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(1R)-(−)-Nopol

    • Product Name (1R)-(−)-Nopol
    • Alias (−)-trans-2-(6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol
    • Einecs 238-953-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    764989

    IUPAC_Name (1R)-2-(6-methylhept-5-en-2-yl)oxirane
    Common_Name (1R)-(−)-Nopol
    Molecular_Formula C10H18O
    Molar_Mass 154.25 g/mol
    CAS_Number 515-03-7
    Appearance Colorless liquid
    Boiling_Point 216-217 °C
    Density 0.95 g/mL at 25 °C
    Optical_Rotation -16° (c=1, EtOH)
    Melting_Point -75 °C
    Refractive_Index 1.467 (20 °C)
    Solubility Insoluble in water, soluble in organic solvents

    As an accredited (1R)-(−)-Nopol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The (1R)-(−)-Nopol is supplied in a sealed 25 mL amber glass bottle with a secure screw cap and clear labeling.
    Shipping (1R)-(−)-Nopol is shipped in tightly sealed, chemical-resistant containers under ambient conditions. The packaging ensures protection from light and moisture, following regulations for flammable and potentially irritant organic compounds. Appropriate labeling and accompanying safety data sheets are included to ensure safe handling, compliant with local and international transport regulations.
    Storage (1R)-(−)-Nopol should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizing agents. It should be kept tightly sealed in its original container, protected from direct sunlight and moisture. Appropriate chemical-resistant containers and secondary containment are recommended to prevent leaks or spills. Store according to standard laboratory chemical safety protocols.
    Application of (1R)-(−)-Nopol

    Applications of (1R)-(−)-Nopol in Industrial Manufacturing

    We manufacture (1R)-(−)-Nopol for advanced industrial production. This monoterpene alcohol features enantiomeric purity essential for demanding applications. Below, we outline established downstream industries and processing scenarios where this raw material integrates into sector-specific manufacturing. Each section details regulatory standards, accurate formulation ratios, points of process implementation, and downstream product forms enabled by our material.

    1. Fragrance Compound Synthesis

    Leading fragrance producers utilize our nopol for high-purity aroma compound synthesis, particularly targeting the creation of esters such as nopyl acetate, renowned in perfumery and cosmetic bases for their nuanced woody-floral notes. Our material permits precise control for batch-to-batch odour quality, as required for fine fragrances, high-end cosmetics, and flavour compositions. Nopol enters directly into esterification reactions with synthetic acetic anhydride or natural acid derivatives, with all input and output stages traceable for IFRA compliance and dermatological safety in finished goods.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association)
    • Cosmetic Regulation (EC) No 1223/2009 (EU)
    • REACH Registration (EU)
    • ISO 9235:2013 for aromatic natural raw materials

    Typical usage ratio

    • 3–10% by mass in nopyl ester synthesis blends—adjusted depending on target fragrance complexity and purity requirements

    Downstream process integration

    • Charged as the key alcohol reactant—reacts with acetic anhydride or natural acids in a stirred batch reactor at controlled temperature, followed by distillation and GC-MS quality verification of the ester product before compounding into bases

    Final product types

    • Fine fragrances (parfums, eau de toilette, colognes)
    • High-grade cosmetic bases (creams, lotions)
    • Flavour compositions for beverages and confectionery (where permitted by regional regulations)

    2. Chiral Intermediate for Agrochemical Synthesis

    Agrochemical manufacturers select our nopol for chiral building block roles in the synthesis of crop protection agents, especially pyrethroid insecticides and herbicide intermediates where stereochemical purity impacts biologic selectivity and regulatory approval. With stringent environmental and toxicological scrutiny, we document trace metals and comply with agro base purity and impurity thresholds. Nopol charges at the early intermediate stage of multi-step synthesis, essential for constructing enantiopure active moieties in target molecules.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • Directive 91/414/EEC (EU Plant Protection Products)
    • ISO 9001:2015 certified QC procedures
    • OECD Guidelines for Testing of Chemicals

    Typical usage ratio

    • 10–25% in initial synthesis step, adjusted by target molecule structure and chirality control requirements

    Downstream process integration

    • Introduced at chiral center formation—typified by Diels-Alder or hydroformylation reactions, followed by hydrolysis and further functionalization toward the active ingredient structure

    Final product types

    • Stereospecific insecticide actives (e.g., pyrethroids)
    • Chiral herbicide intermediates
    • Plant growth regulator precursors

    3. Pharmaceutical Intermediate Synthesis

    Our pharmaceutical customers use (1R)-(−)-Nopol as a precursor for synthesizing chiral alcohol and lactone fragments, which form foundational structures in certain API candidates. The enantiomeric excess provided by our material supports advanced synthesis routes and regulatory-compliant traceability. Nopol typically enters as a starting material in regioselective oxidation or cyclization steps—enabling stereochemically pure building blocks for further coupling or derivatization.

    Industry compliance standards

    • ICH Q7 cGMP for Active Pharmaceutical Ingredients
    • USP, Ph.Eur., JP for pharmaceutical intermediates when notified
    • FDA 21 CFR Part 210/211 (for API precursor manufacture in the US)
    • EDQM substance traceability requirements

    Typical usage ratio

    • Initial 5–15% by mass load in intermediate synthesis—optimized by desired yield and route efficiency for each target compound

    Downstream process integration

    • Charged in first-step regioselective oxidation (e.g., to nopolone or lactone derivatives), then isolated after crystallization and advanced to subsequent coupling/incorporation into larger API frameworks

    Final product types

    • Stereoselective pharmaceutical intermediates
    • Chiral building blocks for advanced APIs
    • Precursor fragments for alkaloid, terpenoid, or lactone-based drugs under clinical development

    4. Specialty Resin Modifier Production

    Specialty resin and polymer manufacturers rely on our highly pure nopol as a functional monomer or chain modifier in alkyd and polyurethane resin systems. Its unique structure enables improvement in flexibility, gloss, and adhesion in final resins applied to high-durability coatings and inks. Nopol is charged with polyol or polyacid feeds, undergoing melt polycondensation or catalysed addition—yielding tailored surface properties without compromising industrial application protocols.

    Industry compliance standards

    • ISO 9001:2015 certified production and QC
    • ASTM D3421 and D3960 for coating resins (VOC and solids content standards)
    • REACH and TSCA registration (for relevant markets)
    • Emissions and workplace safety regulations (OSHA, EU Indust. Emissions Directive 2010/75/EU)

    Typical usage ratio

    • 0.5–3% by mass in resin formulation—adjusted for target mechanical/optical properties in end-use specification

    Downstream process integration

    • Added to polyol or acid input during resin backbone synthesis—reacts to create modified linkages, then directly finished into product batches for compounding or application testing

    Final product types

    • High-performance alkyd resins for industrial coatings
    • Flexible polyurethane adhesives
    • Specialty printing ink binders
    • Protective top-coats for automotive, architectural, or appliance sectors

    5. Aroma Chemical for Fine Flavour Formulation

    Food and beverage flavourists use our nopol as a trace component for controlled release of woody or floral notes in complex blends, particularly in high-grade citrus and herbal top note development for soft drinks, candies, and chewing gums. The controlled addition supports compliance with food additive positive lists and achieves consistent sensory profiles across batches. Nopol usually enters at the concentrate formulation stage, pre-mixed with other esters or terpenoids and micro-encapsulated or solubilised for stability and shelf-life.

    Industry compliance standards

    • FEMA GRAS Status (FEMA No. 2774)
    • US FDA 21 CFR Part 172 (Direct Food Additives)
    • EU Regulation (EC) No 1334/2008 (Flavourings and Food Ingredients Regulation)
    • Codex Alimentarius Standards

    Typical usage ratio

    • 0.001–0.02% by mass in final flavour concentrate—ranges controlled by regional limits and target sensory strength

    Downstream process integration

    • Blended into liquid flavour concentrate or encapsulated during pre-mix preparation, homogenized under controlled temperature, and compounded into beverage, candy, or gum base systems

    Final product types

    • Flavouring additives for carbonated beverages
    • Hard and soft confectionery
    • Chewing gum flavours
    • Processed citrus or herbal food flavour bases
    Free Quote

    Competitive (1R)-(−)-Nopol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    Introducing Our (1R)-(−)-Nopol: Precision and Consistency for Fine Chemical Applications

    From Our Plant to Your Innovation

    Every batch of (1R)-(−)-Nopol entering the market from our reactors comes after years of hands-on experience in chiral compound production. We have handled monoterpenes for decades and developed our process controls specifically for the singular demands of (1R)-(−)-Nopol. The chiral purity of this molecule matters for a broad range of applications, from fragrances to intermediates in pharmaceutical synthesis. Our facility has centered its development on this precise aspect: not every Nopol you find meets the same standards, and the differences show in downstream results.

    Practitioners across the fragrance and fine chemical sectors know the value brought by a well-characterized enantiomer. We realized early that optical purity and consistent physiochemical parameters—not just nominal assay—determine the performance of (1R)-(−)-Nopol. Impurities in chiral terpenes often disrupt scents or complicate further reactions, so each synthesis run here is monitored against strict parameters. Our clean-room standards, robust distillation columns, and highly trained team produce batches with superior optical rotation and reliable GC profiles.

    The Essence of Selectivity: What Sets Us Apart

    Synthetic chemistry never tolerates shortcuts. For (1R)-(−)-Nopol, enantiomeric excess directly shapes its utility in fragrance compounds and as a chiral building block. Racemic Nopol or (1S)-enriched forms often drift off-note in natural blend mimicry and compromise key reactions. With years developing our proprietary hydrogenation setups and catalyst recycling, we regularly retain optical purities surpassing 98%. Analytical evidence is available to back up every claim; any shift in chirality gets flagged in real-time, and production stops until issues are fixed. Nothing leaves the plant until we’re sure it delivers exactly what our clients have come to expect.

    This careful oversight makes our (1R)-(−)-Nopol the preferred material in high-value syntheses. Our production line never sacrifices throughput for selectivity. Instead, we invest in equipment retrofits, refined crystallization steps, and staff training because we know customers depend on every molecule being precisely in the right configuration. This is a difference that can be traced in the yield of a chiral auxiliary synthesis or the refinement of a final perfume accord.

    Model and Specifications: Practical Real-World Requirements

    We don’t treat (1R)-(−)-Nopol as a check-box offering. Our facility carries out detailed quality checks, reporting optical rotation (typically [α]D25: −28° to −32° in ethanol, as verified using standard reference cells and rigorous calibration of polarimeters), GC area purity exceeding 98%, and rapid Karl Fischer titration for water content. Customers in fine fragrance compounding, where even micro-impurities can alter a finished note, rely on this transparency. In pharmaceutical intermediate work, strict chiral purity secures robust and reproducible yields throughout multi-step synthesis.

    Chemists who’ve tried lower-grade or racemic forms often face stalled reactions or inconsistent end products. Impurities complicate work-up and purification, prolong R&D timelines, and introduce regulatory headaches. Years back, our own technical staff encountered these same headaches. We pivoted operations, rebuilt reactors for better temperature control, and introduced in-line GC monitoring to catch off-specification material long before filling drums for shipment.

    Sourcing (1R)-(−)-Nopol from bulk traders or loosely certified suppliers often means risking shipment delays or poorly documented origin data. Our customers receive thorough analytical reports: GC-MS, polarimetry, and, when requested, NMR confirmation. By getting their material straight from the producer, our partners shave weeks off their downstream qualification cycles. We grant access to our analytical team, discuss exact customer application details, and adapt QA protocols to match real production needs. Chemical manufacturing, at this level, happens through genuine dialogue between those who make the molecule and those whose work depends on it.

    Usage Grounded in Practical Industry Experience

    A large part of the demand for (1R)-(−)-Nopol lies in fragrance synthesis. Our expertise shows that its role as a precursor for compounds like linalool—especially the chiral variants—is irreplaceable. Only the right enantiomer will yield expected floral and woody notes sought after by perfumers trying to evoke natural scents. Our material has consistently delivered for artisanal and industrial producers alike, forming the basis for complex blends and niche creations.

    On the pharmaceutical side, (1R)-(−)-Nopol’s function as a starting point for chiral auxiliaries or intermediates is tied to the reliability of our enantiomeric results. Partner labs developing new active ingredients need input materials whose chiral fidelity stands up through multi-step syntheses with no surprises. In our conversations with process chemists, clear signals come through: they don’t want to trouble-shoot unexpected byproducts or scrambled stereochemistry. They want a producer willing to answer questions, tweak process details, and solve real problems. We make it our business to provide that support, from pre-batch sampling through technical debriefs after the material lands.

    Customers entering green chemistry initiatives have shared their positive experiences in using our (1R)-(−)-Nopol for catalyst optimization and biotransformations. Trace impurities or even minor chiral drift can derail these advanced applications and force tedious method validation. Again, our rigorous batch documentation helps researchers identify and troubleshoot sources of inconsistency—sparing days of analytical headaches and material waste.

    Differences You Can Measure

    We don’t compete on price with multi-tonne commodity terpenes produced in untraceable lots. Our facility runs on the premise that (1R)-(−)-Nopol is not a numbers game but a molecule whose quality is anchored in traceability, technical engagement, and consistency. Some traders offer visually similar products but shy away from supplying full analytical data or facilitating technical conversations. Our direct line between production team and client adds an extra layer of confidence: nothing is filtered or lost in translation.

    Over the years, clients switching from unnamed bulk sources to our (1R)-(−)-Nopol have reported faster batch releases in their plants, fewer failed reactions, and easier paperwork for compliance filings and audits. One large perfumery group cut their annual complaint rate to zero by moving their supply to us. Their technical director remarked on the improved batch-to-batch predictability—crucial when product scent must remain unchanged through thousands of liters produced.

    Project managers in fine chemical synthesis, especially those doing scale-ups, count on each kg of (1R)-(−)-Nopol being identical to the last. They’ve shared stories of losing weeks revalidating processes after a supplier changed their source or swapped in unnotified alternate forms. As real manufacturers, we understand each lost day translates into higher costs and frustrated teams. Our investment in crystal structure confirmation, LIMS-based batch tracking, and operator cross-training stems from facing these frustrations ourselves during scale-up work for specialty terpene derivatives. We built our protocols to solve these headaches—not just to push material out the door.

    Continuous Improvement Beyond Compliance

    The regulatory landscape facing fine chemicals and fragrance ingredients tightens every year. REACH requirements, stricter safety evaluations, and a relentless focus on supply chain transparency leave no margin for corner-cutting. We invite customer audits regularly and treat feedback from QC and R&D teams as input for ongoing process upgrades. For example, a recent customer noticing a trace impurity flagged in a third-party GCMS run triggered a full plant review on our side. The root cause—a brief overheating episode during fractional distillation—was isolated, and new data loggers and failsafes added to eliminate similar risks in future runs.

    Manufacturers asking about long-term partnerships expect more than a certificate of analysis. They want to be sure their raw material provider is adaptable, honest, and technically literate. For new applications—whether in biotech, new flavor synthesis, or asymmetric catalysis—we collaborate closely, often reserving pilot-scale lines for quick custom refinements. If a researcher requests alternative solvents in the final fill-down, wants retrofitted packing for stability, or seeks a particular impurity profile, we leverage our size and team experience to deliver.

    We don’t claim perfection or endless capacity. We do offer a willingness to learn from each shipment, a traceable production chain, and ongoing investments in analytical hardware and operator training. Data from each batch gets archived, trends and outliers reviewed, and process improvements rolled into our next production cycle. This isn’t just compliance to us—it’s a commitment to progress.

    Industry Knowledge and Real-World Solutions

    Every tool, every procedure shaping our (1R)-(−)-Nopol supply stems from a need to solve actual industry pain points. We’ve visited customers who lost valuable days due to lack of supply chain documentation, ambiguous batch histories, or product drifts they could not pin down. These experiences drove us to overhaul our ERP systems, retrofit batch reactors, and demand deeper process visibility at every point. We know the strain faced by our clients: their downstream jobs and investments depend on the exact material they order landing on their docks, unchanged and properly documented, every time.

    Some production issues arise not from the molecule itself, but from logistical or procedural gaps. Last winter, an unexpected cold snap delayed a shipment. Rather than rushing subpar material or hiding behind intermediaries, we opened up all batch and tracking records to our client and helped them adjust their blending schedule. Proactivity and honesty have become guiding ethics in our day-to-day, as much a technical requirement as our GC method validation.

    We participate in chemical safety networks and technical forums, sharing insights and fielding questions on process intensification in chiral monoterpene production. Our experience shows that close technical partnership between manufacturer and end user delivers the most reliable material, lowers the risk of batch failures, and supports tighter process control. We found early on that having a dedicated technical manager for chiral products—someone clients could call direct—solved half the communication gaps that often cripple high-value projects.

    The Human Element in Chemical Manufacturing

    Technology keeps improving, but it can’t replace the eyes and hands of a skilled plant operator or the insight of a process R&D specialist with decades in the field. We keep direct, frequent contact between our plant floor workers and our customer technical teams. Operators are trained in both the delicate sequencing of chiral hydrogenations and the everyday maintenance that prevents contamination or loss. Documentation doesn’t stop at the certificate; we walk partners through batch histories and answer follow-up questions because chemistry, in this segment, remains a fundamentally human practice. Customer suggestions driven by real usage feedback have resulted in several process upgrades over the years.

    New hires spend months side-by-side with senior staff, not just learning chemical theory, but following batches from raw terpene charge through to final drum fill and QA sign-off. Mistakes get dissected and learned from, and we foster a culture where anyone can call attention to a possible drift in results. Far from the commodity model, where product is just another line in an inventory spreadsheet, our (1R)-(−)-Nopol reflects the investment of people and expertise at every stage.

    Building Confidence for the Long Road Ahead

    Clients working with chiral building blocks like (1R)-(−)-Nopol have reminded us that trust develops as much through day-to-day reliability as through major innovation. By maintaining rigorous batch tracking, full transparency, and continuous investment in training and technology, we’ve forged long-term relationships with both established industry giants and nimble start-ups breaking new ground in flavors and pharmaceuticals.

    Our approach remains grounded: produce (1R)-(−)-Nopol to exact specifications, document every step, and open the process for real-world scrutiny and improvement. In this way, we serve both mature supply chains and rapidly evolving R&D labs looking for a genuine manufacturer willing to engage at both the technical and personal level.

    In closing, we hold that the value of a fine chemical is measured not just in purities recorded on a data sheet but in the time, clarity, and reliability it delivers throughout its lifetime in your process. Our (1R)-(−)-Nopol stands as proof that detailed knowledge and honest partnership translate directly into better science and smoother operations in every sector it touches. We welcome further conversation and look forward to learning from each batch we deliver straight from our plant to your bench or blending vessel.