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11Α,17Α-Dihydroxyprogesterone belongs to the steroid class and plays a key role as an intermediate in pharmaceutical manufacturing, especially in the synthesis of corticosteroids and related compounds. In industrial practice, this compound finds value due to its reactivity and functional groups that give it a unique position as a building block for many active pharmaceutical ingredients. As a raw material, it forms the backbone for further chemical modifications, often bringing high yield and purity, which remain critical in large-scale synthesis.
The molecular formula for 11Α,17Α-Dihydroxyprogesterone is C21H30O4, which translates to a molar mass of about 346.46 g/mol. Structurally, this molecule wraps its hydroxy groups at the 11 and 17 positions of the steroid nucleus, giving it distinct chemical behaviors. Its arrangement brings out crystalline qualities, and the compact carbon skeleton lends strength and resilience to the molecule. Each group on the molecule can be targeted by chemists for precise transformations, raising the value of this compound for specialized reactions.
This compound usually appears as white to off-white flakes or crystalline powder, providing a physical form easy to handle in an industrial laboratory or production line. Typical melting points range from about 230°C to 240°C, a clear indicator of its high thermal stability. Solubility tells a story too: it dissolves well in organic solvents such as chloroform and methanol, but stays mostly insoluble in water, making it easier to isolate and purify using common lab techniques. Density tends to fall around 1.2 g/cm³, and its powder or flake appearance suits standardized measuring equipment. Its stable solid state makes it suitable for long-term bulk storage under dry, cool, and dark conditions.
As a raw material, purity levels often exceed 98%, reflecting careful manufacturing and rigorous quality control standards. Typical batch documentation comes with detailed certificates of analysis, including melting point, moisture content, and residual solvent results. Customers often receive 11Α,17Α-Dihydroxyprogesterone as solid flakes, fine powder, or even compressed pearls, all packed in inert containers that keep out moisture and contaminants. Product is typically distributed by weight, from small gram-level quantities for laboratory use to multi-kilogram drums for larger manufacturing. The material sometimes finds itself dissolved for immediate chemical processing, but most plants prefer solid forms for extended shelf life and minimized degradation.
On shipment documents, this compound falls under Harmonized System Code 2937230000, which covers related steroidal structures. This code streamlines import and export paperwork, helping customs understand exactly what is being transported and enabling smooth global supply chain operations. Handling raw chemical materials in this group means following all transport and storage rules; manufacturers secure the product in approved packaging with clear labeling, safety data sheets, and hazard markings.
Care in handling 11Α,17Α-Dihydroxyprogesterone proves essential. Safety data sheets detail specifics for workers: avoid dust inhalation, skin contact, and eye exposure by using gloves, goggles, and masks. Even though the compound is not acutely toxic, its steroid nature makes long-term exposure a concern, urging workplaces to keep strong ventilation and spill protocols. Should a spill or leak occur, collect powder with minimal dust generation and store in secure, labeled containment. For waste, follow chemical disposal regulations and never flush into drains. Because some downstream products come with hormonal or biological activity, keeping byproducts out of the wild environment helps ensure they never disrupt sensitive ecosystems. Safe storage means away from flame sources and sunlight, with storage at moderate temperatures to avoid degradation or clumping.
Research chemists and pharmaceutical producers both look for the consistent quality that quality 11Α,17Α-Dihydroxyprogesterone brings. From corticosteroid development to custom synthesis, reliability of raw materials underpins safe and efficient production lines. Flake and powder forms work well in both batch and continuous processes, fitting feeding hoppers and reactors across a range of scales. Advances in medical synthesis methods drive even more demand for clean, well-characterized raw material, keeping this compound present on inventory sheets for large and small labs. Each handled lot traces back to published studies or pilot production runs, reflecting efforts to meet strict pharmaceutical requirements and transparent supply chains.
Producers mindful of both product quality and worker health will keep focus on improved dust control, efficient extraction and purification, and lower-waste process cycles. Research points to greener solvents and closed-loop energy systems that cut down on emissions, setting a new standard for chemical manufacturing. While regulatory agencies tighten both environmental and workplace standards, smart handling and responsive quality management keep production lines safe. Building out infrastructure for safe collection, labeling, and documentation makes it easier for everyone touching the product to avoid unnecessary risk and safeguard public health.
Molecular Formula: C21H30O4
Molecular Weight: 346.46 g/mol
HS Code: 2937230000
Appearance: White/off-white flakes, powder, or crystals
Melting Point: 230-240°C
Density: ~1.2 g/cm³
Solubility: Good in most organic solvents, low in water
Packing: Sealed drums, moisture-resistant containers
Purity: Typically above 98%
Storage: Cool, dry, protected from light
Hazards: Avoid prolonged exposure, wear protective equipment, handle spills with care
Every year sees rising demand for reliable, safe, and well-characterized raw materials in pharma and research sectors. Factories that keep their eyes on purity and ecological footprint find themselves ahead in both compliance and market access. Real-world handling and usage show the importance of standardized, detailed chemical profiles and packaging that stands up to long hauls and changing weather. Good chemistry puts people and planet first, and ongoing updates to manufacturing practice reflect those commitments.
