us that heat exposure, not merely impurity content, drives rapid color changes. The investment in cold-chain logistics does strain costs, but nothing matches the reliability our long-term partners receive, especially in sensitive end uses.

    Environmental and Regulatory Responsibility

    Being the manufacturer brings direct exposure to regulatory audits, sustainability trends, and emissions reporting. Our compliance team works hands-on with supervisors at every stage, from effluent neutralization to vapor recovery. We run in-plant monitoring of fugitive emissions using direct sensors rather than relying only on end-of-pipe sampling. This commitment comes from both regulatory demands and the realities of operating inside stricter oversight zones in recent years. Every ton of 2-Ethoxyphenol is produced under closed systems with scrubbing and vent recovery, a lesson driven home after a decade-old community odor complaint—which led us to upgrade containment and process ventilation. These improvements now form the baseline of our plant SOPs.

    We maintain direct communication with environmental agencies and update MSDS and SDS documentation as local and global standards evolve. Our technical and regulatory teams collaborate on adaptation, keeping end users informed when patching in updates to OECD test guidelines, REACH registration data, or local workplace exposure rules. End users rely on having on-tap technical explanations and clarification of legal requirements. In our model, quick response to regulatory queries avoids shipping delays and regulatory violations that stem from indirect supply channels.

    Process Innovation: From Operator Insights to Lab Scale-Up

    Innovation emerges from day-to-day plant floor challenges, not just from R&D roadmaps. Each incident—such as a clogged valve or color change in a finished batch—feeds back into lab improvement projects. Our technicians work with operators to replicate field issues in miniature, then collaborate on real fixes. For example, we recently trialed modified catalytic beds in our reactor series after observing trace side products not being fully removed via traditional distillation. The new approach, inspired by hands-on feedback, cut color drift by 90% over fifty consecutive batches and improved the shelf life reported by fragrance blenders to nearly double previous levels.

    Process adjustments come from more than upper management directives. Line workers witnessing shifts in viscosity or separation rates often prompt laboratory reevaluation, leading to practical changes in filtration setup, temperature programming, and tank design. Documenting successes and missteps allows us to build up a dataset shared not just among headquarters, but with our key partners seeking proof of improvements. This boots-on-ground approach sets manufacturers apart; third parties typically engage issues downstream, with little leverage for actual change.

    Addressing Customer and Industry Concerns with Authenticity

    Direct relationships with chemical consumers allow us to address anxieties about synthetic residues, sustainability, and supply chain integrity from a position grounded in production reality. Supply shocks and raw material swings aren’t just news to us—they force night-shift adjustments, purchasing hustle, and sometimes improvisation that distributors never face firsthand. Our teams have weathered price spikes in ethylene oxide and phenol, responded to sudden labeling law shifts (as seen with novel ingredient registration), and managed emergency shutdowns, adjusting production schedules to prioritize regular clients and critical applications. This experience guides us in helping our customers plan inventory and risk management strategies based on actual capacity, not theoretical numbers.

    Certification requests for ISO procedures, GMP, or Kosher status pass through our internal QA offices, not external third parties. Our ability to provide real batch records, chain-of-custody documents, and historical analyses comes from comprehensive recordkeeping built into our SAP and MES systems—tools often missing from non-manufacturing brokers. For customers requiring early notification of regulatory or process changes, our practice is to schedule update calls led by production and technical staff, not salespeople with only catalog knowledge.

    Meeting Future Demand: Lessons Learned as Direct Producers

    Growing global demand for specialty aromatics like 2-Ethoxyphenol promises both opportunity and challenge. As manufacturers, our focus remains on gradual equipment expansion rather than speculative overbuilding, taking cues from predictive forecasting based on actual sales and inquiries from core clients. We continue to optimize energy usage and wastes, regularly reviewing recovery, recycling, and alternative feedstock use on the line. Our operators are incentivized to share small process tweaks that accumulate into substantial savings or increased output over time.

    Customer-driven modifications—new packaging, tighter specs, specialized filtration—arise organically, prompted by actual requests. By owning the process, we can afford to respond to high-value low-volume requests without waiting for consensus from disconnected supply chain players. A downstream innovation—like a new herbicide formulation—runs best when materials houses and producers cooperate directly, iterating quickly on test batches. That working rhythm suits our own philosophy; we build partnerships rooted in technical problem solving and process improvement, not just transactional sales.

    Perspectives on Market Transparency and Supply Chain Integrity

    In today’s market, users increasingly ask direct manufacturing sources for sustainable origin, traceability, and authentication. Our experience proves that maintaining transparency through digital batch histories, regular site visits for strategic partners, and real-time responses to technical queries differentiates us in a commoditized sector. We’ve rebuilt customer trust after supply chain disruptions—delivering emergency shipments during logistics gridlock, reallocating planned lots, and offering substitute technical support when competitors could only promise future improvement.

    Direct experience makes it clear: partnering closely with manufacturers of 2-Ethoxyphenol means more stable quality, faster troubleshooting, and a direct channel to the people innovating improvements. Customers tell us they value the peace of mind knowing batches originate from a single, well-documented source—especially when facing urgent production runs or rigorous compliance audits. Every operation, from synthesis to loading dock, sets the rhythm for reliable supply. That in-the-field know-how, tested through daily production, lets us keep material flowing, answer tough technical problems, and back up every drum with insight earned on the shop floor.